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  • apoptosis
  • miR-15b and miR-16 regulate TNF mediated hepatocyte apoptosis via BCL2 in acute liver failure," Apoptosis , vol. 17, no. 7, pp. 702-716, 2012. (hindawi.com)
  • The regulatory role of microRNA-1187 in TNF- α -mediated hepatocyte apoptosis in acute liver failure," International Journal of Molecular Medicine , vol. 29, no. 4, pp. 663-668, 2012. (hindawi.com)
  • Nucleosomes, formed during apoptosis, can complex with high-mobility group box 1 (HMGB1) protein and may play a pathogenic role in liver injury. (semanticscholar.org)
  • Echinacoside ameliorates D-galactosamine plus lipopolysaccharide-induced acute liver injury in mice via inhibition of apoptosis and inflammation. (semanticscholar.org)
  • 2016
  • In 2016, he was elected as the President of APASL Tokyo, the President of 52nd Annual Meeting of Japan Society of Hepatology, and the President of Funabashi Central Hospital. (lidsen.com)
  • cirrhotic patients
  • In fact high-protein diets are well tolerated in cirrhotic patients [ 2 ], with consensus supporting the need for normal or high dietary protein (1-1.5 g/kg protein and 25-40 kcal/kg per day) [ 2 , 3 ]. (hindawi.com)
  • In most cirrhotic patients, a modified eating pattern, based on several meals and a late evening snack, is adequate [ 4 , 6 ]. (hindawi.com)
  • Outcome scoring systems for short-term prognosis in critically ill cirrhotic patients," Shock , vol. 36, no. 5, pp. 445-450, 2011. (hindawi.com)
  • 2001
  • The mean cost of hospitalization for patients with ACLF is three times more than the cost of patients hospitalized with cirrhosis, and five times more than the cost of patients hospitalized with congestive heart failure The estimated mortality rates in patients with ACLF has decreased from 65% in 2001 to 50% in 2011. (statpearls.com)
  • ACLF
  • In this study, we try to assess the association between expression of NK cells and its receptors and prognosis of patients with ACLF in advanced phase. (scirp.org)
  • According to whether their total bilirubin within 7 days of average daily rise is ≥17.1 umol/L or not, we differentiated patients with ACLF into advanced phase and not-advanced phase. (scirp.org)
  • A total of 35 inpatients with HBV related acute-on-chronic liver failure (HBV-ACLF) were recruited from October 2010 to September 2012 from our department. (scirp.org)
  • There were 53 ACLF patients and 53 patients without ACLF in this study. (hindawi.com)
  • The 28-day and 90-day mortality rates were also obviously high in patients with ACLF (38.3% and 74.5%, resp. (hindawi.com)
  • Therefore, recognition and intervention of the predictors of mortality in ACLF patients can prevent or reverse the process and improve the survival rate. (hindawi.com)
  • Several patients with ACLF have been recently reported [ 3 - 7 ]. (hindawi.com)
  • An estimated 40% to 50% of patients are labeled to have an unrecognized precipitating event leading to ACLF. (statpearls.com)
  • When compared to the most common causes of hospitalization in the United States, the healthcare burden per patient is much higher in patients with ACLF. (statpearls.com)
  • Systemic inflammation with elevated leukocytosis, cytokines, and chemokines including IL-6, IL8 are observed in patients with ACLF. (statpearls.com)
  • And it had beneficial effects for patients with LF, especially in ACLF based on the D value of MELD. (hindawi.com)
  • stem cells
  • A study about immunomodulatory effect and efficacy and prognosis of human umbilical cord mesenchymal stem cells in patients with chronic hepatitis B-induced decompensated liver cirrhosis. (semanticscholar.org)
  • Human umbilical cord matrix stem cells efficiently rescue acute liver failure through paracrine effects rather than hepatic differentiation. (semanticscholar.org)
  • Proangiogenic features of Wharton's jelly-derived mesenchymal stromal/stem cells and their ability to form functional vessels," International Journal of Biochemistry and Cell Biology , vol. 45, no. 3, pp. 560-570, 2013. (hindawi.com)
  • 2013). Wharton's jelly-derived mesenchymal stem cells promote myocardial regeneration and cardiac repair after miniswine acute myocardial infarction. (springer.com)
  • regeneration
  • Evidence for non-traditional activation of complement factor C3 during murine liver regeneration," Molecular Immunology , vol. 45, no. 11, pp. 3125-3132, 2008. (hindawi.com)
  • The proinflammatory mediators C3a and C5a are essential for liver regeneration," The Journal of Experimental Medicine , vol. 198, no. 6, pp. 913-923, 2003. (hindawi.com)
  • The pathophysiology is based on the understanding that an acute precipitating event in a patient with the chronic liver condition would injure hepatocytes leading to the accumulation of a cascade of inflammatory cytokines, resulting in further hepatic injury in the presence of failure of hepatocyte regeneration. (statpearls.com)
  • Both newly described and 'classic' pro-inflammatory cytokines, such as tumour necrosis factor-alpha, have been implicated in both hepatic injury and liver regeneration. (semanticscholar.org)
  • cells
  • Our results demonstrated that patients who died had lower expression of NK cells and inhibitory receptor KIR3DL1, higher levels of FASL. (scirp.org)
  • CD4 + CD25 + regulatory T cells control T helper cell type 1 responses to foreign antigens induced by mature dendritic cells in vivo," The Journal of Experimental Medicine , vol. 198, no. 2, pp. 259-266, 2003. (hindawi.com)
  • High level of IL-27 positively correlated with Th17 cells may indicate liver injury in patients infected with HBV," Liver International , vol. 34, no. 2, pp. 266-273, 2014. (hindawi.com)
  • Intranasal versus intraperitoneal delivery of human umbilical cord tissue-derived cultured mesenchymal stromal cells in a murine model of neonatal lung injury," American Journal of Pathology , vol. 184, no. 12, pp. 3344-3358, 2014. (hindawi.com)
  • Effect of multipotent stromal cells on the function of cell mitochondria in regenerating liver," Bulletin of Experimental Biology and Medicine , vol. 158, no. 4, pp. 566-572, 2015. (hindawi.com)
  • Multiple injections of human umbilical cord-derived mesenchymal stromal cells through the tail vein improve microcirculation and the microenvironment in a rat model of radiation myelopathy," Journal of Translational Medicine , vol. 12, no. 1, article 246, 2014. (hindawi.com)
  • The role of human umbilical cord tissue-derived mesenchymal stromal cells (UCX®) in the treatment of inflammatory arthritis," Journal of Translational Medicine , vol. 11, article 18, 2013. (hindawi.com)
  • A total of 79 patients (ages 30-80) with left ventricle ejection fractions ranging between 25 and 45 % will be randomized in a 2:1:1 pattern in order to receive an intramyocardial injection of either HUC-MSCs or autologous bone marrow-derived mononuclear cells (BM-MNCs) in combination with coronary arterial bypass grafting (CABG) surgery. (springer.com)
  • The control group of patients will receive no cells and undergo CABG alone. (springer.com)