Isosorbide dinitrate is sold in the US under the brand names Dilatrate-SR by Schwarz and Isordil by Valeant, according to FDA Orange Book. (wikipedia.org)
Isordil is contraindicated in patients who have allergy to isosorbide dinitrate or any of its other ingredients although allergic reactions to organic nitrates are extremely rare, but they do occur sometimes. (awccanadianpharmacy.org)
Isosorbide dinitrate is sold under the brand names Isordil by Biovail , Cedocard, Sorbitrate and Isotrate. (curecrowd.com)
Order Isordil 2.5,5 mg Tablets (isosorbide dinitrate) from Canada & Save! (thecanadianpharmacy.com)
Nitrates2
Similar to other nitrites and organic nitrates, isosorbide dinitrate is converted to nitric oxide (NO), an active intermediate compound which activates the enzyme guanylate cyclase (atrial natriuretic peptide receptor A). This stimulates the synthesis of cyclic guanosine 3',5'-monophosphate (cGMP) which then activates a series of protein kinase-dependent phosphorylations in the smooth muscle cells, eventually resulting in the dephosphorylation of the myosin light chain of the smooth muscle fiber. (wikipedia.org)
Your doctor needs to know if you have previous heart attack or heart failure, an unusual or allergic reaction to isosorbide dinitrate, nitrates, other medicines, foods, dyes, or preservatives, you pregnant or trying to get pregnant or you are breast-feeding. (awccanadianpharmacy.org)
Mononitrate1
With an overall half-life of about 5 hours, the 5-mononitrate is cleared from the serum by denitration to isosorbide, glucuronidation to the 5-mononitrate glucuronide, and denitration/hydration to sorbitol. (nih.gov)
Tablets7
Isosorbide dinitrate is available as 40 mg extended-release tablets. (nih.gov)
it is not known whether similar increases in bioavailability appear during the course of chronic therapy with Isosorbide Dinitrate Extended-release Tablets. (nih.gov)
Actiza Pharmaceutical is a genuine supplier, wholesaler, manufacturers and exporters of isosorbide dinitrate tablets. (actizapharma.com)
If you are also looking for Isosorbide Dinitrate Tablets such as Isosorbide Dinitrate 10 mg tablet, Isosorbide Dinitrate 20 mg tablet then you can feel free to contact us. (actizapharma.com)
Conformance of Isosorbide Dinitrate Extended-release Tablets with the USP release test is pending. (prescriptiondrugs.com)
Isosorbide Dinitrate Extended-release Tablets are indicated for the prevention of angina pectoris due to coronary artery disease. (prescriptiondrugs.com)
Isosorbide Dinitrate Extended-release Tablets are contraindicated in patients who are allergic to isosorbide dinitrate or to any of its other ingredients. (prescriptiondrugs.com)
BiDil3
Compare Isosorbide Dinitrate/Hydralazine (Bidil) prices available at Canadian and international online pharmacies with local U.S. pharmacy coupon prices. (pharmacychecker.com)
Isosorbide and hydralazine in a fixed-dose combination (BiDil) has provoked controversy as the first drug approved by the Food and Drug Administration marketed for a single racial-ethnic group, African Americans, in the treatment of congestive heart failure. (annfammed.org)
Family physicians have no doubt been approached by their African American patients with congestive heart failure (and perhaps with other heart diseases), asking about the new "for blacks only" medicine, isosorbide dinitrate and hydralazine hydrochloride (BiDil). (annfammed.org)
Hydralazine11
Side effects are reported by people who take Isosorbide dinitrate and hydralazine hydrochloride. (ehealthme.com)
1 person who takes Isosorbide Dinitrate And Hydralazine Hydrochloride and has side effects is studied. (ehealthme.com)
the active ingredients of Isosorbide dinitrate and hydralazine hydrochloride) and Isosorbide dinitrate and hydralazine hydrochloride (the brand name). (ehealthme.com)
Isosorbide acts as a nitric oxide donor and hydralazine as an antioxidant, and so together they might ameliorate the long-term effects of heart failure. (annfammed.org)
A combination of isosorbide and hydralazine (160 mg and 300 mg total daily dose, respectively) was compared with enalapril (20 mg) in the second Vasodilator-Heart Failure Trial. (annfammed.org)
A later retrospective review of those data, however, found that white patients had disproportionate benefit from enalapril, whereas the subset of African American patients appeared to receive substantially more benefit from the isosorbide-hydralazine therapy. (annfammed.org)
6 As of this point, no one had yet tested the hypothesis that isosorbide and hydralazine, added to a regimen that already included an angiotensin-converting enzyme (ACE) inhibitor, might provide benefit to patients with congestive heart failure. (annfammed.org)
About 1,000 patients were randomized to a fixed-dose combination of isosorbide and hydralazine (target daily dose, 120 mg and 225 mg, respectively) or placebo added to their existing medications (69% were on ACE inhibitors at baseline). (annfammed.org)
ISDN3
Isosorbide dinitrate (ISDN), an organic nitrate, is a vasodilator with effects on both arteries and veins. (nih.gov)
Isosorbide dinitrate (ISDN) (also known as Dilatrate) is a nitrate used pharmacologically as a vasodilator , e.g. in angina pectoris but also for anal fissure , a condition which is known to involve decreased blood supply leading to poor healing. (curecrowd.com)
Dizabol had a more significant relaxant effect than 10-5 M isosorbide dinitrate (ISDN). (bvsalud.org)
Amplification of the vasodilatory effects of isosorbide dinitrate by sildenafil can result in severe hypotension. (prescriptiondrugs.com)
Angina1
Preventive administration of intravenous N-acetylcysteine and development of tolerance to isosorbide dinitrate in patients with angina pectoris. (naturalnews.com)
Coronary3
Eighty-four consecutive patients undergoing coronary procedures using radial approach were randomly assigned between two types of local anesthesia (double blind): 5 ml lidocaine (group L)-5 ml lidocaine + 0.5 mg dinitrate isosorbide (group LN). The primary endpoint was the duration of radial puncture (from beginning of local anesthesia to sheath insertion) and the total number of punctures. (nih.gov)
During coronary angiography, 15 μg of acetylcholine and 0.5 mg isosorbide dinitrate were infused into the coronary artery. (bmj.com)
In addition, Isosorbide Dinitrate should not be used if you have the following conditions: Alcohol, Allergic reactions, Anemia, Avanafil Brain hemorrhage, Head injury. (actizapharma.com)
Medications2
Isosorbide dinitrate is in the nitrate family of medications and works by dilating blood vessels. (wikipedia.org)
Other medications included amlodipine, isosorbide-dinitrate and ASA (b -blockers were stopped because of COPD). (ispub.com)
Oral6
The onset of action for Isosorbide Dinitrate is thirty minutes and the onset of action for oral extended release is 12-24 hours. (wikipedia.org)
Absorption of isosorbide dinitrate after oral dosing is nearly complete, but bioavailability is highly variable (10% to 90%), with extensive first-pass metabolism in the liver. (nih.gov)
Each Isosorbide Dinitrate Extended-release tablet, for oral administration, contains 40 mg of isosorbide dinitrate, in a matrix that causes the active drug to be released over a sustained period. (nih.gov)
The onset of action of controlled-release oral isosorbide dinitrate is not sufficiently rapid for this product to be useful in aborting an acute anginal episode. (prescriptiondrugs.com)
The benefits of controlled-release oral isosorbide dinitrate in patients with acute myocardial infarction or congestive heart failure have not been established. (prescriptiondrugs.com)
Because the effects of controlled-release oral isosorbide dinitrate are so difficult to terminate rapidly, this formulation is not recommended in these settings. (prescriptiondrugs.com)
Hemodynamic2
Characterization of Hemodynamic Response to Isosorbide Dinitrate Durin" by Douglas C. Anderson, S. R. Horton et al. (cedarville.edu)
If one elects to use isosorbide dinitrate in these conditions, careful clinical or hemodynamic monitoring must be used to avoid the hazards of hypotension and tachycardia. (prescriptiondrugs.com)
Hypotension1
In the short run, isosorbide dinitrate can cause severe headaches, necessitating analgesic administration for relief of pain, as well as severe hypotension, and, in certain cases, bradycardia. (wikipedia.org)
Dilatation1
The principal pharmacological action of isosorbide dinitrate is relaxation of vascular smooth muscle and consequent dilatation of peripheral arteries and veins, especially the latter. (nih.gov)
Congestive1
Isosorbide Dinitrate is used for Severe Chest Pain, Congestive Cardiac Failure and other conditions.Isosorbide Dinitrate improves the patient's condition by performing the following functions:Widening the blood vessels in the heart.If you use other drugs or over the counter products at the same time, the effects of Isosorbide Dinitrate may change. (actizapharma.com)
Acute2
Objective To determine the effectiveness of isosorbide dinitrate in combination with tenoxicam compared with tenoxicam alone for the relief of acute renal colic. (inonu.edu.tr)
1980. Acute and chronic propylene glycol dinitrate exposure in the monkey. (cdc.gov)
Medicines1
The following is a list of possible side-effects that may occur in medicines that contain Isosorbide Dinitrate. (actizapharma.com)
Organic2
Isosorbide dinitrate is a white, crystalline, odorless compound which is stable in air and in solution, has a melting point of 70°C and has an optical rotation of +134° (c=1.0, alcohol, 20°C). Isosorbide dinitrate is freely soluble in organic solvents such as acetone, alcohol, and ether, but is only sparingly soluble in water. (nih.gov)
The chemical name for isosorbide dinitrate is 1,4:3,6-dianhydro-D-glucitol 2, 5-dinitrate, an organic nitrate whose structural formula is and whose molecular weight is 236.14. (prescriptiondrugs.com)
Safely1
How should I handle Isosorbide Dinitrate safely? (singhealth.com.sg)
Chronic1
Potentiation of isosorbide dinitrate effects with N-acetylcysteine in patients with chronic heart failure. (naturalnews.com)
Effects3
isosorbide dinitrate increases effects of cabergoline by decreasing metabolism. (medscape.com)
isosorbide dinitrate increases effects of ergotamine by decreasing metabolism. (medscape.com)
Medication2
Isosorbide dinitrate is a medication used for heart failure, esophageal spasms, and to treat and prevent chest pain from not enough blood flow to the heart. (wikipedia.org)
Isosorbide dinitrate is available as a generic medication. (wikipedia.org)
Effect3
apalutamide will decrease the level or effect of isosorbide dinitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
idelalisib will increase the level or effect of isosorbide dinitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
ivosidenib will decrease the level or effect of isosorbide dinitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
People1
N-Acetyl-Cysteine - People taking isosorbide dinitrate might benefit from supplements of the amino acid N-acetyl-Cysteine. (naturalnews.com)
Volume1
Once absorbed, the volume of distribution of isosorbide dinitrate is 2 to 4 L/kg, and this volume is cleared at the rate of 2 to 4 L/min, so ISDN's half-life in serum is about an hour. (nih.gov)