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  • alterations
  • Specifically, the fibroblasts become enlarged and show increased activity of 5'-nucleotidase, and the S1 segment of the proximal tubule shows similar alterations as in various models of hypoxia. (uni-regensburg.de)
  • progression
  • A clearer picture of AGT expression in the proximal tubules is therefore important for understanding the development and progression of DN. (ijbs.com)
  • Moreover, empagliflozin slowed kidney disease progression and reduced the need for renal replacement therapy. (springer.com)
  • Further analysis will determine the kidney meprin targets and metabolic pathways which play a role in the progression of DN. (rti.org)
  • mice
  • ADAM17 hypomorphic mice, specific ADAM17 inhibitor-treated WT mice, or mice with inducible KO of ADAM17 in proximal tubule (Slc34a1-Cre) were significantly protected against these effects. (jci.org)
  • fatty
  • Mitochondrial fatty acid oxidation is the source of the increased net ROS production, and the site of electron leakage is located proximal to coenzyme Q at the electron transfer flavoprotein that shuttles electrons from acyl-CoA dehydrogenases to coenzyme Q. (diabetesjournals.org)
  • selective
  • Our kidneys are designed to filter out all kinds of impurities from the blood stream, a process that's not particularly selective. (medgadget.com)
  • When the glomeruli and proximal tubules work well together, filtration and selective re-absorption ensure the purity and essence of our natural fluids. (medgadget.com)
  • injury
  • Early prediction of polymyxin-induced nephrotoxicity with next-generation urinary kidney injury biomarkers," Toxicological Sciences , vol. 137, no. 2, Article ID kft247, pp. 278-291, 2014. (hindawi.com)
  • Kidney fibrosis following kidney injury is an unresolved health problem and causes significant morbidity and mortality worldwide. (jci.org)
  • Enzyme-linked immunosorbent assays (ELISA) were used to determine the levels of two tubular kidney injury markers, neutrophil gelatinase associated lipocalin (NGAL) and kidney injury molecule 1 (KIM-1). (rti.org)
  • blood
  • The tubules and accompanying blood vessels are 3D printed right next to each other inside an extracellular matrix. (medgadget.com)
  • This is a big leap over previous research that led to the development of the proximal tubules, but without the matching blood vessels. (medgadget.com)
  • The reabsorbed molecules move into the interstitial fluid of the kidney and are absorbed back into the blood. (sciencephoto.com)
  • various
  • The technology mimics the re-absorptive properties of the proximal tubules and it can be used to test various drugs and other therapies in order to evaluate how they would perform in a real kidney. (medgadget.com)