• however, only Ammi Visnaga contains khellin. (wikipedia.org)
  • However, studies have shown that khellin is not the active ingredient in Ammi Visnaga extract. (wikipedia.org)
  • Upon studying calcium oxalate nucleation, ammi visnaga extract as a whole was shown to prolong nucleation time as well as change stone conformation, while khellin alone had no effect. (wikipedia.org)
  • Khellin has been used as an herbal folk medicine, with use in the Mediterranean dating back to Ancient Egypt, to treat a variety of maladies including: renal colic, kidney stones, coronary disease, bronchial asthma, vitiligo, and psoriasis. (wikipedia.org)
  • As a result, many healing properties have been attributed to Khellin that are actually due to other constituents in the extract. (wikipedia.org)
  • Comparative photosensitizing effects produced by khellin, meladinine and Psoralea L. (Leguminosea) extract]. (nih.gov)
  • Khellin treatment via the intraperitoneal (i.p.) injection significantly ameliorates hyperglycemia and protects the function and survival of ß cells in two diabetic mouse models caused by ER stress-induced ß cell death. (nih.gov)
  • So far, in our parent R01 award, we have achieved these exciting results in animal models with Khellin treatment via the i.p. injection. (nih.gov)
  • In a pilot study, we have treated the Akita diabetic mice with Khellin added to diet and observed that similar to the i.p. injection, the oral treatment of Khellin also significantly lowered blood glucose levels in Akita mice. (nih.gov)
  • Unique combination in VITILIGO treatment with Khellin Ext. Cucis Melo Ext. (yapbioceuticals.com)
  • Vitimed Plus Tablet : The only Tablet truly work for melanin genesis Unique combination in VITILIGO treatment with Khellin Ext, Cucus Mellow Ext. Picrohiza Kurroa, Gikgo Biloba. (yapbioceuticals.com)
  • In our parent R01 award, we have identified a natural product Khellin as a molecule of cytoprotection against ER stress in a high throughput screen. (nih.gov)
  • These findings revealed for the first time that the natural product Khellin increases functional ß cell mass, improves insulin resistance, and ameliorates diabetes and obesity by inhibiting ER stress-induced IRE1a hyperactivation. (nih.gov)
  • As a natural extension, in the Dietary Supplements application, we will test the hypothesis that oral Khellin improves diabetic and obese conditions by inhibiting IRE1a activation. (nih.gov)
  • [ 34 ] Topical khellin and natural sunlight therapy have been suggested for patients with recalcitrant palmoplantar pompholyx. (medscape.com)
  • Importantly, we discovered that Khellin selectively inhibits the ER stress-induced activation of one of three UPR pathways, the IRE1a pathway, but with no effect on the other two UPR pathways: PERK and ATF6. (nih.gov)
  • In Aim 1, we will determine the effect of Khellin orally taken from diet on ß cell function and survival in Akita diabetic mice. (nih.gov)
  • The effect of Khellin on ER stress/UPR in ß cells will be examined. (nih.gov)
  • In Aim 2, we will determine the effect of orally taken Khellin in insulin sensitivity and obesity in diet-induced insulin resistant and obesity mouse model. (nih.gov)
  • The effect of Khellin on ER stress/UPR in adipose tissue, liver, and skeletal muscles will be examined. (nih.gov)
  • Hypocholesterolemic effect of khellin and methoxsalen in male albino rats. (nih.gov)
  • 8. High performance liquid chromatography analysis of the furanochromones khellin and visnagin in various organs of Ammi visnaga (L.) Lam. (nih.gov)