• Formally, PEL is defined by the World Health Organization, 2016 as a KSHV/HHV8-positive and KSHV/HHV8-driven large B-cell lymphoma. (wikipedia.org)
  • This finding may help determine how KSHV causes primary effusion lymphoma in humans. (cdc.gov)
  • Kaposi's sarcoma-associated herpesvirus (KSHV) causes Kaposi sarcoma, primary effusion lymphoma, and the plasma cell variant of multicentric Castleman disease in humans ( 1 ). (cdc.gov)
  • KSHV is the second human oncogenic herpesvirus, associated with Kaposi's sarcoma (KS) and pleural effusion lymphomas (PELs) or body cavity based lymphomas (BCBLs). (pennmedicine.org)
  • KSHV infects human B-cells and endothelial cells. (pennmedicine.org)
  • Kaposi sarcoma herpesvirus (KSHV) is specifically associated with Kaposi sarcoma (KS) and 2 B cell lymphoproliferative diseases, namely primary effusion lymphoma (PEL) and multicentric Castleman disease (MCD). (jci.org)
  • In addition, they showed increased numbers of cells expressing cytoplasmic IgM-λ, a thus far enigmatic feature of the KSHV-infected cells in MCD. (jci.org)
  • In the setting of HIV disease, Epstein-Barr Virus (EBV) and Kaposi's Sarcoma-associated Herpesvirus (KSHV/HHV-8) may transform B cells into lymphomas. (prn.org)
  • This viral protein, named KSHV vPK, or KSHV ORF36, when expressed in mice, can cause the mice to develop lymphomas at an eight-fold higher rate than mice that don't express the viral gene," said UNC Lineberger's Blossom Damania, PhD , vice dean for research in the UNC School of Medicine, and the Boshamer Distinguished Professor in the UNC School of Medicine Department of Microbiology and Immunology, who led the study. (unchealthcare.org)
  • It is a rare malignancy of plasmablastic cells that occurs in individuals that are infected with the Kaposi's sarcoma-associated herpesvirus (i.e. (wikipedia.org)
  • Identification of primary effusion lymphoma and immunohistochemical staining of primary effusion lymphoma cells with Kaposi's sarcoma-associated herpesvirus latent nuclear-associated antigen (LANA)-specific antibody. (cdc.gov)
  • Today, Kaposi sarcoma is most commonly found in people with HIV/AIDS and is related to an infection with the human herpesvirus 8 (HHV-8). (cancer.net)
  • There is growing evidence that host cells try to control Herpesvirus infections by activating the autophagic machinery. (mdpi.com)
  • In the past biennium, working groups have concluded that there is sufficient evidence to classify infection with human immunodeficiency virus (HIV-1), human T-cell lymphotropic virus (HTLV-1), Epstein-Barr virus (EBV) and the Kaposi sarcoma-associated herpesvirus 8 as carcinogenic to humans (IARC 0RQRJUDSKV, Vol. 67 and 70). (who.int)
  • Non-Hodgkin lymphoma (NHL) is a cancer of the lymphatic system. (cancer.net)
  • The most common IRIS-defining diagnoses were candidiasis (all forms), cytomegalovirus infection, disseminated Mycobacterium avium intracellulare, Pneumocystis pneumonia, varicella zoster, Kaposi's sarcoma and non-Hodgkin lymphoma. (nih.gov)
  • But sometimes non-Hodgkin lymphoma (NHL) develops in people who don't have any of the risk factors described below. (cancer.ca)
  • The incidence of PBL is estimated to account for less than 5% of all cases of non-Hodgkin lymphoma (NHL) in HIV-positive individuals. (hindawi.com)
  • Kaposi's sarcoma, non-Hodgkin lymphoma (NHL), and invasive cervical carcinoma are among the three AIDS-defining malignancies, and, of these, Kaposi's sarcoma and AIDS-related non-Hodgkin lymphoma are the most common [ 1 ]. (hindawi.com)
  • Primary effusion lymphoma is a type of non-Hodgkin lymphoma with poor prognosis and survival rates. (unchealthcare.org)
  • For other discussions on lymphoma, see the overview topic Non-Hodgkin Lymphoma . (medscape.com)
  • EBV is a known cause of various Epstein-Barr virus-associated lymphoproliferative diseases including various B-cell lymphomas. (wikipedia.org)
  • Infection with Kaposi sarcoma-associated herpes virus has been linked to the development of three human cancers, including Kaposi's sarcoma, which is a cancer of the cells that line the blood vessels or lymphatic system, as well as two B lymphoproliferative diseases, primary effusion lymphoma and multicentric Castleman's disease. (unchealthcare.org)
  • CAR T cells: engineering patients' immune cells to treat their cancers. (medlineplus.gov)
  • According to the American Cancer Society (ACS), around 80 percent of all skin cancers are basal cell cancers. (healthline.com)
  • According to the ACS, doctors diagnose an estimated 5.4 million basal and squamous cell cancers each year. (healthline.com)
  • In addition, melanomas are more likely to spread than basal and squamous cell skin cancers. (healthline.com)
  • In the specific case of the association between the HIV virus and Kaposi sarcoma, as well as some other cancers. (bwfund.org)
  • One-fifth of cancers worldwide are due to chronic infections, mainly from hepatitis B viruses HBV (causing liver), human papilloma viruses HPV (causing cervix), Helicobacter pylori (causing stomach), schistosomes (causing bladder), the liver fluke (bile duct) and human immunodeficiency virus HIV (Kaposi sarcoma and lymphomas). (allcountries.org)
  • the main tumors appear to be virally related and include Kaposi sarcoma associated HHV-8, lymphomas associated with EBV, and cervical and anal cancers associated with HPV. (intelligentdental.com)
  • 2. The most common cancers in the African Region are cancers of the cervix, breast, liver and prostate as well as Kaposi's sarcoma and non-Hodgkin's lymphoma. (who.int)
  • Significant differences in survival were revealed when comparison was made with developing countries, for people with cancers that can be successfully treated by chemotherapy (malignant lymphomas, leukaemia, testicular tumours) and modest differences for neoplasms that can be cured by early detection and surgical intervention. (who.int)
  • It is also associated with the development of multicentric Castleman's disease (MCD) and primary effusion (body cavity-based) lymphomas (PEL). (prn.org)
  • Histopathology of peripheral nerve and sympathetic ganglion from a patient with autonomic failure, oat-cell carcinoma of the lung, and positive anti-HU antibody titer. (medscape.com)
  • Only a few tumours have been reported originating from this location including lymphoma, 1 Kaposi's sarcoma, 2 adenocarcinoma, 3 angiofibroma, 4 and squamous cell carcinoma. (bmj.com)
  • Basal cell carcinoma begins in the basal cells, which are the skin cells that replace old cells in the lower level of the epidermis . (healthline.com)
  • Typically, basal cell carcinoma doesn't spread to other areas of the body. (healthline.com)
  • Without treatment, these skin lesions may develop into squamous cell carcinoma. (healthline.com)
  • HPV infections have received particular attention in recent years, as high-risk strains have been linked to some cases of oral squamous cell carcinoma. (medscape.com)
  • HHV-4, also known as Epstein-Barr virus (EBV), causes the primary infection infectious mononucleosis , and it is implicated in various diseases, such as African Burkitt lymphoma , other immunoproliferative disorders, and nasopharyngeal carcinoma. (medscape.com)
  • Global burden of HPV-attributable squamous cell carcinoma of the anus in 2020, according to sex and HIV status: A worldwide analysis. (who.int)
  • Epidemiology of Renal Cell Carcinoma: 2022 Update. (who.int)
  • For more than a century, since first described in 1872 by Moritz Kaposi* as "idiopathic multiple pigmented sarcoma," dermatologists focused on classical Kaposi sarcoma (KS) - violaceous patches, plaques, and tumors on the lower extremities of elderly men of either Mediterranean or Eastern European (Ashkenazi Jewish) descent. (aad.org)
  • Moritz Kaposi, a Hungarian dermatologist in 1872, first described it. (bvsalud.org)
  • In his original article entitled "Idiopathic multiple sarcoma of the skin", Moritz Kaposi described the indolent and rare disease that is known as classic or sporadic Kaposi sarcoma. (bvsalud.org)
  • Less frequently, individuals present with extracavitary primary effusion lymphomas, i.e., solid tumor masses not accompanied by effusions. (wikipedia.org)
  • Primary effussion lymphoma is an extremely aggressive cancer that is highly resistant to various chemotherapy treatments. (wikipedia.org)
  • We determined the complete genome sequence of a virus isolated from a mantled guereza that died of primary effusion lymphoma. (cdc.gov)
  • We describe a novel rhadinovirus of the Old World primate genus Colobus ( 14 ), subfamily Colobinae, which was detected in a mantled guereza ( Colobus guereza kikuyensis ) that died of primary effusion lymphoma. (cdc.gov)
  • A necropsy conducted at the German Primate Centre, Göttingen, Germany, led to a diagnosis of primary effusion lymphoma. (cdc.gov)
  • [ 5 , 6 ] In a localized primary infection, the virus penetrates the mucosal epithelium and invades the cells of the basal layer, where the viral DNA inserts into the host DNA. (medscape.com)
  • AIDS-related NHL can be categorized into systemic NHL, primary CNS lymphoma, and primary effusion lymphoma [ 2 ]. (hindawi.com)
  • EBV, an almost identical gammaherpesvirus, has been linked to a higher incidence of immunoblastic lymphoma and a heightened risk of primary central nervous system lymphoma. (prn.org)
  • In addition, the authors detected tumors in the modified mice that were similar to those seen in primary effusion lymphoma. (unchealthcare.org)
  • B-cell lymphomas account for the majority of nodal lymphomas, whereas primary cutaneous B-cell lymphomas (CBCLs) represent 20-25% of all cutaneous lymphomas. (medscape.com)
  • Likewise, with primary cutaneous lymphomas associated with a poorer prognosis, treatment is different for isolated or grouped lesions than for multiple lesions (see Treatment and Management). (medscape.com)
  • Diseases formerly designated as reticulosis or reticulosarcomatosis are currently classified according to the World Health Organization (WHO)/European Organization for Research and Treatment of Cancer (EORTC) classification (WHO-EORTC classification) for primary cutaneous lymphomas and the WHO classification. (medscape.com)
  • This helps your body get rid of cancer cells. (medlineplus.gov)
  • Scientists can make special antibodies in a lab that seek out cancer cells instead of bacteria. (medlineplus.gov)
  • Some monoclonal antibodies work by sticking to cancer cells. (medlineplus.gov)
  • Other monoclonal antibodies work by blocking signals on the surface of the cancer cell that tell it to divide. (medlineplus.gov)
  • Another type of monoclonal antibody carries radiation or a chemotherapy drug to cancer cells. (medlineplus.gov)
  • These cancer-killing substances are attached to the monoclonal antibodies, which then deliver the toxins to the cancer cells. (medlineplus.gov)
  • Cancer cells can use these checkpoints to avoid being attacked by the immune system. (medlineplus.gov)
  • Immune checkpoint inhibitors are a newer type of monoclonal antibody that act on these checkpoints to boost the immune system so it can attack cancer cells. (medlineplus.gov)
  • Interferon alpha (INF-alfa) makes certain immune cells better able to attack cancer cells. (medlineplus.gov)
  • This type of therapy uses viruses that have been altered in a lab to infect and kill cancer cells. (medlineplus.gov)
  • These antigens tell the immune system to target and kill other cancer cells in the body. (medlineplus.gov)
  • Most types of cancer begin when healthy cells change and grow out of control, forming a mass called a tumor. (cancer.net)
  • People with HIV/AIDS have a higher risk of developing abnormal cells in the cervix that can become cancer. (cancer.net)
  • The rest of this guide focuses on Kaposi sarcoma, NHL, and cervical cancer in people with HIV/AIDS. (cancer.net)
  • The cells are also how physicians identify the type of skin cancer. (healthline.com)
  • Squamous cell cancer affects the cells on the outermost part of the epidermis. (healthline.com)
  • When squamous cell cancer forms in the skin, it's known as cutaneous squamous cell cancer. (healthline.com)
  • The Skin Cancer Foundation says that squamous cell cancer is the second most common type of skin cancer. (healthline.com)
  • This type of cancer develops from cells that give your skin color. (healthline.com)
  • Merkel cell skin cancer is a rare form of skin cancer caused by an overgrowth of Merkel cells. (healthline.com)
  • A 2021 review showed an estimated 1,500 cases of Merkel cell cancer reported annually in the United States. (healthline.com)
  • She uses flax seed oil instead of hemp oil to cure cancer - through effecting changes in cell walls - using these omega3 and omega6 laden medicinal oils. (pakalertpress.com)
  • v] Their research was published in the Journal of the National Cancer Institute Advance Access on December 25th of 2007 in a paper entitled Inhibition of Cancer Cell Invasion by Cannabinoids via Increased Expression of Tissue Inhibitor of Matrix Metalloproteinases-1. (pakalertpress.com)
  • This is the first set of experiments to show that the compound, Delta-tetrahydrocannabinol (THC), inhibits EGF-induced growth and migration in epidermal growth factor receptor (EGFR) expressing non-small cell lung cancer cell lines. (pakalertpress.com)
  • Scientists at UNC Lineberger Comprehensive Cancer Center are zeroing in on how Kaposi sarcoma-associated herpes virus can lead to cancer in people. (unchealthcare.org)
  • She is also a Leukemia and Lymphoma Society Research Scholar, and has received major support from the V Foundation, the American Herpes Foundation, the American Association for Cancer Research, and the American Heart Association. (bwfund.org)
  • One defining feature of cancer is the rapid creation of abnormal cells which grow beyond their usual boundaries, and which can invade adjoining parts of the body and spread to other organs, a process referred to as metastasis. (allcountries.org)
  • Cancer occurs because of changes of the genes responsible for cell growth and repair. (allcountries.org)
  • Cancer arises from one single cell . (allcountries.org)
  • Cancer refers to a group of diseases characterized by abnormal cell proliferation with a tendency to invade adjacent tissues and produce metastases. (who.int)
  • Others have described plasmablastic lymphoma as a unique variant of DLBCL with a propensity to develop in HIV-positive patients with frequent involvement of the oral cavity [ 3 - 5 ]. (hindawi.com)
  • Of the NHL subtypes seen in HIV-positive individuals, the incidence of DLBCL is estimated to account for almost 50% of the cases while the incidence of plasmablastic lymphoma is estimated to account for less than 5% of the cases [ 3 , 4 ]. (hindawi.com)
  • With an active viral infection, a virus makes copies of itself and bursts the host cell (killing it) to set the newly-formed virus particles free. (medicinenet.com)
  • The body has white blood cells that work as a part of the immune system to defend against infection and disease. (healthline.com)
  • If the CD4 count of a person living with HIV falls below 200 cells per cubic milliliter (cells/mm3) , or if they develop an opportunistic infection, the person is said to have AIDS. (medicalnewstoday.com)
  • We present a case of a patient with HIV/AIDS who presented with a tender left lower extremity cutaneous mass over a site of previous cryptococcal infection and was found to have plasmablastic lymphoma (PBL). (hindawi.com)
  • We present a rare case of a 63-year-old HIV-positive male who was found to have plasmablastic lymphoma on biopsy of a tender left lower extremity cutaneous mass occurring over a previous site of cryptococcal infection. (hindawi.com)
  • Another hypothesis is that free virus infects germ compartment host cells, probably early in infection, leading to an immune-privileged, isolated reservoir of HIV infection and reproduction. (prn.org)
  • Інфекція вірусом імунодефіциту людини (ВІЛ) Human immunodeficiency virus (HIV) infection results from 1 of 2 similar retroviruses (HIV-1 and HIV-2) that destroy CD4+ lymphocytes and impair cell-mediated immunity, increasing risk of certain. (msdmanuals.com)
  • Kaposi sarcoma is rare in HIV negative patients and it is associated with HHV-8 infection. (bvsalud.org)
  • Kaposi sarcoma is one of the first recognized opportunistic diseases in HIV infection and is still the most common malignancy associated with AIDS 32 . (bvsalud.org)
  • HHV-8 is associated with Kaposi sarcoma (KS), and evidence links it with body-cavity lymphomas and Castleman disease. (medscape.com)
  • Since the 1982 definition was published, human T-cell lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) has been recognized as the cause of AIDS. (cdc.gov)
  • An angioma or haemangioma is a benign tumour formed by the dilation of blood vessels or the formation of new ones by the proliferation of endothelial cells. (dermnetnz.org)
  • According to Bishop and Lynch: "After infecting endothelial cells, HHV-8 activates the mTOR pathway, alters the cells to have mesenchymal differentiation, and promotes aberrant angiogenesis. (aad.org)
  • In vitro studies show that the virus can infect various cell types such as endothelial cells and B-lymphocytes 15 . (bvsalud.org)
  • Interestingly, these tumors exhibited characteristics of transdifferentiation and acquired expression of histiocytic/dendritic cell markers. (jci.org)
  • Kaposi sarcoma (KS) appears as red, brown, or purple patches or tumors on the skin. (healthline.com)
  • Plasmablasts are immature plasma cells, i.e. lymphocytes of the B-cell type that have differentiated into plasmablasts but because of their malignant nature do not differentiate into mature plasma cells but rather proliferate excessively and thereby cause life-threatening disease. (wikipedia.org)
  • This lymphoma also belongs to a group of lymphoid neoplasms with plasmablastic differentiation that involve malignant plasmablasts but differ from PEL in the types of tissues where they accumulate, the gene abnormalities they carry, and/or the predisposing conditions involved in their development. (wikipedia.org)
  • The definitive diagnosis can be made with biopsy which typically shows malignant lymphoid cells that stain positive for plasma cell markers and negative for B-cell markers. (hindawi.com)
  • The transformation from a normal cell into a tumour cell is a multistage process, typically a progression from a pre-cancerous lesion to malignant tumours. (allcountries.org)
  • Marginal zone B-cell lymphoma (MZL) (MALT-type) is an indolent cutaneous lymphoma, accounting for approximately 10% of all cutaneous lymphomas. (medscape.com)
  • HIV/AIDS-related Kaposi sarcoma causes lesions to arise in more than 1 area of the body, including the skin, lymph nodes, and organs such as the liver, spleen, lungs, and digestive tract. (cancer.net)
  • Several covariates-age, sex, combined HIV exposure category, CD4 cell counts, antiretroviral treatment and AIDS-defining illnesses-were included in the parametric model to predict factors associated with future mortality. (who.int)
  • Oral features of HIV / AIDS reflect the T-cell immune defect and are, thus, mainly the consequence of fungal or viral infections. (intelligentdental.com)
  • Patients with HIV/AIDS are also at increased risk of developing Kaposi sarcoma. (bvsalud.org)
  • The aim of this article is to present two cases of Kaposi sarcoma in the hard palate of HIV/AIDS male patients. (bvsalud.org)
  • Kaposi sarcoma should be considered in the differential diagnosis of any AIDS patient who presents with bluish, smooth, firm, nonpulsatile macule or nodule in the region of the hard palate. (bvsalud.org)
  • About 15% of all diagnosed cases of AIDS have associated Kaposi sarcoma 4 . (bvsalud.org)
  • Regular blood tests will check the number of CD4 cells in the body (called the CD4 cell count ) and the viral load. (kidshealth.org)
  • Symptoms of the viral illness occur as a result of cell damage, tissue destruction, and the associated immune response. (medicinenet.com)
  • We studied 2,610 patients seen during 1996-2007 who initiated or resumed highly active combination antiretroviral therapy (cART) and, during the next 6 months, demonstrated a decline in plasma HIV-RNA viral load of at least 0.5 log(10) copies/ml or an increase of at least 50% in CD4 cell count per microliter. (nih.gov)
  • IRIS was independently associated with CD4 cell count less than 50 cells/μl vs. at least 200 cells/μl [odds ratio (OR) 5.0] and a viral load of at least 5.0 log(10) copies vs. less than 4.0 log(10) copies (OR 2.3). (nih.gov)
  • Here, we have revealed the role of viral FLICE-inhibitory protein (vFLIP) in the initiation of PEL and MCD by specifically expressing vFLIP at different stages of B cell differentiation in vivo. (jci.org)
  • These results define immunological functions for vFLIP in vivo and reveal what we believe to be a novel viral-mediated tumorigenic mechanism involving B cell reprogramming. (jci.org)
  • In HHV-1 and HHV-2 oral infections, viral replication within the oral epithelium may cause lysis of epithelial cells, with vesicle formation. (medscape.com)
  • UNC Lineberger researchers led by Blossom Damania, PhD, and Penny Anders, PhD, published a paper in the Journal of Clinical Investigation that explains how the viral protein vPK helps drive abnormal growth of immune cells called B cells. (unchealthcare.org)
  • Blossom Damania, PhD, and Penny Anders, PhD, report how the viral protein vPK helps drive abnormal growth of B cells. (unchealthcare.org)
  • UNC Lineberger researchers report in the Journal of Clinical Investigation how the viral protein vPK helps drive abnormal growth of immune cells called B cells. (unchealthcare.org)
  • Approximately 66 percent of mice with the viral gene developed lymphoma, compared to 8 percent who did not have the gene. (unchealthcare.org)
  • LANA also maintains the viral episome and prevents Fas-induced programmed cell death. (aad.org)
  • At the time of a 2003 review, there were only 2 reports of extraoral plasmablastic lymphoma [ 4 ]. (hindawi.com)
  • Kaposi sarcoma in people with HIV is also called epidemic Kaposi sarcoma. (cancer.net)
  • Most reports on the epidemic of Kaposi sarcoma has been described in homosexual men and very few cases have been reported among heterosexual men. (bvsalud.org)
  • The purpose of this paper is to present two cases of Kaposi sarcoma in its epidemic form in HIV positive patients. (bvsalud.org)
  • In PEL, the proliferating plasmablastoid cells commonly accumulate within body cavities to produce effusions (i.e. accumulations of fluid), primarily in the pleural, pericardial, or peritoneal cavities, without forming a contiguous tumor mass. (wikipedia.org)
  • Histopathological analysis of the biopsy showed sheets of epithelioid cells with prominent nucleoli and vesicular cells on a routine haematoxylin and eosin stain (fig 3). (bmj.com)
  • The diagnosis of CBCL is established by analysis of skin biopsy specimen, using histomorphology and cytomorphology, immunohistochemistry and phenotypic features, and genotyping and cytogenetic studies (see Workup of Cutaneous B-Cell Lymphoma). (medscape.com)
  • Subsequently, inadequate regulation of cell proliferation and defective oncogene and/or suppressor gene expression promote the transition from preneoplastic conditions to neoplasia. (medscape.com)
  • Kaposi's sarcoma is a neoplasm of vascular endothelium that is characterized by proliferation of spindle cells, neoangiogenesis, inflammation and edema 17 . (bvsalud.org)
  • Semen is a complex mixture of fluids and cells from several organs including the testis, epididymis, seminal vesicles, prostate, and urethra. (prn.org)
  • Lymphoma begins when healthy cells in the lymphatic system change and grow out of control, which may form a tumor. (cancer.net)
  • [ 1 , 2 ] They can be defined as lymphoproliferative skin infiltrates of T-cell, B-cell, or natural killer cell lineage, which primarily occur in and remain confined to the skin in most patients, without detectable extracutaneous manifestations at diagnosis. (medscape.com)
  • Prior to now the cellular mechanisms underlying this effect were unclear and the relevance of the findings to the behavior of tumor cells in vivo remains to be determined. (pakalertpress.com)
  • Kaposi sarcoma is a type of soft-tissue sarcoma that has traditionally occurred in older men of Jewish or Mediterranean descent, young men in Africa, or people who have had organ transplantation. (cancer.net)
  • The dysfunction may be due to problems in antibody production, impaired cell-mediated immunity, a combined type of antibody/cellular deficiency, impaired phagocytosis, or complement deficiency. (ssa.gov)
  • The plasmacytoid cells in PEL are also commonly infected with the Epstein-Barr virus (i.e. (wikipedia.org)
  • Rather, p53 accumulation by either knockdown of Mdm2 or addition of an Mdm2 inhibitor, Nutlin-3, before irradiation strongly attenuated the UV-induced DDR and increased cell survival. (rupress.org)
  • Viruses infect a host by introducing their genetic material into the cells and hijacking the cell's internal machinery to make more virus particles. (medicinenet.com)
  • In other cases, virus particles "bud" off the host cell over a period of time before killing the host cell. (medicinenet.com)
  • Either way, new virus particles are then free to infect other cells. (medicinenet.com)
  • The cold sore virus remains in your cells in a dormant state. (medicinenet.com)
  • The virus makes more copies of itself, releases new virus particles, and kills more host cells. (medicinenet.com)
  • Over time, the virus damages more and more of these cells until the immune system is not strong enough to fight off infections. (medicalnewstoday.com)
  • La microbiología forense es un área científica que ha surgido con la necesidad de investigar los delitos biológicos, como en el caso de la transmisión intencional del virus de la inmunodeficiencia humana (VIH). (scielo.sa.cr)
  • So for example, there are several signal transduction pathways, which are essentially pathways that our cell uses to proliferate or stay quiescent or not grow. (bwfund.org)
  • Through immune suppression and inflammation, the HHV-8 infected cells can persist and proliferate. (aad.org)
  • Kaposi sarcoma is a vascular neoplasm composed of endothelium-lined vascular spaces and spindle-shaped cells. (bvsalud.org)