• The main reaction they catalyze is: CO2-CH2-CO-S-CoA + CH3-CO-S-PKS → CH3-CO-CH2-CO-S-PKS + CoA-H + CO2 Like FASs, PKSs will use a β-ketoacylsynthase (KS), an optional (malonyl) acyl transferase (MAT/AT), and a phosphopantethienylated acyl carrier protein (ACP) or coenzymeA (CoA). (wikipedia.org)
  • Beta ketoacyl acyl carrier protein synthase II (KASII) from Synechocystis sp. (expasy.org)
  • Therefore, molecular docking was also used in the present study to simulate the binding of cordycepin with different antibacterial targets, such as β-ketoacyl-(acyl-carrier-protein) synthase III (FabH), DNA gyrase B and thymidylate kinase, in order to identify the most likely antimicrobial mechanism of cordycepin. (spandidos-publications.com)
  • Overexpression of Rv0494 in Mycobacterium bovis BCG reduced the basal level expression of kas operon genes, thereby suggesting the repressor nature of this protein in fatty acid synthase II regulation. (microbiologyresearch.org)
  • β-Ketoacyl-acyl carrier protein synthase II of Escherichia coli. (illinois.edu)
  • 2014) A human fatty acid synthase inhibitor binds β-ketoacyl reductase in the keto-substrate site. (guidetopharmacology.org)
  • Fatty acid synthase (FAS) is the enzyme system involved in de novo fatty acid synthesis. (wikipedia.org)
  • The dominant enzyme in the KS1 family is 3-ketoacyl-ACP synthase III (KAS III), also known as 3-oxoacyl-ACP synthase III and β-ketoacyl-ACP synthase III, and is defined as EC 2.3.1.180. (wikipedia.org)
  • So far a relatively unexplored target is the cell wall enzyme β-ketoacyl-ACP-synthase "KasA", which plays a crucial role in maintaining the membrane impermeability and hence the cell ability to resist to With 9.6 million new cases and 1.5 million deaths in 2014, tuberculosis (TB) is alongside with AIDS the most deadly infection. (uni-wuerzburg.de)
  • So far a relatively unexplored target is the cell wall enzyme β-ketoacyl-ACP-synthase "KasA", which plays a crucial role in maintaining the membrane impermeability and hence the cell ability to resist to the immune response and drug therapy. (uni-wuerzburg.de)
  • KasA is a key enzyme in the fatty acid synthase "FAS-II" elongation cycle, responsible for the extension of the growing acyl chain within the biosynthesis of precursors for the most hydrophobic constituents of the cell wall - mycolic acids. (uni-wuerzburg.de)
  • It is a substrate for succinyl-CoA:3-ketoacid-coenzyme A transferase, hydroxymethylglutaryl-CoA synthase, short-chain 3-hydroxyacyl-CoA dehydrogenase, peroxisomal bifunctional enzyme, acetyl-CoA acetyltransferase, and 3-ketoacyl-CoA thiolase. (hmdb.ca)
  • 3-Ketoacyl-CoA synthase (KCS) is a rate-limiting enzyme for VLCFA biosynthesis. (bvsalud.org)
  • 3-Ketoacyl-CoA synthase I in Arabidopsis thaliana is involved in very long chain fatty acid synthesis, which plays a role in wax biosynthesis. (wikipedia.org)
  • Ketoacyl synthases (KSs) catalyze the condensation reaction of acyl-CoA or acyl-acyl ACP with malonyl-CoA to form 3-ketoacyl-CoA or with malonyl-ACP to form 3-ketoacyl-ACP. (wikipedia.org)
  • KSs exist as individual enzymes, as they do in type II fatty acid synthesis and type II polyketide synthesis, or as domains in large multidomain enzymes, such as type I fatty acid synthases (FASs) and polyketide synthases (PKSs). (wikipedia.org)
  • The most common enzymes in this family are 3-ketoacyl-CoA synthases, fatty acid elongases and very long-chain fatty acid condensing enzymes. (wikipedia.org)
  • FAE ( Fatty Acid Elongation ) like genes take part in the biosynthesis of VLCFAs, growth regulation, and stress responses, and are further comprised of KCS ( Ketoacyl-CoA synthase ) and ELO ( Elongation Defective Elongase ) sub-gene families. (nature.com)
  • X-ray structure of human Fatty Acid Synthase Psi/KR Tri-Domain complexed with NADPH and GSK2194069. (guidetopharmacology.org)
  • 2008) Synthesis of novel beta-lactone inhibitors of fatty acid synthase. (guidetopharmacology.org)
  • 3-Ketoacyl-ACP synthase I (E.C. 2.3.1.41) is involved in the process of chain-elongation in type II FAS. (wikipedia.org)
  • FAS is an iterative multienzyme consisting of several component enzymes, one of which is ketoacyl synthase. (wikipedia.org)
  • Polyketide synthases (PKS) are structurally and functionally related to FAS's, both which are enzymes that catalyze the condensation of activated primary metabolites such as acetyl-CoA and malonyl-CoA. (wikipedia.org)
  • While there are many slightly different enzymes in this family, the two most common 3-ketoacyl-ACP synthase I and synthase II. (wikipedia.org)
  • The main reaction they catalyze is: CO2-CH2-CO-S-CoA + CH3-CO-S-PKS → CH3-CO-CH2-CO-S-PKS + CoA-H + CO2 Like FASs, PKSs will use a β-ketoacylsynthase (KS), an optional (malonyl) acyl transferase (MAT/AT), and a phosphopantethienylated acyl carrier protein (ACP) or coenzymeA (CoA). (wikipedia.org)
  • β-ketoacyl-acyl carrier protein (ACP) synthase III (FabH) is an especially promising target, since it catalyzes the first, rate-limiting condensation reaction to initiate the elongation cycle of fatty acid synthesis. (nih.gov)
  • revealed that the ß-ketoacyl-acyl carrier protein synthase KasB (encoded by the kasB gene)-deficient mutant strain synthesized mycolates with shorter chain lengths. (medscape.com)
  • The beta-ketoacyl-acyl carrier protein (ACP) synthase III encoded by mtfabH (mtFabH) links FAS-I and FAS-II, catalyzing the condensation of FAS-I-derived acyl-CoAs with malonyl-acyl carrier protein (ACP). (birmingham.ac.uk)
  • 2. Effect of modification of the length and flexibility of the acyl carrier protein-thioesterase interdomain linker on functionality of the animal fatty acid synthase. (nih.gov)
  • Role of active site histidines and lysine in Cys-His-His-type beta-ketoacyl-acyl carrier protein synthases. (nih.gov)
  • 12. Characterization of recombinant thioesterase and acyl carrier protein domains of chicken fatty acid synthase expressed in Escherichia coli. (nih.gov)
  • 15. A mammalian type I fatty acid synthase acyl carrier protein domain does not sequester acyl chains. (nih.gov)
  • 19. Heterologously expressed acyl carrier protein domain of rat fatty acid synthase functions in Escherichia coli fatty acid synthase and Streptomyces coelicolor polyketide synthase systems. (nih.gov)
  • The mtm genes would code for an aromatase (mtmQ), a polypeptide of unknown function (mtmX), a beta-ketoacylsynthase (mtmP) and a related 'chain length factor' (mtmK), an acyl carrier protein (mtmS) and a beta-ketoreductase (mtmT1). (nih.gov)
  • An enzyme of long-chain fatty acid synthesis, that adds a two-carbon unit from malonyl-(acyl carrier protein) to another molecule of fatty acyl-(acyl carrier protein), giving a beta-ketoacyl-(acyl carrier protein) with the release of carbon dioxide. (nih.gov)
  • The 3-ketoacyl-ACP synthase (KAS) III proteins are one of the most abundant enzymes in nature, as they are involved in the biosynthesis of fatty acids and natural products. (rsc.org)
  • beta-ketoacyl carrier protein synthase as a drug target, implications from the crystal structure of a complex with the inhibitor cerulenin. (berkeley.edu)
  • Here, structures of chloramphenicol acetyltransferase III (CATIII) and Escherichia coli ketoacylsynthase III (FabH) from crystals grown in the presence of partially hydrolyzed AcOCoA and the respective nucleophile are presented. (nih.gov)
  • Polyketide synthases (PKS) are structurally and functionally related to FAS's, both which are enzymes that catalyze the condensation of activated primary metabolites such as acetyl-CoA and malonyl-CoA. (wikipedia.org)
  • The deduced products of five of these genes resembled components of type-II polyketide synthases. (nih.gov)
  • Grandes complejos de enzimas constituidos por cierto número de componentes enzimáticos que se encuentran en STREPTOMYCES y biosintetizan MACRÓLIDOS y otros policétidos. (bvsalud.org)
  • KasA is a key enzyme in the fatty acid synthase "FAS-II" elongation cycle, responsible for the extension of the growing acyl chain within the biosynthesis of precursors for the most hydrophobic constituents of the cell wall - mycolic acids. (uni-wuerzburg.de)
  • Thiolactomycin derivatives concentrating on another enzyme in 58558-08-0 IC50 type II fatty acidity biosynthesis, -ketoacyl-ACP synthase, possess powerful activity against (MIC = 0.2 g/ml) (12). (cancer8.info)
  • Hu, Y. and Cronan, J. E(2020) α-Proteobacteria synthesize biotin precursor pimeloyl-ACP using the BioZ 3-ketoacyl-ACP synthase and lysine catabolism. (illinois.edu)
  • 18. Human fatty acid synthase: structure and substrate selectivity of the thioesterase domain. (nih.gov)
  • The most common enzymes in this family are 3-ketoacyl-CoA synthases, fatty acid elongases and very long-chain fatty acid condensing enzymes. (wikipedia.org)
  • chain 3-ketoacyl-ACP synthase in the Pseudomonas putida F1 unsaturated fatty acid synthesis pathway. (illinois.edu)
  • Ketoacyl synthases (KSs) catalyze the condensation reaction of acyl-CoA or acyl-acyl ACP with malonyl-CoA to form 3-ketoacyl-CoA or with malonyl-ACP to form 3-ketoacyl-ACP. (wikipedia.org)
  • 20. Comparative docking of dual conformations in human fatty acid synthase thioesterase domain reveals potential binding cavity for virtual screening of ligands. (nih.gov)
  • Spermine/spermidine synthase domain, Spermidine synthase tetramerisation domain [Interproscan]. (ntu.edu.sg)
  • 6. Structural basis for selectivity in a highly reducing type II polyketide synthase. (nih.gov)
  • While there are many slightly different enzymes in this family, the two most common 3-ketoacyl-ACP synthase I and synthase II. (wikipedia.org)
  • The structure of beta-ketoacyl synthase is similar to that of the thiolase family (pfam00108) and also chalcone synthase. (nih.gov)
  • The active site of beta-ketoacyl synthase is located between the N and C-terminal domains. (nih.gov)
  • Antifungal activity is via inhibition of 1,3-beta-glucan synthase production of BETA-GLUCANS. (lookformedical.com)