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  • deficiency
  • Therefore, the chorioallantoic attachment phenotype in Mrj mutants is not due to a deficiency of the normal keratin cytoskeleton, but rather is cytotoxicity caused by keratin aggregates that disrupt chorion trophoblast cell organization and function. (biologists.org)
  • Here, we show that Mrj deficiency prevents normal keratin turnover, resulting in the formation of large keratin aggregates that are toxic to trophoblast cells, inhibiting their normal function. (biologists.org)
  • human
  • In human skin, keratinocytes of the basal layer of epidermis and the outer root sheath of hair follicles express K5 and K14 as their main keratins. (ulaval.ca)
  • Rabbit anti-human K18 (IN-2) polyclonal antibody was raised against a synthetic peptide corresponding to an internal sequence of human keratin-18. (pressreleaseforum.com)
  • Rabbit anti-human K19 (IN) polyclonal antibody was raised against a synthetic peptide corresponding to an internal sequence of human keratin-19. (pressreleaseforum.com)
  • positive
  • Subsequently, we divided the oral lichen planus cases into thin and thick parts based on the mean values of epithelial thickness from the control samples, and counted the positive rate of collagen IV, keratin 19, desmoglein 1, and Ki-67. (go.jp)
  • The keratin 19 positive rate in oral lichen planus cases was significantly lower than in the controls. (go.jp)
  • study
  • Using transgenic models to study the pathogenesis of keratin-based inherited skin diseases. (nih.gov)
  • patients
  • Sixteen patients (76%) had diabetes mellitus, 17 patients (81%) had arterial hypertension and 19 patients (90%) had BMI above 25kg/m2. (usp.br)