• In vivo, in acute kidney injury (AKI) and chronic kidney disease (CKD, fibrosis) patients, soluble AREG is indeed highly upregulated in human urine, and both ADAM17 and AREG expression show strong positive correlation with fibrosis markers in related kidney biopsies. (jci.org)
  • Prolonged expression of Kim-1, however, leads to inflammation and tubule damage, mimicking chronic kidney disease. (grantome.com)
  • The findings from this study will shed light on the role of Kim-1 in acute and chronic kidney injury, as well as highlight the potential therapeutic benefits of modulating Kim-1 function in kidney injury. (grantome.com)
  • This study will highlight the role of Kim-, the most upregulated protein in the injured proximal tubule, in kidney injury and illustrate the therapeutic potential of modulating Kim-1 in acute and chronic kidney injury. (grantome.com)
  • Chronic kidney disease is a substantial health problem effecting a large portion of the US population. (bu.edu)
  • Presence of excess protein, particularly albumin, in the urine of patients with chronic kidney disease is an independent risk factor for cardiovascular disease and progression to end stage renal disease. (bu.edu)
  • This thesis will explore the results of these two studies in the context of proximal tubule damage in chronic kidney disease, and discuss the potential for protein autophagy to improve our understanding and treatment of chronic kidney disease. (bu.edu)
  • Therefore, the major goal of the study is to analyse for the first time the host responses in kidney-transplant recipients with chronic HEV infection and to compare them to the host responses in kidney-transplant recipients without viral infection (controls), to identify a specific peripheral signature using blood microarray-based gene expression profiling. (bioportfolio.com)
  • If peripheral and liver signatures are parallel, peripheral signature may become a non-invasive tool of exploration of chronic HEV infection in kidney-transplant recipients. (bioportfolio.com)
  • Bone Biopsy Results in Chronic Kidney Disease: a Single-Center Experience. (bioportfolio.com)
  • Time to rethink the use of bone biopsy to prevent fractures in patients with chronic kidney disease. (bioportfolio.com)
  • The purpose of this review is to provide evidence to justify the use of bone biopsy data to guide decisions regarding fracture prevention in patients with chronic kidney disease (CKD). (bioportfolio.com)
  • Their blood pressure usually normalizes, but they quickly develop chronic kidney disease, which is characterized by reduced kidney function that worsens over time. (medlineplus.gov)
  • This project received funding from the National Institutes of Health to elucidate the mechanisms linking obesity, the gut microbiota, acid-base homeostasis, renal lipid abnormalities, and chronic kidney disease. (ttuhsc.edu)
  • Obesity increases the risk of chronic kidney disease (CKD), and is associated with accelerated CKD progression, but the pathogenic mechanisms linking obesity to CKD are incompletely understood. (ttuhsc.edu)
  • High water hardness associated with high water fluoride and the geographical distribution of Chronic Kidney Disease of unknown etiology (CKDu) in Sri Lanka are well correlated. (fluoridealert.org)
  • Chronic kidney disease (CKD) is viewed as part of the rising worldwide non-communicable disease burden. (fluoridealert.org)
  • Due to the elusive nature of the disease, it has been named "Chronic Kidney Disease of unknown etiology" (CKDu). (fluoridealert.org)
  • Kidney, Renal tubule - Vacuolation, Cytoplasmic in a treated male B6C3F1 mouse from a chronic study. (nih.gov)
  • Indeed, advances in biomarker discovery and a greater appreciation of tubulointerstitial histopathology and the role of tubular hypoxia in the pathogenesis of chronic kidney disease have given us pause to reconsider the current "glomerulocentric" paradigm and focus attention on the proximal tubule that by virtue of the high energy requirements and reliance on aerobic metabolism render it particularly susceptible to the derangements of the diabetic state. (diabetesjournals.org)
  • Bioactive lipids are altered in the kidney of chronic undernourished rats: is there any correlation with the progression of prevalent nephropathies? (biomedcentral.com)
  • Undernutrition during childhood leads to chronic diseases in adult life including hypertension, diabetes and chronic kidney disease. (biomedcentral.com)
  • Here we explore the hypothesis that physiological alterations in the bioactive lipids pattern within kidney tissue might be involved in the progression of chronic kidney disease. (biomedcentral.com)
  • Results point to an imbalance in the bioactive lipid generation with further consequences to key events related to kidney function, thus contributing to the establishment of chronic kidney disease. (biomedcentral.com)
  • The team already used their technology to study how glucose is transported from the proximal tubules into the blood vessels and how hyperglycemia, a common diabetes-related condition, can wreak havoc on the kidneys. (medgadget.com)
  • substances passed along by the proximal convoluted tubule, from which most of the dissolved components needed by the body-particularly glucose, amino acids, and sodium bicarbonate-have been reabsorbed into the blood. (britannica.com)
  • 90% of the kidney cortex) engage in active uptake and transepithelial transport of glucose, but only a small amount of glucose, if any, is used for ATP production ( 14 ). (diabetesjournals.org)
  • Moreover, diabetes causes a decrease in kidney glucose oxidation due to the inhibition of pyruvate dehydrogenase activity ( 15 ). (diabetesjournals.org)
  • Sglt2 −/− mice had glucosuria, polyuria, and increased food and fluid intake without differences in plasma glucose concentrations, GFR, or urinary excretion of other proximal tubular substrates (including amino acids) compared with WT mice. (asnjournals.org)
  • As a consequence of renal glomerular filtration, approximately 180 g/d glucose enter the tubular system of the kidneys in a healthy individual with normoglycemia, which is equivalent to approximately one third of the total energy consumed by the human body. (asnjournals.org)
  • The Role of the Kidney in Glucose HomeostasisMaria Mota1, Eugen Mota2 and Ilie-Robert Dinu2 Department of Diabetes, Nutrition, Metabolic Diseases, University of Medicine and Pharmacy Craiova, Romania Department of Nephrology, University of Medicine and Pharmacy Craiova, Romania1. (amazonaws.com)
  • IntroductionIt is only in recent years that the attention was drawn on the important role of the kidney in glucose homeostasis. (amazonaws.com)
  • Role of the Kidney in Normal Glucose Homeostasis and in the Hyperglycaemia of Diabetes Mellitus: Therapeutic Implications. (amazonaws.com)
  • The Relationship of Kidney Function to the Glucose Utilization of the Extraabdominal Tissues. (amazonaws.com)
  • The Role of Kidney in Glucose Homeostasis - SGLT2 Inhibitors, a New Approach in Diabetes Treatment. (amazonaws.com)
  • Early non-human studiesThe first researchers in this field, Bergman and Drury brought the first clues about the involvement of the kidney in glucose homeostasis in 1938 . (amazonaws.com)
  • Journal Article] Dual regulation of gluconeogenesis by insulin and glucose in the proximal tubules of the kidney. (nii.ac.jp)
  • But other parts of the kidneys, the proximal tubules, are charged with returning wanted nutrients back into the body. (medgadget.com)
  • The upper parts of the kidneys are partially protected by the eleventh and twelfth ribs, and each whole kidney is surrounded by two layers of fat (the perirenal and pararenal fat) which help to cushion it. (bionity.com)
  • It has also been used to prevent methotrexate-induced kidney damage by alkalinalizing one's urine, hence speeding up methotrexate excretion by increasing its solubility in urine. (wikipedia.org)
  • These two effects would lead to increased synthesis of dopamine and decreased serotonin synthesis by the proximal tubule, an effect that would be expected to decrease in vivo serotonin excretion. (physiology.org)
  • Mechanisms of active H + secretion in the proximal tubule. (springer.com)
  • The effects of angiotensin II on total ammonia (tNH3) production and net secretion were investigated using in vitro microperfused mouse S2 proximal tubule segments incubated in Krebs-Ringer bicarbonate buffer containing 0.5 mM L-glutamine. (nih.gov)
  • Luminal secretion of ammonia in the mouse proximal tubule perfused in vitro. (nih.gov)
  • The emphasis is on gastric acid secretion and the role of the H+, K+-ATPase, but molecular and cellular information on other P-, V- and F-type H+-ATPases, in bone, kidney, plants and yeast, as well as other cation ATPases, are included for important comparisons. (ebooks.com)
  • Early prediction of polymyxin-induced nephrotoxicity with next-generation urinary kidney injury biomarkers," Toxicological Sciences , vol. 137, no. 2, Article ID kft247, pp. 278-291, 2014. (hindawi.com)
  • A recent study in rats indicates that urinary AGT originates from the AGT formed and secreted in the proximal tubules, and not from AGT in plasma [ 12 ]. (ijbs.com)
  • A few selected membranes in the kidney , amphibian urinary bladder , and erythrocyte have very high water permeability and are thought to contain specialized water transporting units termed " water channels . (ndif.org)
  • In this module, we turn our attention to the urinary system and specifically to the functions of the kidney, a filter of the blood. (coursera.org)
  • Localization of D-amino acid oxidase mRNA in the mouse kidney and the effect of testosterone treatment' Histochemistry and Cell Biology. (nii.ac.jp)
  • Fully polarized proximal tubules, closed lumen, hundreds of structures per well more mature phenotype, high level of megalin, OAT1, OCT2 and CYP3A4 expression. (cytoo.com)
  • A mass of dense hemoglobin completely fills the tubule lumen and outlines the microvilli (MV) of the brush border. (ucsd.edu)
  • These genes are involved in the renin-angiotensin system, which regulates blood pressure and the balance of fluids and salts in the body and plays a role in kidney development before birth. (medlineplus.gov)
  • Changes in glomerular structure such as mesangial expansion, reduction in capillary surface, and podocyte loss are undoubtedly major features of diabetic kidney disease that help differentiate it from other forms of glomerulonephritis. (diabetesjournals.org)
  • These findings are, however, juxtaposed with the more recent knowledge that some patients with advanced disease display neither substantial glomerular pathology nor proteinuria and that kidney function declines well before traditional indicators of kidney disease such as microalbuminuria or creatinine-based estimated glomerular filtration rate (eGFR) decline ( 2 ). (diabetesjournals.org)
  • Moreover, the diabetes-induced injury to the proximal tubule may in turn lead to glomerular pathology and postglomerular hypoperfusion, while fibrotic expansion of the interstitium compresses and further disrupts the local microvasculature. (diabetesjournals.org)
  • Our preliminary data suggest that Kim-1-mediated phagocytosis induces autophagy and cytoprotection in PTCs following acute kidney injury. (grantome.com)
  • Structural changes in the proximal tubule of kidneys from hypophysectomized rats. (elsevier.com)
  • 2016. Proteomic Analysis of Minimally Damaged Renal Tubular Tissue from Two-Kidney-One-Clip Hypertensive Rats Demonstrates Extensive Changes Compared to Tissue from Controls. (uib.no)
  • Membrane fractions from kidney homogenates of undernourished rats (RBD) were submitted to lipid extraction and analysis by thin layer chromatography and cholesterol determination. (biomedcentral.com)
  • Kidneys from RBD rats had 25% lower cholesterol content, which disturb membrane microdomains, affecting Ca 2+ homeostasis and the enzymes responsible for important lipid mediators such as phosphatidylinositol-4 kinase, sphingosine kinase, diacylglicerol kinase and phospholipase A 2 . (biomedcentral.com)
  • Ceramide levels are augmented in kidney tissue from RBD rats (18.7 ± 1.4 vs. 21.7 ± 1.5 fmol.mg −1 .min −1 ) indicating an ongoing renal lesion. (biomedcentral.com)
  • In this study, the suppression subtractive hybridization (SSH) method was used to generate up- and down-regulated subtracted cDNA libraries in the kidney of streptozotocin (STZ)-induced diabetic rats. (mdpi.com)
  • The down- and up-regulated cDNA libraries differentially expressed in the kidney of STZ diabetic rats have been successfully constructed and some identified genes could be highly important in DN. (mdpi.com)
  • Selenocysteine Se -conjugates have previously been proposed as kidney-selective prodrugs of pharmacologically active selenols because of their active uptake and bioactivation by cysteine conjugate β-lyases in the kidney. (aspetjournals.org)
  • Likewise, infusion of equimolar amounts of the kidney-specific precursors for dopamine and serotonin, γ- l -glutamyl- l -DOPA or γ- l -glutamyl 5-HTP in humans showed no evidence of competitive inhibition of synthesis of either amine ( 20 ). (physiology.org)
  • In humans, the kidneys are located in the posterior part of the abdomen . (bionity.com)
  • For undamaged tubules a basal rate was obtained followed by activation with 15 μM carbonyl cyanide 289 290 291 and 292 ions (t-butyldimethylsilyl derivatives of succinate) was recorded and plotted against the corresponding concentration by using linear regression analysis. (stopvivisection.info)
  • The expression of the D-amino-acid oxidase gene in the mouse kidney was examined by in situ hybridization. (nii.ac.jp)