DiseasesAnalytical, Diagnostic and Therapeutic Techniques and EquipmentAnthropology, Education, Sociology and Social PhenomenaHumanitiesInformation ScienceHealth CareGeographicals
KansasHeart FailureQuality of LifeQuestionnairesMissouriCardiomyopathy, DilatedCardiomyopathy, HypertrophicCardiomyopathiesCardiomyopathy, RestrictiveHealth StatusTakotsubo CardiomyopathyCardiomyopathy, Hypertrophic, FamilialChagas Cardiomyopathy
KCCQWild-type or hereditaryATTR-CMClinicalEjection fractionIschemicQuality-of-lAmerica Heart InstitutePatientsScoreOutcomesHeartTreatmentHospitalExperienceAmyloid cardiomyopathyObstructive hypertrophic cardiomyopathyEjection FractionHeart FailureDapagliflozinNYHASymptomsCardiacScoresBaselineLifeMissouri
KCCQ18
  • We adapted the Kansas City Cardiomyopathy Questionnaire (KCCQ-23), an internationally validated, CHF-specific PROM and tested its use in measuring outcomes in an outpatient CHF clinic at a cardiac referral hospital in Tanzania. (figshare.com)
  • The APOLLO trial also included Kansas City Cardiomyopathy Questionnaire (KCCQ) quality-of-life score improvement as part of the composite primary endpoint. (medpagetoday.com)
  • Previously, the ATTR-ACT trial of tafamidis in ATTR-CM demonstrated a reduction in all-cause mortality, cardiovascular-related hospitalization and declines in functional capacity by 6 minute walk distance (6MWD) and quality of life assessed by the Kansas City Cardiomyopathy Questionnaire overall summary score (KCCQ-OS), as compared with placebo. (news-medical.net)
  • Among seven survivors with Kansas City Cardiomyopathy Questionnaire (KCCQ) data, mean increase in KCCQ score was 29.9±26.3 at one year with improvement of ≥10 points in five (71.4%) patients. (nih.gov)
  • Patients with the Corvia Atrial Shunt, which is implanted between the left and right atria, showed a significant 50% reduction in the rate of HF events and a sustained improvement in quality of life compared to sham control, with 42% greater improvement in Kansas City Cardiomyopathy Questionnaire (KCCQ) overall summary score. (biospace.com)
  • Investigators selected primary endpoints of 1) a change from base-line in the Kansas City Cardiomyopathy Questionnaire clinical summary score (KCCQ-CSS) and 2) a change in body weight. (pharmacytimes.com)
  • The change from baseline to month 30 for the 6-minute walk test and the score on the Kansas City Cardiomyopathy Questionnaire-Overall Summary (KCCQ-OS) were the key secondary endpoints of the trial. (hcplive.com)
  • Jardiance improved the Kansas City Cardiomyopathy Questionnaire total symptom score (KCCQ-TSS) from baseline to day 90 by an average of 4.5 points compared to placebo. (seekingalpha.com)
  • After 12 weeks of treatment, improvement in the Kansas City Cardiomyopathy Questionnaire (KCCQ) clinical summary score was 5.8 points greater in patients treated with dapagliflozin versus placebo ( P = 0.001), Mikhail Kosiborod, MD (Saint Luke's Mid America Heart Institute, Kansas City, MO), reported Sunday at the Heart Failure Society of America 2021 meeting in Denver, CO. (tctmd.com)
  • We sought to analyse quality of life (QoL) measures derived from two questionnaires widely used in clinical trials, the Kansas City Cardiomyopathy Questionnaire (KCCQ) and the EuroQoL 5 dimensions (EQ-5D), and to compare their prognostic value in men and women with heart failure and reduced ejection fraction (HFrEF). (uib.no)
  • But interestingly, they had better quality of life on the Kansas City Cardiomyopathy Questionnaire (KCCQ) and were less likely to have major comorbidities such as prior CABG or PCI, history of MI, and diabetes. (tctmd.com)
  • Health status was assessed at baseline and at 1, 6, and 12 months after TAVR using the Kansas City Cardiomyopathy Questionnaire (KCCQ), the Short Form-12, and the EuroQol-5D. (stanford.edu)
  • Kansas City Cardiomyopathy Questionnaire (KCCQ). (bvsalud.org)
  • Apart from using the BiovitalsHFTM patient-facing companion app for syncing physiology data from sensors, it will be used to capture electronic patient-reported outcomes (ePROs) such as medication adherence, symptoms, the Kansas City Cardiomyopathy Questionnaire (KCCQ) responses, and the guided mobile-based 2-minute-step-test. (hitconsultant.net)
  • They recorded lower Kansas City Cardiomyopathy Questionnaire (KCCQ) scores and shorter six-minute walk distances. (reliasmedia.com)
  • Other comparisons include clinical parameters such as heart failure hospitalizations, 6-minute walk test, Kansas City Cardiomyopathy Questionnaire (KCCQ), and other echocardiographic parameters. (edu.au)
  • The trial results also showed a symptom benefit in patient-reported outcomes measured by the Kansas City Cardiomyopathy Questionnaire (KCCQ) total symptom score1. (globalpharmalive.com)
  • Results show that an IV injection strategy is safe and well-tolerated.In addition, the data illustrate statistically significant improvement in 6-minute walk test, quality-of-life scores as assessed by Kansas City Cardiomyopathy Questionnaire (KCCQ) and favorable immune modulatory benefits. (medicalresearch.com)
Wild-type or hereditary2
  • VYNDAQEL and VYNDAMAX are transthyretin stabilizers indicated for the treatment of the cardiomyopathy of wild-type or hereditary transthyretin-mediated amyloidosis in adults to reduce cardiovascular mortality and cardiovascular-related hospitalization. (nih.gov)
  • Primary results yielded from a phase 3 trial demonstrate that Pfizer's tafamidis significantly reduced the hierarchical combination of all-cause mortality and frequency of cardiovascular-associated hospitalizations compared with placebo over 30 months in patients with wild-type or hereditary transthyretin amyloid cardiomyopathy (ATTR-CM). (hcplive.com)
ATTR-CM1
  • Acoramidis improves outcomes in patients with transthyretin amyloid cardiomyopathy (ATTR-CM) compared with placebo, according to late-breaking research presented in a Hot Line session today at ESC Congress 2023. (news-medical.net)
Clinical3
  • It causes an infiltrative, restrictive cardiomyopathy resulting in clinical heart failure, usually with preserved ejection fraction. (news-medical.net)
  • This educational hub pulls together the latest clinical data, guidelines, congress updates as well as original video content and expert interviews on the management of cardiomyopathies. (radcliffe-group-pre-prod.com)
  • Based on these promising findings, study sponsor CardioCell is planning larger studies based on IV delivery of itMSCs for heart failure indication, including assessment of clinical benefit in both non-ischemic and ischemic cardiomyopathy. (medicalresearch.com)
Ejection fraction2
  • For example, an investigational product used to treat patients with heart failure could be assessed by measuring a biomarker of the heart's output (left ventricular ejection fraction) as well as through a COA, a subjective measure of how the patient feels (the Kansas City Cardiomyopathy Questionnaire). (nature.com)
  • The 614 patients enrolled in COAPT had been diagnosed with ischemic or non-ischemic cardiomyopathy (ejection fraction 20% to 50%), moderate-to-severe or worse MR, or New York Heart Association (NYHA) functional class II-IV HF despite maximally tolerated GDMT. (reliasmedia.com)
Ischemic1
  • The hierarchical composite primary endpoint included change in health status according to the overall summary score on the Kansas City Cardiomyopathy Questionnaire at 12 months, cardiovascular death or non-fatal ischemic stroke at 12 months, and total heart failure rate up to 24 months. (sense-studios.com)
Quality-of-l3
  • Participants will be randomized to early or delayed implementation of a validated health-related quality of life survey (the Kansas City Cardiomyopathy Questionnaire). (stanford.edu)
  • Secondary endpoints include major adverse cardiovascular and cerebrovascular events at 30 days, days alive out of the hospital at six months, recovery of left ventricular function, need for durable ventricular assist device or heart transplant, and health-related quality of life as measured by responses to the Kansas City Cardiomyopathy Questionnaire at one year. (fdanews.com)
  • Assessment was performed at baseline and after completion of training protocol and included 6-minute walked distance, quality of life (Kansas City Cardiomyopathy Questionnaire and Minnesota Living with Heart Failure Questionnaire), depressive symptoms (Beck Depression Inventory and Zung self-rated depression scores), B-type natriuretic peptide, endothelial function (flow-mediated dilatation), and left ventricular diastolic function. (lomr.org)
America Heart Institute1
  • The Mid America Heart Institute (MAHI) is located in Kansas City, Missouri and is one of the first and largest hospitals developed and designed specifically for cardiovascular care. (wikipedia.org)
Patients1
  • Researchers analyzed transcutaneous mitral valve repair in patients with moderate-to-severe or worse mitral valve regurgitation caused by cardiomyopathy and heart failure despite maximally tolerated guideline-directed medical therapy. (reliasmedia.com)
Score2
  • The DETERMINE-Reduced and DETERMINE-Preserved trials demonstrated varying benefits of dapagliflozin on Kansas City Cardiomyopathy Questionnaire Total Symptom Score and Physical Limitation Scale as well as 6-minute walk distance. (ajmc.com)
  • In looking at long-term outcomes, researchers found that when compared to nonsmokers, current/recent smokers had higher one-year postdischarge mortality but this was association was lost when adjusted for patient characteristics, and a lower unadjusted and adjusted Kansas City Cardiomyopathy Questionnaire-Overall Summary Score. (acc.org)
Outcomes1
  • Secondary outcomes included echocardiographic parameters and patient-reported health status, assessed with the Kansas City Cardiomyopathy Questionnaire. (houstonmethodist.org)
Heart3
  • The Heart Institute is affiliated with the University of Missouri-Kansas City School of Medicine and has earned the certification as a Comprehensive Cardiac Center from the Joint Commission. (wikipedia.org)
  • At that time, the vast majority of all heart procedures in the Kansas City area and over 20% of cardiovascular procedures in both Kansas and Missouri were done by providers on staff at Saint Luke's Hospital. (wikipedia.org)
  • This is a randomized study evaluating the effect of routinely collecting a standardized questionnaire of heart failure health status during heart failure clinic visits. (stanford.edu)
Treatment1
  • In the analysis pooling data from a pilot study and the APOLLO trial, the high-risk patient population studied with at least moderate-severe symptomatic mitral regurgitation (MR) not considered candidates for surgical treatment had "reduced but continued primary endpoint events after 30 days, largely due to underlying myocardial dysfunction," reported Martin B. Leon, MD, of Columbia University/NewYork-Presbyterian Hospital and the Cardiovascular Research Foundation in New York City. (medpagetoday.com)
Hospital1
  • It is a subsidiary of the not-for-profit Saint Luke's Hospital of Kansas City and is a part of Saint Luke's Health System. (wikipedia.org)
Experience1
Amyloid cardiomyopathy8
  • Accumulation of amyloid fibrils composed of misfolded transthyretin protein in the heart leads to transthyretin amyloid cardiomyopathy and heart failure. (medscape.com)
  • Transthyretin amyloid cardiomyopathy is a rare but severe cause of restrictive cardiomyopathy, caused by the accumulation of transthyretin fibrils in the myocardium. (nih.gov)
  • This activity reviews the pathophysiology, diagnosis, and treatment of Transthyretin amyloid cardiomyopathy and highlights the role of the interprofessional team in evaluating and treating patients with this condition. (nih.gov)
  • Summarize the epidemiology of transthyretin amyloid cardiomyopathy. (nih.gov)
  • Explain the common cardiac and non-cardiac findings associated with transthyretin amyloid cardiomyopathy. (nih.gov)
  • Describe the typical imaging findings associated with transthyretin amyloid cardiomyopathy. (nih.gov)
  • Outline the available treatment options for transthyretin amyloid cardiomyopathy. (nih.gov)
  • Transthyretin amyloid cardiomyopathy (ATTR-CM) is one of the types of systemic amyloidosis in which misfolded transthyretin (TTR) protein gets deposited in the myocardium. (nih.gov)
Obstructive hypertrophic cardiomyopathy1
  • Treatment with a novel myosin-inhibiting agent may improve symptoms and hemodynamics enough in patients with obstructive hypertrophic cardiomyopathy (OHCM) so that they can avoid or at least delay septal reduction therapy (SRT), suggests a randomized trial of modest size and duration. (medscape.com)
Ejection Fraction2
  • Association of Serial Kansas City Cardiomyopathy Questionnaire Assessments With Death and Hospitalization in Patients With Heart Failure With Preserved and Reduced Ejection Fraction: A Secondary Analysis of 2 Randomized Clinical Trials. (nih.gov)
  • Secondary end points included changes over time in 6-minute walk test distance, NT-proBNP (N-terminal pro-B-type natriuretic peptide) concentration, left ventricular ejection fraction, and quality-of-life scores on the Kansas City Cardiomyopathy Questionnaire. (stanfordhealthcare.org)
Heart Failure4
  • 9. Association of Cardiac Biomarkers With the Kansas City Cardiomyopathy Questionnaire in Patients With Chronic Kidney Disease Without Heart Failure. (nih.gov)
  • Health status measured by Kansas City Cardiomyopathy Questionnaire-12 in primary prevention implantable cardioverter defibrillator patients with heart failure. (hig.se)
  • The number of symptoms and symptom distress (physical symptoms on the Memorial Symptom Assessment Scale-Short Form), depression (Geriatric Depression Scale-Short Form), and heart failure-related quality of life (Kansas City Cardiomyopathy Questionnaire) were measured cross-sectionally in 60 patients with heart failure from two outpatient cardiology clinics. (nih.gov)
  • This phase 2 study assessed the effects of the oral selective p38 mitogen-activated protein kinase inhibitor ARRY-371797 on functional capacity and cardiac function in patients with LMNA-related dilated cardiomyopathy.METHODS: Patients with LMNA-related dilated cardiomyopathy in New York Heart Association class II-IIIA, on background heart failure treatment, received ARRY-371797 100 or 400 mg twice daily for 48 weeks. (stanfordhealthcare.org)
Dapagliflozin1
  • The DETERMINE-Reduced and DETERMINE-Preserved trials demonstrated varying benefits of dapagliflozin on Kansas City Cardiomyopathy Questionnaire Total Symptom Score and Physical Limitation Scale as well as 6-minute walk distance. (ajmc.com)
NYHA1
  • Symptoms and physical functioning, as assessed by the Kansas City Cardiomyopathy Questionnaire (patient assessment) and NYHA classification (physician assessment), were also favourably impacted by LCZ696 vs. enalapril. (biomedcentral.com)
Symptoms1
  • The drug also notably improved scores on the Kansas City Cardiomyopathy Questionnaire, a critical tool in evaluating the physical limitations and symptoms of HFpEF. (healthandmedicine.net)
Cardiac4
  • The Heart Institute is affiliated with the University of Missouri-Kansas City School of Medicine and has earned the certification as a Comprehensive Cardiac Center from the Joint Commission. (wikipedia.org)
  • They will perform clinical and biological exams, electrocardiography, echocardiography, cardiac MRI, and scintigraphy, as well as a life quality questionnaire and a functional walking test. (rarediseaseadvisor.com)
  • HF is caused by structural and/or functional cardiac abnormality, mainly by following aetiologies: coronary artery disease, arterial hypertension, valvular heart disease, inflammatory heart disease and/or primary cardiomyopathy. (cfrjournal.com)
  • The autopsy and death certificate, Occupational Health Specialist from the NIOSH Fire completed by the County Coroner, listed "cardiac Fighter Fatality Investigation Team traveled to arrhythmia due to mitral valve prolapse" as the cause Kansas to conduct an on-site investigation of the of death. (cdc.gov)
Scores1
  • There was a trend toward improvement in Kansas City Cardiomyopathy Questionnaire Overall and Clinical Summary scores at week 12. (stanfordhealthcare.org)
Baseline1
  • QoL was assessed at baseline, 1 month, and 1 year using the Kansas City Cardiomyopathy Questionnaire, Medical Outcomes Study Short Form-36, and EQ-5D. (duke.edu)
Life1
  • BACKGROUND: Lamin A/C gene (LMNA)-related dilated cardiomyopathy is a serious and life-threatening condition with a high unmet medical need. (stanfordhealthcare.org)
Missouri1
  • At that time, the vast majority of all heart procedures in the Kansas City area and over 20% of cardiovascular procedures in both Kansas and Missouri were done by providers on staff at Saint Luke's Hospital. (wikipedia.org)