• In 2021, the US Food and Drug Administration approved pilocarpine hydrochloride as an eyedrop treatment for presbyopia, age-related difficulty with near-in vision. (wikipedia.org)
  • Pill with imprint 54 647 is White, Round and has been identified as Pilocarpine Hydrochloride 5 mg. (drugs.com)
  • Summary: Weight increased is found among people who take Pilocarpine hydrochloride, especially for people who are female, 60+ old. (bodyloveconference.com)
  • The phase IV clinical study analyzes which people take Pilocarpine hydrochloride and have Weight increased. (bodyloveconference.com)
  • It is created by eHealthMe based on reports of 553 people who have side effects when taking Pilocarpine hydrochloride from the FDA, and is updated regularly. (bodyloveconference.com)
  • Pilocarpine hydrochloride 1.25% treatment can improve distance corrected near vision without significantly compromising corrected distance visual acuity. (optometryadvisor.com)
  • Researchers conducted a randomized, controlled, multicenter, phase 3 study to evaluate the safety, efficacy, and pharmacokinetics of pilocarpine hydrochloride 1.25% compared with vehicle when administered twice daily during a 2-week study duration. (optometryadvisor.com)
  • 57.4% women) with objective and subjective evidence of presbyopia impacting daily activities and randomly assigned them to treatment with pilocarpine hydrochloride 1.25% (n=114) or vehicle treatment (n=116). (optometryadvisor.com)
  • Overall, a significantly greater proportion of participants achieved the primary and secondary outcome measures with pilocarpine hydrochloride 1.25% compared with vehicle - between-treatment differences were 27.3% (95% CI, 17.3%-37.4%) and 26.4% (95% CI, 16.8%-36.0%), respectively. (optometryadvisor.com)
  • Headache , which was reported in 8.8% (n=10) of individuals treated with pilocarpine hydrochloride 1.25% and 3.4% (n=4) of vehicle group participants, was the most common treatment-related adverse event. (optometryadvisor.com)
  • It is also worth noting that the reductions in pupil size observed over time in the pilocarpine [hydrochloride] 1.25% [twice daily] group mirrored visual acuity improvements from Hour 0 to Hour 9, suggesting a mechanism of action primarily based on pupil constriction. (optometryadvisor.com)
  • Study limitations include failure to evaluate treatment efficacy after administration of the second daily pilocarpine hydrochloride 1.25% dose beyond 3 hours and failure to compare vision improvements vs a control group using spectacles or contact lenses. (optometryadvisor.com)
  • Pilocarpine hydrochloride (HCl), a hydrophilic drug is used in the management of intraocular pressure in glaucoma. (aston.ac.uk)
  • The patients were randomly allocated into the Pilocarpine hydrochloride 1% mouthwash group and the placebo one. (ac.ir)
  • Participants in this group will receive Pilocarpine hydrochloride tablets three times a day, an hour before meals, from the first radiochemotherapy session until the end of treatment. (who.int)
  • Participants in this group will receive both Pilocarpine hydrochloride tablets and Diode Laser treatment, beginning with the first radiochemotherapy session and ending with the final treatment. (who.int)
  • Here I further determined and quantified the effects of amiloride on the occurrence of limbic seizures and status epilepticus-induced by intraperitoneal administration of pilocarpine, a muscarinic acetylcholine receptor agonist. (nih.gov)
  • Pretreatment with various doses (5, 10, 30, 100, and 200 mg/kg) of amiloride significantly delayed the onset of the first episode of limbic seizures and the occurrence of status epilepticus following administration of pilocarpine (380 mg/kg). (nih.gov)
  • Epilepsy was induced by giving pilocarpine (300mg/kg) and sodium valproate (300mg/kg) was given as standard anti-epileptic drug Pilocarpine was administered (300 mg /kg body weight) intraperitoneally to the mice on 15th day while naringenin was administered orally (20 and 40 mg/kg body weight) for 15 days prior to administration of pilocarpine. (phcog.com)
  • The intraperitoneal administration of pilocarpine enhanced lipid peroxidation, caused reduction in antioxidant enzymes, viz. (phcog.com)
  • In the first experiment, 62% (15/24) of 6-OHDA pre-treated rats and 45% (11/24) of those receiving ascorbic acid as control solution progressed to motor limbic seizures evolving to SE, after the administration of pilocarpine. (scielo.br)
  • At the dose of 100 and 200 mg/kg, amiloride suppressed limbic seizures in 33% of pilocarpine-treated animals and significantly reduced the seizure severity score in 67% of the remaining animals. (nih.gov)
  • Susceptibility to pilocarpine-induced status epilepticus (SE), as well as spontaneous and recurrent seizures (SRSs) frequency during the chronic period of the model were determined. (scielo.br)
  • In general terms, epileptic discharge, seizure-like behaviors in the chronic phase of Pilocarpine experimental model, sudden unexpected death in epilepsy and consequently epileptic seizures have been associated with an imbalance between excitation and inhibition in specific brain circuitries ( Bozzi and Borrelli, 2013 BOZZI, Y. and BORRELLI, E., 2013. (scielo.br)
  • Pilocarpine was isolated in 1874 by Hardy and Gerrard and has been used to treat glaucoma for more than 100 years. (wikipedia.org)
  • Pilocarpine has been used in the treatment of chronic open-angle glaucoma and acute angle-closure glaucoma for over 100 years. (curecrowd.com)
  • Pilocarpine Nitrate (Pilocarpine-nitrate) is most often used as an eye drop to treat Glaucoma, but is sometimes used to treat some other conditions of the eye. (pocketpills.com)
  • Isopto Carpine is a brand of eye drops containing the active ingredient pilocarpine, which is used to treat certain types of glaucoma and other eye conditions. (canadapharmacy.com)
  • Pilocarpine stimulates the secretion of large amounts of saliva and sweat. (wikipedia.org)
  • Conclusions: Oral pilocarpine induced an increase in goblet cells number and an amelioration of conjunctival epithelium not dependent on tear secretion. (unime.it)
  • These findings suggest that amiloride may modulate seizure generation and propagation, probably via mechanisms involving acid-sensing ion channels in the pilocarpine model of temporal lobe epilepsy. (nih.gov)
  • In a recent publication, we have shown a potent interaction between the cholinergic and GABAergic systems in regard to seizure generation and developed the pilocarpine(pilo)/picrotoxin(PTX) model, in which combined injections of these agents have induced status epilepticus (SE) in rats. (unifesp.br)
  • We have utilized lithium-pilocarpine model of SE in adult Wistar rats to assess the potential effect of licofelone on seizure susceptibility. (j-epilepsy.org)
  • Non-Status Epilepticus female rats show seizure-like behaviors in the chronic phase of Pilocarpine experimental model. (scielo.br)
  • A rat model of epilepsy was constructed with an injection of pilocarpine. (frontiersin.org)
  • The present study investigated the effects of naringenin in pilocarpine-induced epilepsy in mice. (phcog.com)
  • Naringenin, one of the most frequently occurring flavanone in citrus fruits, was evaluated for its shielding effect against the pilocarpine induced behavioural, oxidative and histopathological alterations in rodent model of epilepsy. (phcog.com)
  • In the present work, we describe the effects of dopamine depletion after the administration of 6-hidroxidopamine (6-OHDA) into the substantia nigra pars compacta of male rats submitted to the pilocarpine model of epilepsy. (scielo.br)
  • Scholars@Duke publication: D1 and D2 dopamine receptor interactions with pilocarpine-induced oral activity in rats. (duke.edu)
  • In the present experiment, the effects of the D1 drugs had similar effects in rats concurrently given pilocarpine. (duke.edu)
  • Rats were coadministered CPF (0.5-5mg/kg) and pilocarpine (approximately 13 mg/kg) iv. (cdc.gov)
  • Pilocarpine works by causing the pupil of the eye to shrink and decreasing the amount of fluid within the eye. (webmd.com)
  • Pilocarpine causes constriction of the pupil of the eye. (pocketpills.com)
  • Pilocarpine is aclassic cholinergic agent useful for thiscondition, now available generically in2 strengths. (pharmacytimes.com)
  • Pilocarpine tablets are used to treat dryness of the mouth and throat caused by a decrease in the amount of saliva that may occur after radiation treatment for cancer of the head and neck or in patients with Sjogren's syndrome. (bodyloveconference.com)
  • Pilocarpine is used in the treatment of Xerostomia and belongs to the drug class cholinergic agonists . (drugs.com)
  • Pilocarpine is also used to treat dry mouth ( xerostomia ) which can occur, for example, as a side effect of radiation therapy for head and neck cancers. (curecrowd.com)
  • This study aimed to evaluate the impact of 1% Pilocarpine mouthwash on salivary flow in patients with radiation-induced xerostomia. (ac.ir)
  • 1% Pilocarpine mouthwash is recommended for managing radiation-induced xerostomia. (ac.ir)
  • Haddad P, Karimi M. A randomized, double-blind, placebo-controlled trial of concomitant pilocarpine with head and neck irradiation for prevention of radiation-induced xerostomia. (ac.ir)
  • Pilocarpine is a medication used to reduce pressure inside the eye and treat dry mouth. (wikipedia.org)
  • Pilocarpine is in the miotics family of medication. (wikipedia.org)
  • Pilocarpine is an eye medication used to treat neurogenic keratoconjunctivitis sicca (dry eye caused by a nerve problem). (hardypaw.com)
  • The most commonly prescribed medication for hyposalivation is Pilocarpine. (ac.ir)
  • Pilocarpine accumulation index was 1.11 or less at the study conclusion among the subgroup participants who underwent pilocarpine plasma level assessment. (optometryadvisor.com)
  • Patients underwent oral pilocarpine treatment for 2 months and were studied before (T0) and after 1 month (T1), 2 months (T2), and 15 days after treatment suspension (T3). (unime.it)
  • Animals injected with three specific dose combinations (pilocarpine dose/picrotoxin dose), 150/0.5, 75/1.5 and 50/2.0 mg/kg, evoked status epilepticus (SE) within 23, 31 and 27 min, respectively. (unifesp.br)
  • Mortality rates for 150/0.5, 75/1.5 and 50/2.0 mg/kg (pilocarpine dose/picrotoxin dose) were 53, 42 and 51%, respectively. (unifesp.br)
  • It may be used to treat a form of dry eye called aqueous deficient dry eye (ADDE) Pilocarpine is sometimes used immediately before certain types of corneal grafts and cataract surgery. (wikipedia.org)
  • Pilocarpine is a parasympathomimetic alkaloid obtained from the leaves of tropical American shrubs from the genus Pilocarpus . (curecrowd.com)
  • To investigate the relationship between dopamine (DA) and acetylcholine (ACh) systems in the control of oral movement, we studied the effects of specific D1 and D2 drugs on vacuous chewing movements induced by the muscarinic ACh agonist, pilocarpine. (duke.edu)
  • Plants in the genus Pilocarpus are the only known sources of pilocarpine, and commercial production is derived entirely from the leaves of Pilocarpus microphyllus (Maranham Jaborandi). (wikipedia.org)
  • Use of pilocarpine may result in a range of adverse effects, most of them related to its non-selective action as a muscarinic receptor agonist. (wikipedia.org)
  • Pilocarpine is a drug that acts as a muscarinic receptor agonist. (wikipedia.org)
  • Pilocarpine is often used as an antidote for scopolamine , atropine , and hyoscyamine poisoning. (curecrowd.com)
  • Thus, we have decided to evaluate potential contributions of picrotoxin, a GABA, channel blocker, on pilocarpine-induced SE. (unifesp.br)
  • Single injections of 150 mg/kg of pilocarpine or 3 mg/kg of picrotoxin did not evoke any form of sustained epileptic activity. (unifesp.br)
  • the present study reveals a proconvulsant role for picrotoxin when co-administered with subconvulsant doses of pilocarpine. (unifesp.br)
  • Pilocarpine may increase ureteral smooth muscle tone and could precipitate renal colic, particularly in patients with nephrolithiasis. (medscape.co.uk)
  • Aim: To evaluate the effect of oral pilocarpine treatment on conjunctival epithelium of patients with Sjo ̈gren's syndrome (SS). (unime.it)
  • After a 2- to 4-week run-in period with timolol 0.5% twice daily, patients were assigned in randomized fashion to three study groups: one group received add-on therapy of latanoprost 0.005% once daily, the second group received add-on therapy of pilocarpine 2% three times daily, and the third group switched to latanoprost 0.005% once daily. (unict.it)
  • Conclusion: A significantly greater reduction in diurnal IOP was achieved after addition of latanoprost than after addition of pilocarpine in patients in whom IOP was not adequately controlled with timolol alone. (unict.it)
  • Although salivary flow rates were measured during only the first 90 minutes of the dosing interval, results of previous studies16 in healthy participants indicate that the pilocarpine effect on flow rates lasts 3 to 5 hours. (bodyloveconference.com)
  • The research team performed a pilocarpine plasma level assessment among a subgroup of 10% of study participants and evaluated treatment-related adverse events among the entire cohort. (optometryadvisor.com)
  • We aimed at optimizing pilocarpine HCl niosomes and evaluating the effect of sonication on its stability-indicating properties such as particle size, polydispersity index (PDI), zeta potential and entrapment efficiency. (aston.ac.uk)
  • The effect of sulpiride in reducing oral movement activity was eliminated by pilocarpine, while the effect of LY 171555 in reducing oral movement was enhanced by pilocarpine. (duke.edu)
  • A classic stimulator of the salivationlacrimation-urination-defecation response,pilocarpine is a cholinergic drug that actsupon muscarinic receptors. (pharmacytimes.com)
  • Pilocarpine is used to stimulate sweat glands in a sweat test to measure the concentration of chloride and sodium that is excreted in sweat. (wikipedia.org)
  • Pilocarpine strongly increases arterial pressure which activates baroreceptors, thereby enhancing the activity of NTS and CVLM neurons, before the release of inhibitory signals in the RVLM trying to reduce sympathetic activation. (bodyloveconference.com)
  • Pilocarpine niosomes were prepared by ether injection method. (aston.ac.uk)
  • Tishler, M 1998, ' Pilocarpine--new use for an old drug ', Harefuah , vol. 135, no. 3-4, pp. 150-152. (tau.ac.il)
  • Combined with in-vitro proliferation assays using CRISPR-Cas9/RNAi and patient survival analysis, MEK inhibitors PD19830 and BRD-K12244279, pilocarpine, and tremorine were discovered as potential new drug options for treating breast cancer. (cdc.gov)