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  • progression
  • Large studies with long follow-up durations are necessary to identify and categorize the risk factors for the development of MPN-related glomerulopathy, to standardize therapeutic regimens, and to determine whether aggressive management of the myelofibrosis slows the progression of kidney disease. (biomedcentral.com)
  • patient
  • We describe the first case in the medical literature of an early manifestation of MPN-related glomerulopathy in a patient recently diagnosed with PMF, and significant improvement in kidney function upon successful therapy of PMF with ruxolitinib, an oral JAK inhibitor. (biomedcentral.com)
  • primary
  • Primary myelofibrosis (PMF) is a type of myeloproliferative neoplasm (MPN) characterized by the predominant proliferation of megakaryocytes and granulocytes in the bone marrow, leading to the deposition of fibrous tissue, and by a propensity toward extramedullary hematopoiesis. (biomedcentral.com)
  • multiple
  • Its tissues show densely packed fibrosarcoma-like cells evidencing high rates of mitosis, less infiltration of normal kidney tissue, and multiple areas of hemorrhage and cysts. (wikipedia.org)