• Sirius Red histochemical staining was used to determine the type of collagen in keloid tissue and normal skin samples. (frontiersin.org)
  • In the keloid samples, from the superficial to the deep dermis, type I collagen increased and type III collagen decreased, and fibroblasts from the superficial dermis of the keloid were found to migrate more rapidly. (frontiersin.org)
  • Objectives: To use multiphoton microscopy to image collagen fibers and matrix structure in nonfixed human keloid tissue and normal human facial skin obtained following surgery and to compare the findings to existing knowledge of normal skin and keloid morphology to determine if this technology is a suitable adjunct for conventional histology. (elsevier.com)
  • Results: Compared with normal skin, keloids showed disorganized collagen fibers arranged in complex swirls and bundles 20 to 30 μm in diameter. (elsevier.com)
  • Several studies have reported on certain aspects of the characteristics of different sites within a keloid lesion, but detailed studies on the keloid dermis at different depths within a keloid lesion are scarce. (frontiersin.org)
  • The aim of this study was to investigate the histology of the keloid dermis at different depths. (frontiersin.org)
  • The migratory properties of fibroblasts within the keloid dermis at different depths was compared, using an in vitro migration assay. (frontiersin.org)
  • The findings of this study showed that although the papillary and reticular dermis could be clearly distinguished in normal skin, three tissue layers were identified in the keloid dermis. (frontiersin.org)
  • In conclusion, the findings of this study showed that different depths within the keloid dermis displayed different biological features. (frontiersin.org)
  • The superficial dermis may initiate keloid formation, in which layer intralesional injection of pharmaceuticals and other treatments should be performed for keloid. (frontiersin.org)
  • Differences between normal and keloid tissue were subtle but apparent. (elsevier.com)
  • Keloid is characterized by the deposition of an excess of extracellular matrix (ECM). (frontiersin.org)
  • The SRT-100™ delivers a precise, calibrated dose of Superficial Radiation Therapy that only penetrates the uppermost layers of skin, safely destroying the cells that form keloids - and keeping the skin smooth as the incision heals. (sensushealthcare.com)
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