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  • bone
  • Because MSCs are generally harvested from mesenchymal tissues, such as bone marrow, adipose tissue, or umbilical cord as adherent cells, MSCs comprise crude cell populations and are heterogeneous. (mdpi.com)
  • Mesenchymal stem cells ( MSCs) are cells that reside in tissues such as bone marrow, fat tissue, dermis, and the umbilical cord, and are useful for cell-based therapy in humans because of their low risk of tumorigenesis [ 1 , 2 ]. (mdpi.com)
  • That could be about to change: A Florida State University research team in Tallahassee, Fla. reports that it has designed a biomedical device that will allow stem cells derived from adult bone marrow to be grown in sufficient quantities to permit far more research - and allow faster growth of tissues that can be transplanted into patients. (scienceblog.com)
  • The perfusion bioreactor can be used to reproduce mesenchymal stem cells and to direct their differentiation into bone, cartilage, muscle, heart muscle, fat or nerve tissue," Ma said. (scienceblog.com)
  • Among the varieties of biological mineralization in nature, e.g., shell, coral, and bone, this special issue "Hard Tissue Biology" presented by Histochemistry and Cell Biology, focuses on the bone, cartilage, and teeth in mammals. (springer.com)
  • During the past decade, molecular and cellular mechanisms in the development/metabolism of bone, cartilage, and teeth has been expounded, and to that end, we believe a special issue of "Hard Tissue Biology" will provide up-to-date and invaluable information to the readers of this journal. (springer.com)
  • Molecular cell biology on cell differentiation and tissue development of bone, cartilage, and teeth are important issues in hard tissue biology. (springer.com)
  • The discovery of runt-related transcription factor 2 (Runx2), also known as Cbfa-1,-a key transcription factor associated with osteoblast differentiation and chondrocyte maturation, as well as receptor activator of nuclear factor-κB ligand (RANKL)/RANK/osteoprotegerin system was epoch-making and highlighted in the research field of molecular cell biology in bone. (springer.com)
  • Minqi Li's research team ( 2018a ) reports that IGF2 messenger RNA-binding proteins (IMPs)-a family of onco-fetal RNA-binding proteins that play an important role in cell migration, renewal and metabolism, is involved in bone remodeling by regulating the activity of osteoclasts and impairing their adhesion. (springer.com)
  • This issue also presents research on pathological bone response in inflammatory diseases, and osteoclastic function in osteolytic pathology. (springer.com)
  • cells
  • These cells are more flexible and less specialized than cells from adult tissue, easier to grow, and more adaptable to new environments. (statnews.com)
  • Ongoing research using cells derived from fetal tissue includes work on neurodegenerative diseases such as Parkinson's, Alzheimer's, amyotrophic lateral sclerosis, spinal cord injury, stroke, retinal disease, and age-related macular degeneration. (statnews.com)
  • Stem cells are unique because they can replicate themselves to allow tissue growth, and they contain the information needed to allow the body to construct any part of the organism. (timeshighereducation.com)
  • The issues surrounding the supply of stem cells are being examined by the government. (timeshighereducation.com)
  • Professor Williams said: "We can't rule out using foetal cells because the long-term aim is to enable a patient's cells to generate the healing. (timeshighereducation.com)
  • In both studies, the research-grade lines showed a treatment benefit but the clinical-grade cells did not. (alzforum.org)
  • We don't have clear criteria for the quality of the cells or the mechanism of action," explained Mahendra Rao at the New York Stem Cell Foundation Research Institute, New York City. (alzforum.org)
  • Clinical-grade stem cells from StemCells Inc. formed undifferentiated masses in the brain ventricles of some mice, proliferating and extending neurites into surrounding tissue (arrows). (alzforum.org)
  • The researchers compared human "research-grade" cells versus clinical-grade cells that StemCells Inc. had supplied them. (alzforum.org)
  • In an acute injury model, where cells were transplanted nine days after injury, research-grade cells enhanced performance on numerous motor tests, but clinical-grade cells once again did nothing. (alzforum.org)
  • Since then, specialists have discovered that stem cells can become any of the 200 specialized cells in the body, giving them the ability to repair or replace damaged cells and tissues. (brainandspinalcord.org)
  • At that time, the NIH was awaiting a legal opinion from DHHS to determine whether or not the NIH could fund research utilizing these cells. (nih.gov)
  • I will then describe the legal opinion and the plans for the development of guidelines and oversight that will be in place before NIH would fund research with these cells. (nih.gov)
  • The first is research focused on how stem cells differentiate into specific types of cells. (nih.gov)
  • A second and more practical application of research using these cells is in pharmaceutical development. (nih.gov)
  • The most interesting property of MSCs is that, despite being adult stem cells that belong to the mesenchymal tissue lineage, they are able to differentiate into a broad spectrum of cells beyond the boundary of mesodermal lineage cells into ectodermal or endodermal lineages, and repair tissues. (mdpi.com)
  • The broad spectrum of differentiation ability and tissue-repairing effects of MSCs might be mediated in part by the presence of a novel pluripotent stem cell type recently found in adult human mesenchymal tissues, termed multilineage-differentiating stress enduring (Muse) cells. (mdpi.com)
  • Besides the mechanisms underlying the trophic, anti-inflammatory, and immunomodulatory effects, another important action of MSCs that has been debated over the past decade is the broad spectrum of differentiation beyond the boundaries of tissue stem cells. (mdpi.com)
  • Generally, tissue stem cells generate the cell types of the tissue in which they reside, and thus the range of their differentiation capabilities is usually limited. (mdpi.com)
  • With the advent of tissue engineering, there is great interest in the potential therapeutic application of stem cells for periodontal regeneration, and there has been a marked increase in publications in this area over the past 5 years. (springer.com)
  • It provides the current information about the biology of stem cells derived from all sources-embryo, fetal tissue, and adult. (nih.gov)
  • How and whether stem cells derived from any of these sources can be manipulated to replace cells in diseased tissues, used to screen drugs and toxins, or studied to better understand normal development depends on knowing more about their basic properties. (nih.gov)
  • Like all fields of scientific inquiry, research on stem cells raises as many questions as it answers. (nih.gov)
  • Included in this report is subject matter addressing stem cells from adult, fetal tissue, and embryonic sources. (nih.gov)
  • A general overview of early development is provided in the Appendix to assist the reader in understanding the key events in formation of cells, tissues, and the whole organism. (nih.gov)
  • Are the umbilical cord tissue-derived stem cells used by the Stem Cell Institute approved by the US FDA? (cellmedicine.com)
  • Human umbilical cord tissue-derived mesenchymal stem cells (MSCs) that were isolated and grown in our laboratory in Panama to create master cell banks are currently being used in the United States. (cellmedicine.com)
  • Because they are so rare, the ability to reproduce stem cells in a laboratory becomes particularly significant for further research and clinical trials. (scienceblog.com)
  • By addressing one of the key issues constraining this research - a limited supply of stem cells - he could help advance the development of numerous medical therapies by years," Locke said. (scienceblog.com)
  • Like their parental tissue in vivo , RCCS-grown cells are able to respond to chemical and molecular gradients in three dimensions (i.e. at their apical, basal, and lateral surfaces) because they are cultured on the surface of porous microcarrier beads. (jove.com)
  • Consequently, the spatial constraints imposed by the environment profoundly affect how cells sense and decode signals from the surrounding microenvironment, thus implying an important role for the 3-D milieu 13 . (jove.com)
  • The Senate unanimously passed two other bills: S. 2754, which requires the NIH to fund research on alternative methods of creating stem cells, and S. 3504, which bans "fetal farming," the solicitation or acceptance of tissue from fetuses created solely for the purpose of research. (seedmagazine.com)
  • The research team of Ohshima ( 2018 ) examines how gene expression of nestin (known to be expressed in undifferentiated cells during neurogenesis and myogenesis) is regulated in odontoblasts, using nestin-EGFP (enhanced GFP) transgenic mice. (springer.com)
  • Extrapancreatic tissues such as liver may serve as potential sources of tissue for generating insulin-producing cells. (jove.com)
  • Moreover end-point histological analysis allows us to perform detailed phenotypic analysis of grafted cells and/or the surrounding tissue, based on the use of fluorescent reporter proteins and/or direct cell labeling with specific antibodies. (jove.com)
  • proteins
  • Recent studies have revealed that biological functions of several membrane transporters and enzymes (tissue nonspecific alkaline phosphatase, ENPP1, PHOSPHO1 and ANK, etc.) equipped in the matrix vesicles, as well as non-collagenous proteins, are coordinated to enable the spatiotemporal crystallization of calcium phosphate (hydroxyapatite). (springer.com)
  • 1993
  • The NIH Revitalization Act of 1993 imposed additional restrictions on fetal tissue research, including mandated written informed consent from the donor as well as a signed statement from the attending physician affirming that the decision to abort and the decision to donate tissue for research are not related. (statnews.com)
  • And in 1993, members of Congress on both sides of the aisle voted to legalize fetal tissue research , even in cases when the samples were obtained from legal abortion procedures, when they approved the National Institutes of Health Revitalization Act. (thinkprogress.org)
  • organ
  • More recently, nuclear magnetic resonance imaging (MRI) and nuclear magnetic spectroscopy (NMR) have been introduced to prenatal care as tools to reveal biochemical information about fetal soft tissues, as well as organ structure and function. (questia.com)
  • transplantation
  • that is, for the generation of tissue used for transplantation, which some individuals feel is unethical, since upon uterine implantation, this embryo could develop into a human being. (wdxcyber.com)
  • The tissues grown then will be suitable for clinical transplantation. (scienceblog.com)
  • However, to date results regarding functional outcome and/or tissue regeneration following stem cell transplantation are quite diverse. (jove.com)
  • researchers
  • STANFORD, Calif. - A single dose of antibiotics can significantly aid healing of the severe tearing that occurs in vaginal tissues during many births, according to researchers at Lucile Packard Children's Hospital at Stanford, the Stanford University School of Medicine and Santa Clara Valley Medical Center. (infectioncontroltoday.com)
  • Researchers from the University of Chicago, University of Alberta and other institutions announce in the September issue of Nature Genetics --available online August 10--that the FOXC1 gene contributes to Dandy-Walker malformation (DWM), a brain defect that occurs in 1 of every 5,000 births. (newswise.com)
  • In this special issue on "Hard Tissue Biology", Hasegawa ( 2018 ) reviews the ultrastructure and cell biology of matrix vesicles-mediated mineralization, by introducing her own and other researchers' evidence. (springer.com)
  • brains
  • The role of the gene in Dandy-Walker malformation dispels the fog surrounding what goes awry in the brains of children born with the disorder. (newswise.com)
  • placenta
  • Indeed, the use of donated fetal tissue has shown us how the Zika virus crosses the placenta and alters human brain development. (statnews.com)
  • Well-controlled trophoblast invasion at maternal-fetal interface is a critical event for the normal development of placenta. (jove.com)
  • The major cell type of the fetal portion of the placenta is the trophoblast. (jove.com)
  • medical
  • Fetal tissue research has been vital for scientific and medical advances that have saved millions of lives. (statnews.com)
  • Indeed, there is no reason to believe that the use of fetal tissue in medical research has any influence on a woman's decision to terminate a pregnancy. (statnews.com)
  • The interdisciplinary research collaboration funding will come from the Medical Research Council, the Biotechnology and Biological Sciences Research Council and the Engineering and Physical Sciences Research Council. (timeshighereducation.com)
  • Known as somatic cell nuclear transfer, this process is highly controversial due to both medical and ethical concerns and is illegal in the United States, the United Kingdom and Australia, where any research involving human cloning is prohibited. (wdxcyber.com)
  • In some instances, actual costs, such as the cost to transport tissue to leading research centers, are reimbursed, which is standard across the medical field. (talkingpointsmemo.com)
  • Governor Abbott believes human and fetal remains should not be treated like medical waste," she said in a statement , "and the proposed rule changes affirms the value and dignity of all life. (burntorangereport.com)
  • They also underlie a host of other federal regulations and guidelines for medical research, and they have worked their way into the private sector as well. (consciencelaws.org)
  • Universities and hospitals routinely use -- or try to use -- the three principles when approving research projects, deciding who qualifies for certain medical treatments, and even who lives, who dies, and who makes those decisions.Thus, bioethics is really a brand-new ethical theory, a brand-new way of determining right and wrong. (consciencelaws.org)
  • How did it come about that our government and its non-elected experts, rather than religious leaders or even traditional philosophers, acquired the power to define what is normatively ethical for all Americans facing complex medical or scientific issues? (consciencelaws.org)
  • regeneration
  • Periodontal regeneration, the restoration of the periodontal tissues destroyed by periodontitis, has been an important objective of periodontal therapies for many years. (springer.com)
  • 2018 ) introduce a method of tissue engineering of cartilage regeneration, focusing on autologous chondrocyte implantation method as well as biodegradable polymers such as poly-L-lactic acid. (springer.com)
  • morally
  • It is "morally impermissible to engage in any research, for any purpose, that involves the destruction of human beings at any stage of their lives, including the embryonic stage, or in any condition, however weak or dependent. (cbhd.org)
  • By a 19 to 0 vote, the group concluded that the practice should be considered morally acceptable because aborted fetal tissue is analogous to cadaver tissue, which is often used in scientific research. (thinkprogress.org)
  • pregnancy
  • Elective abortion, the source of most fetal tissue used in research, has been permitted throughout pregnancy since 1973. (cbhd.org)
  • Objective To study trends in termination of pregnancy for fetal anomaly over 10 years and to assess the contribution of autopsy to the final diagnosis and counselling after termination. (bmj.com)
  • Conclusions Though there has been an increase in the rate of terminations of pregnancy for fetal anomaly, there has been a decline in the autopsy rate. (bmj.com)
  • First, more attention has been turned toward pre-conceptual care, which aims to detect and treat certain health issues prior to pregnancy, such as smoking, diabetes and eating disorders. (questia.com)
  • recombination
  • Results from tissue recombination experiments documented well that stromal androgen receptor (AR) plays essential roles in prostate development, but epithelial AR has little roles in prostate development. (jove.com)
  • renal capsule
  • Moreover, subcutaneous hormone pellet implantation, in combination with renal capsule xenografting of BPH tissue, is useful to better understand hormonal regulation of benign prostate growth, and to test new therapies targeting sex steroid hormone pathways. (jove.com)
  • cell
  • The general area of research has been controversial because it involves stem-cell engineering. (timeshighereducation.com)
  • When transplanted two months after injury, the research-grade cell line modestly improved the animals' gait, but the clinical-grade line did not. (alzforum.org)
  • As a result, stem cell technology is imbued in an ethical conflict between destructive human embyro research on the one hand, and the magnitude of the potential benefits to patients, on the other. (mja.com.au)
  • Studying normal cell and tissue development will provide an understanding of abnormal growth and development which, in turn, could lead to the discovery of new ways to prevent and treat birth defects and even cancer. (nih.gov)
  • Fetal tissue sampling and cell sorting are also new testing methods of prenatal care, but experts argue that both still need perfecting. (questia.com)
  • however other tissues and cell lines can be substituted in. (jove.com)
  • organism
  • In the last several decades, investments in basic research have yielded extensive knowledge about the many and complex processes involved in the development of an organism, including the control of cellular development. (nih.gov)
  • prostate cancer
  • The aim of the study is to identify potential biomarkers for early diagnosis of prostate cancer (PCa) among androgen-regulated genes (ARG) and to evaluate comparative expression of these genes in normal prostate and normal prostate-related androgen-sensitive tissues that do not (or rarely) give rise to cancer. (jove.com)
  • Progress in prostate cancer research is severely limited by the availability of human-derived and hormone-naïve model systems, which limit our ability to understand genetic and molecular events underlying prostate disease initiation. (jove.com)
  • stages
  • such groups feel that human life begins at conception or in the early stages of fetal development (14 days after conception). (wdxcyber.com)
  • Oocyte growth in vitro has also been the subject of extensive research utilizing growing oocytes at various stages in several species, including mice, cattle, pig, sheep, goat, and horse. (pieronline.jp)
  • bioreactor
  • Collaborating with Ma on his perfusion bioreactor research were post-doctoral student Feng Zhao and former graduate student Warren Grayson. (scienceblog.com)
  • practice
  • Those "ethical principles" were to be translated into practice as the basis of federal regulations concerning the use of human subjects in research.In 1974, Casper Weinberger, President Gerald Ford's health, education, and welfare secretary, appointed an eleven-member commission that in 1978 issued a document called the Belmont Report, which identified and defined three ethical principles: respect for persons, justice, and beneficence. (consciencelaws.org)
  • important
  • Why is fetal tissue so important ? (statnews.com)
  • Federal law was adjusted in 1975 to add language clarifying that this research be "conducted only in accordance with any applicable State or local laws regarding such activities," and only for "the development of important biomedical knowledge which cannot be obtained by other means. (statnews.com)
  • First, let me say that we understand and respect the different points of view that have been expressed about the important ethical and moral issues involved in this research. (nih.gov)
  • In developing the important safeguards that will govern funding for this research, NIH intends to consult with those representative of a broad range of views. (nih.gov)
  • Bioethics
  • The Center is a Christian bioethics research center at Trinity International University in Deerfield, Illinois. (cbhd.org)
  • findings
  • Britain then has to capitalise on the research findings to stay ahead in the field. (timeshighereducation.com)
  • Using available databases and bioinformatics methods we also aimed to evaluate potential target genes of confirmed differentially expressed miRNA and validate these findings in GC tissues. (jove.com)
  • 2016
  • Russia's Internet Research Agency used Facebook, Twitter and Instagram to stoke divisions among Americans and favor Donald Trump during the 2016 presidential election, according to Special Counsel Robert Mueller. (sacbee.com)