• Argentinian mammarenavirus, better known as the Junin virus or Junín virus (JUNV), is an arenavirus in the Mammarenavirus genus that causes Argentine hemorrhagic fever (AHF). (wikipedia.org)
  • family members, Lassa disease (LASV) and Junin disease (JUNV) generate regular annual outbreaks of serious human being hemorrhagic fever (HF) in endemic regions of Western world Africa and Argentina, respectively. (cancerdir.com)
  • Infections by pathogenic New World mammarenaviruses (NWM)s, including Junín virus (JUNV), can result in a severe life-threatening viral hemorrhagic fever syndrome. (bvsalud.org)
  • In the present study, we evaluated ARN-75039 against pathogenic JUNV in the rigorous guinea pig infection model. (bvsalud.org)
  • Arenaviruses are no exception to this, and previous findings have demonstrated that the nucleoprotein (NP) of the highly pathogenic Junín virus (JUNV) exists as three additional N-terminally truncated isoforms of 53 kD (NP53kD), 47 kD (NP47kD), and 40 kD (NP40kD). (uni-greifswald.de)
  • Assess the balance of attenuation, immunogenicity and protective immunity of K33S rCan in the guinea pig model of lethal JUNV infection. (hhs.gov)
  • The live- attenuated Candid#1 strain of Junín virus (JUNV) is currently used in Argentina to protect against Argentine hemorrhagic fever, but this virus carries the distinct liability that attenuation is solely dependent on a single phenylalanine-to-isoleucine substitution at position 427 (F427I) in the GP2 fusion subunit of the JUNV envelope glycoprotein (GPC). (hhs.gov)
  • Taken together, the data from this study suggest a model whereby JUNV generates a pool of smaller NP isoforms with a predominantly cytoplasmic distribution. (uni-greifswald.de)
  • Pilot studies indicate that K33S rCan is indeed attenuated in guinea pigs and capable of eliciting protective immunity against lethal challenge with JUNV. (hhs.gov)
  • Importantly, significant protection against JUNV challenge was observed even when ARN-75039 was withheld until 6 days after the viral challenge when clinical signs of disease are starting to develop. (bvsalud.org)
  • The New World (NW) mammarenavirus Junín (JUNV) is the etiological agent of Argentine hemorrhagic fever, a human endemic disease of Argentina. (bvsalud.org)
  • Our study demonstrates that a NW mammarenavirus as JUNV interacts differently with the antiviral protein PML than LCMV. (bvsalud.org)
  • Although an effective vaccine has been developed, JUNV infections are generally treated with supportive care and in some cases convalescent serum. (justia.com)