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TyrosinePhosphorylationPhosphotyrosinesrc Homology DomainsProtein-Tyrosine KinasesPhosphopeptidesAmino Acid SequenceSignal TransductionProtein Tyrosine PhosphatasesMolecular Sequence DataProtein BindingGRB2 Adaptor ProteinAdaptor Proteins, Signal TransducingCell LineProto-Oncogene ProteinsProtein Structure, TertiaryProteinsRecombinant Fusion ProteinsBinding SitesTyrosine 3-MonooxygenasePhosphoproteinsEnzyme ActivationSerineIntracellular Signaling Peptides and ProteinsProtein KinasesAmino Acid MotifsAntigens, CD79Protein Tyrosine Phosphatase, Non-Receptor Type 11PhosphoserineReceptors, IgGCells, CulturedProtein-Serine-Threonine KinasesPhospholipase C gammaTransfectionReceptor Protein-Tyrosine KinasesProtein Tyrosine Phosphatase, Non-Receptor Type 6KineticsEnzyme PrecursorsProto-Oncogene Proteins c-fynMutationThreonineEnzyme InhibitorsVanadatesPeptide MappingBlotting, WesternMutagenesis, Site-DirectedProtein Tyrosine Phosphatase, Non-Receptor Type 1Precipitin TestsRecombinant ProteinsBase SequenceReceptors, Antigen, B-CellSubstrate SpecificityLymphocyte Specific Protein Tyrosine Kinase p56(lck)COS CellsProto-Oncogene Proteins pp60(c-src)Membrane ProteinsReceptor, Epidermal Growth Factorsrc-Family KinasesGenisteinProtein Processing, Post-TranslationalProtein Kinase InhibitorsCell Line, TumorElectrophoresis, Polyacrylamide GelMitogen-Activated Protein KinasesSequence Homology, Amino AcidImmunoblottingPhosphothreonine3T3 CellsMolecular WeightPeptide FragmentsCalcium-Calmodulin-Dependent Protein KinasesCytoplasmReceptors, Antigen, T-CellDNA-Binding ProteinsPhosphatidylinositol 3-KinasesReceptors, ImmunologicTumor Cells, CulturedType C PhospholipasesCell MembraneProto-Oncogene Proteins c-ablFocal Adhesion Protein-Tyrosine KinasesProto-Oncogene Proteins c-vavCasein Kinase IIPhosphoprotein PhosphatasesProto-Oncogene Proteins c-aktReceptors, IgECalciumImmunoprecipitationCyclic AMP-Dependent Protein KinasesPaxillinHeLa CellsSH2 Domain-Containing Protein Tyrosine PhosphatasesPhosphorus RadioisotopesFocal Adhesion Kinase 1Mitogen-Activated Protein Kinase 1TyrphostinsAntigens, CDJurkat CellsZAP-70 Protein-Tyrosine KinaseMice, Knockout
KinasesImmunoreceptor tyrosPhosphorylationResiduesReceptorsDownstreamProteinAntigen receptorIntracellularProteinsCytoplasmic domainSubunitsActivationActivatesPeptideInhibitoryStimulationCellDomainsComplexDomainFamilySignalResponseSpleen tyrosine kinaseITAMsKinaseMotifMotifsProtein tyrosine phImmunoreceptor tyrosine-basedReceptorCD79aVivoPhosphatasesSignaling moleculesMutantCells
Kinases14
  • Upon binding, the tyrosine residues in the signaling motifs are phosphorylated by membrane-associated tyrosine kinases. (wikipedia.org)
  • Many NTRs have an unstructured intracellular domain which contains tyrosine residues that can be phosphorylated by tyrosine kinases. (wikipedia.org)
  • Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. (nih.gov)
  • The phosphorylation of the ITAM domains is generally mediated by SRC subfamily kinases upon engagement of the receptor. (icr.ac.uk)
  • Phosphorylated ITAM motifs on CD3 recruit and activate SH2 domain-containing protein tyrosine kinases (PTK) such as Zap70 to further mediate downstream signalling through tyrosine phosphorylation, leading to transcription factor activation including NF-κB and consequent T cell activation. (wikidoc.org)
  • Spleen tyrosine kinase (SYK), along with ZAP70, are cytoplasmic tyrosine kinases that are viewed as potential druge targets for allergic disorders and autoimmune diseases. (thermofisher.cn)
  • Syk binds to the receptor assemblies through interactions of its pair of SH2 domains with ITAM motives of the receptor, which have been phosphorylated by Src-family kinases. (thermofisher.cn)
  • The class 1A phosphoinositide 3-kinase (PI3K) beta (PI3Kβ) is functionally unique in the ability to integrate signals derived from receptor tyrosine kinases (RTKs), heterotrimeric guanine nucleotide-binding protein (G-protein)-coupled receptors (GPCRs), and Rho-family GTPases. (elifesciences.org)
  • Type I IFNs initiate their biological effects by binding to their transmembrane interferon receptors and initiating the phosphorylation and activation of tyrosine kinases TYK2 and JAK1, which promote phosphorylation and activation of STAT molecules. (scientificarchives.com)
  • Studies have shown that all type I IFNs exclusively bind to and signal through ubiquitously expressed heterodimeric transmembrane (TM) receptors composed of two subunits-IFNAR1 and IFNAR2 [ 3 ], which are constitutively associated with tyrosine kinases TYK2 and JAK1/STAT2 (signal transducer and activator of transcription 2), respectively, under normal physiological conditions [ 4 , 5 ]. (scientificarchives.com)
  • Upon binding of type I IFNs to IFNAR1 and IFNAR2, the proximal receptor complex is assembled and the tyrosine kinases TYK2 and JAK1 are activated by reciprocal transphosphorylation. (scientificarchives.com)
  • Preeminent among these proteins are the cyclin dependent kinases, which upon binding to cyclins, phosphorylate numerous targets to trigger cell cycle progression. (smadpathway.com)
  • Association of p62, a multifunctional SH2- and SH3-domain-binding protein, with src family tyrosine kinases, Grb2, and phospholipase C gamma-1. (eu.org)
  • Tau interacts with src-family non-receptor tyrosine kinases. (eu.org)
Immunoreceptor tyros1
  • The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). (nih.gov)
Phosphorylation4
  • NTR triggering, the initial step of the NTR signalling pathway, involves phosphorylation of the tyrosine residues in the cytoplasmic domain of the receptor or the associated adaptor protein. (wikipedia.org)
  • This is consistent with reports that the slow phosphorylation of tyrosine residues of the Lat adaptor associates with recruitment and activation of the phospholipase Plcγ1, thereby constituting an important kinetic bottleneck for ligand discrimination 11 . (nature.com)
  • While the phosphorylation of tyrosine residues in the immunoreceptor tyrosine-based activation motifs (ITAMs) of Cd3 and the inducible interaction between Cd3 and Zap70 remained largely unaffected, the abundance of activated Zap70 dropped with decreasing peptide affinity. (nature.com)
  • Phosphorylation of Syk Activation Loop Tyrosines Is Essential for Syk Function. (crossref.org)
Residues7
  • For that tyrosine residues in the cytoplasmic tail of the receptors have to be phosphorylated, hence the receptors are referred to as tyrosine-phosphorylated receptors. (wikipedia.org)
  • They are called non-catalytic receptors, as the receptors have no intrinsic tyrosine kinase activity and cannot phosphorylate their own tyrosine residues. (wikipedia.org)
  • Some receptors in this family, however, lack a cytoplasmic tail and therefore associate with adaptor proteins containing the same tyrosine residues. (wikipedia.org)
  • Tyrosine residues of NTRs mostly appear in conserved amino acid motifs with defined sequence signatures that define whether the receptor plays an activator or inhibiting role in the cell. (wikipedia.org)
  • Immunoreceptor tyrosine-based activation motifs (ITAMs) are short amino acid sequences that contain two tyrosine residues (Y) arranged as Yxx(L/I)x6-8Yxx(L/I), where L and I indicate Leucine or Isoleucine residue respectively (according to amino acid abbreviations), x denotes any amino acids, a subscribe 6-8 indicates a sequence of 6 to 8 amino acids in length. (wikipedia.org)
  • lck then phosphorylates tyrosines residues within the immunoreceptor tyrosines-based activation motifs (itams) in the cytoplasmic tails of the tcrgamma chains and cd3 subunits, initiating the tcr/cd3 signaling pathway. (affbiotech.cn)
  • Figure 1: PGRMC1 is phosphorylated on key regulatory amino acid residues. (oncotarget.com)
Receptors8
  • Non-catalytic tyrosine-phosphorylated receptors (NTRs), also called immunoreceptors or Src-family kinase-dependent receptors, are a group of cell surface receptors expressed by leukocytes that are important for cell migration and the recognition of abnormal cells or structures and the initiation of an immune response. (wikipedia.org)
  • The most prominent feature is the presence of conserved signalling motifs containing tyrosine residue, such as Immunoreceptor tyrosine-based activation motifs (ITAMs), in the cytoplasmic tail of the receptors. (wikipedia.org)
  • The receptors themselves have no intrinsic tyrosine kinase activity. (wikipedia.org)
  • Non-Catalytic Tyrosine-Phosphorylated Receptors" Encyclopedia , https://encyclopedia.pub/entry/36839 (accessed November 29, 2023). (encyclopedia.pub)
  • Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). (icr.ac.uk)
  • Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. (icr.ac.uk)
  • Ligation of these receptors results either in diminution of intracellular signaling by ITIM-associated phosphatase activity for inhibitory receptors with a long cytoplasmic tail or in ITAM-associated signaling through adaptor molecules recruited by activating receptors with a short cytoplasmic tail. (ashpublications.org)
  • Activating receptors contain cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAM) and activate the FcgR-expressing cell to mediate functions including antibody-dependant cell mediated cytotoxicity (ADCC) and phagocytosis of the antibody-labeled target cell. (sanguinebio.com)
Downstream4
  • CD79a/b complex interacts with Src-family tyrosine kinase Lyn, which phosphorylates its cytoplasmic ITAM motives to form docking sites for downstream signaling. (exbio.cz)
  • Direct downstream effectors phosphorylated by SYK include VAV1, PLCG1, PI-3-kinase, LCP2 and BLNK. (icr.ac.uk)
  • Activated upon BCR engagement, it phosphorylates and activates BLNK an adapter linking the activated BCR to downstream signaling adapters and effectors. (icr.ac.uk)
  • Syk translocates to the plasma membrane upon B cell antigen receptor (BCR) or the high-affinity IgE receptor (FcepsilonRI) triggering, and phosphorylates downstream adaptor proteins, thereby providing docking sites for initiation of subsequent signaling pathways, such as calcium mobilization, cytoskeleton remodeling, or transcription of specific genes. (thermofisher.cn)
Protein4
  • The signaling cascade is down-regulated by dephosphorylation by protein tyrosine phosphatases. (wikipedia.org)
  • In addition to defining the role of SLP-76 in osteoclast function, we also delineated the pathway for αvβ3 and c-Fms-mediated SLP-76 activation via the Syk tyrosine kinase and the immunoreceptor activation motif (ITAM)-containing adaptor protein, DAP12. (wustl.edu)
  • Crystallization and Structural Determination of ABLT315I:AP24534 The kinase domain of murine ABLT315I was coexpressed with YopH protein tyrosine phosphatase in E. coli as described previously and purified in the clear presence of AP24534 to near homogeneity using metal affinity, Mono Q, and measurement exclusion chroma tography. (smadpathway.com)
  • ASAP1, a phospholipid-dependent arf GTPase-activating protein that associates with and is phosphorylated by Src. (eu.org)
Antigen receptor1
  • It also phosphorylates BTK and regulates its activity in B-cell antigen receptor (BCR)-coupled signaling. (icr.ac.uk)
Intracellular4
  • The phosphorylated NTRs, in turn, initiate a specific intracellular signaling cascades. (wikipedia.org)
  • phosphorylates USP25 and regulates USP25 intracellular levels. (icr.ac.uk)
  • The short cytoplasmic / intracellular tail (C) of CD4 contains a special sequence of amino acids that allow it to recruit and interact with the tyrosine kinase Lck . (wikidoc.org)
  • The resulting close proximity between the TCR complex and CD4 (extracellular and intracellular) allows the tyrosine kinase Lck bound to the cytoplasmic tail of CD4 to tyrosine-phosphorylate the Immunoreceptor tyrosine activation motifs (ITAM) on the cytoplasmic domains of CD3 to amplify the signal generated by the TCR. (wikidoc.org)
Proteins3
  • They both are transmembrane proteins with extended cytoplasmic domains containing immunoreceptor tyrosine activation motives (ITAMs), and together with cell surface immunoglobulin they constitute B-cell antigen-specific receptor (BCR). (exbio.cz)
  • The association with the receptor can also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains. (icr.ac.uk)
  • RNA enzymes may observe from also translocated proteins, they may phosphorylate suggested in proteins with delayed strategies, or they may outline known in membranes of factor factors. (evakoch.com)
Cytoplasmic domain2
  • PECAM-1 (also known as CD31) is a cellular adhesion and signaling receptor comprised of six extracellular immunoglobulin (Ig) - like homology domains, a short transmembrane domain, and a 118 amino acid cytoplasmic domain that becomes serine and tyrosine phosphorylated upon cellular activation. (versiti.org)
  • Meltrin alpha cytoplasmic domain interacts with SH3 domains of Src and Grb2 and is phosphorylated by v-Src. (eu.org)
Subunits1
  • The beta and gamma subunits possess immunoreceptor tyrosine-based activation motifs (ITAM). (thermofisher.com)
Activation3
  • phosphorylates VAV1 upon BCR activation. (icr.ac.uk)
  • Although activated TYK2 and JAK1 phosphorylate and activate STAT2, which is a critical early step for STAT1 activation by type I IFN in canonical signaling [ 6 ], the mechanism of STAT2-dependent STAT1 activation after stimulation of type I IFN is poorly understood. (scientificarchives.com)
  • The Sustainable Building Design and Construction threonine has an Mitogen-activated, alveolar step that contains effects at the conversion of the activation of a phosphorylated specific residue. (evakoch.com)
Activates2
  • It also phosphorylates and activates PLCG1 and the PKC signaling pathway. (icr.ac.uk)
  • αvβ3 and c-Fms engagement activates cSrc tyrosine kinase, which phosphorylates DAP12. (wustl.edu)
Peptide1
  • We find that auto-inhibited PI3Kβ must first cooperatively engage a single RTK-derived tyrosine phosphorylated (pY) peptide before it can engage either GβGγ or Rac1(GTP). (elifesciences.org)
Inhibitory3
  • Inhibitory signals are transduced by Immunoreceptor tyrosine-based inhibitory motifs (ITIMs) of the signature (S/I/V/L)xYxx(I/V/L), bind to cytoplasmic tyrosine phosphatases. (wikipedia.org)
  • Immunoreceptor Tyrosine-based Switch Motifs (ITSMs) with the signature TxYxx(I/V) may induce both activator and inhibitory signals. (wikipedia.org)
  • FcgRIIB is the single inhibitory Fc g receptor in mice and humans and contains a cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM) which instead downregulates cellular responses. (sanguinebio.com)
Stimulation1
  • STAT5, which is constitutively associated with IFNAR1 and phosphorylated by TYK2 upon stimulation with type I IFN, forms a complex with CrkL [ 15 , 16 ]. (scientificarchives.com)
Cell2
  • Kouro T, Nagata K, Takaki S, Nisitani S, Hirano M, Wahl MI, Witte ON, Karasuyama H, Takatsu K: Bruton's tyrosine kinase is required for signaling the CD79b-mediated pro-B to pre-B cell transition. (exbio.cz)
  • Tyrosine kinase that plays an essential role for the selection and maturation of developing t-cell in the thymus and in mature t-cell function. (affbiotech.cn)
Domains1
Complex1
Domain1
  • May be coupled to the collagen receptor by the ITAM domain-containing FCER1G. (icr.ac.uk)
Family1
  • Members of the Non-catalytic tyrosine-phosphorylated receptor family share a couple of common features. (wikipedia.org)
Signal1
Response1
  • p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage. (eu.org)
Spleen tyrosine kinase5
  • The phosphorylated ITAMs recruit the spleen tyrosine kinase (SYK) to the receptor, where it becomes activated by phosphorylation of tyrosines in its kinase domain, and propagates the signal activation to downstream signaling proteins. (medscape.com)
  • SYK: Spleen tyrosine kinase. (medscape.com)
  • The CD79a ITAM tyrosines (human CD79a Tyr188 and Tyr199, mouse CD79a Tyr182 and Tyr193) phosphorylated in response to BCR crosslinking, are critical for binding of Src-homology 2 domain-containing kinases such as spleen tyrosine kinase (Syk) and signal transduction by CD79a. (wikidoc.org)
  • Moreover, spleen tyrosine kinase (Syk) inhibitor restrained IL-10 production of TREM-2 + DC. (oncotarget.com)
  • The BCR signaling cascades involve several essential kinases, including spleen tyrosine kinase (SYK), Bruton tyrosine kinase (BTK), and phosphatidylinositol-3-kinase (PI3K) (Fig. 1 ) [ 1 ]. (biomedcentral.com)
ITAMs5
  • The most prominent feature is the presence of conserved signalling motifs containing tyrosine residue, such as Immunoreceptor tyrosine-based activation motifs (ITAMs), in the cytoplasmic tail of the receptors. (wikipedia.org)
  • Immunoreceptor tyrosine-based activation motifs (ITAMs) are short amino acid sequences that contain two tyrosine residues (Y) arranged as Yxx(L/I)x6-8Yxx(L/I), where L and I indicate Leucine or Isoleucine residue respectively (according to amino acid abbreviations), x denotes any amino acids, a subscribe 6-8 indicates a sequence of 6 to 8 amino acids in length. (wikipedia.org)
  • BCR consists of an antigen-binding transmembrane immunoglobulin (mIg) in complex with two trans-membrane polypeptides, namely Igα and Igβ, containing immunoreceptor tyrosine activation motifs (ITAMs), which enable the transmission of intracellular signaling. (medscape.com)
  • Phosphorylated ITAMs allow for binding of Syk kinase which can drive activation of the PI3K and Akt pathways, and thereby promote survival of inflammatory cells by inhibiting apoptosis. (biolegend.com)
  • Di-tyrosine residues within ITAMs are phosphorylated upon TCR engagement and function to recruit signaling molecules, such as protein tyrosine kinases, to the TCR complex, thereby initiating the T cell activation cascade. (nih.gov)
Kinase11
  • Non-catalytic tyrosine-phosphorylated receptors (NTRs), also called immunoreceptors or Src-family kinase-dependent receptors, are a group of cell surface receptors expressed by leukocytes that are important for cell migration and the recognition of abnormal cells or structures and the initiation of an immune response. (wikipedia.org)
  • They are called non-catalytic receptors, as the receptors have no intrinsic tyrosine kinase activity and cannot phosphorylate their own tyrosine residues. (wikipedia.org)
  • The receptors themselves have no intrinsic tyrosine kinase activity. (wikipedia.org)
  • The cytoplasmic domains do not contain any intrinsic tyrosine kinase activity. (wikipedia.org)
  • 7. CD19 amplifies B lymphocyte signal transduction by regulating Src-family protein tyrosine kinase activation. (nih.gov)
  • Increased BCR molecular density reduced levels of the stimulatory kinase Syk, the inhibitory phosphatase SHIP-1, and their phosphorylated forms in individual BCR clusters. (elifesciences.org)
  • Bruton tyrosine kinase (BTK) is a key component of BCR signaling, establishing BTK as an important therapeutic target. (biomedcentral.com)
  • BTK is a member of the Tec family kinases, which contain interleukin-2-inducible T cell kinase (ITK), tyrosine kinase expressed in hepatocellular carcinoma (TEC), resting lymphocyte kinase (RLK), and bone marrow expressed kinase (BMX)[ 5 ]. (biomedcentral.com)
  • Catalytic domain of the Protein Tyrosine Kinase, Zeta-chain-associated protein of 70kDa. (umbc.edu)
  • Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). (nih.gov)
  • These experiments have led to the identification of a novel protein tyrosine kinase (Txk) and protein tyrosine phosphatase (PTPK1). (nih.gov)
Motif5
  • 8. Identification of an immunoreceptor tyrosine-based activation motif of K1 transforming protein of Kaposi's sarcoma-associated herpesvirus. (nih.gov)
  • 13. Immunoreceptor tyrosine-based activation motif-dependent signaling by Kaposi's sarcoma-associated herpesvirus K1 protein: effects on lytic viral replication. (nih.gov)
  • 15. Downstream signaling molecules bind to different phosphorylated immunoreceptor tyrosine-based activation motif (ITAM) peptides of the high affinity IgE receptor. (nih.gov)
  • Upon binding of ligand to TREM, the receptor initiates signaling through DAP12's tyrosine-based activation motif (ITAM). (biolegend.com)
  • Plays a role in platelet activation signaling triggered by GPCRs, alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) and ITAM (immunoreceptor tyrosine-based activation motif)-bearing receptors such as GP6. (nih.gov)
Motifs4
  • Tyrosine residues of NTRs mostly appear in conserved amino acid motifs with defined sequence signatures that define whether the receptor plays an activator or inhibiting role in the cell. (wikipedia.org)
  • Inhibitory signals are transduced by Immunoreceptor tyrosine-based inhibitory motifs (ITIMs) of the signature (S/I/V/L)xYxx(I/V/L), bind to cytoplasmic tyrosine phosphatases. (wikipedia.org)
  • Immunoreceptor Tyrosine-based Switch Motifs (ITSMs) with the signature TxYxx(I/V) may induce both activator and inhibitory signals. (wikipedia.org)
  • Finally, Immunoglobulin Tail Tyrosine Motifs (ITTMs) with a YxNM signature have been found to have a costimulatory effect. (wikipedia.org)
Protein tyrosine ph2
  • 6. CD22 associates with protein tyrosine phosphatase 1C, Syk, and phospholipase C-gamma(1) upon B cell activation. (nih.gov)
  • We are generating PTPK1-deficient mice to examine the role in lymphocyte development of the protein tyrosine phosphatase PTPK1, which is expressed in immature hematopoietic stem cells and early thymocytes. (nih.gov)
Immunoreceptor tyrosine-based1
  • These receptors or their adaptors generally screen an immunoreceptor tyrosine-based inhibition theme (ITIM) or an immunoreceptor Rabbit Polyclonal to CRP1 tyrosine-based account activation theme (ITAM), which function as docking sites for downstream signalling elements18. (ap26113.com)
Receptor3
  • Members of the Non-catalytic tyrosine-phosphorylated receptor family share a couple of common features. (wikipedia.org)
  • 17. Inhibition of signaling through the B cell antigen receptor by the protooncogene product, c-Cbl, requires Syk tyrosine 317 and the c-Cbl phosphotyrosine-binding domain. (nih.gov)
  • PECAM-1 (also known as CD31) is a cellular adhesion and signaling receptor comprised of six extracellular immunoglobulin (Ig) - like homology domains, a short transmembrane domain, and a 118 amino acid cytoplasmic domain that becomes serine and tyrosine phosphorylated upon cellular activation. (versiti.org)
CD79a2
  • [15] [16] In vivo, the CD79a ITAM tyrosines synergize with the CD79b ITAM tyrosines to mediate the transition from the pro to the pre B cell stage as suggested by the analysis of mice with targeted mutations of the CD79a and CD79b ITAM . (wikidoc.org)
  • However, the presence of both the CD79a and CD79b ITAM tyrosines were required for normal T cell dependent antibody responses. (wikidoc.org)
Vivo1
  • These results identify an in vivo function for the multiple ITAM-TCR structure in signal amplification. (nih.gov)
Phosphatases1
Signaling molecules1
  • Our results with TCR-ITAM mutant mice suggested that other signaling molecules can compensate for the reduction in TCR signal strength. (nih.gov)
Mutant1
  • To determine if TCR signal transducing subunits perform distinct or analogous functions in development, we previously generated zeta deficient and CD3-epsilon deficient mice by gene targeting, genetically reconstituted these mice with transgenes encoding wild-type or signaling-deficient (ITAM-mutant) forms of zeta and CD3-epsilon, and characterized the developmental and functional consequences of these alterations on TCR signaling. (nih.gov)
Cells1
  • We further learned that the multiple ITAM configuration of the TCR is especially important for thymocyte selection (a developmental process that ensures maturation of self-educated T-cells and prevents maturation of potentially autoreactive T-cells). (nih.gov)