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  • enzymology
  • In enzymology, a homoserine kinase (EC 2.7.1.39) is an enzyme that catalyzes the chemical reaction ATP + L-homoserine ⇌ {\displaystyle \rightleftharpoons } ADP + O-phospho-L-homoserine Thus, the two substrates of this enzyme are ATP and L-homoserine, whereas its two products are ADP and O-phospho-L-homoserine. (wikipedia.org)
  • In enzymology, a ceramide kinase, also abbreviated as CERK, (EC 2.7.1.138) is an enzyme that catalyzes the chemical reaction: ATP + ceramide ⇌ {\displaystyle \rightleftharpoons } ADP + ceramide 1-phosphate Thus, the two substrates of this enzyme are ATP and ceramide, whereas its two products are ADP and ceramide-1-phosphate. (wikipedia.org)
  • phosphorylates
  • Pyridoxamine kinase phosphorylates B6 vitamers and functions in a salvage pathway. (ebi.ac.uk)
  • One hypothesis for the functionality of the "open" conformation is that the "open" conformation may assist in the initial nucleoside binding and the release of the monophosphate product Deoxycytidine kinase (dCK) phosphorylates several deoxyribonucleosides and their nucleoside analogues (a nucleoside with a sugar and a different nucleic acid base substitute or analogue that has unique properties when modified) using phosphate groups from ATP and UTP. (wikipedia.org)
  • ubiquitous
  • In addition to those three cytosolic CK isoforms, there are two mitochondrial creatine kinase isoenzymes, the ubiquitous and sarcomeric form. (wikipedia.org)
  • diphosphate Thymidylate kinase is an ubiquitous enzyme of about 25. (ebi.ac.uk)
  • The first X-ray structures of Creatine Kinases, those of both mitochondrial types (sarcomeric-mtCK (in 1996) and ubiquitous mtCK (in 2000), forming highly four-symmetrical octameric structures, as well as that of cytosolic brain-type BB-CK (at 1.4 Angstoms, in 1999), forming symmetric dimers, have been solved by the T. Wallimann and W. Kabsch groups at ETH-Zürich and at MPI-Heidelberg. (wikipedia.org)
  • pyruvate kinase
  • Differential behavior of missense mutations in the intersubunit contact domain of the human pyruvate kinase M2 isozyme. (springer.com)
  • Pyruvate kinase M2: A potential target for regulating inflammation. (springer.com)
  • Anitha M, Kaur G, Baquer NZ, Bamezai R. Dominant negative effect of novel mutations in pyruvate kinase-M2. (springer.com)
  • Different expression of placental pyruvate kinase in normal, preeclamptic and intrauterine growth restriction pregnancies. (springer.com)
  • Chen J, Xie J, Jiang Z, Wang B, Wang Y, Hu X. Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2. (springer.com)
  • Reexpression of pyruvate kinase M2 in type 1 myofibers correlates with altered glucose metabolism in myotonic dystrophy. (springer.com)
  • Dominant negative mutations affect oligomerization of human pyruvate kinase M2 isozyme and promote cellular growth and polyploidy. (springer.com)
  • Pyruvate kinase M2: regulatory circuits and potential for therapeutic intervention. (springer.com)
  • Harada K, Saheki S, Wada K, Tanaka T. Purification of four pyruvate kinase isozymes of rats by affinity elution chromatography. (springer.com)
  • Resveratrol inhibits cancer cell metabolism by down regulating pyruvate kinase M2 via inhibition of mammalian target of rapamycin. (springer.com)
  • Pyruvate kinase M2 and cancer: an updated assessment. (springer.com)
  • Missense mutations in pyruvate kinase M2 promote cancer metabolism, oxidative endurance, anchorage independence, and tumor growth in a dominant negative manner. (springer.com)
  • 1994. Structure of rabbit muscle pyruvate kinase complexed with Mn 2+ , K + , and pyruvate. (siumed.edu)
  • Inhibitor
  • The Kinase Selectivity Profiling Systems provide a convenient 8-tube strip format that is optimized for fast and simple kinase inhibitor profiling. (promega.com)
  • Imatinib - This is tyrosine kinase inhibitor used to treat various different cancers, developed by Novartis and marketed under the name Gleevec. (news-medical.net)
  • Sorafenib - Developed and marketed by Bayer and Onyx Pharmaceuticals, this kinase inhibitor is used to treat advanced renal cell carcinoma and hepatocellular carcinoma. (news-medical.net)
  • Dasatinib - This is a tyrosine kinase inhibitor developed by Bristol-Myers Squibb and approved for use by the US FDA in 2006 for the treatment of chronic myelogenous leukemia. (news-medical.net)
  • Sunitinib - This is a multi-targeted tyrosine kinase inhibitor developed by Pfizer and approved for use by the US FDA in 2006 for the treatment of renal cell carcinoma and imatinib-resistant gastrointestinal stromal tumor. (news-medical.net)
  • Erlotinib - Erlotinib is a reversible tyrosine kinase inhibitor that acts on EGFR, to treat pancreatic cancer, non-small cell lung cancer and several other cancers. (news-medical.net)
  • Nilotinib - Marketed under the trade name Tasigna, this small molecule tyrosine kinase inhibitor is used to treat imatinib-resistant chronic myelogenous leukemia. (news-medical.net)
  • Vandetanib - This drug is a kinase inhibitor of several receptors including VEGFR, EGFR and the RET-tyrosine kinase in the treatment of some thyroid cancers. (news-medical.net)
  • Pazopanib - This multi-targeted receptor tyrosine kinase inhibitor is used in the treatment of renal cell carcinoma and soft tissue carcinoma. (news-medical.net)
  • Kinase Inhibitor - What is a Kinase Inhibitor? (news-medical.net)
  • cyclin
  • cyclin dependent kinases (CDKs). (ebi.ac.uk)
  • The key cell cycle kinases are polo-like kinase (PLK), cyclin-dependent kinase (CDK), and aurora kinases (AURK), which are evolutionarily conserved in eukaryotes from yeast to humans (Vaid et al. (springer.com)
  • The polo-like kinase Plx1 is required for activation of the phosphatase Cdc25C and cyclin B-Cdc2 in Xenopus oocytes. (springer.com)
  • phosphatidylinositol
  • Ceramide kinase has also been demonstrated to regulate localization and level of phosphatidylinositol 4,5-bisphosphate (PIP2) produced from NORPA, a phospholipase C homolog in Drosophila melanogaster. (wikipedia.org)
  • 1989
  • The three RAF kinase family members are: A-RAF B-RAF c-Raf Rossomando AJ, Payne DM, Weber MJ, Sturgill TW (1989). (wikipedia.org)
  • Janus
  • The four JAK family members are: Janus kinase 1 (JAK1) Janus kinase 2 (JAK2) Janus kinase 3 (JAK3) Tyrosine kinase 2 (TYK2) Transgenic mice that do not express JAK1 have defective responses to some cytokines, such as interferon-gamma. (wikipedia.org)
  • humans
  • Leukocyte receptor tyrosine kinase is an enzyme that in humans is encoded by the LTK gene. (wikipedia.org)
  • Vaid R, Sharma N, Chauhan S, Deshta A, Dev K, Sourirajan A. Functions of polo-like kinases: a journey from yeast to humans. (springer.com)
  • Mutations in kinases that lead to a loss-of-function or gain-of-function can cause cancer and disease in humans, including certain types of leukemia and neuroblastomas, glioblastoma, spinocerebellar ataxia (type 14), forms of agammaglobulinaemia, and many others. (wikipedia.org)
  • More than five hundred different kinases have been identified in humans. (wikipedia.org)
  • In humans dolichol kinase is encoded by the DOLK gene. (wikipedia.org)
  • Deoxycytidine kinase (dCK) is an enzyme which is encoded by the DCK gene in humans. (wikipedia.org)
  • In humans, the genes NADK and MNADK encode NAD+ kinases localized in cytosol and mitochondria, respectively. (wikipedia.org)
  • dTMP
  • The function of dTMP kinase in eukaryotes comes from the study of a cell cycle mutant, cdc8, in Saccharomyces cerevisiae. (wikipedia.org)
  • Structural and functional analyses suggest that the cDNA codes for authentic human dTMP kinase. (wikipedia.org)
  • Human
  • Crystal structure of human brain-type creatine kinase with ADP and creatine. (wikipedia.org)
  • Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes. (springer.com)
  • However, in terms of signalling outputs and disease relevance, both kinases and pseudokinases are important signalling modulators in human cells, making kinases very important drug targets. (wikipedia.org)
  • Butyrate kinase is active within the human colon. (wikipedia.org)
  • catalytic
  • Since the consensus sequence residues of a target substrate only make contact with several key amino acids within the catalytic cleft of the kinase (usually through hydrophobic forces and ionic bonds ), a kinase is usually not specific to a single substrate, but instead can phosphorylate a whole "substrate family" which share common recognition sequences. (wikipedia.org)