Jejuni. Medical search. Frequent questions

Campylobacter jejuni (/ˈkæmpɪloʊˌbæktər dʒəˈdʒuːni/) is a species of pathogenic bacteria, one of the most common causes of food poisoning in Europe and in the US. (wikipedia.org)
Campylobacter is a helical-shaped, non-spore-forming, Gram-negative, microaerophilic, nonfermenting motile bacterium with a single flagellum at one or both poles, which are also oxidase-positive and grow optimally at 37 to 42 °C. When exposed to atmospheric oxygen, C. jejuni is able to change into a coccal form. (wikipedia.org)
Campylobacter jejuni was originally named Vibrio jejuni due to its likeness to Vibrio spp. (wikipedia.org)
Campylobacter jejuni isolates were obtained for 51 persons and 23 puppies. (medscape.com)
Campylobacter jejuni is a common raw milk contaminant and is notoriously difficult to isolate from food products, because of its fastidious growth requirements. (cdc.gov)
In May 2014, the Utah Public Health Laboratory (UPHL) notified the Utah Department of Health (UDOH) of specimens from three patients infected with Campylobacter jejuni yielding indistinguishable pulsed-field gel electrophoresis (PFGE) patterns. (cdc.gov)
A confirmed case was defined as the onset of diarrheal illness caused by C. jejuni matching the cluster PFGE pattern or confirmed Campylobacter infection on or after May 1 in a person who had consumed dairy A raw milk 1-10 days before illness onset. (cdc.gov)
Campylobacter jejuni infections are progressively increasing worldwide. (nature.com)
In June 2011, a cluster of suspected cases of Guillain-Barré syndrome (GBS), which can follow Campylobacter jejuni infection, was identified in San Luis Río Colorado (SLRC), Sonora, Mexico and Yuma County, Arizona, USA. (cambridge.org)
A public health concern': Can Campylobacter jejuni survive in raw milk? (dairyreporter.com)
After an outbreak of Campylobacter jejuni, or C. jejuni, in 2020, researchers explored its presence in raw milk. (dairyreporter.com)
During the experiment, the researchers took a DSM 4688 reference strain of C. jejuni from the DSMZ strain collection, and a BfR-CA-1804 field strain from the feaces of a dairy cow at the National Reference Laboratory (NRL) for Campylobacter at the German Federal Institute for Risk Assessment (BfR). (dairyreporter.com)
CCUG 12074 - Campylobacter jejuni subsp. (ccug.se)
Crystal Structure of the Minimal Cas9 from Campylobacter jejuni Reveals the Molecular Diversity in the CRISPR-Cas9 Systems. (broadinstitute.org)
Here, we report the crystal structures of Campylobacter jejuni Cas9 (CjCas9), one of the smallest Cas9 orthologs, in complex with an sgRNA and its target DNA. (broadinstitute.org)
The outer membrane factor CmeC of the efflux machinery CmeABC plays an important role in conferring antibiotic and bile resistance to Campylobacter jejuni. (soton.ac.uk)
Newman, Kahlan E. and Khalid, Syma (2023) Conformational dynamics and putative substrate extrusion pathways of the N-glycosylated outer membrane factor CmeC from Campylobacter jejuni. (soton.ac.uk)
Definition of the disease: Campylobacter jejuni and C. coli can colonise the intestinal tract of most mammals and birds and are the most frequently isolated Campylobacter species in humans with gastro-enteritis. (uu.nl)
Description of the disease: Campylobacter jejuni and C. coli do not cause clinical disease in adult animals except for sporadic cases of abortion in ruminants and very rare cases of hepatitis in ostriches. (uu.nl)
Campylobacter jejuni and C. coli are thermophilic, Gram-negative, highly motile bacteria that, for optimal growth, require microaerobic environment and incubation temperatures of 37-42°C. Agar media containing selective antibiotics are required to isolate these bacteria from faecal/intestinal samples. (uu.nl)
Although Campylobacter jejuni is now recognised as a common enteric pathogen, the mechanisms by which this organism produces enteritis remain ill-defined. (microbiologyresearch.org)
Calva E. , Torres J. , Vazquez M. , Angeles V. , De La Vega H. , Ruiz-Palacios G. M. Campylobacter jejuni chromosomal sequences that hybridize to Vibrio cholerae and Escherichia coli LT enterotoxin genes. (microbiologyresearch.org)
Mcsweegan E. , Walker R. I. Identification and characterization of two Campylobacter jejuni adhesins for cellular and mucous substrates. (microbiologyresearch.org)
Fauchere J. L. , Rosenau A. , Veron M. , Moyen E. N. , Richard S. , Pfister A. Association with HeLa cells of Campylobacter jejuni and Campylobacter coli isolated from human feces. (microbiologyresearch.org)
Fauchere J.-L. , Kervella M. , Rosenau A. , Mohanna K. , Veron M. Adhesion to HeLa cells of Campylobacter jejuni and C coli outer membrane components. (microbiologyresearch.org)
Mcsweegan E. , Buff D. H. , Walker R. I. Intestinal mucus gel and secretory antibody are barriers to Campylobacter jejuni adherence to INT 407 cells. (microbiologyresearch.org)
Black R. E. , Levine M. M. , Clements M. L. , Hughes T. P. , Blaser M. J. Experimental Campylobacter jejuni infection in humans. (microbiologyresearch.org)
Methylation-dependent DNA discrimination in natural transformation of Campylobacter jejuni. (pacb.com)
Campylobacter jejuni, a leading cause of bacterial gastroenteritis, is naturally competent. (pacb.com)
Campylobacter jejuni is a leading cause of foodborne diarrheal infections in the USA (Scallan et al. (frontiersin.org)
Campylobacter jejuni and a variety of waterborne protozoa, including ciliates, flagellates, and alveolates, were detected in the drinking water of intensively reared poultry by a combination of culture and molecular techniques. (ulster.ac.uk)
Campylobacter jejuni infection in Colorado: unexplained excess of cases in males. (cdc.gov)
The most commonly isolated Campylobacter species is C. jejuni, which can be identified via its antibiotic susceptibility profile of cephalothin resistance and naladixic susceptibility in conjunction with its ability to hydrolyze hippurate. (sandra.black)
The truncated hemoglobin III from Campylobacter jejuni (Ctb) contains three potential hydrogen-bond donors in the distal site: TyrB10, TrpG8, and HisE7. (kent.ac.uk)
Dear Campylobacter jejuni, thanks for your visit. (blogspot.com)
Most infections are caused by Campylobacter jejuni . (kitpcr.com)
Campylobacter jejuni is a microaerophilic foodborne pathogen capable of surviving the stressful, oxygen-exposed route from an avian host and entering into the human food chain. (uea.ac.uk)
Campylobacter jejuni 40707L is a microaerophile, mesophilic bacterium that was isolated from human outbreak. (dsmz.de)
Campylobacter jejuni (Jones et al. (dsmz.de)
Decrease quantity for Campylobacter jejuni subsp. (troybio.com)
Increase quantity for Campylobacter jejuni subsp. (troybio.com)
Campylobacter jejuni and related species. (medlineplus.gov)
The transmission dynamics of Campylobacter jejuni among broilers in semi-commercial farms in Jordan. (bvsalud.org)
A Bayesian model framework was applied to a longitudinal dataset on Campylobacter jejuni infection in a Jordan flock to quantify the transmission rate of C. jejuni in broilers within the farm , the day when the flock first became infected, and the within-flock prevalence ( WFP ) at clearance. (bvsalud.org)
Campylobacter jejuni (see image below) is usually the most common cause of community-acquired inflammatory enteritis. (medscape.com)
Scanning electron microscope image of Campylobacter jejuni, illustrating its corkscrew appearance and bipolar flagella. (medscape.com)
Only one human isolate could be re-grown by the reference laboratory and was confirmed as a Campylobacter jejuni subspecies jejuni , with sensitivity to ciprofloxacin, nalidixic acid, gentamicin and tetracycline. (who.int)
Campylobacter jejuni : current status and future trends / editors, Irving Nachamkin, Martin J. Blaser, Lucy S. Tompkins. (who.int)
Primeros resultados de la vigilancia integrada de la resistencia antimicrobiana de patógenos transmitidos por alimentos, campylobacter spp y salmonella spp en tres poblaciones distintas. (bvsalud.org)
with high prevalence of Campylobacter jejuni in all three populationsfollowed by 6% in food, 13% in clinical samples and 3% in birds cloacal feces of Salmonellaspp. (bvsalud.org)

Infection with C. jejuni usually results in enteritis, which is characterised by abdominal pain, diarrhea, fever, and malaise. (wikipedia.org)
citation needed] To initiate infection, C. jejuni must penetrate the gut enterocytes. (wikipedia.org)
Additional cases of C. jejuni infection were identified in October, and UDAF permanently revoked dairy A's permit to sell raw milk on December 1. (cdc.gov)
During May 9-November 6, 2014, a total of 99 cases of C. jejuni infection were identified. (cdc.gov)
On May 21, 2014, UPHL notified UDOH of three laboratory-confirmed cases (in patients A, B, and C) of C. jejuni infection with indistinguishable SmaI PFGE patterns (DBRS16.0196). (cdc.gov)
In the present study secondary abiotic mice were generated by broad-spectrum antibiotic treatment and perorally reassociated with a commensal murine Lactobacillus johnsonii strain either 14 days before (i.e. prophylactic regimen) or 7 days after (i.e. therapeutic regimen) peroral C . jejuni strain 81-176 infection. (nature.com)
Exposure information and an environmental assessment suggested that GBS cases resulted from a large outbreak of C. jejuni infection from inadequately disinfected tap water in SLRC. (cambridge.org)
In dogs, feeding a barf diet is a source of infection for C. jejuni. (laboklin.com)
C. jejuni infection can trigger Guillain-Barré syndrome. (kitpcr.com)
Infection with C. jejuni is most likely to have occurred during the first 8 days of the production cycle, followed by a transmission rate value of 0.13 new infections caused by one infected bird /day (95% CI 0.11-0.17), and a WFP at clearance of 34% (95% CI 0.24-0.47). (bvsalud.org)

List of C. jejuni strains included in MLSA analysis. (cdc.gov)
However, many previous evolution studies were performed using laboratory-adapted bacterial strains rather than clinically relevant pathogens such as C. jejuni . (frontiersin.org)
PEB 1 is a superficial antigen that appears to be a major adhesin and is conserved among C jejuni strains. (medscape.com)
Some strains of C jejuni produce a heat-labile, choleralike enterotoxin, which is important in the watery diarrhea observed in infections. (medscape.com)

C. jejuni releases several different toxins, mainly enterotoxin and cytotoxins, which vary from strain to strain and correlate with the severity of the enteritis (inflammation of the small intestine). (wikipedia.org)
Some anatomical terms derive from the function of the body part in question: so the jejunum , the second part of the small intestine, takes its name from a Latin word meaning "fasting" because early anatomists were so frequently surprised to find the jejunum empty of food in their dissections. (haggardhawks.com)

This chapter focuses on C. jejuni and C. coli in primary livestock production with regard to food safety. (uu.nl)
Polymerase chain reaction assays also can be used for the direct detection of C. jejuni and C. coli. (uu.nl)
Serological tests: serological assays are not routinely in use for the detection of C. jejuni/C. coli colonisation. (uu.nl)
Although C. jejuni can be transformed by C. jejuni-derived DNA, it is poorly transformed by the same DNA propagated in Escherichia coli or produced with PCR. (pacb.com)
We further show that E. coli plasmid and PCR-derived DNA can efficiently transform C. jejuni when only a subset of the CtsM sites are methylated in vitro. (pacb.com)
To investigate this, we expressed and purified C. jejuni PerR in E. coli. (uea.ac.uk)

The decision for such an anastomosis was made because the proximal jejunum was edematous and 3 times dilated with respect to the distal jejunum. (hindawi.com)

2020). Especially notable were large deletions in the gene rpo N (sigma 54) and the downstream region, which in C. jejuni strain 11168 contains a number of pseudogenes. (frontiersin.org)

However, the characteristics of these interactions and factors that may influence the association of C. jejuni with epithelial cells are incompletely described. (microbiologyresearch.org)
C jejuni appears to invade and destroy epithelial cells. (medscape.com)
C jejuni are attracted to mucus and fucose in bile, and the flagella may be important in both chemotaxis and adherence to epithelial cells or mucus. (medscape.com)

jejuni ATCC? (troybio.com)

Of its many species, C. jejuni is considered one of the most important from both a microbiological and public health perspective. (wikipedia.org)
In conclusion, immunomodulatory probiotic species might offer valuable strategies for prophylaxis and/or treatment of C . jejuni induced intestinal, extra-intestinal as well as systemic pro-inflammatory immune responses in vivo . (nature.com)

In 2020, four outbreaks of C. jejuni were reported in the EU, blamed on raw milk vending machines. (dairyreporter.com)

Individuals with recent C. jejuni infections develop Guillain-Barré syndrome at a rate of 0.3 per 1000 infections, about 100 times more often than the general population. (wikipedia.org)
C jejuni infections may also produce serious bacteremic conditions in individuals with AIDS. (medscape.com)

It was shown recently that O-glycosylation of the chicken intestinal mucin attenuates adherence and invasion of C. jejuni in a human colorectal cell line in vitro . (thermofisher.com)
Furthermore, it was also shown that treatment with human MUC2, which contains sulphated O-Glycans, inhibits C. jejuni growth in vitro . (thermofisher.com)
The authors found that sites with the greatest inhibition of C. jejuni growth in vitro and the least colonization in vivo had the highest number of O-glycans. (thermofisher.com)
Consequently, where C. jejuni grew most and inhibition was weakest in the in-vitro experiment, far fewer O-Glycan structures were detected. (thermofisher.com)
We have determined that the ability of C. jejuni to bind to epithelial cell lines in vitro is significantly affected by the growth temperature and growth stage of the bacteria, but not by growth-medium composition. (microbiologyresearch.org)
An in vitro assay showed that C jejuni remained viable when internalized by Tetrahymena pyriformis and Acanthamoeba castellanii for significantly longer (up to 36 h) than when they were in purely a planktonic state. (ulster.ac.uk)

The sites of tissue injury include the jejunum, the ileum, and can extend to involve the colon and rectum. (medscape.com)

The team used one of our liquid chromatography columns (Thermo Scientific Hypercarb Porous Graphitic Carbon LC columns) that were packed with particles in combination with mass spectrometric detection (Thermo Scientific LTQ Linear Ion Trap mass spectrometer) to map structural differences in mucin glycosylation to explain C. jejuni tolerance or pathogenicity for chicken and man respectively. (thermofisher.com)
Quod erat demonstrandum: O-glycans seem to play a role for the pathogenicity of C. jejuni ! (thermofisher.com)

In this work we have employed atomistic equilibrium molecular dynamics simulations of CmeC in a representative model of the C. jejuni outer membrane to characterise the dynamics of the protein and its associated glycans. (soton.ac.uk)

Campylobactor jejuni, primarily responsible for food poising in industrialized countries and, more frightening, responsible for acute diarrheal illness, accountable for 9% of worldwide mortality of children according to UNICEF . (thermofisher.com)

Do you know about Campylobactor jejuni , a gram-negative bacteria commonly found in animal feces? (thermofisher.com)

C. jejuni is the most common type to infect humans, often the result of faecal cross-contamination of either raw meat or raw milk. (dairyreporter.com)

These findings suggest that microorganisms in the gut microbiota of our laboratory mice might contribute to colonization resistance against C . jejuni , thus providing health benefits to the host similar to probiotics 15 . (nature.com)

The first isolation of C. jejuni was in Brussels, Belgium, from stool samples of a patient with diarrhea. (wikipedia.org)

2020). We used a serial transfer study design where five independent highly motile mouse gut adapted populations of C. jejuni were passaged individually in the lab for 35 days. (frontiersin.org)

We were interested in learning how a motile pathogenic bacterium such as C. jejuni evolves in nutrient-rich media compared to the complex environment of the mammalian gut, where motility is required to colonize and survive. (frontiersin.org)
Three motility phenotypes of C. jejuni were observed in each of the five populations we studied: reversibly non-motile, irreversibly non-motile, and motile. (frontiersin.org)
A C. jejuni perR mutant also demonstrated no defect in growth, motility or virulence in the Galleria mellonella insect model. (uea.ac.uk)

DNA extracted from C. jejuni clinical isolate Cj1 was used a positive control for amplification of primers. (cdc.gov)

Following peroral reassociation both C . jejuni and L . johnsonii were able to stably colonize the murine intestinal tract. (nature.com)

C. jejuni is commonly associated with poultry, and is also commonly found in animal feces. (wikipedia.org)

It seems that this most likely happens by cross-contamination during food processing from poultry products as C. jejuni lives commensally in the intestines of chicken. (thermofisher.com)

C. jejuni only grows at high temperatures and low oxygen levels, and cannot grow in raw milk under storage conditions. (dairyreporter.com)

Neither therapeutic nor prophylactic L . johnsonii application, however, could decrease intestinal C . jejuni burdens. (nature.com)

There was significantly more C. jejuni in the data from the IPIUs. (dairyreporter.com)
DNA derived from a ctsM mutant transforms C. jejuni significantly less well than DNA derived from ctsM(+) (parental) cells. (pacb.com)

We investigated the role of PerR in the regulation of oxidative stress defences in C. jejuni and demonstrated that a perR mutant has increased aerotolerance and survival against exposure to oxidative stress. (uea.ac.uk)

In both KO and wildetype animals, equal amounts of C. jejuni can be found in the intestine, but only in the KO mice the bacterium is also found in the liver, suggesting that lower levels of available sulfate and sulfomucins enables the transit of the bacteria through the gut epithelial. (thermofisher.com)

The bowel was dark and edematous indicating gangrenous of the jejunum (Figure 1 ). (hindawi.com)
Jejunostomy tubes are useful for patients with contraindications to gastrostomy (eg, gastrectomy, bowel obstruction proximal to the jejunum). (msdmanuals.com)

One of the main regulatory proteins involved in the protective response of C. jejuni to oxidative stress is the regulatory protein PerR, which regulates gene expression in a metal-dependent manner, controlling the transcription of a set of peroxidases. (uea.ac.uk)

Hypoacylated lipopolysaccharide (LPS) from C. jejuni induces moderate TLR4-mediated inflammatory response in macrophages and such LPS bioactivity may eventually result in the failure of local and systemic bacterial clearance in patients. (wikipedia.org)
Strikingly, C . jejuni induced intestinal, extra-intestinal and systemic secretion of pro-inflammatory mediators (such as IL-6, MCP-1, TNF and nitric oxide) could be alleviated by peroral L . johnsonii challenge. (nature.com)

Our research team, led by Dr Linda Mansfield at Michigan State University, conducted an evolution study to understand the adaptation of host-adapted C. jejuni to growth in the novel environment of nutrient-enriched laboratory growth medium (Sher et al. (frontiersin.org)

Sequential amino acid exchange across b(0,+)-like system in chicken brush border jejunum. (bsc.es)

Further investigations are required into why the perR gene is evolutionary maintained in C. jejuni despite the beneficial nature of its absence for oxidative stress survival. (uea.ac.uk)

The primary absorption site for vitamin D is the jejunum. (medscape.com)

The results suggested that the presence of C. jejuni in raw milk is severely underestimated if CFUs alone are measured. (dairyreporter.com)

Anatomy5

Organisms8

Diseases9

Chemicals and Drugs13

Analytical, Diagnostic and Therapeutic Techniques and Equipment11

Phenomena and Processes9

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture5

Information Science1

Health Care1

Campylobacter50

Infection10

Strains4

Small Intestine2

Coli6

Proximal jejunum1

Strain1

Epithelial cells3

ATCC1

Species2

Outbreaks1

Infections2

Vitro6

Ileum1

Pathogenicity2

Outer membrane1

Diarrheal1

Gram Negative1

Humans1

Resistance1

Isolation1

Highly motile1

Motility3

Clinical1

Intestinal tract1

Commonly1

Poultry1

Oxygen1

Decrease1

Significantly2

Mutant1

Bacterium1

Bowel2

Proteins1

Inflammatory2

Laboratory1

Chicken1

Survival1

Absorption1

Results1