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  • Mice
  • Impaired c-Jun amino terminal kinase activity and T cell differentiation in death receptor 6-deficient mice. (nih.gov)
  • T cells from DR6-deficient mice are substantially impaired in JNK activation. (nih.gov)
  • When DR6(-/-) mice were challenged with protein antigen, their T cells hyperproliferate and display a profound polarization toward a Th2 response whereas Th1 differentiation is not equivalently affected. (nih.gov)
  • Purified naive CD4+ T cells from wild-type and DR6-deficient mice were differentiated into either Th1 cells by activating them with α-CD3 plus α-CD28 in the presence of antibodies to IL-12 and IL-4 or into Th2 cells in the presence of IL-4 and antibody to IFN-γ. (nih.gov)
  • Here we report that the JNK-interacting protein 1 (JIP1) scaffold protein, which binds components of the JNK signaling module, is essential for JNK activation in the adipose tissue of obese mice. (umassmed.edu)
  • Jnk1 -/- Jnk2 -/- mice are nonviable, therefore studies of compound JNK-deficiency have been limited to mouse embryonic fibroblasts (MEF). (umassmed.edu)
  • Here, we report a severe impairment of dendritic structures in the cerebellum and motor cortex of c-Jun N-terminal kinase 1 (JNK1)-deficient mice. (jneurosci.org)
  • inhibit
  • however, the mechanisms by which Gadd45 proteins inhibit cell cycle control are not fully understood. (biomedsearch.com)
  • We hypothesized that targeting both Akt and heat shock protein (HSP) 90 would induce cytotoxic activity against multiple myeloma (MM) cells and target the bone marrow (BM) microenvironment to inhibit angiogenesis, osteoclast formation, as well as migration and adhesion of MM cells. (aacrjournals.org)
  • Genes
  • The interaction and function between c-Jun protein and Jun B protein increase the repertoire of possible regulatory complexes by LMP1 that could play an important role in the regulation of transcription of specific cellular genes in the process of genesis of nasopharyngeal carcinoma. (biomedsearch.com)
  • Of the three JNK genes expressed in the brain, neural JNK1 displays elevated constitutive activity that is not stress related (Coffey et al. (jneurosci.org)
  • transcription factor
  • It binds tumor necrosis factor (TNF)-receptor-associated factors (TRAFs), activates NFkappaB and triggers the transcription factor activating protein-1 (AP-1) via the c-Jun N-terminal kinase (JNK) cascade, but its specific contribution to AP-1 has not been elucidated fully. (biomedsearch.com)
  • Insulin enhancer binding protein-1 (ISL-1), a LIM-homeodomain transcription factor, is essential for the heart, motor neuron and pancreas development. (nih.gov)
  • kinetics
  • S-layer protein exerted its antiviral effect with different kinetics than mannan, a known viral inhibitor that also acts on DC-SIGN (Yu et al. (medworm.com)
  • Knockout
  • Understanding the role of JNK in epithelial cells is now possible with the creation of conditional JNK knockout animals. (umassmed.edu)
  • Cells
  • Epstein-Barr virus (EBV) encoded latent membrane protein 1 (LMP1) is essential for the immortalization of human B cells and is linked etiologically to several human tumors. (biomedsearch.com)
  • Confocal images of COS-7 cells expressing mutant Tiam1 proteins. (nih.gov)
  • In this model, CagA expression in epithelial cells enhances the growth and invasion of tumors in a JNK-dependent manner. (nih.gov)
  • In addition, re-epithelialization requires long-range Rho kinase-, JNK- and, to some extent, planar cell polarity-dependent epithelial rearrangements within the following epidermis, involving radial intercalations, flattening and directed elongations of cells. (zfin.org)
  • Finally, I examined the role of JNK in mouse mammary gland development by establishing JNK-deficient primary mouse mammary epithelial cells and evaluating JNK-deficient mammary gland transplants. (umassmed.edu)
  • Materials and Methods Isolation of S-Layer Proteins S-layer proteins were extracted from overnight cultures of L. acidophilus ATCC 4356 cells grown in MRS medium at 37°C by using 6. (medworm.com)
  • novel
  • Our data uncover a novel genetic interaction between CagA and JNK signaling and demonstrate its potential importance in promoting tumor progression. (nih.gov)
  • The laboratory is currently engaged in work to better understand the molecular mechanisms responsible for this novel form of JNK-mediated ∆9-THC tolerance. (elsevier.com)
  • These results reveal a novel antagonism between JNK and ERK, potentially providing a mechanism for fine-tuning the dendritic arbor. (jneurosci.org)
  • Carcinoma
  • Using immunohistochemical analysis, we found that protein expression of Gadd45gamma, but not Gadd45alpha, was down-regulated in hepatocellular carcinoma. (biomedsearch.com)
  • p21WAF1 immunohistochemical expression in breast carcinoma: correlations with clinicopathological data, oestrogen receptor status, MIB1 expression, p53 gene and protein alterations and relapse-free survival," The British Journal of Cancer , vol. 74, no. 2, pp. 208-215, 1996. (hindawi.com)
  • PI3K
  • The impairment of insulin-mediated glucose uptake is correlated to the circulating FFA levels, and such resistance to insulin might be due to FFA-mediated inactivation of phosphoinositide 3-kinase (PI3K) [ 7 ]. (pubmedcentralcanada.ca)
  • binds
  • The HSP90 inhibitor 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (17-DMAG) binds to the HSP90 protein and inhibits its function. (aacrjournals.org)
  • Cytoplasmic
  • Here, we report that cytoplasmic JNK1 activity increases during neuronal differentiation and that compartment-specific inhibition of this pool reveals a causal role for JNK in regulating dendritic shape. (jneurosci.org)
  • amino
  • To determine whether membrane localization is the only function of the NH2-terminal PH domain, we fused the NH2terminal 20 amino acids of c-Src, containing the myristoylation site and a basic region, in front of a C580 Tiam1 protein, resulting in MS-C580 Tiam1 (see Materials and Methods). (nih.gov)
  • AbstractFull-length infectious cDNA clones for recombinant HY12 bovine enteroviruses designated as rHY12-3A-2-HA, rHY12-3A-3-HA, and rHY12-3A-9-HA were constructed by the insertion of an epitope from influenza virus hemagglutinin (HA) at the N-terminus of the HY12-encoded 3A protein at amino acid positions 2, 3, and 9. (medworm.com)
  • inhibitor
  • A peptide inhibitor of c-Jun N-terminal kinase protects against both aminoglycoside and acoustic trauma-induced auditory hair cell death and hearing loss. (semanticscholar.org)
  • SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. (semanticscholar.org)
  • neuronal
  • Growth factors may mediate neuronal survival by regulating signaling cascades downstream of the small GTP binding proteins ras, rac, and cdc42 (for review, see Denhardt, 1996 ). (jneurosci.org)