Junb transcription factor ap 1. Medical search. Frequent questions

JunB proto-oncogene, AP-1 transcription f. (gsea-msigdb.org)
JunB proto-oncogene, AP-1 tra. (gsea-msigdb.org)

PURPOSE: Patritumab deruxtecan, or HER3-DXd, is an antibody-drug conjugate consisting of a fully human monoclonal antibody to human epidermal growth factor receptor 3 (HER3) attached to a topoisomerase I inhibitor payload via a stable tetrapeptide-based cleavable linker. (bvsalud.org)
The mouse monoclonal PSA antibody (Dianova DIA-PSA, clone HAM18) was used at 1:100 and 1:800. (cancercurehere.com)
The protein c- Jun was detected by antibody-blocking experiments, and Jun-B was detected by gel supershift assay of the activating protein (AP-1) complex. (usuhs.edu)
Humanized anti-CD123 antibody facilitates NK cell antibody-dependent cell-mediated cytotoxicity (ADCC) of Hodgkin lymphoma targets via ARF6/PLD-1. (rndsystems.com)
JunB Antibody detects endogenous levels of total JunB. (affbiotech.com)

Genetic instability of tumor cells may lead to altered expression of apoptotic proteins and immune-regulatory molecules, such as transforming growth factor-beta. (medscape.com)
1) Characterize novel families of oncoproteins (Pbx and Meis) that dimerize with and regulate the DNA binding properties of Hox proteins. (stanford.edu)
These are frequently activated by fusion to other transcriptional proteins resulting in chimeric transcription factors. (stanford.edu)
The early response gene proteins, Fos and Jun family, are components of the transcription factor AP-1 that, depending on its composition, could be related with proliferation, differentiation or cellular death. (usp.br)
The results showed that ACTH and FGF2 treatments modify the expression pattern of these proteins, inducing consistent and expressive increase of JunB expression in the ACTH-treated cells, suggesting an AP1 composition with JunB/c-Fos or FosB. (usp.br)
PEP interacts with JunB proteins to mediate the interplay between aerobic glycolysis and Th17 differentiation, selectively targeting autoimmune cells. (oist.jp)
These data suggest that the 243- and 289-amino acid E1A proteins both interact functionally with the cAMP signaling system to activate transcription of a cellular gene and AP-1-binding activity. (princeton.edu)
AP-1 proteins are primarily considered to be oncogenic. (biomedcentral.com)
Most of the important insights regarding the specific function of AP-1 proteins have been established through the use of mice with either loss- or gain-of-function manipulations of various members of the bZIP protein family [ 13 ]. (biomedcentral.com)
The proteins c-Jun and Jun-B are detected in the AP-1 complex after administration of lipopolysaccharide. (usuhs.edu)
A hallmark of events observed during segmentation was the induction of multiple transcription factors, including a large group of homeobox proteins in pace with decay of a large fraction of maternal transcripts. (biomedcentral.com)
On the biochemistry function, POGLUT2 can catalyze to transfer the glucose from UDP-glucose to a serine residue and specifically target extracellular epidermal growth factor (EGF) repeats of proteins such as Notch signaling members (NOTCH1 and NOTCH3) ( 9 , 10 ), thereby affecting Notch signaling pathway ( 11 ). (frontiersin.org)
We subsequent investigated if AS601245 would inhibit the induction of phosphorylation of AP 1 proteins that are reportedly JNK substrates. (alkpathway.com)

We demonstrate here that GSK-3 maintains the MLL leukemia stem cell transcriptional program by promoting the conditional association of CREB and its coactivators TORC and CBP with homedomain protein MEIS1, a critical component of the MLL-subordinate program, which in turn facilitates HOX-mediated transcription and transformation. (stanford.edu)
Transcriptional run-on analysis demonstrated that ionizing radiation stimulates the rate of c-jun gene transcription. (wustl.edu)
These two cell types differed, however, in their NF-κB and AP-1 binding after lipopolysaccharide stimulation, possibly due to differences in the expression of the subunits that comprise these transcriptional complexes. (ersjournals.com)
The c-Jun protein, along with c-Fos, is a component of the AP-1 transcriptional complex. (avivasysbio.com)
Both estrogen and antiestrogen can mediate transcriptional activity via the recently identified ER 3 -β (1, 2, 3) . (aacrjournals.org)
Significantly differentially expressed (SDE) immunological genes and transcription factor (TF) were selected for functional pathways and transcriptional signaling identification. (frontiersin.org)

This is an all-inclusive cell-based luciferase reporter assay kit targeting the Human Activator Protein-1 (AP-1). (indigobiosciences.com)
INDIGO's AP-1 reporter assay utilizes proprietary mammalian cells that have been engineered to provide constitutive expression of the Human Activator Protein-1 (AP-1). (indigobiosciences.com)
Transcription factor binding sites, including that for activator protein (AP)-1, were found in this region. (quantichrome.com)
The calcium-mediated transient up-regulation of Sema3A expression was significantly suppressed by mitogen-activated protein kinase [ MAPK ]/extracellular signal-regulated kinase [ERK] ( MEK ) 1/2 or AP-1 inhibitors. (quantichrome.com)
Significant E1A-dependent induction of c-fos mRNA and AP-1-binding activity was observed in cells expressing either E1A protein. (princeton.edu)
The c-jun gene encodes a component of the AP-1 protein complex and is important in early signaling events involved in various cellular functions. (wustl.edu)
The c-Jun dimerization protein 2, JDP2 is an AP-1 repressor protein that potently inhibits AP-1 transcription. (biomedcentral.com)
Electrophoretic mobility shift assays were performed in order to examine nuclear factor (NF)-κB and activator protein (AP)-1 binding activities. (ersjournals.com)
protein phosphatase 1 catalytic subunit a. (gsea-msigdb.org)
tight junction protein 1 [Source:HGNC Sym. (gsea-msigdb.org)
Dopamine acts in the striatum through the D 1 and D 2 subfamilies of G-protein-coupled receptors. (jneurosci.org)
Increased cAMP can activate protein kinase A, which phosphorylates the transcription factor cAMP response element-binding protein (CREB). (jneurosci.org)
FYN binding protein 1 [Source. (gsea-msigdb.org)
The response to GLP-1 was mimicked by forskolin and largely inhibited by the protein kinase A (PKA) inhibitors, H89 and myristoylated PKI(14-22) amide, indicating partial mediation via a cAMP/PKA pathway. (diabetesjournals.org)
We have previously identified NFAT (nuclear factor of activated T-cells) as a key regulator of insulin gene transcription in pancreatic β-cells that is activated by the calcium/calmodulin-dependent protein phosphatase 2B (calcineurin) in response to increased [Ca 2+ ] i ( 10 ). (diabetesjournals.org)
JNK specicity with the inhibitory result is more suggested by our nding that inhib itors of the mitogen activated protein kinase family, such as the ERK inhibitor U0126 or even the p38 inhibitor SB202190, exhibited no inhibitory exercise on HIV 1 reactivation. (alkpathway.com)

T-cell receptor (TCR)-dependent induction of the transcription factor IRF4 is essential for eTreg differentiation, but how IRF4 activity is regulated in Treg cells is still unclear. (elsevierpure.com)
The variety of AP-1 dimer configurations confer versatility to this transcription factor in regulating numerous physiological (cell proliferation, differentiation, apoptosis, migration) and pathological activities (cancer, inflammation, transplant rejection) in the cell. (indigobiosciences.com)
PEP was found to bind to JunB, an AP-1 transcription factor that plays a key role in pathogenic Th17 differentiation, inhibiting DNA-binding of the JunB/BATF/IRF4 complex at the Il17a locus. (oist.jp)
The AP-1 transcription factor plays a major role in cell proliferation, apoptosis, differentiation and developmental processes. (biomedcentral.com)
Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-kappa B. JunB potentiates function of BRCA1 activation domain 1 (AD1) through a coiled-coil-mediated interaction.JunB is an important regulator of erythroid Differentiation. (avivasysbio.com)
MiR-155 also upregulates Mxd1/Mad1, a network of basic helix-loop-helix leucine zipper transcription factors which mediate cellular proliferation, differentiation, and apoptosis, through regulating BCL6. (biomedcentral.com)
The aim of this dataset was to study in detail the transcription kinetics initiated by cytokine IL-4 in early differentiation of Th2 cells. (gsea-msigdb.org)
Finally, we found that transcription factors Jun , Fos , Atf3 , and Egr1 were upregulated in protective cells, especially Egr1 was predicted to be involved in the regulation of genes related to antioxidant stress and angiogenesis, suggesting a role in promoting differentiation into this cell phenotype. (hindawi.com)
The scRNA-seq analysis was used to characterize the dynamic changes associated with fibroblast differentiation and identified Gpx3 as a factor that might be involved in the regulation of myocardial fibrosis under cardiac pressure overload. (hindawi.com)

For example, GLP-1 potentiates glucose-induced insulin exocytosis. (diabetesjournals.org)

[ 12 ] part of the AP-1 transcription factor complex involved in cell proliferation and apoptosis, in virtually all CD30 + lymphomas. (medscape.com)

Nesse trabalho utilizamos culturas de células primárias de adrenal de ratos para avaliar por imunocitoquímica e por imunoblotting, os efeitos do ACTH e do FGF2, na expressão das proteínas c-Fos, FosB, Fra1, Fra2, c-Jun, JunB e JunD. (usp.br)

This mechanism also applies to hematopoietic cells transformed by other HOX genes, including CDX2, which is highly expressed in a majority of acute myeloid leukemias, thus providing a molecular approach based on GSK-3 inhibitory strategies to target HOX-associated transcription in a broad spectrum of leukemias. (stanford.edu)
Products of the adenovirus E1A gene can act synergistically with cAMP to activate transcription of several viral early genes and the cellular genes c-fos and jun-B. Transcription factor AP-1-binding activity is also induced by the combined action of E1A and cAMP. (princeton.edu)
Moreover, transcription factors and their target genes form vast interacting gene regulatory networks which can be exquisitely stable. (amegroups.org)
Using the 6-hydroxydopamine lesion model of Parkinson's disease and differential display PCR, we have identified a set of more than 30 genes whose expression rapidly increases in response to stimulation of striatal dopamine D 1 receptors. (jneurosci.org)
Some of the induced genes, such as CREM, CHOP, and MAP kinase phosphatase-1, may be components of a homeostatic response to excessive stimulation. (jneurosci.org)
MicroRNAs (miRNAs) are short (about 21 nucleotides long) strands of non-coding RNA that regulate the expression of multiple genes [ 1 ]. (biomedcentral.com)

Here we show that the AP-1 transcription factor, JunB, is expressed in eTreg cells and promotes an IRF4-dependent transcription program. (elsevierpure.com)
Mechanistically, JunB facilitates the accumulation of IRF4 at a subset of IRF4 target sites, including those located near Icos and Ctla4. (elsevierpure.com)
Thus, JunB is a critical regulator of IRF4-dependent Treg effector programs, highlighting important functions for AP-1 in Treg-mediated immune homeostasis. (elsevierpure.com)

WW domain containing transcription regula. (gsea-msigdb.org)

Growth factors, such as Epidermal growth factor can also suppress miR-203 in epithelial cells. (wikipedia.org)
We assessed the efficacy and safety of HER3-DXd in patients with epidermal growth factor receptor (EGFR)-mutated non-small-cell lung cancer (NSCLC). (bvsalud.org)
Calcium-inducible MAPK/AP-1 signaling drives semaphorin 3A expression in normal human epidermal keratinocytes. (quantichrome.com)

JunB is involved in many types of human carcinoma including T-cell lymphomas, CML,primary cutaneous lymphomas. (avivasysbio.com)

The team discovered that phosphoenolpyruvate (PEP) inhibits JunB-dependent Th17 generation. (oist.jp)
Inhibits MEK-1 and MEK-2 (IC 50 values of 0.07 and 0.06 μ M respectively) with little or no effect on the activities of PKC, Abl, Raf, MEKK, ERK, JNK, MKK-3, MKK-4/SEK, MKK-6, Cdk2 or Cdk4. (rndsystems.com)

O ACTH induz aumento consistente da expressão de JunB, o que sugere uma composição de AP1 formada por JunB/c-Fos ou FosB. (usp.br)

They demonstrated that c-jun suppresses, while another member of the AP-1 transcription factor complex, JUNB increases miR-203 expression. (wikipedia.org)
Lipopolysaccharide induced increases in AP-1 and Zif268 consensus DNA- binding activity in mouse liver. (usuhs.edu)

We sought to examine the potential of JDP2 to inhibit c-Jun/AP-1 oncogenic activity in mice. (biomedcentral.com)

Also, since BCL6 interacts with several co-repressor complexes to inhibit transcription, and its gene is frequently trans-located and hyper-mutated in diffuse large B cell lymphoma (DLBCL), miR-155 acts to enhance transcription and contribute to the pathogenesis of DLBCL. (biomedcentral.com)

Although the role of AP-1 in cell proliferation is well established [ 12 ], activating mutations of this complex have never been found in human cancer. (biomedcentral.com)

The CD30 antigen is a type 1 transmembrane glycoprotein of the tumor necrosis factor receptor superfamily. (medscape.com)
Cell-to-cell signalling is induced by specific ligands such as growth factors which activate their cognate receptor molecules. (amegroups.org)
activin A receptor type 1 [Source:HGNC Sy. (gsea-msigdb.org)
When the level of estrogen receptor (ER)-β mRNA in tumors, determined by reverse transcription-PCR, was assessed according to either ER status or PR status alone, determined by ligand binding assays, the level of ER-β mRNA was significantly lower in PR+ tumors compared with PR−tumors ( P = 0.036), and no association with ER status was found. (aacrjournals.org)

This complex process is regulated by the interplay of transcription factors with a chromatin environment, both of which provide the epigenetic information maintaining cell-type specific gene expression patterns. (amegroups.org)

AP-1 is activated by a variety of physiological and environmental stimuli such as growth factors, cytokines, stress, ultraviolet radiation, and bacterial and viral infections. (indigobiosciences.com)
Transcription factor involved in regulating gene activity following the primary growth factor response. (abcam.cn)
latent transforming growth factor beta bi. (gsea-msigdb.org)
transforming growth factor beta 1 [Source. (gsea-msigdb.org)
Genome-wide transcript analysis showed that B. anthracis undergoes considerable changes in gene expression during growth in iron-depleted media, including the regulation of known and candidate virulence factors. (omictools.com)

Both glucose and GLP-1 stimulate insulin promoter activity, stabilize proinsulin mRNA, and increase proinsulin biosynthesis ( 14 ). (diabetesjournals.org)

The activity of these elements is controlled by transcription factors (TFs) which bind to DNA wrapped into chromatin, leading to the modification of the chromatin landscape, and the assembly of the transcription machinery. (amegroups.org)
Consequently, it's conceivable that the observed inhibitory activity of AS601245 on HIV one reactivation could be exerted through mod ied AP one interaction with these crucial transcription element bind ing web-sites. (alkpathway.com)

Mice lacking JunB in Treg cells develop multi-organ autoimmunity, concomitant with aberrant activation of T helper cells. (elsevierpure.com)

AP-1 is one of the transcription factors found at the receiving end of multiple signaling pathways. (biomedcentral.com)
These data suggest that the synergistic action of glucose and GLP-1 to promote insulin gene transcription is mediated through NFAT via PKA- and calcineurin-dependent pathways in pancreatic β-cells. (diabetesjournals.org)
Two signaling pathways arising from glucose metabolism converge to activate NFAT-mediated insulin gene transcription. (diabetesjournals.org)

The dimer composition of AP-1, the cell type and the stage of development are all important in the regulation of AP-1 activity. (indigobiosciences.com)
These results demonstrate that the calcium-mediated transient up-regulation of Sema3A in NHEKs is involved in the MEK/ ERK and AP-1 signaling axis. (quantichrome.com)
Glucose metabolism is central to the regulation of β-cell function ( 11 ), and GLP-1 is a potent hormonal incretin that has been shown to markedly enhance the stimulatory effects of glucose on β-cells ( 12 , 13 ). (diabetesjournals.org)

In addition to AP-1 Reporter Cells, this kit provides two optimized media for use during cell culture and in diluting the user's test samples, a reference activator, Luciferase Detection Reagent, and a cell culture-ready assay plate. (indigobiosciences.com)
Dose-dependent inhibition of AP-1 Human AP-1 Reporter Cells were treated with an ~EC80 concentration of PMA (10 nM) and then challenged with the inhibitors JNK Inhibitor V, CC-401, PD98059, CAY 10561, and PKC inhibitors Bisindolylmaleimide I and XI (all from Cayman Chemical, USA). (indigobiosciences.com)
Although Th17-related cytokines or transcription factors are attractive therapeutic targets to combat autoimmune responses, treatments often also attack helpful, gut-resident Th17 cells, compromising gut homeostasis and host defense. (oist.jp)
As JunB is required for generation of autoimmune Th17 cells but not for gut-resident Th17 cells, PEP selectively targets autoimmune Th17 cells without triggering intestinal side effects. (oist.jp)
In this study, GLP-1 (100 nmol/l), in the presence of glucose (11 mmol/l), induced a ∼71-fold increase in insulin gene promoter activity in INS-1 pancreatic β-cells, an effect that was an order of magnitude larger than with either stimulant alone. (diabetesjournals.org)
Glucose and GLP-1 also synergistically activated NFAT (nuclear factor of activated T-cells)-mediated transcription from a minimal promoter construct containing tandem NFAT consensus sequences. (diabetesjournals.org)
The rate of insulin gene transcription in pancreatic β-cells is regulated by a complex integration of signals derived from nutrients, hormones, and neurotransmitters ( 1 - 5 ). (diabetesjournals.org)
As seen in Fig. 6A, the results of PMA stimulation on JNK activation, as measured by changes while in the degree of phosphorylated JNK, were fairly modest in both the parental Jurkat cell popula tion as well as the latently HIV 1 infected CA5 T cells. (alkpathway.com)
PMA led to c Jun, c Fos, and JunB activation within the latently HIV 1 infected CA5 T cells. (alkpathway.com)
Interleukin (IL)-9-producing subset called Th9 cell, Th22 cells which primarily secrete IL-22, IL-13 and tumor necrosis factor- and Th25 cells via producing IL-25 are believed to be important for initiating allergic reactions and developing airway inflammation. (cdc.gov)

cadherin 1 [Source:HGNC Symbol;Acc:HGNC:1. (gsea-msigdb.org)
catenin beta 1 [Source:HGNC Symbol;Acc:HG. (gsea-msigdb.org)
histone deacetylase 1 [Source:HGNC Symbol. (gsea-msigdb.org)

inhibitor of DNA binding 1 [Source:HGNC S. (gsea-msigdb.org)
Significantly, the actions of both GLP-1 and forskolin were abolished by the selective Ca 2+ /calmodulin-dependent phosphatase 2B (calcineurin) inhibitor, FK506, as well as by the chelation of intracellular Ca 2+ by BAPTA (bis(2-aminophenoxy)ethane- N,N,N ′ ,N ′-tetraacetate). (diabetesjournals.org)
Taken together, these information deliver evi dence that AS601245 is just not a common transcription inhibitor but would seem to fairly selectively stop reactivation of latent HIV one infection. (alkpathway.com)
In help from the concept that AP 1 binding for the LTR is one particular target of AS601245 as an inhibitor of HIV one reactivation, we located that a second JNK inhibitor, SP600215, also inhibited HIV 1 reactiva tion but with less efciency. (alkpathway.com)

JunB promotes expression of Treg effector molecules, such as ICOS and CTLA4, in BATF-dependent and BATF-independent manners, and is also required for homeostasis and suppressive functions of eTreg. (elsevierpure.com)
Sema3A expression was increased by the co-overexpression of JunB and Fra-2 in the presence of 0.1 or 1.4 mM calcium. (quantichrome.com)
This suggests that GzB expression may be a factor contributing to the favourable response of this lymphoma to treatment. (biomedcentral.com)
In this review, we highlight the main signals and transcription factors and how they are integrated at the level of chromatin programming and gene expression control. (amegroups.org)
These transcription factors likely have important roles in the reprogramming of gene expression that leads to the acute-phase response. (usuhs.edu)
The gene expression profile was standardized (i.e., means and variances in each sample are 0 and 1, respectively). (biomedcentral.com)
To perform gene selection using gene singular value vectors, \(x_{\ell _{1},i_{1}}\) for synthetic data and \(x_{\ell _{5},i}\) for real gene expression profiles, we have to decide which singular value vectors are used for the selection. (biomedcentral.com)
Mutations of the three AP 1 internet sites during the enhancer element of the HIV 1 extended terminal repeat are already dem onstrated to substantially decrease HIV one expression. (alkpathway.com)

Dose-response activation of AP-1 using PMA. (indigobiosciences.com)
To discover regardless of whether JNK would certainly be the molecular tar get of AS601245 while in the selleck context of HIV one reactivation, we initially investigated whether and just how the HIV 1 reactivating stimuli applied would set off JNK activation. (alkpathway.com)
AS601245 addition delayed PMA induced c Jun activation and lowered c Fos and JunB activation by 50% or 70%, respectively. (alkpathway.com)

Lymphomatoid papulosis is part of a spectrum of CD30 (Ki-1)-positive cutaneous lymphoproliferative diseases (CD30 + LPDs), including lymphomatoid papulosis, pcALCL, and borderline CD30 + lesions. (medscape.com)
Also see Cutaneous CD30+ (Ki-1) Anaplastic Large-Cell Lymphoma . (medscape.com)

TGFB induced factor homeobox 1 [Source:HG. (gsea-msigdb.org)

This gene encodes a basic motif-leucine zipper transcription factor of the Maf subfamily. (en-academic.com)

Scenario 1 evaluated all postoperatively available guidelines including pathological tumor stage, pathological lymph node status (pN), medical margin status, preoperative serum PSA value and pathological Gleason grade acquired after the morphological evaluation of the entire resected prostate. (cancercurehere.com)
Constant with its lack of anti tumor activity when administered systemically, the parental STAT3 decoy exhibited a comparatively brief serum half life of around 1. (alkpathway.com)

however, mRNAs encoding a subset of factors important for error-free replication and chromosome segregation, including TIPIN, PLK2 and PLK3, remain at low abundance. (babraham.ac.uk)

Most of the papers being reviewed here confirm the role of miR-155 in oncogenesis (EMBO Mol Med 1:288-295, 2009). (biomedcentral.com)

Although inhalation of toxic gases and particles is the major risk factor for COPD 3 , viral infections, particularly childhood infection, add to the risk of developing this condition 1 . (ersjournals.com)

One pathway results from the direct effect of increased [Ca 2+ ] i , which activates calcineurin, and in turn, it upregulates insulin gene transcription via NFAT. (diabetesjournals.org)
The second pathway also involves glucose metabolism but appears to be driven by glucose-derived factors that target insulin gene transcription independently of [Ca 2+ ] i . (diabetesjournals.org)

Monocytes (MC) are bone marrow (BM) derived mononuclear phagocytes that play an important role in innate immune response and are the major immune cell population in chronic tissue inflammatory ( 1 , 2 ). (frontiersin.org)
JNK would be an intriguing candidate target to describe our ob servations, as AP one, which has become described as very important for ef cient HIV 1 transcription, is usually a nicely described JNK substrate. (alkpathway.com)

Post-traumatic stress disorder (PTSD) [ 1 ] is primarily a mental illness caused by stressors. (biomedcentral.com)

Anatomy16

Organisms8

Chemicals and Drugs137

Analytical, Diagnostic and Therapeutic Techniques and Equipment22

Phenomena and Processes70

Disciplines and Occupations1

Information Science3

Proto-oncogene2

Antibody5

Proteins13

Transcriptional6

Protein16

Differentiation9

Potentiates1

Apoptosis1

JunD1

Genes6

IRF43

Regula1

Epidermal3

Lymphomas1

Inhibits2

FosB1

Increases2

JDP21

Interacts1

Proliferation1

Receptor4

Interplay1

Growth5

MRNA1

Bind2

Mice1

Pathways3

Regulation3

Cells10

Source:HGNC Symbol3

Inhibitor4

Expression8

Activation3

Cutaneous2

Homeobox1

Gene encodes1

Tumor2

Subset1

Oncogenesis1

Viral1

Pathway2

Important2

Primarily1