Tumor location, necrosis, mitosis and the Ki-67 index were related to the survival of the ependymomas, but Ki67 was the only independent prognostic factor. (nih.gov)
Ki-67 is commonly used as a proliferation marker because it is not detected in G0 cells, but increases steadily from G1 through mitosis. (thermofisher.com)
Ki-67 is present during all active phases of the cell cycle (G1, S, G2, and mitosis), but is absent from resting cells (G0). (thermofisher.com)
Ki-67 is detected within the nucleus during interphase but redistributes to the chromosomes during mitosis. (thermofisher.com)
Immunohistochemistry1
For immunohistochemistry, all meningioma tumors at Elhassan Medical Laboratory for histopathology and cytology during the above mentioned period were processed for ki 67 antigen. (journalcra.com)
Protein12
MKI67 FHA domain-interacting nucleolar phosphoprotein is a protein that in humans is encoded by the MKI67IP gene. (wikipedia.org)
and cell differentiation ( SOX2 and TGFB3 ) as well as immunohistochemical assay for VEGFA, TP53, Bcl2, TGFB1, and Ki67 protein expression have been performed in 85 FFPE RCC tumor specimens. (hindawi.com)
The advanced pathological grade was associated with strong TGFB1, VEGFA, and Ki67 protein expression and absent Tp53 staining. (hindawi.com)
Human recombinant protein fragment corresponding to amino acids 1160-1493 of human MKI67 produced in E.coli. (thermofisher.com)
Ki-67 is a nuclear protein that is expressed during various stages in the cell cycle, particularly during late G1, S, G2, and M phases. (thermofisher.com)
Description: The monoclonal antibody SolA15 recognizes mouse and rat Ki-67, a 300 kDa nuclear protein. (thermofisher.com)
Ki-67 has been shown to interact with the DNA-bound protein chromobox protein homolog 3 (CBX3) (heterochromatin). (thermofisher.com)
Antigen KI-67 also known as Ki-67 or MKI67 is a protein that in humans is encoded by the MKI67 gene (antigen identified by monoclonal antibody Ki-67). (journalcra.com)
The antigen KI-67 is a nuclear protein that is associated with and may be necessary for cellular proliferation. (journalcra.com)
Ki-67 is a nuclear, non-histone protein that is expressed only during active phases of the cell cycle (G1, S, G2 and M), but not in the resting phases (G0 and G1 early phase). (abeomics.com)
In vivo results further demonstrated that LWA mitigated solid tumour development by regulating Ki-67 and cyclin D1 protein expression. (gp120inhibitor.com)
Cellular proliferation1
The cellular proliferation marker Ki-67 was decreased robustly in ATP1B2-suppressed tumors (Number 6G). (tech-strategy.org)
Monoclonal3
The following product was used in this experiment: Ki67 Monoclonal Antibody (OTI5D7), TrueMAB™ from Thermo Fisher Scientific, catalog # TA801577. (thermofisher.com)
The following product was used in this experiment: Ki-67 Monoclonal Antibody (SolA15), Brilliant Ultra Violet™ 615, eBioscience™ from Thermo Fisher Scientific, catalog # 366-5698-82, RRID AB_2925428. (thermofisher.com)
Cells were then surface-stained with CD45R (B220) Monoclonal Antibody, FITC (Product # 11-0452-82) and stained intracellularly, using the Foxp3/Transcription Factor Staining Buffer Set (Product # 00-5523-00) and protocol, with 1.0 µg of Ki-67 Monoclonal Antibody, Brilliant Ultra Violet 615. (thermofisher.com)
Tumor4
Additionally, RELA fusions, mostly presented in pediatric grade III intracranial ependymomas, indicated decreased survival times of patients, and closely related to the patients' age, tumor grade, cellularity, cellular atypia, necrosis and Ki67 index in the intracranial ependymal tumors, whereas reduction of H3K27me3 predicted the worse prognosis in ependymal tumors. (nih.gov)
In studies of tumor cells, the "Ki-67 labeling index" refers to the number of Ki-67 positive cells within the population and this is used to predict outcome of particular cancer types. (thermofisher.com)
Ki-67 is an excellent marker to determine the growth fraction of a given cell population, the fraction of Ki-67-positive tumor cells (the Ki-67 labeling index) is often correlated with the clinical course of cancer. (journalcra.com)
Clinicians need more reliable ER/PGR/HER2/Ki-67 assessment in FFPE tumor tissues. (cepheid.com)
Chromosomes1
Ki-67 is shown to have a cell cycle dependent topographical distribution with perinucleolar expression at G1, expression in the nuclear matrix at G2, and expression on the chromosomes during M phase. (thermofisher.com)
Marker3
Ki-67 is routinely used as a neuronal marker of cell cycling and proliferation. (thermofisher.com)
Ki-67 is used as a marker for determining the growth fraction of a given population of cells. (thermofisher.com)
Although the antigen has also been associated with ribosomal RNA transcription, it is strongly linked to cell proliferation and has thus been indicated as an effective marker in grading the proliferation rate of tumors, including those of the brain, breast, cervix, and prostate. (abeomics.com)
Ribosomal1
Inactivation of antigen KI-67 leads to inhibition of ribosomal RNA synthesis. (journalcra.com)
Tumors1
The correlation between low Ki-67 index and histologically low-grade tumors is strong. (thermofisher.com)
Results: Positive immmuno-staining for Ki67 was identified in 88% of the patients. (journalcra.com)
Human2
There are two conserved sequence motifs within the FHA Ki67 binding domain: TPVCTP and LERRKS, this domain binds to the forkhead-associated domain of human Ki67. (wikipedia.org)
The SolA15 antibody also recognizes human, non-human primate and canine Ki-67. (thermofisher.com)
Domain-interacting nucleolar ph2
MKI67 FHA domain-interacting nucleolar phosphoprotein is a protein that in humans is encoded by the MKI67IP gene. (wikipedia.org)
MKI67 FHA domain-interacting nucleolar phosphoprotein contains an RNA recognition motif (RRM) near to the N-terminus and a FHA Ki67 binding domain near to the C-terminus. (wikipedia.org)
Tumor1
In studies of tumor cells, the "Ki-67 labeling index" refers to the number of Ki-67 positive cells within the population and this is used to predict outcome of particular cancer types. (thermofisher.com)
Cells3
Cells were then surface-stained with CD45R (B220) Monoclonal Antibody, FITC (Product # 11-0452-82) and stained intracellularly, using the Foxp3/Transcription Factor Staining Buffer Set (Product # 00-5523-00) and protocol, with 1.0 µg of Ki-67 Monoclonal Antibody, Brilliant Ultra Violet 395. (thermofisher.com)
Ki-67 is used as a marker for determining the growth fraction of a given population of cells. (thermofisher.com)
Here, to comprehensively map cell lineages, we use single-cell RNA sequencing and antigen receptor analysis of almost half a million cells from up to 5 anatomical regions in the developing and up to 11 distinct anatomical regions in the healthy paediatric and adult human gut. (nature.com)