• LAK cells are also capable of acting against cells that do not display the major histocompatibility complex, as has been shown by the ability to cause lysis in non-immunogenic, allogeneic and syngeneic tumors. (wikipedia.org)
  • LAK cells, along with the administration of IL-2 have been experimentally used to treat cancer in mice and humans, but there is very high toxicity with this treatment - Severe fluid retention was the major side effect of therapy, although all side effects resolved after interleukin-2 administration was stopped. (wikipedia.org)
  • PCI cells showed augmented ICAM-1 and HLA-ABC expression when incubated with interferon γ (IFNγ) and tumour necrosis factor α. (semanticscholar.org)
  • The biological relevance of innate sources of IL-10 was suggested by the finding that IL-10 −/− SCID mice, which lack B and T cells, exhibit improved survival following T. gondii infection compared with SCID mice ( 7 ). (jimmunol.org)
  • Taken together, these reports indicate major biological functions for NK cell-derived IL-10 in a variety of viral, bacterial, and parasitic infections. (jimmunol.org)
  • RATIONALE: Biological therapies use different ways to stimulate the immune system and stop tumor cells from growing. (clinicaltrials.gov)
  • Combining biological therapies with indomethacin and cyclophosphamide may kill more tumor cells. (clinicaltrials.gov)
  • The AHR is a ligand-activated transcription factor that interacts with a structurally diverse array of ligands, which comprise synthetic compounds such as 2,3,7,8-tetrachlorodibenzo- p -dioxin and endogenous molecules, which include certain tryptophan and arachidonic acid metabolites ( 12 ). (jimmunol.org)
  • The cells kill by releasing small cytoplasmic granules of proteins called perforin and granzyme that cause the target cell to die by apoptosis . (bionity.com)
  • They were named "natural killers" because of the initial notion that they do not require activation in order to kill cells that are "missing self" markers of major histocompatibility complex (MHC) class I . However, it is now known that the cells are activated. (bionity.com)
  • Overexpression of Nrf2 inhibited the PBK/TOPK KD-induced decrease in cdc2 and cyclin B expression and cell cycle arrest, and blocked ROS production and apoptosis. (nih.gov)
  • Upon release in close proximity to a cell slated for killing, perforin forms pores in the cell membrane of the target cell through which the granzymes and associated molecules can enter, inducing apoptosis . (bionity.com)
  • lysing a virus-infected cell would only release the virions, whereas apoptosis leads to destruction of the virus inside. (bionity.com)
  • The result showed that the decreased level of GSH induced necrotic cell death, while the increased GSH induced apoptosis. (nii.ac.jp)
  • As these are stress-molecules, released by cells upon viral infection, they serve to signal to the NK-cell the presence of viral pathogens. (bionity.com)
  • A common evolutionary adaption to this seen in both intracellular microbes and tumours is a chronic down-regulation of these MHC I molecules, rendering the cell impervious to T-cell mediated immunity. (bionity.com)
  • 3086432 ). These NK cell subsets lack CD3 expression and are phenotypically and functionally distinct. (miltenyibiotec.com)
  • Additional NK cell subsets can be identified according to their tissue distribution. (miltenyibiotec.com)
  • These IL-2-pulsed LAK cells express cytolytic activity comparable to that of nonpulsed PBMC (cultured continuously in IL-2) at 3 days of culture. (aacrjournals.org)
  • The acquisition of cytolytic activity followed the same kinetics for both pulsed and nonpulsed mononuclear cells and was maintained when tested at day 7. (aacrjournals.org)
  • Interestingly, only PBMC obtained from cancer patients receiving in vivo IL-2 infusions could be induced to generate the same levels of cytolytic activity as those in nonpulsed cells using this pulse procedure. (aacrjournals.org)
  • Our study demonstrates that for the generation of maximum LAK cell cytolytic activity, LAK cell precursors must be primed in vivo with IL-2. (aacrjournals.org)
  • Serum obtained from cancer patients undergoing IL-2/LAK cell therapy did not inhibit the maturation of the pulsed mononuclear cells into LAK cells. (aacrjournals.org)
  • Improved understanding of the cellular and molecular basis of renal cell carcinoma recognition opens new avenues of research with the potential to develop better immunotherapies for patients with metastatic disease. (curehunter.com)
  • Active cellular therapies usually involve the removal of immune cells from the blood or from a tumor. (wikipedia.org)
  • The result showed the heterogeneity among the cell lines. (nii.ac.jp)
  • GM3 showed positive and negative threshould of antibody binding, and GM2 gave stronger reaction when GM3 co-existed nearly equally on the cell surface. (nii.ac.jp)
  • The results may suggest better antibody react ions against the mitotic cells. (nii.ac.jp)
  • In another experiment, we have found that the cell dendity greatly affects the level of antibody binding against GM3. (nii.ac.jp)
  • Implementation of this procedure could eliminate the high cost of cell culture which normally accompanies IL-2/LAK cell therapy. (aacrjournals.org)
  • Such an approach could make IL-2/LAK cell therapy more accessible for cancer patients. (aacrjournals.org)
  • Phase I/II study of inhaled doxorubicin combined with platinum-based therapy for advanced non-small cell lung cancer. (semanticscholar.org)
  • Plasmapheresis is a type of medical therapy involving separation of plasma from red blood cells. (bionity.com)
  • Correlate the lytic activity or lymphokine production of TIL (generated in culture from the patient's tumor) with clinical response to therapy. (clinicaltrials.gov)
  • V. Generate and use lymphokine-activated killer (LAK) cells in those patients who do not have TIL available for therapy and evaluate LAK cells in the same manner as TIL. (clinicaltrials.gov)
  • The only US-approved cell-based therapy is Dendreon's Provenge, for the treatment of prostate cancer. (wikipedia.org)
  • Patients deficient in NK cells prove to be highly susceptible to early phases of herpes virus infection. (bionity.com)
  • Second-line age-adjusted International Prognostic Index in patients with advanced non-Hodgkin lymphoma after T-cell depleted allogeneic hematopoietic SCT. (nih.gov)
  • Transplantation in remission improves the disease-free survival of patients with advanced myelodysplastic syndromes treated with myeloablative T cell-depleted stem cell transplants from HLA-identical siblings. (nih.gov)
  • Prognostic impact of the Controlling Nutritional Status score following curative nephrectomy for patients with renal cell carcinoma: Erratum. (annals.org)
  • The pathogenesis of group A streptococcal cell wall-induced polyarthritis in the rat: comparative studies in arthritis resistant and susceptible inbred rat strains. (springer.com)
  • The 4 main resistant factors, drug influx, efflux, DNA-Pt adducts and DNA repair, were investigated concerning CDDP sensitivity using several ca … More ncer cell lines. (nii.ac.jp)