Jnk mitogen activated protein kinases. Medical search. Frequent questions

Here, we show that bergenin, a phytochemical isolated from tender leaves of Shorea robusta , activates the MAP kinase and ERK pathways and induces TNF-α, NO and IL-12 production in infected macrophages. (frontiersin.org)
Once activated, p53 coordinates multiple downstream pathways, thereby maintaining the homeostasis of the host cell or organism (if the stress is mild, transient, and repairable) or eliminating damaged cells (if the stress is acute, prolonged, and difficult to resist). (nature.com)
JNK pathways are activated by stress and inflammatory signals. (thermofisher.com)
Cripto-1 overexpression in U87 glioblastoma cells activates MAPK, focal adhesion and ErbB pathways. (eurekaselect.com)
IL-21 activates both the Raf-ERK-MAPK and the Jak/STAT signaling pathways. (intechopen.com)
UV-B-induced DNA damage can trigger cell signaling pathways to activate defense systems, leading to DNA repair and/or apoptosis ( 6 ). (spandidos-publications.com)
These data demonstrate that the JNK and PTEN signaling pathways can cooperate to regulate the progression of prostate neoplasia to invasive adenocarcinoma. (mssm.edu)
Activation of DR3 by TL1A induced the formation of a signaling complex containing TRADD, TRAF2, and RIP and activated the NF-κB and the ERK, JNK, and p38 mitogen-activated protein kinase pathways. (enzolifesciences.com)
Upon peptidoglycan detection, Nod1 and Nod2 recruit and associate with the adaptor protein Rip2, triggering proinflammatory pathways such as NF- κ B and the mitogen-activated protein (MAP) kinases p38, JNK, and ERK [ 4 ]. (hindawi.com)
We were thinking about whether TAp73 could have any regulatory function in various Nomilin other apoptotic pathways, like the JNK signaling pathway, upon cisplatin treatment. (igesip.org)
Our studies demonstrate the existence of alternative (RNase L- and PKR-independent) dsRNA-triggered signaling pathways that lead to the stimulation of stress-activated MAPKs. (elsevierpure.com)
Unraveling the underlying signaling pathways provides novel information: pretubulysin induces proteasomal degradation of Mcl-1 by activation of mitogen-activated protein kinase (especially JNK (c-Jun N-terminal kinase)) and phosphorylation of Mcl-1, which is then targeted by the SCF(Fbw7) E3 ubiquitin ligase complex for ubiquitination and degradation. (uni-frankfurt.de)

Mitogen-activated protein kinase kinase kinase 1 (MAP3K1) is a signal transduction enzyme that in humans is encoded by the autosomal MAP3K1 gene. (wikipedia.org)
Cytokine signaling through MAP3K1 utilises two-stage cell signaling to recruit the signal transduction mechanism to cytokine receptors and then release the signal transduction components, altered by post-translational modification, from the cellular membrane to activate MAPKs. (wikipedia.org)
MAPKs are Serine-threonine protein kinases that are activated in response to a variety of extracellular stimuli, and mediate signal transduction from the cell surface to the nucleus. (thermofisher.com)
The c-Jun NH 2 -terminal kinase (JNK) signal transduction pathway is implicated in cancer, but the role of JNK in tumorigenesis is poorly understood. (mssm.edu)

Genetic analysis has demonstrated that the E3 Ub ligase and the kinase domains of MAP3K1 are required for MAPK activation. (wikipedia.org)
It belongs to the MAPK superfamily of stress-activated protein kinases. (thermofisher.com)
p38 acts as a stress-activated MAPK that is preferentially activated by diverse cellular stressors, including UV-B-induced oxidative stress ( 9 ). (spandidos-publications.com)
They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. (nih.gov)
The aim of this study was to evaluate the role of mitogen-activated protein kinase (MAPK) family in serum-induced secretion of LIF and IL-6 by bone marrow stromal cells. (unboundmedicine.com)
FCS also induced activation of extracellular signal-regulated kinase (ERK), p38 MAPK and c-Jun NH(2)-terminal kinase (JNK). (unboundmedicine.com)
3: Both PD98059 (MAPK/ERK kinase inhibitor) and SB203580 (p38 MAPK inhibitor) attenuated FCS-induced LIF protein production and gene expression. (unboundmedicine.com)
5: These findings demonstrate that both ERK and p38 MAPK are involved in FCS-induced LIF secretion, whereas only p38 MAPK is important for IL-6 secretion, and that FCS-induced activation of JNK has no effect on the production of LIF and IL-6. (unboundmedicine.com)
The expression of HMGB1, c-Jun N-terminal kinase (JNK), extracellular-signal-regulated kinase (ERK), and p38 mitogen-activated protein kinase (p38 MAPK) was assessed with immunofluorescence and western blot analysis. (molvis.org)
We describe here a novel form of dsRNA-triggered signaling that leads to the stimulation of the p38 mitogen-activated protein kinase (p38 MAPK) and the c-Jun NH 2 -terminal kinase (JNK) and of their respective activators MKK3/6 and SEK1/MKK4. (elsevierpure.com)
The dsRNA-dependent signaling to p38 MAPK was largely intact in cells lacking both RNase L and the dsRNA-activated protein kinase (PKR), i.e., the two best-characterized mediators of dsRNA-triggered antiviral responses. (elsevierpure.com)
We propose that p38 MAPK is a general participant in dsRNA-triggered cellular responses, whereas the activation of JNK might be restricted to cells with reduced rates of protein synthesis. (elsevierpure.com)
Activation of p38 MAPK (but not of JNK) was demonstrated in mouse fibroblasts in response to infection with encephalomyocarditis virus (ECMV), a picornavirus that replicates through a dsRNA intermediate. (elsevierpure.com)

A subgroup of mitogen-activated protein kinases that activate TRANSCRIPTION FACTOR AP-1 via the phosphorylation of C-JUN PROTEINS. (rush.edu)
Mitogen-activated protein kinase kinases (MAP2Ks) are substrates for direct phosphorylation by the MAP3K1 protein kinase. (wikipedia.org)
The mitogen-activated protein kinases ERK1/2, SAPK/JNK and p38 were activated via phosphorylation following 1-h exposures. (cdc.gov)
Hexavalent chromium up-regulated p-38 phosphorylation 23-fold and SAPK/JNK phosphorylation 17-fold, with a comparatively modest 4-fold increase in ERK1/2 phosphorylation. (cdc.gov)
Manganese caused a two- to four-fold increase in SAPK/JNK and ERK 1/2 phosphorylation, with no observed effects on p38 kinase. (cdc.gov)
Both vinY822F and vin −/− cells exhibit increased interaction between paxillin and focal adhesion kinase (FAK) and increased paxillin and FAK phosphorylation. (rupress.org)
Conclusions TGF-β-mediated phosphorylation of individual serine/threonine sites in the linker region of Smad2 occurs in a highly specific manner by kinases. (iium.edu.my)

however, TGF-β signalling also activates numerous serine/threonine kinases that phosphorylate Smad2 in its linker region. (iium.edu.my)

A screen of 72 inhibitors against 456 human kinases. (guidetomalariapharmacology.org)
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfiler TM service. (guidetomalariapharmacology.org)
A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase Hotspot SM platform. (guidetomalariapharmacology.org)
We have previously examined the specificities of 28 commercially available compounds, reported to be relatively selective inhibitors of particular serine/threonine-specific protein kinases [Davies, Reddy, Caivano and Cohen (2000) Biochem. (nih.gov)
The expression of phosphorylated Smad linker proteins were determined following TGF-β stimulation in the absence and presence of different serine/threonine kinase inhibitors in vascular endothelial cells. (iium.edu.my)
Furthermore, inhibiting c-Jun NH 2 -terminal kinase (JNK) with chemical inhibitors or short hairpin RNA abrogated all collagen I-induced changes. (nebraska.edu)
Collectively, our results suggest a role of JNK in the activation of PSCs, and a potential application of JNK inhibitors for the treatment of pancreatic fibrosis and inflammation. (aspetjournals.org)

Role of galectin-1 in urinary bladder urothelial carcinoma cell invasion through the JNK pathway. (rush.edu)
Here, we demonstrate that the JNK signaling pathway reduces the development of invasive adenocarcinoma in the phosphatase and tensin homolog (Pten) conditional deletion model of prostate cancer. (mssm.edu)
Thr220 and Ser245 are phosphorylated by phosphoinositide 3 kinase (PI3K), while Ser255 was phosphorylated by the PI3K/Akt pathway. (iium.edu.my)
c-Jun N-terminal kinase (JNK) signaling pathway by up-regulating the manifestation of its target growth arrest and DNA-damage-inducible protein GADD45 alpha (GADD45) and consequently activating mitogen-activated protein kinase kinase-4 (MKK4). (igesip.org)
Our study offers shown that TAp73 triggered the JNK apoptotic signaling pathway in response to cisplatin in ovarian malignancy cells. (igesip.org)
The JNK signaling pathway replies to various tension stimuli, through the transduction from the upstream MAPKKK including MEKKs, and eventually activation of JNK by phosphorylated at Thr and Tyr sites with the JNK immediate upstream kinases MKK4/MKK7. (igesip.org)
The JNK signaling pathway works as an integral positive modulator of cell apoptotic response to tension stimuli [9]C[11]. (igesip.org)
Furthermore, the JNK signaling pathway plays a part in cisplatin-dependent apoptosis in cancer cells [12]C[15] critically. (igesip.org)
Blocking HMGB1, ROS, or the JNK pathway may attenuate VEGF-A production, suggesting HMGB1 and related signaling molecules play a role in diabetic retinopathy. (molvis.org)
Here, using different experimental approaches, especially designer receptor exclusively activated by designer drug (DREADD) chemogenetic technology, we found that sustained activation of G q -protein signaling impairs the functionality of striatal neurons and we unveil the precise molecular mechanism underlying this process: a phospholipase C/Ca 2+ /proline-rich tyrosine kinase 2/cJun N -terminal kinase pathway. (jneurosci.org)
To analyze this effect anatomically, we manipulated G q -protein-dependent signaling selectively in neurons belonging to the direct or indirect striatal pathway. (jneurosci.org)
Acute G q -protein activation in direct-pathway or indirect-pathway neurons produced an enhancement or a decrease, respectively, of activity-dependent parameters. (jneurosci.org)
In contrast, sustained G q -protein activation impaired the functionality of direct-pathway and indirect-pathway neurons and disrupted the behavioral performance and electroencephalography-related activity tasks controlled by either anatomical framework. (jneurosci.org)
Pretubulysin induces cell death via the intrinsic apoptosis pathway by abrogating the expression of pivotal antiapoptotic proteins, namely Mcl-1 and Bcl-xL, and shows distinct chemosensitizing properties in combination with TRAIL in two- and three-dimensional cell culture models. (uni-frankfurt.de)

MAP3K1 (or MEKK1) is a serine/threonine kinase and ubiquitin ligase that performs a pivotal role in a network of enzymes integrating cellular receptor responses to a number of mitogenic and metabolic stimuli, including: TNF receptor superfamily (TNFRs), T-cell receptor (TCR), Epidermal growth factor receptor (EGFR), and TGF beta receptor (TGFβR). (wikipedia.org)
The secreted decoy receptor 3 (DcR3), a soluble protein of the tumor necrosis factor receptor (TNFR) superfamily blocks the action of TL1A. (enzolifesciences.com)
The JNK belongs to a superfamily of mitogen-activated protein (MAP) kinases. (igesip.org)

Yan J, Kong W, Zhang Q, Beyer EC, Walcott G, Fast VG, Ai X. c-Jun N-terminal kinase activation contributes to reduced connexin43 and development of atrial arrhythmias. (rush.edu)
The MAP3K1 kinase domain may also be a modest activator of IκB kinase activation. (wikipedia.org)
Among these cell-signaling proteins, activation of p53 is important in cells with UV radiation-induced DNA damage ( 4 , 7 ). (spandidos-publications.com)
Activation of MAP kinases by hexavalent chromium, manganese and nickel in human lung epithelial cells. (cdc.gov)
Similarly, prevention of JNK activation in the prostate epithelium (ΔMkk4 ΔMkk7 ΔPten mice) causes rapid development of invasive adenocarcinoma. (mssm.edu)
Moreover, JNK inhibition decreased supernatant eATP concentration and inhibited Pannexin1 activation, as determined by YoPro-1 uptake in liver cells in a dose-dependent manner. (elsevierpure.com)
These results suggest that JNK regulates activation of Panx1 channels, and provide evidence that Pannexin1-dependent pathophysiological eATP release in lipoapoptosis is capable of stimulating migration of human monocytes, and may participate in the recruitment of monocytes in chronic liver injury induced by saturated FFA. (elsevierpure.com)
HN activates a cellular signaling cascade that intervenes (at least) in activation of c-Jun N-terminal kinase. (elsevierpure.com)
Activation of JNK activates and phosphorylates the downstream transcription aspect c-Jun and various other transcription elements [9], [10]. (igesip.org)
We here evaluated the effects of SP600125 (anthra[1,9- cd ]pyrazole-6 (2 H )-one), an inhibitor of c-Jun NH 2 -terminal kinase (JNK), on the activation of PSCs. (aspetjournals.org)
Activation of JNK was determined by Western blotting using anti-phosphospecific JNK and c-Jun antibodies. (aspetjournals.org)
SP600125 inhibited interleukin-1β-induced JNK activity and activator protein-1 activation, but it did not affect the activation of extracellular-regulated kinase, p38 mitogen-activated protein kinase, and nuclear factor-κB. (aspetjournals.org)
In contrast, activation of both MKK4 and JNK by dsRNA was greatly reduced in cells lacking RNase L (or lacking both RNase L and PKR) but was restored in these cells when introduction of dsRNA was followed by inhibition of ongoing protein synthesis or transcription. (elsevierpure.com)
These results are consistent with the notion that the role of RNase L and PKR in the activation of MKK4 and JNK is the elimination, via inhibition of protein synthesis, of a labile negative regulator(s) of the signaling to JNK acting upstream of SEK1/MKK4. (elsevierpure.com)
In the course of these studies, we identified a long- sought site of RNase L-mediated cleavage in the 28S rRNA, which could cause inhibition of translation, thus allowing the activation of JNK by dsRNA. (elsevierpure.com)

These findings suggest that stress-activated MAPKs participate in mediating inflammatory and febrile responses to viral infections. (elsevierpure.com)

Here, we show that vinculin null (vin −/− ) cells and cells expressing a vinculin Y822F mutant have increased survival due to up-regulated activity of extracellular signal-regulated kinase (ERK). (rupress.org)
Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. (nih.gov)
In response to pancreatic injury and in cell culture, pancreatic stellate cells (PSCs) are transformed ("activated") into highly proliferative myofibroblast-like cells that express α-smooth muscle actin and produce extracellular matrix components. (aspetjournals.org)

We have mapped brimapitide to JNK3, as this appears to be the isozyme used in [ 3 ], but it is likely to inhibit kinase activity of all JNK enzymes. (guidetomalariapharmacology.org)
The JNK protein kinases consist of Jnk1, Jnk2 and Jnk3. (igesip.org)

Human recombinant protein fragment corresponding to amino acids 1-384 of human JNK1 produced in E.coli. (thermofisher.com)

We show that JNK1 is activated in response to collagen I, which increases tumorigenesis by up-regulating N-cadherin expression and by increasing motility. (nebraska.edu)
4: Expression of a dominant-negative mutant form of JNK1 that blocked FCS-induced JNK activity had no effect on protein production and gene expression of these cytokines. (unboundmedicine.com)

Inhibition of c-Jun NH 2 -terminal kinase (JNK) in liver cells with SP600125 blocked migration of monocytes in a dose-dependent manner, indicating that JNK stimulates release of chemoattractants in lipoapoptosis. (elsevierpure.com)
Inhibition of JNK activity by a specific inhibitor or small interfering RNA (siRNA) significantly abrogated TAp73-mediated apoptosis induced by cisplatin. (igesip.org)
Furthermore, inhibition of GADD45 by siRNA inactivated MKK4/JNK activities and also clogged TAp73-mediated apoptosis induction by cisplatin. (igesip.org)

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. (nih.gov)

In addition, UV induces the generation of reactive oxygen species (ROS), which overwhelm the antioxidant defense system, resulting in oxidative stress and damage to cell structure, DNA, proteins and lipids ( 5 ). (spandidos-publications.com)

JNK is involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. (thermofisher.com)
UV can be directly absorbed by cellular macromolecules, thus leading to photochemical modification of DNA and proteins ( 4 ). (spandidos-publications.com)
The observed effects of welding fume metals on cellular signaling in lung epithelium demonstrate a potentially significant interplay between stress-response signaling (p38 and SAPK/JNK) and anti-apototic signaling (ERK 1/2) that is dependant on the specific metal or combination of metals involved. (cdc.gov)

PSCs were isolated from rat pancreas tissue and used in their culture-activated, myofibroblast-like phenotype unless otherwise stated. (aspetjournals.org)

JNK Mitogen-Activated Protein Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (rush.edu)

This gene product shows selectivity for members of the ERK family of MAP kinases and is localized to the cytoplasm and nucleus. (nih.gov)
The p73 gene encodes more than 20 protein isoforms due to the usage of different promoters and on the other hand post-transcriptional splicing. (igesip.org)
These main PG groups are further classified into families according to their gene homology, core protein properties, size, and modular composition. (hindawi.com)

Role of mitogen-activated protein kinases and Mcl-1 in apoptosis induction by withaferin A in human breast cancer cells. (rush.edu)

Activated inflammatory cel s, in- persistent inflammation cluding neutrophils and macrophag- es, produce reactive oxygen species and reactive nitrogen species. (who.int)

Our results suggest that the combined use of Roscovitine and Kenpaullone may be useful for identifying substrates and physiological roles of cyclin-dependent protein kinases, whereas the combined use of Kenpaullone and LiCl may be useful for identifying substrates and physiological roles of glycogen synthase kinase 3. (nih.gov)

Our data suggested that Fogmyosin signaling may regulate the growth of nTSG mutation-induced tumors through modulating JNK signaling activity. (edu.hk)
Depletion of NUP107 inhibits the growth of GBM cell lines through p53 protein stabilization. (bvsalud.org)
SP600125 inhibited platelet-derived growth factor-induced proliferation, inducible monocyte chemoattractant protein-1 production, and serum-induced type I collagen production. (aspetjournals.org)

PGs, molecules which consist of a protein core that is covalently modified with GAG chains, are distributed both to the ECM "proper" associated with the cell membrane as well as located to intracellular compartment. (hindawi.com)

Of these, indirubin-3'-monoxime, SP 600125, KT 5823 and ML-9 were found to inhibit a number of protein kinases and conclusions drawn from their use in cell-based assays are likely to be erroneous. (nih.gov)

On activated T cells, TL1A functions specifically via its surface-bound receptor DR3, (a member of the death-domain containing TNF receptor family) to promote cell survival and secretion of proinflammatory cytokines. (enzolifesciences.com)

High-mobility group box 1 protein (HMGB1) has been reported to be a potent proangiogenic factor induced by inflammatory stress. (molvis.org)

The JNK-deficient progenitor cells display increased proliferation and tumorigenic potential compared with progenitor cells from control prostate tumors. (mssm.edu)

Lipoapoptotic supernatants stimulated monocyte migration with the magnitude similar to a monocyte chemoattractant protein, CCL2 (MCP-1). (elsevierpure.com)
MCP-1, monocyte chemoattractant protein-1. (aspetjournals.org)

BCMA associates with BAFF, APRIL, TNF receptor-associated factor (TRAF) 1, TRAF2, and TRAF3 and activates NF-κB, Elk-1, c-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase. (enzolifesciences.com)

Activated PSCs are implicated in the pathogenesis of pancreatic fibrosis and inflammation. (aspetjournals.org)

These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. (nih.gov)
Methods Proteins were quantified by Western blotting using specific antibodies to individual phosphorylated Smad2 linker region residues. (iium.edu.my)

TY - JOUR T1 - Role of mitogen-activated protein kinase family in serum-induced leukaemia inhibitory factor and interleukin-6 secretion by bone marrow stromal cells. (unboundmedicine.com)

Compared with the BSA controls, the RGC-5 cells incubated with AGE-BSA showed a dose- and time-dependent increase in VEGF-A mRNA and VEGF-A protein secretion in the supernatant, with the highest levels achieved at 24 h. (molvis.org)

Mice with JNK deficiency in the prostate epithelium (ΔJnk ΔPten mice) develop androgen-independent metastatic prostate cancer more rapidly than control (ΔPten) mice. (mssm.edu)

JNK is expressed as ten different isoforms due to differential mRNA splicing. (thermofisher.com)

BCMA (B cell maturation) is a nonglycosylated integral membrane type I protein that is preferentially expressed in mature B lymphocytes and belongs structurally to the TNF receptor family. (enzolifesciences.com)

Adhesion complexes (i.e., focal adhesions and focal complexes) and cell-cell contacts are specialized structures that harbor a large number of cytoskeletal proteins and one of the highest concentrations of signaling molecules in cells ( Ruoslahti and Obrink, 1996 ). (rupress.org)

Nucleotide-binding oligomerization domain proteins (NODs) are modular cytoplasmic proteins implicated in the recognition of peptidoglycan-derived molecules. (hindawi.com)

Ricchiuti N, Chenoweth K, Gao X, Bare DJ, Yan J, Ai X. Long-Term Alcohol-Activated c-Jun N-terminal Kinase Isoform 2 Preserves Cardiac Function but Drives Ca2+-Triggered Arrhythmias. (rush.edu)
C-Jun N-terminal Kinase (JNK) is also known as Mitogen-activated protein kinase (MAPK8). (thermofisher.com)

MAP3K1 contains a protein kinase domain, PHD finger (which has a RING finger domain-like structure) that serves as an E3 ubiquitin ligase, and scaffold protein regions that mediate protein-protein interactions. (wikipedia.org)

Anatomy21

Organisms8

Chemicals and Drugs171

Analytical, Diagnostic and Therapeutic Techniques and Equipment12

Phenomena and Processes40

Information Science3

Pathways12

Signal Transduction4

MAPK13

Phosphorylation7

Serine-Threoni1

Inhibitors7

Pathway14

Superfamily3

Activation15

MAPKs1

Extracellular3

JNK32

Amino Acids1

JNK12

Inhibition3

Dual-specificity1

Induces1

Cellular3

Phenotype1

MeSH1

Gene3

Apoptosis induction1

Reactive oxygen1

Substrates1

Growth3

Intracellular1

Inhibit1

Cytokines1

Inflammatory1

Proliferation1

Monocyte2

TRAF21

Pancreatic1

Residues2

Serum-induced1

Supernatant1

Mice1

Differential1

Belongs1

Signaling molecules1

Cytoplasmic1

Terminal2

Ubiquitin1