• In humans, plasma kallikrein (encoded by KLKB1 gene) has no known paralogue, while tissue kallikrein-related peptidases (KLKs) encode a family of fifteen closely related serine proteases. (wikipedia.org)
  • Some serine proteases are expressed in nearly all tissues and fluids of the human body, such as the human kallikreins and kallikrein-related peptidases with specialization for often unique substrates and accurate timing of activity. (nih.gov)
  • The Role of Kallikrein-Related Peptidases in Atopic Dermatitis. (bvsalud.org)
  • Distinct from plasma kallikrein, tissue kallikreins (KLKs) are expressed throughout the human body and perform various physiological roles. (wikipedia.org)
  • Similar to KLKB1, three tissue kallikreins KLK1, KLK2 and KLK12 also participate in regulation of blood pressure via the activation of bradykinin. (wikipedia.org)
  • hk3, human kallikrein gene 3) and human glandular kallikrein (hK2) are used as tumor markers for prostate cancer. (wikipedia.org)
  • Kallikreins are a subgroup of serine proteases, enzymes capable of cleaving peptide bonds in proteins. (wikipedia.org)
  • The venom of solenodons and some shrews like the northern short-tailed shrew consist of multiple copies of kallikrein 1 (KLK1) serine proteases. (wikipedia.org)
  • It is also capable of generating plasmin from plasminogen: Kallikrein is homologous to factor XI and consists of four apple domains and one serine protease domain. (wikipedia.org)
  • A glycoprotein that is a kallikrein-like serine proteinase and an esterase, produced by epithelial cells of both normal and malignant prostate tissue. (usda.gov)
  • DX-88 is a yeast-derived recombinant plasma kallikrein inhibitor. (biocentury.com)
  • Many substrates are available including those suitable for assessing the activity of Matrix Metalloproteinases (MMPs), Cathepsins, Kallikreins, Coagulation Factors, and more. (rndsystems.com)
  • 4) A clinically significant history of poor response to bradykinin receptor-2 (BR2) blocker, C1-INH therapy, or plasma kallikrein inhibitor therapy for the management of HAE, in the opinion of the Investigator. (who.int)
  • Called kallikreins, they're proteins that can digest other proteins, and they're secreted in saliva. (bgr.com)
  • The 4K test measures four different kallikrein proteins, including prostate-specific antigen ( PSA ), total PSA, intact PSA, and human kallikrein 2. (medscape.com)
  • In further NRS-funded research, the role of kallikreins -- enzymes also involved in immune response -- is now being studied in rosacea by Dr. Joseph Rothnagel and colleagues at the University of Queensland, Australia. (rosacea.org)
  • A Four-kallikrein Panel Predicts High-grade Cancer on Biopsy: Independent Validation in a Community Cohort. (lu.se)
  • Predicting High-Grade Cancer at Ten-Core Prostate Biopsy Using Four Kallikrein Markers Measured in Blood in the ProtecT Study. (lu.se)
  • As some kallikreins are able to catalyse the activation of other kallikreins, several cascades involving these proteases have been implicated in the regulation of homeostatic functions. (wikipedia.org)
  • We will utilize multiple different approaches to discover and evaluate novel noninvasive diagnostic and prognostic biomarkers, including measurements of four kallikrein markers and microseminoprotein- beta (MSP) in blood adjusted with the interaction from GWAS-based genetic variation in certain biomarker-encoding gene loci to further improve the specificity in our previously reported detection of lethal PCa-forms at very early, curable stages. (lu.se)
  • The caterpillar known as Lagoa crispata contains poison glands attached to hypodermic spines, which produce and inject venom that has been characterized as kallikrein in nature. (wikipedia.org)
  • 1. To determine the effects of diuresis and changes in electrolyte balance on kallikrein gene expression, renal kallikrein mRNA levels were correlated with urine volumes, urinary electrolyte levels, haematocrit and plasma electrolyte levels in rats treated with substances with a range of diuretic activities. (edu.au)
  • Prostaglandin (PG) E 2 , kallikrein, urine volume, sodium and potassium excretion rates remained constant after captopril. (portlandpress.com)
  • The KLKB1 gene encoding plasma kallikrein is located on chromosome 4q34-35. (wikipedia.org)
  • 4. Kallikrein gene expression in kidney was increased after 72h treatment with furosemide, after 24 or 72h treatment with benzyl furosemide or amiloride hydrochloride and was unchanged after 24 or 72 h treatment with isofurosemide or chlorothiazide, compared with vehicle-treated controls. (edu.au)
  • 6. Neither diuresis nor measurable changes in plasma or urinary electrolytes correlate with changes in renal kallikrein gene expression after diuretic treatment of rats. (edu.au)
  • The KLKB1 gene mutations that cause prekallikrein deficiency reduce or eliminate functional plasma kallikrein, which likely impairs the intrinsic coagulation pathway. (medlineplus.gov)
  • This protein, when converted to an active form called plasma kallikrein in the blood, is involved in the early stages of blood clotting . (medlineplus.gov)
  • Plasma kallikrein plays a role in a process called the intrinsic coagulation pathway (also called the contact activation pathway). (medlineplus.gov)
  • Researchers suggest that this lack (deficiency) of functional plasma kallikrein protein does not generally cause any symptoms because another process called the extrinsic coagulation pathway (also known as the tissue factor pathway) can compensate for the impaired intrinsic coagulation pathway. (medlineplus.gov)
  • KalVista has been making substantial advances with our portfolio of oral small molecule plasma kallikrein inhibitors for treatment of HAE. (haei.org)
  • Improving the Specificity of Screening for Lethal Prostate Cancer Using Prostate-specific Antigen and a Panel of Kallikrein Markers: A Nested Case-Control Study. (lu.se)
  • Prekallikrein Kinin-kallikrein system Kinin Aprotinin List of cutaneous conditions Raspi G (September 1996). (wikipedia.org)
  • Prekallikrein is cleaved by Factor XII to form kallikrein, which then cleaves Factor XII first to alpha-factor XIIa and then to beta-factor XIIa. (lu.se)
  • To extend our recent observations of the possible downregulation of glomerular B2-kinin-binding sites, we investigated density (Bmax) of bradykinin (BK)-binding sites in glomerular membranes of both the clipped (C) and nonclipped (NC) kidneys of two-kidney, one-clip (2K-1C) Goldblatt hypertensive rats, in relation to tissue kallikrein activity and glomerular three-dimensional structure. (physiology.org)
  • Kallikreins are responsible for the coordination of various physiological functions including blood pressure, semen liquefaction and skin desquamation. (wikipedia.org)
  • Plasma Kallikrein Inhibitors in Cardiovascular Disease: An Innovative Therapeutic Approach. (nih.gov)
  • Plasma kallikrein inhibitors in bovine plasma. (embl.de)
  • Plasma prekallikrein is the liver-derived precursor of the trypsin-like serine protease plasma kallikrein (PK) and circulates in plasma bound to high molecular weight kininogen. (nih.gov)
  • Although the pathogenesis of rosacea is not fully understood, recent evidence in vitro as well as in vivo has supported the role of increased levels of the trypsin-like serine protease, kallikrein 5, in initiating an augmented inflammatory response in rosacea. (irosacea.org)
  • 18. Evolutionary history of tissue kallikreins. (nih.gov)
  • Bjorkqvist J, Jamsa A, Renne T. Plasma kallikrein: the bradykinin-producing enzyme. (medlineplus.gov)
  • 9. Kallikreins as biomarkers for prostate cancer. (nih.gov)
  • While the function of the majority of the kallikreins remains to be elucidated, two members are useful biomarkers for prostate cancer and several others are potentially useful biomarkers for breast cancer, Alzheimer's, and Parkinson's disease. (unifesp.br)
  • The kallikrein-related peptidase family: Dysregulation and functions during cancer progression. (bvsalud.org)
  • 4. The molecular function of kallikrein-related peptidase 14 demonstrates a key modulatory role in advanced prostate cancer. (nih.gov)
  • 17. Human kallikrein-related peptidase 14 (KLK14) is a new activator component of the KLK proteolytic cascade. (nih.gov)
  • 14. Seminal fluid characterization for male fertility and prostate cancer: kallikrein-related serine proteases and whole proteome approaches. (nih.gov)
  • Human kallikreins are serine proteases that comprise a recently identified large and closely related 15-member family. (unifesp.br)
  • Human kallikrein -related peptidases (KLKs) are secreted serine peptidases which are aberrantly expressed in many cancers and have great potential in developing targeted therapies . (bvsalud.org)
  • 3. Kallikrein-related peptidases (KLKs) as emerging therapeutic targets: focus on prostate cancer and skin pathologies. (nih.gov)
  • Matriptase initiates activation of epidermal pro-kallikrein and disease onset in a mouse model of Netherton syndrome. (nih.gov)
  • The humanized IgG1 antibody hu11B6 internalizes into prostate and prostate cancer (PCa) cells by binding to the catalytic cleft of human kallikrein 2 (hK2), a prostate specific enzyme governed by the AR-pathway. (wustl.edu)
  • Kallikrein 5-Mediated Inflammation in Rosacea: Clinically Relevant Correlations with Acute and Chronic Manifestations in Rosacea and How Individual Treatments May Provide Therapeutic Benefit. (irosacea.org)
  • In this article, the authors review the literature supporting the role of kallikrein 5 in the pathophysiology of rosacea, including how therapeutic interventions modulate the effects of kallikrein 5, thus providing further support for this pathophysiological model that at least partially explains many of the clinical features of cutaneous rosacea. (irosacea.org)
  • The human being kallikrein 8 proteins (KLK8) is indicated in many regular tissues like the salivary gland56. (dc-thera.org)
  • Reduced corporal fibrosis to protect erectile function by inhibiting the Rho-kinase/LIM-kinase/cofilin pathway in the aged transgenic rat harboring human tissue kallikrein 1. (harvard.edu)
  • Preserved Erectile Function in the Aged Transgenic Rat Harboring Human Tissue Kallikrein 1. (harvard.edu)
  • Human tissue kallikrein (human K1) is the best functionally characterized member of this family, and is known to play an important role in blood pressure regulation. (unifesp.br)
  • The increase in the quantity and magnitude of biological activity of kallikrein 5 leads to production of greater quantities of cathelicidin (LL-37), an antimicrobial peptide associated with increases in innate cutaneous inflammation, vasodilation, and vascular proliferation, all of which are characteristic features of rosacea. (irosacea.org)
  • Its synergy of TLR2-Regul and SK5R complexes regulate the activity of Kallikrein-5 (a protease that induces inflammation and vascular problems) so skin is soothed and calmed. (hqhair.com)
  • The Kallikrein-Kinin system is a complex network of blood proteins and enzymes that plays a significant role in the regulation of blood pressure, inflammation, and pain perception. (lookformedical.com)
  • 7. The miRNA-kallikrein axis of interaction: a new dimension in the pathogenesis of prostate cancer. (nih.gov)
  • The contact activation and kallikrein/kinin systems: pathophysiologic and physiologic activities. (nih.gov)
  • Tumor accumulation of [ 177 Lu]hu11B6 peaked at 168 h with a specific uptake of 29 ± 9.1 percent injected activity per gram (%IA/g) and low accumulation in normal organs except in the submandibular gland (15 ± 4.5 %IA/g), attributed to a cross-reaction with mice kallikreins in this organ, was seen. (wustl.edu)