ReductaseThioesteraseMitochondrialSynthetaseFattyEnzymePyruvateCatalyticEnzymesEnsemblInterproscanDatasetsPathwaySpeciesMotifsGeneRolesLipidTransportGenomeSynthetaseEnzymeSynthesisStructural ClassifiSuperfamilyAcyltransferaseCoenzymeSpeciesEscherichiaGenePeptideSintaseInterProMembraneHaemMultifunctionalExperimentallyModificationGolgiAlphaStress proteinCrystal structureDomainGenesBind
Reductase2
- Enoyl-(Acyl carrier protein) reductase [Interproscan]. (ntu.edu.sg)
- Starting from the N-terminus, these units include β-ketoacyl synthase (KS), acetyl/malonyl transacylase (AT/MT), β-hydroxyacyl dehydratase (DH), enoyl reductase (ER), β-ketoacyl reductase (KR), acyl carrier protein (ACP), and thioesterase (TE). (aging-us.com)
Thioesterase2
- Both saturated and unsaturated FAs are released from acyl-ACP by acyl-ACP thioesterase (FAT) [ 10 ] and exported to cytosol. (researchsquare.com)
- SYP7 group Qc-type SNARE protein","protein_coding" "MA_10436714g0010","No alias","Picea abies","acyl-CoA thioesterase","protein_coding" "MA_135972g0010","No alias","Picea abies","Acyl-CoA-binding domain-containing protein 3 OS=Oryza sativa subsp. (ntu.edu.sg)
Mitochondrial2
- How do Fatty Acyl-CoA's pass the mitochondrial intermembrane space? (flashcardmachine.com)
- subunit alpha of MPP mitochondrial signal peptidase heterodimer","protein_coding" "Zm00001e017599_P001","No alias","Zea mays","Protein disulfide isomerase-like 2-2 OS=Oryza sativa subsp. (ntu.edu.sg)
Synthetase1
- Acyl CoA Synthetase: What is it/What does it do? (flashcardmachine.com)
Fatty10
- The protein encoded by this gene is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. (nih.gov)
- It also acts as a catalyst for the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. (nih.gov)
- Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD). (nih.gov)
- However, a systematic analysis of fatty acid synthase across pan-cancers has not been carried out. (aging-us.com)
- Methods: We investigated the oncogenic roles of fatty acid synthase in 33 cancers based on the cancer genome atlas and gene expression omnibus. (aging-us.com)
- Results: Fatty acid synthase is profoundly expressed in most cancers and is an important factor in predicting the outcome of cancer patients. (aging-us.com)
- Fatty acid synthase expression is related to tumor-infiltrating immune cells in tumors (e.g. (aging-us.com)
- Moreover, hormone receptor binding- and fatty acid metabolic process-associated pathways are involved in the functional mechanisms of fatty acid synthase. (aging-us.com)
- Conclusions: This study provides a complete understanding of the oncogenic role of fatty acid synthase in human tumors. (aging-us.com)
- The Cancer Genome Atlas (TCGA) project and gene expression omnibus (GEO) dataset contain useful genomic information sets of various tumors [ 1 - 3 ] and can be employed to identify the potential oncogenic role of fatty acid synthase (FASN). (aging-us.com)
Enzyme1
- protein_coding" "AAC74888","manY","Escherichia coli","mannose-specific enzyme IIC component of PTS [Ensembl]. (ntu.edu.sg)
Pyruvate1
- protein_coding" "AAC74323","adhE","Escherichia coli","fused acetaldehyde-CoA dehydrogenase/iron-dependent alcohol dehydrogenase/pyruvate-formate lyase deactivase [Ensembl]. (ntu.edu.sg)
Catalytic1
- The human FASN protein is composed of six catalytic units. (aging-us.com)
Enzymes2
- More importantly, most maize genes encoding lipid-related transcription factors, triacylglycerol (TAG) biosynthetic enzymes, pentose phosphate pathway (PPP) and Calvin Cycle proteins were not regulated during seed oil synthesis, despite the presence of many homologs in the maize genome. (researchsquare.com)
- protein_coding" "AAC74185","ptsG","Escherichia coli","fused glucose-specific PTS enzymes: IIB component/IIC component [Ensembl]. (ntu.edu.sg)
Ensembl8
- protein_coding" "AAC74850","yeaD","Escherichia coli","D-hexose-6-phosphate epimerase-like protein [Ensembl]. (ntu.edu.sg)
- chlorate resistance protein [Ensembl]. (ntu.edu.sg)
- protein_coding" "AAC74155","flgM","Escherichia coli","anti-sigma factor for FliA (sigma 28) [Ensembl]. (ntu.edu.sg)
- protein_coding" "AAC74156","flgA","Escherichia coli","assembly protein for flagellar basal-body periplasmic P ring [Ensembl]. (ntu.edu.sg)
- protein_coding" "AAC74157","flgB","Escherichia coli","flagellar component of cell-proximal portion of basal-body rod [Ensembl]. (ntu.edu.sg)
- protein_coding" "AAC74158","flgC","Escherichia coli","flagellar component of cell-proximal portion of basal-body rod [Ensembl]. (ntu.edu.sg)
- protein_coding" "AAC74163","flgH","Escherichia coli","flagellar protein of basal-body outer-membrane L ring [Ensembl]. (ntu.edu.sg)
- inactive c-di-GMP phosphodiesterase-like EAL domain protein [Ensembl]. (ntu.edu.sg)
Interproscan13
- Pantoate-beta-alanine ligase [Interproscan]. (ntu.edu.sg)
- Protein of unknown function (DUF520) [Interproscan]. (ntu.edu.sg)
- Sigma-54 interaction domain, Bacterial regulatory protein, Propionate catabolism activator [Interproscan]. (ntu.edu.sg)
- Protein of unknown function (DUF454) [Interproscan]. (ntu.edu.sg)
- Binding-protein-dependent transport system inner membrane component [Interproscan]. (ntu.edu.sg)
- FlgN protein [Interproscan]. (ntu.edu.sg)
- Flagella basal body rod protein [Interproscan]. (ntu.edu.sg)
- Flagella basal body rod protein, Flagellar basal body rod FlgEFG protein C-terminal [Interproscan]. (ntu.edu.sg)
- FlgD Ig-like domain, FlgD Tudor-like domain, Flagellar hook capping protein - N-terminal region [Interproscan]. (ntu.edu.sg)
- Flagellar L-ring protein [Interproscan]. (ntu.edu.sg)
- Rod binding protein, Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase [Interproscan]. (ntu.edu.sg)
- HAMP domain, Tar ligand binding domain homologue, Methyl-accepting chemotaxis protein (MCP) signalling domain [Interproscan]. (ntu.edu.sg)
- LysR substrate binding domain, Bacterial regulatory helix-turn-helix protein [Interproscan]. (ntu.edu.sg)
Datasets1
- Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A. Therefore, proteins with higher identification numbers were more conserved. (evpedia.info)
Pathway1
- This Review summarizes the more recent biochemical, cellular and mouse model studies that underscore the importance of the ER acetylation process in maintaining protein homeostasis and autophagy within the secretory pathway, and its impact on developmental and age-associated diseases. (biologists.com)
Species1
- Further, the "HomoloGene" function of the NCBI was used to conduct conserved functional domain analysis of the FASN protein in different species. (aging-us.com)
Motifs1
- The corresponding gene, AtWRINKLED1 ( AtWRI1, At3g54320), encodes a protein with two APETALA2-ethylene responsive element-binding protein (AP2/EREBP) motifs that is a signature for plant-specific transcription factors involved in a wide range of developmental processes [ 5 , 6 ]. (biomedcentral.com)
Gene1
- Additionally, several features (e.g., gene expression, survival prognosis, genetic alteration, DNA methylation, protein phosphorylation, immune cells, or relevant cellular pathways) were gathered to evaluate the regulatory mechanism of FASN in the tumorigenesis of cancers. (aging-us.com)
Roles1
- The aggregation of both amyloid beta (Abeta) peptides extracellularly and Tau proteins intracellularly plays key roles in the pathological consequences of AD, which lead to cholinergic neurodegeneration and eventually death. (inra.fr)
Lipid1
- Although lipids are a distinct class of biomolecules, we shall see that they often occur combined, either covalently or through weak bonds, with members of other classes of bio-molecules to yield hybrid molecules such as glycolipids , which contain both carbohydrate and lipid groups, "and lipoproteins , which contain both lipids and proteins. (medmuv.com)
Transport1
- What happens if you lack the proteins to transport Acyl-Coa into the matrix? (flashcardmachine.com)
Genome1
- Rapid whole-genome sequencing identifies a homozygous novel variant, His540Arg, in HSD17B4 resulting in D-bifunctional protein deficiency disorder diagnosis. (nih.gov)
Synthetase3
- Leinamycin biosynthesis revealing unprecedented architectural complexity for a hybrid polyketide synthase and nonribosomal peptide synthetase. (firdi.org.tw)
- The lnm cluster spans 61.3 kb of DNA and consists of 27 genes encoding nonribosomal peptide synthetase (NRPS), polyketide synthase (PKS), hybrid NRPS-PKS, resistance, regulatory, and tailoring enzymes, as well as proteins of unknown function. (firdi.org.tw)
- Together with acyl-protein synthetase (LuxE) and reductase (LuxC), it belongs to a multienzyme complex. (inra.fr)
Enzyme2
- An enzyme of long-chain fatty acid synthesis, that adds a two-carbon unit from malonyl-(acyl carrier protein) to another molecule of fatty acyl-(acyl carrier protein), giving a beta-ketoacyl-(acyl carrier protein) with the release of carbon dioxide. (nih.gov)
- The overall tertiary architecture of the enzyme resembles closely the consensus fold of the rapidly expanding superfamily of alpha/beta hydrolases, although there is no detectable homology with any of its members at the amino acid sequence level. (inra.fr)
Synthesis3
- b) Most proteins related to the TCA cycle were strongly upregulated after 48 h under N−, suggesting that respiration is enhanced after 48 h and that TCA cycle efflux supports the carbon required for lipid synthesis. (biomedcentral.com)
- In the cytosol, inhibition of dihydrofolate reductase (DHFR) by proguanil or pyrimethamine or of dihydropteroate synthase (DHPS) by sulfadoxine [ 9 ], blocks the biosynthesis of folate involved in DNA and RNA synthesis. (biomedcentral.com)
- The NEXT3 synthesis of NOTCH3 is further well-insulated at the S3 matrix by the provirus protein membrane, leading the different integrin migration into the Werge( Groot et al. (evakoch.com)
Structural Classifi1
- SCOPe: Structural Classification of Proteins - extended. (berkeley.edu)
Superfamily1
- BEST Arabidopsis thaliana protein match is: RNI-like superfamily prote. (riken.jp)
Acyltransferase3
- Type I polyketide synthase requiring a discrete acyltransferase for polyketide biosynthesis. (firdi.org.tw)
- Type I polyketide synthases (PKSs) are multifunctional enzymes that are organized into modules, each of which minimally contains a beta-ketoacyl synthase, an acyltransferase (AT), and an acyl carrier protein. (firdi.org.tw)
- a) Kennedy pathway dependent on acyl-CoA and (b) the phospholipid diacylglycerol acyltransferase (PDAT) mediated alternative pathway, which uses fatty acids from lipids turnover. (biomedcentral.com)
Coenzyme2
- The pathway begins in the cytoplasm with acetyl-CoA and acetoacetyl-CoA, which interact with acetyl-CoA acetyltransferase, coenzyme A and water to synthesize hydroxymethylglutaryl-CoA synthase. (smpdb.ca)
- In turn, this synthase teams up with coenzyme A and a hydrogen ion in the endoplasmic reticulum to create 3-hydroxy-3-methylglutaryl-CoA. (smpdb.ca)
Species1
- Probe Set ID Ref Seq Protein ID Signal Strength Name Gene Symbol Species Function Swiss-Prot ID Amino Acid Sequence 1367452_at NP_598278 7.9 small ubiquitin-related modifier 2 precursor Sumo2 Rattus norvegicus " Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. (nih.gov)
Escherichia4
- protein_coding" "AAC73262","fhuC","Escherichia coli","iron(3+)-hydroxamate import ABC transporter ATPase [Ensembl]. (ntu.edu.sg)
- protein_coding" "AAC73263","fhuD","Escherichia coli","iron(3+)-hydroxamate import ABC transporter periplasmic binding protein [Ensembl]. (ntu.edu.sg)
- protein_coding" "AAC73829","ybgE","Escherichia coli","putative inner membrane protein in cydABX-ybgE operon [Ensembl]. (ntu.edu.sg)
- protein_coding" "AAC74417","ogt","Escherichia coli","O-6-alkylguanine-DNA:cysteine-protein methyltransferase [Ensembl]. (ntu.edu.sg)
Gene5
- Following the analysis of transposon Tn5432-induced mutants of Corynebacterium glutamicum ATCC 13032, a gene encoding a protein with a biotin-binding motif was cloned. (uni-bielefeld.de)
- Corynebacterium glutamicum thiosulfate sulfurtransferase (thtR) gene, partial cds, acyl CoA carboxylase (accBC) gene, complete cds. (uni-bielefeld.de)
- The only AT activity identified within the lnm gene cluster is a discrete AT protein encoded by lnmG. (firdi.org.tw)
- The enhanced P. falciparum quiescence capacity of artemisinin-resistant parasites results from an increased ability to manage oxidative damage and an altered cell cycle gene regulation within a complex network involving the unfolded protein response, the PI3K/PI3P/AKT pathway, the PfPK4/eIF2α cascade and yet unidentified transcription factor(s), with minimal energetic requirements and fatty acid metabolism maintained in the mitochondrion and apicoplast. (biomedcentral.com)
- Encodes a transducin protein whose gene expression is induced by UV-B. This induction is reduced in hy5 mutant and may be a target of HY5 during UV-B response. (or.jp)
Peptide1
- Compounds consisting of a short peptide chain conjugated with an acyl chain. (lookformedical.com)
Sintase1
- A ácido graxo sintase (en inglés Fatty acid synthase ou FAS ) é un encima que nos humanos está codificado no xene FASN [ 1 ] situado no cromosoma 17 e que intervén na síntese de ácidos graxos . (wikipedia.org)
InterPro1
- CONTAINS InterPro DOMAIN/s: Protein-tyrosine phosphatase-like, PTPLA (InterP. (riken.jp)
Membrane2
- A broad category of membrane transport proteins that specifically transport FREE FATTY ACIDS across cellular membranes. (lookformedical.com)
- HlyD membrane-fusion protein of T1SS, Barrel-sandwich domain of CusB or HlyD membrane-fusion [Interproscan]. (ntu.edu.sg)
Haem2
- Artemisinin and its derivatives are also responsible for alkylation of proteins and haem leading to oxidative damages [ 7 ]. (biomedcentral.com)
- GTP, gap and article), 3) organization of the catabolism upon Following of the such back-to-back acid, and components production, germ and dissociation, with partial X to the severe XIAP, 4) physiological resulting and cycle protein microRNA, and 5) GTP haem and allowing of the tissue-specific new metalloproteinase. (evakoch.com)
Multifunctional1
- These findings unveiled a previously unknown PKS architecture that is characterized by a discrete, iteratively acting AT protein that loads the extender units in trans to "AT-less" multifunctional type I PKS proteins for polyketide biosynthesis. (firdi.org.tw)
Experimentally1
- We used strong primary sequence conservation based on experimentally proved proteins as the main criterion, followed by verification with tertiary structure superpositions, mechanisms, and catalytic residue positions, to accurately define TE families. (inra.fr)
Modification1
- This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. (nih.gov)
Golgi1
- Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (nih.gov)
Alpha1
- Transcription by RNA POL II is bona fide assumed for protein coding genes but must be supported by alpha-amanitin data if the end product is an RNA. (expasy.org)
Stress protein1
- Peroxide stress protein YaaA [Interproscan]. (ntu.edu.sg)
Crystal structure1
- beta-ketoacyl carrier protein synthase as a drug target, implications from the crystal structure of a complex with the inhibitor cerulenin. (berkeley.edu)
Domain1
- protein_coding" "OT_08G03760.1","No alias","Ostreococcus tauri","Limiting CO2-inducible protein B/C, beta carbonyic anhydrase domain [Interproscan]. (ntu.edu.sg)
Genes1
- Sequence analysis of 11-kb DNA revealed three genes, lnmG, lnmH, and lnmI, and the deduced product of lnmI is characterized by domains characteristic to both NRPS and polyketide synthase (PKS). (firdi.org.tw)
Bind3
- Encodes a basic soluble protein which can independently bind to either PHYA or PHYB, regardless of whether the phytochromes are in the Pr or Pfr state. (or.jp)
- From there, the calcium ions bind to the protein troponin which displaces the tropomysoin filaments from the binding sites on the actin filaments. (smpdb.ca)
- As the download Windows 7 Annoyances of times is to public end, defects can bind involved an phosphorylated citron of the IL1R and IL18R leading structures, capping dermatan medicine influencing to endothelial end proteins known by reverse isoforms( TLRs). (evakoch.com)