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  • channelopathy
  • KATP channelopathy caused by missense mutation (Thr1547Ile) of the ABCC9 gene conferring predisposition to adrenergic AF originating from the vein of Marshall. (ovid.com)
  • The intact KCNJ11-encoded KATP channel is thus a required safety element preventing hypertension-induced heart failure, with channel dysfunction a molecular substrate for stress-associated channelopathy in cardiovascular disease. (ovid.com)
  • glucose
  • However, the most frequently cited hypothesis proposes that glucose deficit hyperpolarizes the α-cells, relieving a depolarization-induced inactivation of ion channels involved in action potential firing and glucagon release ( 11 ). (diabetesjournals.org)
  • The ATP-sensitive K + (K ATP ) channel has been implicated in detecting glucose-induced generation of ATP in most models of glucose sensing except those with intrinsic α-cell sensing by the Na + /K + pump ( 8 ), the sarco(endo)plasmatic Ca 2+ ATPase (SERCA) ( 9 , 10 ) or AMP-activated protein kinase ( 12 ). (diabetesjournals.org)
  • Neuronal injury induced by oxygen-glucose deprivation (OGD) in vitro and permanent middle cerebral artery occlusion (pMCAO) in vivo was increased by blocking K ATP channel by tolbutamide. (empr.com)
  • Functional
  • Expression of dimeric SUR1-Kir6.2 constructs results in functional channels with very similar properties to those formed from coexpression of the parental monomers, consistent with a 1:1 SUR1/Kir6.2 stoichiometry being sufficient to form the K ATP channel. (rupress.org)
  • Because K ATP channels may have diverse functional roles in neurons and glia, further studies are needed to explore the potential of K ATP channels as targets of therapies against neuropathic pain and neurodegeneration. (springer.com)
  • The forced expression of dSUR protein in Xenopus oocytes shows an inwardly rectifying potassium current, and this current is abolished by the sulfonylurea glybenclamide, a K ATP channel blocker, indicating that dSUR might be a functional ortholog of the mammalian SUR2 protein ( 17 ). (pnas.org)
  • myocardial
  • Audience: Clinicians and basic scientists who have a direct interest in the KATP channel as well as those groups who are interested in the entire concept of myocardial protection and its relationship to academic and clinical medicine. (ebook.de)
  • Methods
  • METHODS: Single channel activity was measured with the patch-clamp technique in the inside-out (i/o) and open-cell attached (oca) configuration. (ru.nl)
  • protective
  • We hypothesized that mitochondrial KATP mediates the protective response in hypertrophied hearts. (ahajournals.org)
  • and the clinical implications of the use of agents that mimic the opening of this channel, with reference to its protective nature and its use in the treatment of angina. (ebook.de)
  • R- 801 is formed from the covalent fusion of 2 distinct moieties, each with demonstrated tissue protective properties: 1) a mito-K+-ATP channel activating moiety derived from pinacidil, and 2) a pyrrolidine nitroxide domain that acts as superoxide dismutase and catalase mimetics and a peroxynitrite decomposition catalyst. (grantome.com)
  • openers
  • 7: Is there a potential role for the KATP openers in the treatment of Angina? (ebook.de)
  • sulfonylurea
  • These results suggest that sulfonylurea treatment in T2DM patients may inhibit neuroprotective effects of K ATP channels and increase the risk of stroke," the authors write. (empr.com)
  • activator
  • Moreover, neither the PKG activator nor exogenous H(2)O(2) was able to enhance the function of K(ATP) channels in the presence of Ca(2+) chelators and calmodulin antagonists, whereas the stimulatory effect of H(2)O(2) was unaffected by 5-HD. (nih.gov)