• The acquisition cost of isoproterenol ( Isuprel®) has dramatically increased from approximately $60 per vial in 2012 to over $2,150 per vial today, a nearly 4000% increase. (blogspot.com)
  • These effects of acetylcholine on epicardium are attended by an accentuation of the spike and dome morphology of the action potential, are readily reversed with atropine, fail to appear when epicardium is pretreated with the transient outward current blocker 4-aminopyridine, are accentuated in the presence of isoproterenol (10(-7) to 5 x 10(-6) M), and persist in the presence of propranolol. (ahajournals.org)
  • To compare the hemodynamic effects of isoproterenol, dopamine, and dobutamine in the immature animal, each drug was infused into anesthetized open chest puppies and cardiac output was measured, as were systemic arterial blood pressure, heart rate, and renal artery blood flow. (ovid.com)
  • Systemic arterial mean blood pressure was increased by dopamine and dobutamine, but decreased by isoproterenol. (ovid.com)
  • Dopamine produced a significant increase of renal artery blood flow while renal artery blood flow was unchanged by dobutamine and decreased by isoproterenol. (ovid.com)
  • Dopamine and dobutamine may have potential advantages over isoproterenol in augmenting cardiovascular function in young animals. (ovid.com)
  • We infused isoproterenol (0.1 μg/kg body weight per min) and dopamine (10 μg/kg per min) and measured myocardial and total body V̇ o 2 and regional blood flows in chronically instrumented 7-week old lambs with and without a left to right shunt. (onlinejacc.org)
  • We conclude that the catecholamines isoproterenol and dopamine do not lead to a mismatch between myocardial oxygen supply and demand, nor do they change blood flow distribution unfavorably in 7-week old lambs with a left to right shunt. (onlinejacc.org)
  • We demonstrated that isoproterenol is superior to dopamine, because it shifts the balance between oxygen supply and consumption toward supply so that systemic oxygen extraction reserve increases. (onlinejacc.org)
  • In a previous study we demonstrated that in lambs with an aortopulmonary left to right shunt, isoproterenol increased systemic blood flow more than dopamine did, because isoproterenol increased heart rate . (onlinejacc.org)
  • We also demonstrated that dobutamine evoked a similar hemodynamic response to that of isoproterenol, although less marked. (onlinejacc.org)
  • THURSDAY, Aug. 10, 2017 (HealthDay News) -- Increases in the price of nitroprusside and isoproterenol correlated with reductions in their use, according to a letter to the editor published online Aug. 9 in the New England Journal of Medicine . (doctorslounge.com)
  • El-Demerdash E, Awad AS, Taha RM, El-Hady AM, Sayed-Ahmed MM (2005) Probucol attenuates oxidative stress and energy decline in isoproterenol-induced heart failure in rat. (springer.com)
  • Ask your doctor before using propranolol together with isoproterenol. (drugs.com)
  • Three hours after adenoviral infection, myocytes were treated with a variety of agents (including PTX 0.5 μg/ml, SB 203580 10 μM, LY294002 10 μM, or propranolol 10 μM) as indicated, 1 h before the addition of isoproterenol (ISO, 1 μM). (pnas.org)
  • In 4 patients, parasystolic activity ceased to be manifest when the concomitantly enhanced (by isoproterenol) sinus cycle lengths became shorter than 430 ms. This phenomenon reflected a tachycardia-dependent parasystolic concealment, presumably as a result of interference in the parasystolic-ventricular junction. (biomedsearch.com)
  • Isoproterenol facilitated induction of sustained monomorphic ventricular tachycardia (cycle length 163 +/- 26 msec) in 5 of the 10 animals with no inducible baseline arrhythmia (P less than 0.05). (biomedsearch.com)
  • Isoproterenol can produce an elevated heart rate (tachycardia), which predisposes patients to cardiac dysrhythmias. (chemeurope.com)
  • There is no specific information comparing use of isoproterenol, metaproterenol, or terbutaline in children with use in other age groups. (mayoclinic.org)
  • PURPOSE: The authors studied the involvement of cAMP-dependent second messenger systems in the inhibition of rod outer segment (ROS) phagocytosis by isoproterenol (ISO) and forskolin (FSK) using two membrane-permeant analogs of cyclic adenosine monophosphate (cAMP), the Rp and Sp diastereoisomers of cyclic adenosine 3',5' monophosphothioate (cAMPS). (arvojournals.org)
  • Isoproterenol plus FSK showed an additive effect on the inhibition of phagocytosis, suggesting that they act at two independent sites. (arvojournals.org)
  • Increases in the price of nitroprusside and isoproterenol correlated with reductions in their use, according to a letter to the editor published online Aug. 9 in the New England Journal of Medicine . (doctorslounge.com)
  • Umesh N. Khot, M.D., from the Cleveland Clinic, and colleagues examined the impact of price increases on physician prescribing for nitroprusside or isoproterenol using data from 47 hospitals in the Vizient (formerly University HealthSystem Consortium) database. (doctorslounge.com)
  • Exposure of the hearts to 0.1 microM isoproterenol for up to 1 minute was associated with significant (up to threefold) increases in phospholamban and troponin I phosphorylation, but there was no significant increase in 32P incorporation into phospholipids. (ahajournals.org)
  • However, longer exposure (2 minutes or more) to isoproterenol was associated with increases in the degree of 32P labeling of phosphatidylinositols and phosphatidic acid. (ahajournals.org)
  • In hibernating ground squirrels, the dual effect of isoproterenol is not observed: isoproterenol increases Ca 2+ current at any V h values. (portlandpress.com)
  • Isoproterenol produced increases in GOT, LDH and .alpha. (eurekamag.com)
  • This is not a list of all drugs or health problems that interact with isoproterenol. (drugs.com)
  • You must check to make sure that it is safe for you to take isoproterenol with all of your drugs and health problems. (drugs.com)
  • Note that this list does not include a variety of over the counter drugs and vitamins that could also counteract and alter Isoproterenol. (rebates.com)
  • We sought to assess whether isoproterenol stress echocardiography could detect in advance in which patients hypertrophic cardiomyopathy would progress to a phase resembling dilated cardiomyopathy. (onlinejacc.org)
  • It is proposed that aminophylline and isoproterenol may increase cyclic adenosine monophosphate (AMP) and prevent platelet aggregation along the endothelial surfaces of the microcirculation, and may thereby help to maintain improved perfusion of the injured spinal cord. (elsevier.com)
  • This isoproterenol-induced CPA was reversed by the coinjection of Rp-cyclic adenosine monophosphorothioate (Rp-cAMPS), a selective PKA inhibitor. (jneurosci.org)
  • The filarial parasites Litomosoides carinii and Dipetalonema viteae both show transcuticular uptake of adenosine 3', 5'-cyclic monophosphate but isoproterenol is taken up by D. viteae only. (nebraska.edu)
  • Young mice chronically treated with β-aminopropionitrile (BAPN) were subsequently given injections of graded doses of isoproterenol, and the response of various tissues to IPR in synthesizing DNA was analyzed. (aacrjournals.org)
  • Insulin and isoproterenol differentially regulate mitogen-activated protein kinase-dependent Na(+)-K(+)-2Cl(-) cotransporter activity in skeletal muscle. (semanticscholar.org)
  • To study the precise mechanisms regulating NKCC activity, rat soleus and plantaris muscles were stimulated ex vivo by insulin or isoproterenol (ISO). (semanticscholar.org)
  • Isoproterenol is used widely for inducing heart failure in mice. (springer.com)
  • To identify new cardiac biomarkers, a quantitative proteomic analysis has been performed on serum and heart tissue proteins from three species of nonhuman primates following isoproterenol (ISO) treatment. (sri.com)
  • Isoproterenol is usually used to treat symptoms of emphysema, heart attack and bronchitis. (rebates.com)
  • Isoproterenol in the presence of coronary artery occlusion increased heart rate 33 ± 4 beats/min and dP/dt 630 ± 90 mm Hg/sec and decreased mean arterial pressure by 6.3 ± 1.6 mm Hg. (ovid.com)
  • Cardiac edema induced by isoproterenol, determined as changes in heart weight and by histology, did not differ between SHR-SP and WKY. (eurekamag.com)
  • Isoproterenol increased myocardial V̇ o 2 , parallel to the increase in heart rate. (onlinejacc.org)
  • Increased DNA binding activities of redox sensitive transcription factors NF-κB, and AP-1 in isoproterenol treated heart was partially reversed by the TA extract. (imedpub.com)
  • Because of the time base of the display, the increased heart rate also caused by isoproterenol is not apparent. (washington.edu)
  • We also produced a pairwise similarity matrix to illustrate relatedness of animal models with human heart disease and identified ischemia as the human condition that most resembles isoproterenol treatment. (biomedcentral.com)