Benefit from proteasome inhibitorsImmune checkpointProteasome inhibitor sensitivitySmall moleculeCholinesterase inhibitorsProton pump inhibCheckpoint inhibitorAdenocarcinomaEndothelialToxicityMultiple myelomaKinaseEGFRMatrix metalloproteinasesCYP3A4Epithelial tight junctionPostsynapticBasalHepaticSynapticCancersPotentAdjacentVitroSelectiveNeuromuscular transmissionProteinsReceptorTight-junction integrityAntibodiesMyastheniaInhibitionProtectsTreatmentChemotherapyPatientsCancerGeneIntegrityChannel blockerShown
Benefit from proteasome inhibitors2
- A gene known as TJP1 (tight junction protein 1) could help determine which multiple myeloma patients would best benefit from proteasome inhibitors such as bortezomib, as well as combination approaches to enhance proteasome inhibitor sensitivity, according to a study led by The University of Texas MD Anderson Cancer Center. (news-medical.net)
- Our findings provide a rationale for use of TJP1 as the first biomarker to select patients who are most and least likely to benefit from proteasome inhibitors. (mdanderson.org)
Immune checkpoint3
- Domvanalimab (from Gilead Sciences) is an experimental immune checkpoint inhibitor, and zimberelimab (from Arcus Biosciences) is an investigational angiogenesis inhibitor. (medscape.com)
- Further randomized trials investigate the benefit of antibodies and immune checkpoint inhibitors in locoregional and advanced metastatic gastric cancer with promising results. (unige.ch)
- Several targeted therapies have shown efficacy in patients with advanced gastric cancer (GC) and gastroesophageal junction adenocarcinoma (GEJC), including anti-angiogenic agents and immune checkpoint inhibito. (biomedcentral.com)
Proteasome inhibitor sensitivity1
- TJP1 has not previously been known to play any role as a mediator of proteasome inhibitor sensitivity in multiple myeloma. (mdanderson.org)
Small molecule2
- Their experiments demonstrated that treating mice with a small molecule inhibitor that specifically target the hepatic gap junction protein connexion 32 (Cx32) provides significant protection against liver damage and death resulting from subsequent or simultaneous challenge with known hepatotoxic drugs such as acetaminophen. (genengnews.com)
- FOSTER CITY, Calif. & MONMOUTH JUNCTION, N.J., Apr 20, 2011 (BUSINESS WIRE) -- Gilead Sciences, Inc. (Nasdaq: GILD) and MicroDose Therapeutx, Inc. today announced that the companies have entered into an exclusive worldwide license and collaboration agreement for the development and commercialization of MDT-637, MicroDose's inhalable small molecule antiviral fusion inhibitor for the treatment of respiratory syncytial virus (RSV). (gilead.com)
Cholinesterase inhibitors3
- Which of the following community emergency response agencies should be involved in planning for disasters such as those involving mass exposures to cholinesterase inhibitors? (cdc.gov)
- Which of the following are among the 4 major types of pathology caused by cholinesterase inhibitors? (cdc.gov)
- Introduction of cholinesterase inhibitors can cause a depolarization block. (proteopedia.org)
Proton pump inhib3
- The agents used include antacids, H2 receptor antagonists, proton pump inhibitors, and prokinetic agents. (medscape.com)
- Proton pump inhibitors (PPIs) inhibit gastric acid secretion by inhibition of the H + /K + ATPase enzyme system in the gastric parietal cells. (medscape.com)
- Further treatment included intravenous administration of fluids and proton pump inhibitors, with nihil-per-month restriction. (hindawi.com)
Checkpoint inhibitor1
- Nivolumab has been approved since April 2016 as a checkpoint inhibitor for the treatment of adults with locally advanced or metastatic nonsquamous non-small-cell lung cancer (NSCLC) who have already undergone chemotherapy. (news-medical.net)
Adenocarcinoma6
- Locally advanced unresectable or metastatic gastric, gastroesophageal junction, or esophageal adenocarcinoma. (medscape.com)
- The approval encompasses gastric, gastroesophageal junction (GEJ), and esophageal adenocarcinoma and follows FDA priority review designation for the nivolumab-chemotherapy combination earlier this year. (medpagetoday.com)
- Nivolumab is the first PD-1 inhibitor to demonstrate superior overall survival and [progression-free survival] in combination with chemotherapy in previously untreated patients with advanced gastric, gastroesophageal junction, and esophageal adenocarcinoma," said principal investigator Markus Moehler, MD, of Johannes-Gutenberg University Clinic in Mainz, Germany, during the virtual meeting of the European Society for Medical Oncology. (medpagetoday.com)
- The usefulness of HER2 targeted therapy in gastric cancer was demonstrated in the ToGA trial, where HER2-positive patients with advanced gastric and gastroesophageal junction adenocarcinoma were randomized to receive 5-FU/capecitabine and cisplatin, either alone or in combination with trastuzumab. (wjgnet.com)
- As a consequence of the positive results of the ToGA trial, patients with advanced gastric or gastroesophageal junction adenocarcinoma are now routinely tested for HER2. (wjgnet.com)
- Histologically confirmed adenocarcinoma of the stomach or gastroesophageal junction. (who.int)
Endothelial3
- We found reduced expression of the endothelial cell tight junction protein claudin-5 (Cldn5) and abnormal blood vessel morphology in nucleus accumbens (NAc) of stress-susceptible but not resilient mice. (nih.gov)
- Tight junctions (TJs) are present between the cerebral endothelial cells and serve the function of limiting the paracellular flux of molecules across the BBB. (hindawi.com)
- However, it is uncertain whether ulinastatin can improve renal microcirculation by acting on the endothelial adhesion junction. (scienceopen.com)
Toxicity3
- Which of the following medical conditions can be mimicked by cholinesterase inhibitor toxicity? (cdc.gov)
- Which of the following are true about laboratory tests for cholinesterase inhibitor toxicity? (cdc.gov)
- Their paper is titled "Gap junction inhibition prevents drug-induced liver toxicity and fulminant hepatic failure. (genengnews.com)
Multiple myeloma1
- Proteasome inhibitors form the cornerstone of our standard therapy for multiple myeloma. (mdanderson.org)
Kinase3
- Erlotinib is a type of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor. (news-medical.net)
- Our study examined the effect of a selective Rho kinase inhibitor, Y-27632, on corneal wound healing and potential stromal scarring after superficial keratectomy. (molvis.org)
- Up to 50% of these AChR antibody‒negative patients have antibodies to muscle-specific receptor tyrosine kinase (MuSK), a surface membrane enzyme that helps AChR molecules aggregate during development of the neuromuscular junction. (msdmanuals.com)
EGFR1
- This study allows us to identify promising future directions to overcome proteasome inhibitor resistance in patients with high signaling through EGFR/JAK1/STAT3 pathway by offering combination therapies such as bortezomib with either the EGFR inhibitor erlotinib, or a JAK1 inhibitor such as ruxolitinib," said Orlowski. (mdanderson.org)
Matrix metalloproteinases1
- An inhibitor of matrix metalloproteinases (MMPs) decreased the transmigration of microglia in our system, indicating that MMPs play a role in microglial chemotaxis. (portlandpress.com)
CYP3A41
- Use of strong inhibitors or inducers of CYP3A4. (who.int)
Epithelial tight junction1
Postsynaptic4
- Myasthenia gravis is an autoimmune disease from the neuromuscular junction (NMJ) due to antibodies that assault Maraviroc the different parts of the postsynaptic membrane impair neuromuscular transmitting and result in weakness and exhaustion of skeletal muscle tissue. (healthweeks.com)
- This was largely due to 2 primary points of contention: (1) Which side of the nerve-muscle junction was the defect in MG (the presynaptic nerve endings or the postsynaptic motor end plate)? (medscape.com)
- these antibodies bind to AChRs on the postsynaptic membrane at the neuromuscular junction and interrupt neuromuscular transmission. (msdmanuals.com)
- Myasthenia gravis is a relatively rare autoimmune disorder of peripheral nerves in which antibodies form against acetylcholine (ACh) nicotinic postsynaptic receptors at the myoneural junction. (medscape.com)
Basal2
- Similarly, adherence junctions (AJs) are more basal than TJs and are defined by their cytoplasmic face being linked to the actin cytoskeleton [ 8 ]. (hindawi.com)
- There was no effect of COV treatment on basal or inhibitor-mediated bioelectric responses, indicating that ion transport and tight junction integrity in the airway epithelium were unaffected by COV. (cdc.gov)
Hepatic1
- Previous work by the MIT/MGH and Rutgers team, along with independent research, has demonstrated a link between liver inflammation and the hepatic gap junctions that enable direct intercellular communication between coupled cells in the liver. (genengnews.com)
Synaptic4
- It is embedded in the cell wall of post synaptic nerves at the skeletal neuromuscular junction. (proteopedia.org)
- Increases speed of synaptic vesicle recycling and changes synaptic performance in ex vivo murine neuromuscular junction. (tocris.com)
- shifts synaptic vesicle recycling to a fast mode at the mouse neuromuscular junction. (tocris.com)
- Ripple oscillations persist in the absence of chemical synaptic transmission and inhibitors of gap junctions were shown to block high-frequency oscillations in hippocampal slices. (medscimonit.com)
Cancers2
- Allosteric SHP2 inhibitors within cancers: Gps unit perfect junction regarding RAS, opposition, and the defense microenvironment. (pimpathway.com)
- In this article, we'll take a look at what PARP1 inhibitors are and their connection to BRCA-mutated cancers. (biotechprimer.com)
Potent1
- Pemetrexed is an antimetabolic agent and is well-known as a potent inhibitor of thymidylate synthase (TS). (scirp.org)
Adjacent2
- AChR antibodies are typically of the immunoglobulin (Ig)G1 and IgG3 (human) subclasses can lead to complement-mediated attack and being able to bind divalently to adjacent AChRs around the muscle surface can also increase the rate of AChR internalisation (for a review of the earlier history of MG research see 2 The resulting loss of AChRs at the neuromuscular junction (NMJ) impairs neuromuscular transmission (see Physique 1). (healthweeks.com)
- Tight junctions between adjacent epithelial cells constitute the physiological barrier to fluid and macromolecules in epithelium. (nih.gov)
Vitro1
- The investigators moved on to think about evaluating the therapeutic potential of pharmacologically inhibiting Cx32, using 2-aminoethoxy-dipenyl-borate (2APB), a compound previously shown to transiently inhibit Cx32 gap junctions in vitro, and which they confirmed was specific to the Cx32 gap junction protein. (genengnews.com)
Selective1
- Additionally, these drugs, both non-selective inhibitors and selective cyclooxygenase-2 inhibitors, are frequently associated with side effects, impairing patients' compliance to their use 6 . (bvsalud.org)
Neuromuscular transmission1
- The document notes that acquired myasthenia gravis is a disorder of neuromuscular transmission, resulting from binding of autoantibodies to components of the neuromuscular junction, most commonly the acetylcholine receptor. (medscape.com)
Proteins1
- The effect of YXQNW on cerebral microvascular exudation was associated with the inhibition of the low-expression of junction proteins, especially AJs mediated by Rho GTPase-activating protein 21 (Arhgap21), while the effect on CH was associated with the inhibition of leukocyte adhesion, the release of MMP-9 derived from macrophage, and low-expression and degradation of collagen IV and laminin in the vascular basement membrane. (bvsalud.org)
Receptor1
- Amplification of the human epidermal growth factor receptor 2 ( HER2 ) gene and overexpression of the HER2 protein is found in 15%-20% of patients with gastric and gastroesophageal junction cancer. (wjgnet.com)
Tight-junction integrity1
- This decreased inflammatory tone was associated with a lower intestinal permeability and improved tight-junction integrity compared to controls. (bmj.com)
Antibodies2
- MuSK antibodies are predominantly IgG4 and cause disassembly of the neuromuscular junction by disrupting the physiological Maraviroc function of MuSK in synapse maintenance and adaptation. (healthweeks.com)
- Here we discuss how knowledge of neuromuscular junction structure and function has fed into understanding the mechanisms of AChR and MuSK antibodies. (healthweeks.com)
Myasthenia1
- When discussing diseases of the neuromuscular junction (NMJ), many physicians first think of myasthenia gravis (MG). This is entirely appropriate, as research into the pathogenesis of MG has always been at the center of our understanding of the NMJ. (medscape.com)
Inhibition1
- Ulinastatin effectively protects the adhesion junction and helps ameliorate the perfusion of kidney capillaries during sepsis by the inhibition of autophagy and the expression of inflammatory factors. (scienceopen.com)
Protects1
- Gap junction protein inhibitor protects mice from death and liver damage after hepatotoxic drug challenge. (genengnews.com)
Treatment3
- We reported an intriguing case in which a non-small cell lung cancer patient who was refractory to pretreatment with S-1, a strong TS inhibitor, showed good response to pemetrexed treatment. (scirp.org)
- Initial in vivo studies demonstrated that mice deficient in Cx32, the primary gap junction protein in the liver, were far less susceptible than wild-type mice to actual liver damage and inflammation caused by treatment with the hepatotoxin thioacetamide (TAA). (genengnews.com)
- The spatial patterns of liver injury in the TAA-treated wild-type mice led the authors to postulate that gap junction communication between cells might promote the propagation and amplification of an injury signal after TAA treatment. (genengnews.com)
Chemotherapy2
- Patients with oligometastatic gastric and esophagogastric junction cancer are randomized after chemotherapy to either undergo resection followed by adjuvant chemotherapy or to undergo definitive chemotherapy. (unige.ch)
- A PARP1 inhibitor is usually administered in combination with chemotherapy or radiation therapy, which increases the incidence of apoptosis-triggering DNA damage. (biotechprimer.com)
Patients1
- PARP1 inhibitors are back in the headlines after Astra Zeneca's (Cambridge, England) and Merck's (Kenilworth, New Jersey) Lynparza approval by FDA to treat pancreatic cancer patients based on the positive Phase III results. (biotechprimer.com)
Cancer1
- Overall, this review will discuss the current status of HER2 in gastric and gastroesophageal junction cancer and the future direction in relation to HER2 target therapy. (wjgnet.com)
Gene1
- junction model per million distinctively mapped reads (RPJM) and reads per kilobase of gene model per million mapped reads (RPGM) for quantitating splice junction and gene manifestation. (ecologicalsgardens.com)
Integrity2
- These findings suggest that chronic social stress alters BBB integrity through loss of tight junction protein Cldn5, promoting peripheral IL-6 passage across the BBB and depression. (nih.gov)
- Conclusions: The results of this study suggest that carbenoxolone as a gap-junction channel blocker can decelerate the learning performances of rats in a spatial memory task, such as the MWM, that requires the integrity of the hippocampus. (medscimonit.com)
Channel blocker1
- Transepithelial potential difference, short-circuit current and transepithelial resistance were measured using tracheas mounted in Ussing chambers and treated with the ion transport inhibitors amiloride (Na+ channel blocker), NPPB (Cl- channel blocker) and ouabain (Na+, K+ -pump blocker). (cdc.gov)
Shown1
- MDT-637 is a fusion inhibitor that has been shown to block RSV infection in preclinical testing. (gilead.com)