• Although similar in catalytic activity, MMP-9 and MMP-2 may play different roles in response to kainic acid-induced seizure and neuronal degeneration. (ovid.com)
  • After sparteine pretreatment (13mg/kg, administered 30min before the convulsive drug), the animals administered pentylenetetrazole and pilocarpine exhibited reduced mortality rates compared with the corresponding control groups, while the animals administered kainic acid exhibited a delayed onset of convulsive behavior and decreased seizure duration compared with the corresponding control group. (deepdyve.com)
  • Ben-Ari, Y., Tremblay, E., and Ottersen, 0.P., 1980, Injections of kainic acid into the amygdaloid complex of the rat: an electrographic, clinical and histological study in relation to the pathology of epilepsy, Neuroscience 5: 515. (springer.com)
  • GABA benzodiazepine and histamine-H1 receptors in the guinea pig cerebellum: effects of kainic acid injections studied by autoradiographic methods. (nih.gov)
  • Walaas, Ivar 1981-01-01 00:00:00 Abstract: The activity of soluble and particulate guanylate cyclase (EC 4.6.1.2) has been compared with the distribution of neurotransmitter candidates in three rat forebrain nuclei, and the effects of local kainic acid injections into these nuclei have been tested. (deepdyve.com)
  • The objective of this study was to determine whether MMPs are expressed in various regional areas of rat brain after administration of the neurotoxin, kainic acid. (ovid.com)
  • The animals of the control groups, which received intraperitoneal pentylenetetrazole (90mg/kg), kainic acid (9mg/kg) or pilocarpine (370mg/kg), exhibited convulsive behavior and epileptiform activity. (deepdyve.com)
  • Kainic acid, or kainate, is an acid that naturally occurrs in some seaweed. (wikipedia.org)
  • Sensitive indices of neural injury were used to evaluate the time course of kainic acid (KA)-induced hippocampal damage in adult C57BL/6J mice (4 months), a strain previously reported to be resistant to kainate-induced neurotoxicity. (cdc.gov)
  • By using kainic acid (KA) to perform chemical lesions in the guinea pig cerebellum, we have caused degeneration of Purkinje cells without affecting cell morphology. (nih.gov)
  • Furthermore, we demonstrate both in vitro and in vivo that exogenous MMP-7 enhances proNGF cleavage and provides neuroprotection following kainic acid treatment. (jneurosci.org)
  • Alternatively, the kainic acid-mediated astrogliosis is not caspase 3-dependent, although caspase 3 cleavage of glial fibrillary acidic protein occurred. (biomedcentral.com)
  • To provoke the release of [ 3 H]aspartic acid from cerebellar slices, 10 µM KA (Potashner and Gerard, 1983) or at least 500 µM KA (Ferkany and Coyle, 1983) are necessary. (springer.com)
  • The substrate for cyclization was prepared by coupling the acid 15 with the alcohol 16 , followed by selective deprotection and oxidation. (organic-chemistry.org)
  • The roles of caspase 3 on the kainic acid-mediated neurodegeneration, dendritic plasticity alteration, neurogenesis, microglial activation and gliosis are not fully understood. (biomedcentral.com)
  • Dihydrokainic acid is an organic compound that contains two carboxylic acid functional groups, making it a dicarboxylic acid. (wikipedia.org)
  • Fatty acid amide hydrolase (FAAH), which is distributed throughout the brain, is thought to be the primary mediator for the hydrolysis of released endocannabinoids (Cravatt et al. (aspetjournals.org)
  • A second aim of our study was to determine whether kainic acid has any effect on spike-and-wave discharges or on the transition from basal activity to the spike-and-wave discharges. (jneurosci.org)