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  • cytokines
  • Interestingly, a significant number of mice that express both the K14-A β b transgene and the autoreactive 2-2-3 TCR spontaneously develop inflammatory skin disease with mononuclear infiltrates, induction of MHC class II expression on keratinocytes, and T helper 1 cytokines. (pnas.org)
  • However, activated keratinocytes produce inflammatory cytokines, including tumor necrosis factor α (TNF-α) and IL-1 ( 5 - 7 ) and clearly express both MHC class II molecules and the intercellular adhesion molecule-1 (ICAM-1). (pnas.org)
  • Bacterial ghosts (BGs) as non-living bacterial envelopes devoid of cytoplasmic content with preserved and intact inner and outer membrane structures of their living counterparts have been used to study the ability of their surface components for the induction of antimicrobial peptides and pro-inflammatory cytokines in human primary keratinocytes (KCs). (nih.gov)
  • Keratinocytes are also able to produce a variety of cytokines, growth factors, interleukins and complement factors. (promocell.com)
  • outward
  • Application of the M-channel enhancer retigabine (3-10 μM) to isolated cultured rat keratinocytes: (a) increased outward membrane currents recorded under voltage clamp, (b) produced ~3 mV hyperpolarization at rest, (c) enhanced ~3-fold the release of ATP induced by the TRPV3 agonist carvacrol (1 mM) and (d) increased the amplitude of the carvacrol-induced intracellular Ca(2+) transient measured with Fura-2. (sigmaaldrich.com)
  • invasion
  • Treating cocultures with the γ-secretase inhibitor DAPT that blocks the production of the NICD or depleting the Notch ligand DLL1 from keratinocytes prevented invasion into Matrigel. (sciencemag.org)
  • inhibition
  • Susanne Brodesser and Thomas Kolter, "Dihydroceramide Desaturase Inhibition by a Cyclopropanated Dihydroceramide Analog in Cultured Keratinocytes," Journal of Lipids , vol. 2011, Article ID 724015, 9 pages, 2011. (hindawi.com)