EnkephalinsEnkephalin, Ala(2)-MePhe(4)-Gly(5)-Enkephalin, LeucineEnkephalin, MethioninePolymorphism, GeneticEnkephalin, D-Penicillamine (2,5)-Enkephalin, Leucine-2-AlanineAnesthetics, DissociativeEndorphinsReceptors, OpioidReceptors, Opioid, muRNA, Transfer, GlyReceptors, Neurokinin-3Receptors, Opioid, deltaNaloxoneNeurokinin BEthylketocyclazocineTachykininsReceptors, TachykininCyclazocineD-Ala(2),MePhe(4),Met(0)-ol-enkephalinReceptors, Opioid, kappaMorphineGlycineNarcotic AntagonistsSubstance PNeurokinin AAnalgesics, OpioidReceptors, Neurokinin-2AnalgesicsDynorphinsAmino Acid SequenceMolecular Sequence DataNaltrexoneOpioid PeptidesCarboxypeptidase HBenzeneacetamidesBenzomorphansDose-Response Relationship, DrugXylazinebeta-EndorphinGuinea PigsDiprenorphineNarcoticsOligopeptidesNeurokinin-1 Receptor AntagonistsAmino Acid SubstitutionEtorphineMutagenesis, Site-DirectedKineticsExcitatory Amino Acid AntagonistsAlaninePeptide FragmentsProtein PrecursorsAnesthetics, CombinedModels, MolecularReceptors, Neurokinin-1ThiorphanMutationBrainPiperidinesProtein ConformationStructure-Activity RelationshipRats, Sprague-DawleyAnestheticsBinding SitesNeprilysinInjections, SpinalDrug ToleranceMidazolamMorphinansTioproninPeptidesPyrrolidinesBase SequenceAdrenal MedullaThiopentalIrisStereoisomerismReceptors, N-Methyl-D-AspartateDepressive Disorder, Treatment-ResistantAnalgesiaBinding, CompetitivePain MeasurementIleumRats, Inbred StrainsSomatostatinChromaffin GranulesNeuronsPoint MutationAcepromazineAminolevulinic AcidGlobus PallidusCarboxypeptidasesFentanylAmino AcidsAnesthesia, IntravenousSpinal CordAnesthetics, IntravenousMutation, Missense
CAMP1
- METHODS: SH-SY5Y cells (passage 70-80) were used to obtain ketamine dose-response curves for inhibition of 0.4 nM [(3)H][D-Ala(2),MePhe(4),Gly(ol)(5)] enkephalin (DAMGO) binding to mu(2) opioid receptors and of forskolin (1 microM)-stimulated cyclic AMP (cAMP) formation. (ketamine.co.uk)