BenzazepinesTachycardia, SinusSinoatrial NodeCyclic Nucleotide-Gated Cation ChannelsHeart RateHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsAnti-Arrhythmia AgentsCardiovascular AgentsMetoprololAtenololAdrenergic beta-AntagonistsHeart Failure, SystolicVentricular RemodelingCardiotonic AgentsTachycardiaAngina PectorisDouble-Blind MethodArrhythmias, CardiacMyocardial StunningMolecular Docking SimulationIon ChannelsVentricular Dysfunction, LeftTreatment OutcomeHeart FailureDepression, ChemicalDose-Response Relationship, DrugMyocardial InfarctionCarbazolesCoxsackievirus InfectionsMyocardial ContractionElectrocardiographyBiological ClocksPropanolaminesMyocardial Reperfusion InjuryMyocardial IschemiaPotassium ChannelsPhysical Conditioning, AnimalHeart Ventriclesrac1 GTP-Binding ProteinMyocardiumAtherosclerosisDrug Evaluation, PreclinicalStroke VolumeRats, WistarExercise ToleranceVentricular Function, LeftDogsCapillariesCross-Over StudiesDrug Therapy, CombinationHypercholesterolemiaApolipoproteins ECoronary Artery DiseaseChronic DiseaseHeartAction PotentialsRabbitsKaplan-Meier EstimateMuscle ProteinsDisease Models, AnimalTime FactorsBlood PressureMice, Inbred C57BLProspective StudiesOxidative StressFollow-Up Studies