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  • induce
  • It is concluded that self-assembled DNR/Br Tet-MNPs, as one of the potential antitumor agents for hematologic malignancies, may effectively induce apoptosis of K562/A02 cells through elevating the ratio of bax/bcl-2 , activating caspase 3 , and inactivating survivin . (dovepress.com)
  • assays
  • After the K562cells were cultured with phycocyanin for 6 days, flowcytometric assays showed that more K562 cells wereblocked to progress through S-phase and arrested at G1phase. (springer.com)
  • extracts
  • after 48 h action of Sinopodophyllum emodi ethanol extracts in each treatment group on K562 cells, they produced very significant effects on cell cycle distribution. (alliedacademies.org)
  • The K562 cells were seeded in culture flasks at 5 × 10 4 cells/mL, and cultured at 37°C under 5% CO 2 for 14 h, then the medium was changed and different concentrations of Sinopodophyllum emodi ethanol extracts (concentration relative to the Sinopodophyllum emodi crude drug of 25, 50 and 100 g/L) were added, and the cells were drug treated for 48 h. (alliedacademies.org)
  • reduction
  • In addition to reduction of intracellular thiol, caspase-3 like activity was also decreased in a time-dependent manner in cells treated with 2-NDC. (waocp.org)
  • concentration
  • By using the fluorescent Ca2+ indicator fura-2, perforin was shown to cause intracellular Ca2+ concentration to rise transiently into the micromolar range in the absence of cell death. (biochemj.org)
  • UPF1 and GSH increased while UPF17 and α -GSH decreased the activity of CuZnSOD in K562 cells, at peptide concentration of 10 μ M by 42% and 38% or 35% and 24%, respectively. (hindawi.com)
  • hematopoietic
  • The Philadelphia chromosome in CML gives rise to constitutively active protein tyrosine kinase product BCR-ABL, which is important because in patients with CML, there is clonal expansion of hematopoietic cells that express this fusion gene. (biomedcentral.com)
  • intracellular
  • Detection of relative fluorescence intensity of intracellular DNR demonstrated that intracellular DNR was higher in K562/A02 cells treated with DNR/Br Tet-MNPs than that of DNR/Br Tet-Sol. (dovepress.com)
  • gene
  • In addition, CDA gene silencing in K562 cells led to down-regulated p-ERK1/2, t-AKT, p-AKT and BCL-2 expression and up-regulated expression of P21, Bax, cleaved caspase-3/total caspase-3 and cleaved PARP/total PARP. (springer.com)
  • cycle
  • The proportions of G0/G1 and S phase cells decreased, while the proportion of G2/M phase cells increased, all in an apparent dose dependent manner, indicating that the ethanol extract of Sinopodophyllum emodi arrested K562 cell cycle at the G2/M phase. (alliedacademies.org)
  • Rapid
  • The kinetics of the HERG1 current in K562 cells resembled the rapid component of the native cardiac delayed rectifier current, known to be conducted by heterotetrameric HERG1 channels. (deepdyve.com)
  • microM
  • Using K562 cells as a model, we showed that 25-50 microM resveratrol increased NQO1 that peaked at 24-48 h. (semanticscholar.org)
  • Repeated treatments at 45 minutes intervals with 1 microM HNE were performed to maintain the cells in the presence of the aldehyde for 12 hours. (biomedsearch.com)