• My group's research focuses on the cardiovascular risk associated with the spectrum of chronic kidney disease from early in the disease trajectory through to end-stage renal failure requiring either dialysis or kidney transplantation. (ed.ac.uk)
  • Using large datasets, we are investigating the role of high-sensitivity troponin I (and other cardiovascular biomarkers) as a measure of outcome in patients with CKD and those undergoing kidney transplantation. (ed.ac.uk)
  • 10 ] showed that the transplantation of mouse ESCs-derived RPCs can result in the stable integration into proximal tubules with normal morphology and normal polarization injection into developing live newborn mouse kidneys, suggesting the potential of ESCs for application in regenerative therapies. (biomedcentral.com)
  • As a review article, we have a timely overview on COVID-19 in kidney transplantation related to epidemiology, patient management and impact. (tts.org)
  • In liver transplantation, tissue damage at reperfusion is mostly correlated with warm and cold ischemia times and leads in turn to poor graft function [13] and biliary complications [14,15]. (123dok.net)
  • The Food and Drug Administration (FDA) is announcing a public workshop to discuss the effects of ischemia/ reperfusion injury ( IRI ) on outcomes in kidney transplantation. (myast.org)
  • Recent studies have demonstrated that transplantation of functional endothelial cells into ischemic kidney provided a dramatic renoprotective effect. (scienceopen.com)
  • Although kidney transplantation has been an important means for the treatment of patients with end stage of renal disease, the long-term survival rate of the renal allograft remains a challenge. (biomedcentral.com)
  • Identified mechanisms involved in IF/TA after kidney transplantation. (biomedcentral.com)
  • Kidney Transplantation The facts regarding operation methods have been released elsewhere (7). (gasyblog.com)
  • To overcome the shortage of kidney donors, diverse methods have been utilized, including living donor kidney transplantation (LDKT) and extended criteria for deceased donor grafts. (ekjt.org)
  • However, in Jeju, deceased donor kidney transplantation (DDKT) has been restricted due to the prolonged cold ischemia time (CIT) caused by the island's geographic disadvantages and transportation limitations. (ekjt.org)
  • The first successful LDKT in Jeju was significant in that kidney transplantation was implemented by compensating for its geographic limitations. (ekjt.org)
  • Living donor kidney transplantation (LDKT) has also become a major treatment option, with living donor grafts demonstrating similar or better graft survival rates compared to deceased donors. (ekjt.org)
  • Since the first kidney transplantation in South Korea in 1969, the significant benefit of kidney transplantation over dialysis in terms of quality of life and life expectancy has led to a rapid rise in transplant cases nationwide. (ekjt.org)
  • However, kidney transplantation for patients with end-stage renal disease (ESRD) has seldom been performed on Jeju Island. (ekjt.org)
  • Since the first case of deceased kidney transplantation in 1995, only 50 cases of deceased donor kidney transplantation (DDKT) have been performed. (ekjt.org)
  • These results suggested that HSP90β is involved in the process of cerebral ischemia‑reperfusion injury in rats and that inhibition of HSP90β expression increases EAAT2 levels, conferring a neuroprotective effect in MCAO model rats. (spandidos-publications.com)
  • This could lead to an acute kidney injury. (wikipedia.org)
  • While developmental senescence and acute senescence may positively contribute to the fine-tuning of embryogenesis and injury repair, chronic senescence, when unresolved promptly, plays a crucial role in kidney fibrogenesis and CKD progression. (frontiersin.org)
  • 2. The transition from acute kidney injury (AKI) through to chronic kidney disease. (ed.ac.uk)
  • Acute kidney injury (AKI) is a severe disease with high morbidity and mortality. (biomedcentral.com)
  • Acute kidney injury (AKI) is characterized by acute tubular injury and a rapid decline in renal function [ 1 ]. (biomedcentral.com)
  • In response to acute injury, the adult kidney shows some level of regeneration characterized by the proliferation of the surviving cells and the replacement of the necrotic tubular cells with functional tubular epithelium [ 3 ]. (biomedcentral.com)
  • For many years, chronic allograft nephropathy (CAN) was used to describe the progressive loss of renal function in transplanted kidneys over time not related to acute rejection. (biomedcentral.com)
  • Ferroptosis plays an important regulatory role in the occurrence and development of many diseases, such as tumors, neurological diseases, acute kidney injury, ischemia/reperfusion, etc. (nature.com)
  • In-hospital mortality, long-term mortality, acute kidney injury (AKI), and the requirement of continuous renal replacement therapy (CRRT) were assessed as endpoints. (biomedcentral.com)
  • Partial kidney ischemia-reperfusion (IR) injury is the principal cause of acute kidney injury. (hindawi.com)
  • IR promotes a cascade of molecular events that lead to renal vascular and tubular damage and, ultimately, acute kidney injury (AKI) [ 2 - 4 ]. (hindawi.com)
  • Adapted from de Geus HR, Betjes MG, Bakker J. Biomarkers for the prediction of acute kidney injury: a narrative review on current status and future challenges. (medscape.com)
  • To investigate the effect of sevoflurane on renal ischemia-reperfusion injury (IRI) in rats and its regulatory effect on reperfusion injury salvage kinase (RISK) signaling pathway. (ajol.info)
  • Sevoflurane represses the release of inflammatory factors, lowers ROS level and apoptosis of renal cells and improves renal function through activation of RISK signaling pathway in kidney tissues of rats with renal IRI. (ajol.info)
  • We then established the rat ischemia-reperfusion injury (IR) model and transplanted the iPSC-derived RPCs into the injured rats in combination with the hydrogel. (biomedcentral.com)
  • Rats, subjected to bilateral renal ischemia (45 min) followed by reperfusion (6 h), were administered EUK-134 (0.3 and 3 mg/kg, i.v.) prior to and during reperfusion, after which biochemical and histological indicators of renal dysfunction and injury were measured. (scienceopen.com)
  • However, EUK-134 also reduced nitrosative stress caused by I/R in vivo (reduction of iNOS expression and nitrotyrosine formation), which was reflected by a significant reduction in serum NO levels in rats subjected to renal I/R. Specifically, serum NO levels were reduced from 57 ± 12 (n = 12, I/R only) to 23 ± 3 m M (n = 12, I/R +3 mg/kg EUK-134). (scienceopen.com)
  • In two models of partial renal IR with and without ischemia preconditioning (IPC) and using Mas receptor (MasR) blockade, A779 or its vehicle, the renal vascular responses to angiotensin II (Ang II) administration in two-kidney-one-clip (2K1C) hypertensive rats were determined. (hindawi.com)
  • The rats in the IR group underwent 45 min partial kidney ischemia, and the animals in the IPC + IR group underwent two 5 min cycles of partial kidney ischemia followed by 10 min reperfusion and partial kidney ischemia for 45 min. (hindawi.com)
  • These data revealed the important role of MasR after partial kidney IR in the responses of RBF and RVR to Ang II administration in 2K1C hypertensive rats. (hindawi.com)
  • however, DAXX mediates both Fas-dependent and TGF-beta-induced apoptosis and renal induction of TGF-beta is well documented in renal ischemia studies. (wikipedia.org)
  • Several signs and symptoms include injury to the microvascular endothelium, apoptosis of kidney cells due to overstress in the endoplasmic reticulum, dysfunctions of the mitochondria, autophagy, inflammation of the kidneys, and maladaptive repair. (wikipedia.org)
  • Using optical coherence tomography (OCT) we have recently shown that the retina and choroid are thinned in patients with CKD and this thinning relates to the degree of kidney dysfunction as well as inflammation and endothelial dysfunction. (ed.ac.uk)
  • The mechanisms leading to IF/TA in the transplanted kidney include inflammation, activation of renal fibroblasts, and deposition of extracellular matrix proteins. (biomedcentral.com)
  • ALA can prevent I/R injury by reducing the production of free radicals, scavenging free radicals, and reducing inflammation. (geronova.com)
  • N-acetylcysteine is known to impair hemostasis when used for the prevention of perioperative inflammation and ischemia-reperfusion injury. (medscape.com)
  • Blood vessels shrink and undergo apoptosis which results in poor blood flow in the kidneys. (wikipedia.org)
  • Several genetic pathways that lead to apoptosis of kidney cells have been implicated in mice models and in-vitro assays. (wikipedia.org)
  • This shows that the Fas-pathway may play a role in the pathogenesis of the apoptosis of tubule cells during the early ischemic-reperfusion period. (wikipedia.org)
  • Countering NADH production, calcium action on the mitochondrial permeability transition pores increases inner membrane permeability thereby reducing proton potential, causing the matrix to swell and ultimately releasing cytochrome c (an initiator of apoptosis). (benbest.com)
  • Reactive oxygen species (ROS) level was determined using 2,7-dichlorodi-hydro fluorescein diacetate (DCFHDA) while Western blotting was used to determine the expression of apoptosis- and RISK signaling pathway-related proteins in kidney tissues. (ajol.info)
  • Our results revealed that iPSC-derived RPCs can protect AKI rat from renal function impairment and severe tubular injury by up-regulating the renal tubules formation, promoting cell proliferation, reducing apoptosis, and regulating the microenvironment in the injured kidney. (biomedcentral.com)
  • A study has shown that neurons in the ischemic penumbra may undergo apoptosis hours or days after ischemia and alleviating ischemia reperfusion injury is an achievable therapeutic goal in the early intervention of ischemic stroke aimed at limiting the amount of infarction ( 4 ). (spandidos-publications.com)
  • The geography and resulting transportation limitations of Jeju place it at risk for prolonged cold ischemia time (CIT) in deceased donor kidney transplantations, especially in marginal donor grafts. (ekjt.org)
  • Therefore, the significance of LDKT for overcoming prolonged cold ischemia time (CIT) is greater than in other South Korean provinces. (ekjt.org)
  • citation needed] Kidney ischemia can be diagnosed by checking the levels of several biomarkers such as clusterin and cystatin C. While the duration of ischemia was used as a biomarker, it was found that it has significant flaws in predicting renal function outcomes. (wikipedia.org)
  • The development of improved immunosuppressants or, better yet, the development of agents that allow for immunologic tolerance would certainly provide improved clinical outcomes and potentially reduce the risk of infection. (medscape.com)
  • Our goals are to identify cardiovascular risk early in patients with CKD and, through to investigate novel therapies that might reduce this risk and so improve longer-term patient outcomes. (ed.ac.uk)
  • In population-based studies utilising high-fidelity linked healthcare data unique to Scotland, we are investigating temporal trends in the incidence and outcomes of cardiovascular disease, including rates of secondary prevention prescribing, in patients with kidney failure. (ed.ac.uk)
  • We are examining if short- and long-term ET receptor blockade will reduce cardiovascular risk in optimally managed patients with AAV. (ed.ac.uk)
  • On the sixth day, the cats were killed to determine the histological renal damage, renal function, the accumulation of arsenic, and antioxidant activities in the kidney. (springer.com)
  • Trans-resveratrol is a polyphenol with great antioxidant action that reduces the oxidative stress. (bvsalud.org)
  • Oxidative and nitrosative stress plays important roles in the pathogenesis of renal ischemia/reperfusion (I/R) injury. (scienceopen.com)
  • Age-related disorders such as chronic kidney disease (CKD) are increasingly prevalent globally and pose unprecedented challenges. (frontiersin.org)
  • 3. Chorioretinal thinning in chronic kidney disease. (ed.ac.uk)
  • 5. Assessment & treatment of cardiovascular disease in patients with chronic kidney disease. (ed.ac.uk)
  • In underdeveloped countries, diabetic nephropathy, the main glomerular disease, is recognized as one of the main causes for the appearance and evolution of chronic kidney disease (CKD). (scielo.br)
  • Chronic nephrotoxic effects of calcineurin inhibitors may be associated with late allograft dysfunction and reduced allograft half-life. (biomedcentral.com)
  • Renal fibrosis is the hallmark of chronic kidney disease progression and is characterized by an exaggerated wound-healing process with the production of renal scar tissue. (omicsdi.org)
  • Tubulointerstitial fibrosis is a common end point of chronic kidney diseases, and preventing its progression is key to avoiding renal failure. (omicsdi.org)
  • Previous studies have reported that the levels of urinary TFF3 are significantly increased in patients with chronic kidney disease. (omicsdi.org)
  • The ISN has written to the WHO requesting its support in convincing policymakers worldwide to immediately prioritize the vaccination of patients with advanced chronic kidney disease undergoing dialysis. (theisn.org)
  • Chronic kidney disease (CKD) is the highest risk comorbidity for severity of illness and death from COVID-191, and disproportionately affects the poor and disenfranchised. (theisn.org)
  • Here we review the current literature on scutellarin to provide a comprehensive understanding of the pharmacological activity, mechanism of action, toxicity, and therapeutic potential of scutellarin for the treatment of ischemia, diabetic complications, and other chronic diseases. (cdc.gov)
  • In studies of mice models, a high-fat diet can induce greater injury to the kidney with renal ischemia-reperfusion as compared to mice with normal diet. (wikipedia.org)
  • yet at the same time it can induce ischemia-reperfusion injury, which leads to brain damage both in the ischemic core and penumbra area. (spandidos-publications.com)
  • Possible causes of kidney ischemia include the activation of IL-17C and hypoxia due to surgery or transplant. (wikipedia.org)
  • Physical stress such as infarction, surgery and transplant may produce kidney ischemia. (wikipedia.org)
  • Moreover, renal ischemia can cause the delay of graft function after renal transplant and can cause rejection of the transplant. (wikipedia.org)
  • 50 transplant centers were included: 318 (66%) kidney or kidney/pancreas, 73 (15.1%) liver, 57 (11.8%) heart, and 30 (6.2%) lung. (tts.org)
  • The input from this public workshop will help in developing topics for further discussion and may serve to inform recommendations on clinical trial design for products for the mitigation of IRI and/or for the prophylaxis and/or treatment of delayed graft function ( DGF ) and related conditions in kidney transplant recipients. (myast.org)
  • In a 3-month protocol biopsy study in which biopsies were classified according to the presence or absence of arterial intimal thickening, graft survival was significantly reduced in patients with transplant vasculopathy [ 3 ]. (biomedcentral.com)
  • To reduce the frequency of this outcome, continuing improvements in the efficacy of antirejection drugs are a top priority to enhance the long-term survival of transplant recipients. (uthscsa.edu)
  • More complications happen when failure of the kidney functions result in toxicity in various parts of the body which may cause septic shock, hypovolemia, and a need for surgery. (wikipedia.org)
  • To reduce risks of diabetic complications, it would be possible to consider these candidate drugs instead of other drugs, given the same indications. (e-enm.org)
  • A randomized study by Di Biase was the first study showing that performing catheter ablation of atrial fibrillation (AF) without warfarin discontinuation reduces the occurrence of periprocedural stroke and minor bleeding complications compared with bridging with low-molecular-weight heparin (LMWH). (medscape.com)
  • In this review, we discuss current understanding of the role and mechanism of cellular senescence in kidney fibrosis. (frontiersin.org)
  • MasR as an antagonist of AT 1 R has renoprotective effect in a number of kidney disorders, including AKI, hypertensive and diabetic nephropathy, glomerulonephritis, and tubulointerstitial fibrosis [ 14 , 15 ]. (hindawi.com)
  • Among the factors that contribute to kidney fibrosis, the members of the platelet-derived growth factor (PDGF) family are among the best characterized ones. (omicsdi.org)
  • They appear to be the key factors in driving renal fibrosis, independent of the underlying kidney disease. (omicsdi.org)
  • Lysyl oxidase?like 2 is expressed in kidney tissue and is associated with the progression of tubulointerstitial fibrosis. (omicsdi.org)
  • However, little is currently known regarding LOXL2 expression in the kidney and its involvement in tubulointerstitial fibrosis. (omicsdi.org)
  • The aim of this study is to detect the TFF3 mRNA in kidney and elucidate the relationship between renal TFF3 mRNA and tubulointerstitial fibrosis in IgA nephropathy (IgAN). (omicsdi.org)
  • In conclusion, the intricate relations between endothelial and epithelial cells, based in part on the relations between endothelial and inducible nitric oxide synthases, are perturbed in renal ischemia primarily as a result of endothelial dysfunction precipitating epithelial injury. (scienceopen.com)
  • Using mouse models of ischaemia-reperfusion injury, we are investigating the cardiovascular and renal sequelae of AKI and examining new experimental medicine strategies to reduce the risks of developing these. (ed.ac.uk)
  • These sequelae of renal ischemia are a result of endothelial dysfunction, which is most probably responsible for the 'no-reflow' phenomenon and further aggravation of tubular ischemia during the early reperfusion period. (scienceopen.com)
  • Within two minutes of ischemia, extracellular pH can drop from about 7.3 to about 6.7. (benbest.com)
  • The concentrations of renal malondialdehyde, reactive oxygen species, 8-hydroxydeoxyguanosine, serum creatinine, blood urea nitrogen, and renal arsenic accumulation were significantly decreased and reduced renal morphologic injury was observed compared with the As 2 O 3 -treated group. (springer.com)
  • EUK-134 produced a significant reduction in renal dysfunction and injury caused by I/R. Specifically, serum creatinine levels, an indicator of renal dysfunction, were reduced from 227 ± 11 (n = 12, I/R only) to 146 ± 9 µ M (n = 12, I/R +3 mg/kg EUK-134). (scienceopen.com)
  • Follow-up Doppler ultrasonography showed good blood flow to the kidney, and his serum creatinine levels steadily decreased and remained stable. (ekjt.org)
  • Abstract Hepatic ischemia/reperfusion (I/R) injury is a common clinical challenge. (123dok.net)
  • The ISN-KI Early-career Researcher Award recognizes outstanding research in basic and clinical science published in Kidney International (KI) in 2019 and 2020. (theisn.org)
  • The present study aimed to investigate the effects of changes in heat shock protein (HSP)90β expression and verify whether HSP90β regulates EAAT2 expression in a cerebral ischemia‑reperfusion injury model. (spandidos-publications.com)
  • This accounts for 60-97% of renal arterial lesions, which could lead to the occlusion of the renal artery and ischemic atrophy of the kidneys. (wikipedia.org)
  • In mice, B1 cells mainly reside in the peritoneal and pleural cavities, but aberrant B1a cell migration has been found in the pancreas of non-obese diabetic (NOD) mice [ 5 ], and in the kidney, thymus and lung of NZBW F1 mice [ 6 - 8 ]. (oncotarget.com)
  • Living donors are often used for kidney and hematopoietic stem cell transplants, less frequently for segmental liver transplants, and rarely for pancreas and lung transplants. (msdmanuals.com)
  • Ischemia-reperfusion (I/R) injury is a process whereby parenchymal damage caused by blood flow deprivation is accentuated upon organ reperfusion. (123dok.net)
  • Ischemia-reperfusion (I/R) injury is a common complication of surgery, and a major cause of organ dysfunction, especially in the liver. (geronova.com)
  • Histological assessment from the kidney grafts revealed zero significant differences between your mixed groups. (gasyblog.com)
  • In summary, available evidence from the present meta-analysis suggests that perioperative administration of dexmedetomidine in adult cardiac surgery might reduce the incidence of AKI. (medscape.com)
  • Aging kidney and CKD share many common characteristic features with increased cellular senescence, a conserved program characterized by an irreversible cell cycle arrest with altered transcriptome and secretome. (frontiersin.org)
  • Lin H, (Cheng CF*). Activating transcription factor 3, an early cellular adaptive responder in ischemia/reperfusion-induced injury . (sinica.edu.tw)
  • What causes kidney ischemia is not entirely known, but several pathophysiology relating to this disease have been elucidated. (wikipedia.org)
  • ANCA-associated vasculitis (AAV) is a rare, autoimmune disease that commonly involves the kidney. (ed.ac.uk)
  • Cardiovascular disease is the commonest complication of kidney disease and cardiovascular risk is greatest in those with kidney failure. (ed.ac.uk)
  • Taking N-acetyl cysteine by mouth seems to reduce homocysteine levels, a possible risk factor for heart disease. (medlineplus.gov)
  • Remarkably, depletion of B1a cells by osmotic pressure ameliorates the development of type I diabetes [ 5 ], and reduces renal injury after kidney ischemia or reperfusion [ 9 ], indicating the involvement of B1a cells in disease progression. (oncotarget.com)
  • Coronary artery bypass grafting (CABG) is performed for patients with coronary artery disease (CAD) to improve quality of life and reduce cardiac-related mortality. (medscape.com)
  • The aims of premedication are to minimize myocardial oxygen demands by reducing heart rate and systemic arterial pressure and to improve myocardial blood flow with vasodilators. (medscape.com)
  • When ischemic stroke occurs, cerebral ischemia and hypoxia cause the release of excessive excitatory amino acids, mainly glutamic acid and aspartic acid, which exert excitotoxic effects on the central nervous system. (spandidos-publications.com)
  • Cerebrovascular diseases (CVDs) have become a global public health problem and ischemia‑reperfusion injury, the major cause of neurological impairment exacerbation, is closely related to excitotoxicity. (spandidos-publications.com)
  • In vitro, EUK-134 significantly reduced NO production by PTCs incubated with IFN-γ/LPS. (scienceopen.com)
  • TNF- manifestation was significantly reduced the study organizations weighed against Methylprednisolone group (= 0.01) Immunohistochemistry staining for cytochrome c showed zero difference between your groups. (gasyblog.com)
  • Corrigendum to "Novel retinal vascular phenotypes for the potential assessment of long-term risk in living kidney donors. (ed.ac.uk)
  • The winners are: Basic science Sho Hasegawa (Japan) Comprehensive three-dimensional analysis (CUBIC-kidney) visualizes abnormal renal sympathetic nerves after ischemia/reperfusion injury Qi Cao (Australia) Regulatory innate lymphoid cells suppress innate immunity and reduce renal ischemia/reperfusion injury Clinical science Madhav C. Menon (USA) Genome-wide. (theisn.org)
  • We propose that EUK-134 reduces renal I/R injury not only via reduction of oxidative stress, but also by reducing nitrosative stress caused by renal I/R. (scienceopen.com)
  • Renal surgery and coronary artery bypass grafting can produce renal ischemia and reperfusion injury. (wikipedia.org)
  • CABG may be performed as an emergency procedure in the context of an ST-segment elevation MI (STEMI) in cases where it has not been possible to perform percutaneous coronary intervention (PCI) or where PCI has failed and there is persistent pain and ischemia threatening a significant area of myocardium despite medical therapy. (medscape.com)
  • The present study evaluated LOXL2 expression in human and mouse kidney tissues, as well as in cultured renal cells. (omicsdi.org)
  • LOXL2 protein expression was detected in glomerular capillary loops and tubular epithelial cells in human and mouse kidneys. (omicsdi.org)
  • Cell-based therapy with mesenchymal stem cells or renal progenitor cells (RPCs) resident in the kidney has appeared to be an effective strategy for the treatment of AKI. (biomedcentral.com)
  • Here we use a mouse model of ischaemia-reperfusion injury to investigate new experimental medicine strategies to reduce the risk of developing CKD after AKI. (ed.ac.uk)
  • Reperfusion injury refers to the tissue damage inflicted when blood flow is restored after an ischemic period of more than about ten minutes. (benbest.com)
  • Urinary N -acetyl-β- D -glucosaminidase activity, an indicator of tubular damage, was reduced from 42 ± 5 (n = 12, I/R only) to 22 ± 3 IU/l (n = 12, I/R +3 mg/kg EUK-134). (scienceopen.com)
  • Graft process biopsies were performed 4 h after reperfusion to assess early immunohistochemical and histological adjustments. (gasyblog.com)
  • Ischemia is the condition suffered by tissues & organs when deprived of blood flow -- mostly the effects of inadequate nutrient & oxygen. (benbest.com)
  • Enzyme-linked immunosorbent assay (ELISA) was used to assess malonaldehyde (MDA) content and inflammatory factors in kidney tissues and peripheral blood, respectively. (ajol.info)
  • TFF3 is widely expressed in multiple tissues including kidney tissue. (omicsdi.org)
  • Kidneys had been procured, cold-stored in HTK remedy at 4C and transplanted in nephrectomized recipients after a mean cool ischemia period of 19.32 2.92 (SD) hours. (gasyblog.com)