This gene encodes CD18, a protein present in several cell surface receptor complexes found on white blood cells, including lymphocyte function-associated antigen 1 (LFA-1), complement receptor 3 (CR-3), and complement receptor 4 (CR-4). (wikipedia.org)
Antibody5
2000) Inhibition of in vivo neutrophil transmigration by a novel humanized anti-CD11/CD18 monoclonal antibody. (guidetopharmacology.org)
1998) Hu23F2G, an antibody recognizing the leukocyte CD11/CD18 integrin, reduces injury in a rabbit model of transient focal cerebral ischemia. (guidetopharmacology.org)
The C71/16 monoclonal antibody specifically binds to mouse CD18 which is also known as the common β2 chain of LFA-1 (CD11a/CD18, αLβ2 integrin), Mac-1 (CD11b/CD18, αMβ2 integrin), and gp150, 95 (CD11c/CD18, αxβ2 integrin). (bdbiosciences.com)
Applications: Functional Activity (Order SAF formulation)Flow Cytometry: 0.5-1 ug/million cells in 0.1mlImmunofluorescence: 0.5-1 ug/mlOptimal dilution of the CD18 antibody should be determined by the researcher. (m-entrepreneurship.com)
Immunogen: Stimulated human leukocytes were used as the immunogen for the CD18 antibody. (m-entrepreneurship.com)
Background: It recognizes a transmembrane glycoprotein of 95kDa, identified as CD18 or integrin -2 (Workshop III). (m-entrepreneurship.com)
CD112
Physicians' awareness of LAD-I considering delayed separation of umbilical cord marked neutrophilic leukocytosis, and variability in CD11 and CD18 expression levels, and genetic analysis leads to early diagnosis and defining disease severity. (nih.gov)
CD18/CD11 heterodimeric molecules are involved with cell/cell and cell/extracellular adhesion in immune and inflammatory responses. (m-entrepreneurship.com)
Leukocyte3
Mutations in the β2 intergrin ( ITGB2 ) gene lead to absent, reduced, or aberrant CD18 protein expression, resulting in subnormal levels of β2 intergrins on leukocyte membranes. (guidetopharmacology.org)
In order to support the comprehensive classification of Leukocyte Adhesion Deficiency-I (LAD-I) severity by simultaneous screening of CD11a/CD18, this study assessed clinical, laboratory, and genetic findings along with outcomes of 69 LAD-I patients during the last 15 years. (nih.gov)
Molecular complexity of leukocyte surface glycoproteins related to the macrophage differentiation antigen Mac-1. (bdbiosciences.com)
Mutations3
citation needed] LAD1 is caused by mutations in the ITGB2 gene which are inherited autorecessively. (wikipedia.org)
Multiple inherited mutations in the integrin β2 protein (CD18) that reduce expression or function have been identified as the causative factor in patients with LAD1. (guidetopharmacology.org)
Genetic analysis of the patients revealed 14 previously reported and three novel pathogenic mutations in the ITGB2 gene. (nih.gov)
Gene2
Because the CD18 gene has been cloned and sequenced, this disorder is a potential candidate for gene therapy. (wikipedia.org)
ITGB2 (Integrin ?2) Immunomodulatory Gene Variants in Premature Infants With Necrotizing Enterocolitis. (childrensmercy.org)
CD11c2
CD18 non-covalently associates with CD11a, CD11b, or CD11c. (biolegend.com)
Expression of CD18 is limited to leukocytes, where it is widely distributed in consort with the three integrin α chains (CD11a, CD11b, and CD11c). (bdbiosciences.com)
Human peripheral blood lymphocytes were stained with CD18 (clone CBR LFA-1/2) FITC (filled histogram) or mouse IgG1, κ FITC isotype control (open histogram). (biolegend.com)
Human1
Synthetic peptide within Human CD18 (phospho S745). (abcam.cn)
Type1
CD18, also known as integrin β2 subunit, LFA-1 β subunit, and β2 integrin, is a 90 - 95 kD type I glycoprotein. (biolegend.com)
Function1
CD18 and associated α chains function in the adhesion and signaling in hematopoietic cells. (biolegend.com)
Integrin5
Products of Integrin subunit beta 2 (ITGB2) and selectin L (SELL) genes participate in several functional pathways of immune system. (nih.gov)
Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens (PubMed:9558116, PubMed:20008295). (arigobio.com)
Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. (arigobio.com)
In association with beta-2 integrin heterodimer ITGAM/CD11b and ITGB2/CD18, mediates activation of TNF-alpha primed neutrophils including degranulation and superoxide production (PubMed:21193407). (nih.gov)
2006). Together with CD18, also named integrin beta chain-2 (ITGB2), CD11b forms the integrin complement receptor 3 (CR3), which is involved in adhesion processes, phagocytic elimination of pathogens, induction of both inflammatory and tolerogenic responses, and modulation of parallel or downstream host defense pathways (Jurga et al. (sysy-histosure.com)
Mutations in the ITGB2 gene2
citation needed] LAD1 is caused by mutations in the ITGB2 gene which are inherited autorecessively. (wikipedia.org)
Genetic analysis of the patients revealed 14 previously reported and three novel pathogenic mutations in the ITGB2 gene. (bvsalud.org)
The recognized antigen is a heterodimer consisting of ~160 and ~95 kDa, belonging to the family of adhesion molecules CD11b/CD18, also designated as Mac-1 antigen or CR3. (arigobio.com)
Subunit1
In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407). (arigobio.com)
Monoclonal1
The lack of CR3 interferes with chemotaxis, phagocytosis, and respiratory burst Flow cytometry with monoclonal antibodies is used to screen for deficiencies of CD18. (wikipedia.org)
Antibody1
The efficacy of a therapeutic antibody depends on the Fab fragment and its binding activity to the target antigen, but also depends on the Fc fragment and its interaction with key Fc receptors.Therefore, candidates must be tested against a panel of receptors during antibody engineering. (acrobiosystems.com)
Receptor1
CR2/CD21 interacts with C3b degradation products C3dg and C3d and can act synergistically with the B-cell antigen receptor (BCR) in B-cell activation. (medscape.com)
Patients2
The aim of this investigation was to survey the transcript level of ITGB2 and SELL genes as well as methylation status of CpG sites in promoter region of differently expressed gene in PBMCs of SSc patients. (nih.gov)
BACKGROUND: In order to support the comprehensive classification of Leukocyte Adhesion Deficiency-I (LAD-I) severity by simultaneous screening of CD11a/CD18, this study assessed clinical, laboratory, and genetic findings along with outcomes of 69 LAD-I patients during the last 15 years. (bvsalud.org)