• Owing to the lack of both animal models, and sufficient in vitro models to sustain effective replication of JCPyV, the mechanisms of JC virus infection remain largely uncertain and current understanding in pathogenesis is obtained from human autopsy material. (uu.nl)
  • In people with very weak immune systems, the virus can bring on a serious brain infection called progressive multifocal leukoencephalopathy (PML). (webmd.com)
  • JC virus (JCV) seropositivity is a risk factor for progressive multifocal leukoencephalopathy (PML) in patients on natalizumab. (nih.gov)
  • PCR detection of JC virus DNA in brain tissue from patients with and without progressive multifocal leukoencephalopathy. (thefreedictionary.com)
  • The JC virus is a virus which infects the brain of advanced cancer patients and causes PML-- progressive multifocal leukoencephalopathy. (thebody.com)
  • The human neurotropic polyomavirus JC (JCV) causes the fatal CNS demyelinating disease progressive multifocal leukoencephalopathy (PML). (ebscohost.com)
  • Traffic of JC Virus from Sites of Initial Infection to the Brain: The Path to Progressive Multifocal Leukoencephalopathy. (ebscohost.com)
  • Progressive multifocal leukoencephalopathy (PML) is a demyelinating disorder of the human brain caused by infection with the human polyomavirus, JC. (ebscohost.com)
  • Although polyomavirus JC (JCV) is the proven pathogen of progressive multifocal leukoencephalopathy, the fatal demyelinating disease, this virus is ubiquitous as a usually harmless symbiote among human beings. (pnas.org)
  • The polyomavirus JC (JCV), the proven pathogen of the fatal demyelinating disease known as progressive multifocal leukoencephalopathy (PML) ( 1 ), is ubiquitous in human beings, infecting children asymptomatically ( 2 , 3 ). (pnas.org)
  • Progressive multifocal leukoencephalopathy (PML) results from lytic infection of oligodendrocytes by JC virus (JCV). (nih.gov)
  • A mutation in a mouse model of the John Cunningham (JC) virus, which causes progressive multifocal leukoencephalopathy (PML), allows the virus to evade the host immune responses in people with multiple sclerosis (MS), according to a study into the mechanisms of PML. (thisisms.com)
  • Stoner, G. L. 1997-04-01 00:00:00 The central demyelinating disease progressive multifocal leukoencephalopathy (PML) is caused by the human polyomavirus JC virus (JCV). (deepdyve.com)
  • MRI brain showed characteristic appearances of progressive multifocal leukoencephalopathy (PML), confirmed by detection of the JC virus in CSF, despite the absence of any evidence of immunosuppression. (readbyqxmd.com)
  • If a patient becomes immunosuppressed, especially during AIDS, reactivated JC virus can infect lymphocytes, be carried to the brain, infect oligodendroglia glial cells, and produce a demyelinating disease called progressive multifocal leukoencephalopathy . (med-life.net)
  • JC virus granule cell neuronopathy is considered a rare manifestation of JC virus reactivation, thought to be much less common than progressive multifocal leukoencephalopathy 1-4 . (radiopaedia.org)
  • There is conjecture whether these white matter changes are truly due to JC virus granule cell neuronopathy, or due to concurrent infratentorial progressive multifocal leukoencephalopathy 1-3 . (radiopaedia.org)
  • Regardless, supratentorial white matter involvement, on the other hand, is not a feature of JC virus granule cell neuronopathy, and its involvement may be due to other manifestations of the JC virus such as progressive multifocal leukoencephalopathy or immune reconstitution inflammatory syndrome , which are known to manifest concurrently with JC virus granule cell neuronopathy 1-3 . (radiopaedia.org)
  • Progressive multifocal leukoencephalopathy and other disorders caused by JC virus: clinical features and pathogenesis. (radiopaedia.org)
  • 4. Brew BJ, Davies NW, Cinque P, Clifford DB, Nath A. Progressive multifocal leukoencephalopathy and other forms of JC virus disease. (radiopaedia.org)
  • Unfortunately, an unanticipated side effect of these drugs has been the reactivation of JC virus in the patient, resulting in the appearance of the rare, fatal brain disease progressive multifocal leukoencephalopathy (PML). (psu.edu)
  • Although BK virus, JC virus , and simian virus 40 are tumorigenic in experimental animals and can transform mammalian cells in vitro, no convincing epidemiologic evidence exists for their role in human cancers. (thefreedictionary.com)
  • JC virus is found in tonsils, so at one time experts thought it used an oral route, but it is not generally found in saliva or respiratory secretions. (everydayhealth.com)
  • Understanding the underlying mechanisms that lead a normally harmless virus to morph into an opportunistic pathogen capable of killing its host represents an initial step in combating PML. (psu.edu)
  • Genotypes of JC virus in East, Central and Southwest Europe. (semanticscholar.org)
  • Distinctive genotypes of JC virus have been described for the major continental landmasses. (semanticscholar.org)
  • JC virus urinary excretion and seroprevalence. (thisisms.com)
  • The overall risk of PML in people with MS who are positive for the JC virus and are treated with Tysabri is 1 in 250, according to Major. (everydayhealth.com)
  • In South Africa, a study that examined the JC virus in the cerebrospinal fluid (CSF) of patients with suspected PML showed JC virus type 3 in 3 patients, and type 7 and 2 in 1 patient each, confirming that the virus occurs in South African patients. (thefreedictionary.com)
  • Read about the possibility of a vaccine against the JC virus and its implications for MS treatment. (ket-rt.ru)
  • The JCV virus may also be a causative agent of aseptic meningitis (JCVM), as JCV was the only pathogen identified in the CSF of certain patients with meningitis. (wikipedia.org)
  • While it is rare for JC virus to lead to PML, when it happens, the virus is a causative agent, says Eugene Major, PhD , the director of the PML/CLIA laboratory at the National Institute of Neurological Disorders and Stroke (NINDS) at the National Institutes of Health, in Bethesda, Maryland. (everydayhealth.com)
  • For the JC virus to reach the brain and lead to PML, it likely requires a multistep process, Cortese says, adding that it's likely some genetic rearrangements occur that allow the virus to gain access to the central nervous system. (everydayhealth.com)
  • Although JCV has been identified in mononuclear cells in bone marrow and hematogenous dissemination of the virus to the central nervous system has been suspected, JCV has never been clearly demonstrated in the peripheral circulation. (nih.gov)
  • The virus causes PML and other diseases only in cases of immunodeficiency , as in AIDS or during treatment with drugs intended to induce a state of immunosuppression (e.g. organ transplant patients). (wikipedia.org)
  • It is thought that these differences in promoter sequence contribute to the fitness of the virus in the CNS and thus to the development of PML. (wikipedia.org)
  • The complete DNA sequence of the human JC virus, which was found to consist of 5,130 nucleotide pairs, is presented. (semanticscholar.org)
  • Heterogeneous imaging characteristics of JC virus granule cell neuronopathy (GCN): a case series and review of the literature. (radiopaedia.org)
  • The JC virus can be activated when a person's immune system is compromised because of disease or immunosuppressive medication. (ket-rt.ru)
  • Infections are usually asymptomatic, with most people unaware they have the virus unless their immune system is compromised by a disease or disease treatment. (psu.edu)
  • Imatinib, the active ingredient in the Company's lead product IkT-001Pro, is a host-directed protein kinase inhibitor that disrupts the ability of JC virus to reproduce in the patient. (thefreedictionary.com)
  • The "tumor antigen" (T antigen), a nonstructural protein expressed by the viruses, is responsible for cell transformation in animal models. (aacrjournals.org)
  • There are at least 14 subtypes of the virus associated with different human populations. (ed.ac.uk)
  • This test is intended to be used as an aid to the diagnosis of infections caused by JC virus. (labcorp.com)
  • Strikingly, our comparisons of JCV and human phylogenies provided no evidence for codivergence, suggesting that this virus should not be used as a marker for human population history. (ed.ac.uk)
  • Five complete genomes of JC virus Type 3 from Africans and African Americans Agostini, H. T. (deepdyve.com)
  • Gå til Diagnosis and treatment of PML - Another way to diagnose PML is by finding JC virus. (ket-rt.ru)