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  • squamous cell
  • An intergroup phase III comparison of standard radiation therapy and two schedules of concurrent chemoradiotherapy in patients with unresectable squamous cell head and neck cancer," Journal of Clinical Oncology , vol. 21, no. 1, pp. 92-98, 2003. (hindawi.com)
  • Induction chemotherapy with cisplatin and fluorouracil alone or in combination with docetaxel in locally advanced squamous-cell cancer of the head and neck: long-term results of the TAX 324 randomised phase 3 trial," The Lancet Oncology , vol. 12, no. 2, pp. 153-159, 2011. (hindawi.com)
  • embryonic
  • EMT, a highly conserved cellular program in many important phases of embryonic development, is a biological process through which epithelial cells lose their epithelial cobblestone phenotype and acquire fibroblastic and mesenchymal-like phenotypes. (beds.ac.uk)
  • gene
  • NF-kB is a heterodimer of p65 and p50 subunits which, upon activation, translocate into the nucleus and binds to target gene promoters. (bmj.com)
  • Taking advantage of experimental strategies including pharmacological tool and gene knockdown, we showed here that interference with JNK signaling pathway by targeting JNK1/2 or c-Jun reversed the mesenchymal properties of KB/VCR cells to epithelial phenotypes and suppressed the motile capacity of KB/VCR cells, such as migration and invasion. (beds.ac.uk)
  • Tissues
  • Since many cancer tissues contain high dThdPase activity compared with normal tissues, these transfected and untransfected KB cells are useful for studying the role of dThdPase in the activation of pyrimidine antimetabolites and also in angiogenesis. (aacrjournals.org)
  • nuclear
  • Background Pulmonary arterial hypertension (PAH) is associated with pulmonary vascular inflammation, and several of the inflammatory genes involved are regulated by nuclear factor-kB (NF-kB). (bmj.com)
  • We assessed NF-kB activation by immunohistochemical analysis of nuclear p65. (bmj.com)
  • resistant
  • These partial revertant lines, 100 rev and 300 rev , were 2.5- and 3.2-fold resistant to CPT compared to KB. (aacrjournals.org)
  • Comparisons of topoisomerase I (TOP1) activity, content, and protein-linked DNA break production by CPT revealed that resistant and partial revertant lines had one-half the levels as KB, with TOP1 activity that was equally sensitive to CPT in all cell lines tested. (aacrjournals.org)
  • It was previously demonstrated that multidrug-resistant Chinese hamster cell lines contain an amplified, transcriptionally active DNA sequence designated mdr. (pnas.org)
  • molecular
  • In this regard, elucidating the molecular mechanisms underlying aberrant metastatic capacity of MDR cells is quite important, as it may provide new targets for improving the efficiency of chemotherapy. (beds.ac.uk)
  • growth
  • Thaw Medium 2 (BPS Bioscience #60184) , 1 mg/ml of Geneticin (Life Technologies #11811031), and 150 μg/ml of Hygromycin B (Hyclone #SV30070.01) Cells should be grown at 37 o C with 5% CO 2 using complete growth medium (Thaw Medium 2, Geneticin, and Hygromycin B). (bpsbioscience.com)
  • death
  • Immunohistochemistry fluorescent staining method (TUNEL) was performed to indicate the mechanism of cell death and the fragmented DNA band pattern produced was obtained for verification. (hindawi.com)
  • activation
  • NF-kB activation in PAH has not been examined in detail to date. (bmj.com)
  • Conclusion NF-kB activation is present in macrophages and pulmonary arterial endothelial cells in pulmonary arteries of 100-500 mm ED in patients with PAH. (bmj.com)
  • properties
  • These observations support a critical role of JNK signaling in maintaining the mesenchymal properties of KB/VCR cells. (beds.ac.uk)
  • Effect
  • DNA fragments harvested from Brucea -treated cells produced bands in a ladder pattern suggesting the apoptotic effect of the extract. (hindawi.com)
  • products
  • To give you confidence in the health of your cells every step of the way, we've highlighted the technologies and products within cell biology that are critical to maintaining optimal cell health. (thermofisher.com)
  • No matter how you are using your cells, you can count on these products to help keep them healthy. (thermofisher.com)