• 13. Tzanakakis G., Kovalszky I., Heldin P., Nikitovic D. Proteoglycans/glycosaminoglycans: from basic research to clinical practice. (uoc.gr)
  • Proteoglycans, comprised of a core protein to which glycosaminoglycan chains are covalently linked, are an important structural and functional family of macromolecules found in the extracellular matrix. (rpi.edu)
  • A variety of synthetic and semisynthetic molecules and polymers have been examined by tissue engineers that serve as structural, chemical and biological replacements for proteoglycans. (rpi.edu)
  • Currently, he is research interests include investigating the role of glycosaminoglycans and proteoglycans on the development of placental pathology and breast cancer. (mdx.ac.uk)
  • beta-1,4-Gatactosyltransferase 7 (beta 4GalT7) is an essential enzyme in the biosynthesis of glycosaminoglycan (GAG) chains of proteoglycans (PGs). (lu.se)
  • The primary nuclear constituents include glycosaminoglycans, proteoglycans, and collagen. (medscape.com)
  • Glycosaminoglycans (GAGs) are essential functional components of the extracellular matrix (ECM). (degruyter.com)
  • Glycosaminoglycans (GAGs) are multifunctional polysaccharides of the extracellular matrix (ECM) responsible for ECM hydration and binding of cations and proteins due to their negative charge. (degruyter.com)
  • It remains uncertain how brain glycosaminoglycans (GAGs) contribute to the progression of inflammatory disorders like multiple sclerosis (MS). We investigated here neuroinflammation-mediated changes in GAG composition and metabolism using the mouse model of experimental autoimmune encephalomyelitis (EAE) and sham-immunized mice as controls. (mdc-berlin.de)
  • Glycosaminoglycans (GAGs) and GAG-degrading enzymes have wide-ranging applications in the medical and biotechnological industries. (hal.science)
  • The effects of chemokines are modulated by several means, including binding to G-protein coupled receptors (GPCRs), binding to glycosaminoglycans (GAGs), and through post-translational modifications (PTMs). (utmb.edu)
  • GALNS deficiency induces the accumulation of glycosaminoglycans (GAGs), keratan sulfate (KS) and chondroitin-6-sulfate (C6S) in multiple tissues, particularly bone, cartilage, heart valves, and cornea, whereas β-galactosidase deficiency induces the accumulation of only KS in those tissues. (medscape.com)
  • Journal of Biological Chemistry. (lu.se)
  • Journal of Biological Chemistry , 279 (13), 12598-12604. (elsevierpure.com)
  • Read about recent papers on these topics published in the Journal of Biological Chemistry . (asbmb.org)
  • In a study recently published in the Journal of Biological Chemistry , Charlotte B. Spliid of the University of California, San Diego, and Copenhagen University Hospital, Denmark, and an international teamperformed structural analysis of ofCS and found that both placenta- and tumor-derived ofCS had high N-acetylgalactosamine 4-O-sulfation levels. (asbmb.org)
  • In a recent article in the Journal of Biological Chemistry , Morten Dall, Anna Hassing and a team at the University of Copenhagen describe how they determined that removing hepatic nicotinamide phosphoribosyltransferase, or NAMPT, the enzyme responsible for NAD+ formation, increases susceptibility to liver injury in diet-induced metabolic stress. (asbmb.org)
  • In research recently published in the Journal of Biological Chemistry , Natalia Ninkina, Steven J. Millership and Owen M. Peters of Cardiff University and a team in the U.K. aimed to decipher the role β-synuclein plays in uptake of the neurotransmitter dopamine. (asbmb.org)
  • Journal of Biological Chemistry 286(44): 38509-38520, 2011. (uoc.gr)
  • Journal of Biological Chemistry , 292 (38), 15992. (au.dk)
  • The field includes the chemistry of carbohydrates, the enzymology of glycan formation and degradation, the recognition of glycans by specific proteins, the roles of glycans in complex biological systems, and their analysis and manipulation. (cshlpress.com)
  • Hyaluronan, a linear glycosaminoglycan, is an abundant component of extracellular matrix. (nel.edu)
  • Advances in our understanding of biological interactions have lead to a greater appreciation for the need to design tissue engineering scaffolds that incorporate mimetics of key extracellular matrix components. (rpi.edu)
  • Placental malaria infection is mediated by the binding of the malarial VAR2CSA protein to the placental glycosaminoglycan, chondroitin sulfate. (lu.se)
  • Placental malaria is mediated by the protein VAR2CSA interacting with the placental glycosaminoglycan chondroitin sulfate, or CS. (asbmb.org)
  • Placental syndecan-1 and sulphated glycosaminoglycans are decreased in preeclampsia. (mdx.ac.uk)
  • Both arginine mutant proteins and the combined double mutant had dramatically diminished in vivo activity in a leukocyte recruitment assay, suggesting that the lymphotactin-glycosaminoglycan interactions detected in vitro are important for the function of this chemokine. (elsevierpure.com)
  • Background: In all connective tissues the major structural components are fibrous proteins and glycosaminoglycans (GAG's). (uaeu.ac.ae)
  • Proteomics, the systematic study of proteins in biological systems, has expanded the knowledge of protein expression, modification, interaction and function. (neb.com)
  • Antia IU, Yagnik DR, Pantoja Munoz L, Shah AJ, Hills FA (2017).Heparan sulfate disaccharide measurement from biological samples using pre-column derivatization, UPLC-MS and single ion monitoring. (mdx.ac.uk)
  • Inhibition of iduronic acid biosynthesis by ebselen reduces glycosaminoglycan accumulation in mucopolysaccharidosis type I fibroblasts. (uu.se)
  • Inhibition of calcification in vivo by acyl azide cross-linking of a collagen-glycosaminoglycan sponge. (cdc.gov)
  • However, cytoimmunochemistry and x-ray analysis had shown that the earliest abnormality in PXE was abnormal accumulation and metabolism of polyanions (ie, glycosaminoglycans, glycoproteins) within the Bruch membrane. (medscape.com)
  • In addition to the aforementioned, acidic polysaccharides-specifically sulfated glycosaminoglycans-whose presence has been shown by using electrophoretic and chromatographic methods in Eisenia andrei [ 13 ] also fulfil important biological functions. (hindawi.com)
  • Le Vivant repose pour son fonctionnement sur les propriétés structurales et fonctionnelles de grandes familles de biopolymères, parmi lesquelles celle des polysaccharides qui reste encore mal connue, et en particulier ceux exposés à la surface cellulaire ou constituant des glyco-conjugués avec les protéines. (hal.science)
  • AXE STRUCTURAL**- Le progrès des connaissances dans ce domaine nécessite de lever des verrous analytiques en particulier pour la caractérisation structurale et le séquençage de séquences glucidiques bioactives, dont les méthodes font aujourd'hui encore défaut. (hal.science)
  • Lymphotactin, the unique member of the "C" chemokine subclass, is a highly basic protein that binds heparin, a glycosaminoglycan, with high affinity (∼10 nM). (elsevierpure.com)
  • Substitutions in and around this binding site and surface plasmon resonance analysis of heparin binding affinity identified two arginine residues of lymphotactin as critical for glycosaminoglycan binding. (elsevierpure.com)
  • Our results demonstrate that like other chemokines, lymphotactin utilizes highly specific glycosaminoglycan-binding sites that represent potential targets for drug development. (elsevierpure.com)
  • Biological properties of chemokines are believed to be influenced by their association with glycosaminoglycans. (pasteur.fr)
  • Post-translational modifications of chemokines, such as nitration, which occurs due to the production of reactive species during oxidative stress, can also alter their biological activity. (utmb.edu)
  • Institute of Science in Society and Department of Biological Sciences, Open University, U.K. (i-sis.org.uk)
  • This review focuses on the recent in vivo and in vitro tissue engineering applications of three basic types of neoproteoglycan structures, protein-glycosaminoglycan conjugates, nano-glycosaminoglycan composites and polymer-glycosaminoglycan complexes. (rpi.edu)
  • International journal of molecular sciences , 18 (8), Article 1692. (utmb.edu)
  • European Journal of Human Genetics,21(3), 310-316. (sc.edu)
  • In contradiction, the biological effects of fragmented low molecular weight hyaluronan are suggested to be pro-angiogenic and pro-inflammatory. (nel.edu)
  • These glycosaminoglycans markedly prevented thrombosis formation and thrombin-induced platelet aggregation in a dose- and molecular weight-dependent manner in vitro and in vivo. (myjournals.org)
  • The biological relevance of these in vitro findings was investigated. (pasteur.fr)
  • FEBS Journal 278(19): 3782-92, 2011. (uoc.gr)
  • Biophysical Journal , 113 (3), 580-596. (au.dk)
  • Biophysical Journal , 113 (12), 2621-2633. (au.dk)
  • This is a high molecular weight polysaccharide with unique physico-chemical properties, as well as cell biological functions. (uaeu.ac.ae)
  • Angiogenesis can be induced or inhibited by complex biological systems. (bilkent.edu.tr)
  • 2). Glycomics, the systematic study of all glycan structures in a biological system, relies on effective enzymatic and analytical techniques for correlation of glycan structure with function. (neb.com)
  • Consecutive pathway and cluster analysis led to the identification of biological processes, namely processes involving binding and processing of nucleic acids, LRP1-dependent endocytosis, and exosome formation. (degruyter.com)
  • Mammalian cells produce PGs, which are involved in biological processes such as cell growth and differentiation. (lu.se)
  • Several studies demonstrate the biological advantages of rhBMP-2 on bone regeneration of the jaws. (bvsalud.org)
  • In a dog study, it was found that sulfate and glycosaminoglycan act as chondroprotective agents. (myspinalcareclinic.com)
  • Threshold limit values for chemical substances and physical agents and biological exposure indices for 1994 to 1995. (cdc.gov)
  • Nature of glycosaminoglycan and organization of extracellular materials. (rupress.org)
  • Editors select a small number of articles recently published in the journal that they believe will be particularly interesting to readers, or important in the respective research area. (mdpi.com)
  • The aim is to provide a snapshot of some of the most exciting work published in the various research areas of the journal. (mdpi.com)