• Intramolecular lyases, oxidoreductases and transferases catalyze the interconversion of structural isomers. (wikipedia.org)
  • Although racemases and epimerases (EC 5.1) and cis-trans isomerases (EC 5.2) are sensibly grouped according to changes of stereochemistry, the overall chemistry of intramolecular oxidoreductases (EC 5.3), intramolecular transferases (EC 5.4) and intramolecular lyases (EC 5.5) is challenging. (researchgate.net)
  • In addition, the separation of groups of isomerases sharing similar chemistry such as oxidosqualene cyclases and pseudouridine synthases from chemically complex sub-subclasses like intramolecular transferases acting on \other groups' (EC 5.4.99) might also improve the classification. (researchgate.net)
  • Isomerases are a general class of enzymes that convert a molecule from one isomer to another. (wikipedia.org)
  • The sub-categories of isomerases containing racemases, epimerases and cis-trans isomers are examples of enzymes catalyzing the interconversion of stereoisomers. (wikipedia.org)
  • Calculating isomerase kinetics from experimental data can be more difficult than for other enzymes because the use of product inhibition experiments is impractical. (wikipedia.org)
  • This dissertation explores aspects of the chemistry and evolution of a small class of enzymes catalysing geometrical and structural rearrangements between isomers, the isomerases (EC 5). (researchgate.net)
  • Enzymes of the isomerase class that catalyze reactions in which a group can be regarded as eliminated from one part of a molecule, leaving a double bond, while remaining covalently attached to the molecule. (ucdenver.edu)
  • The isomerization energy, for example, for converting from a stable cis isomer to the less stable trans isomer is greater than for the reverse reaction, explaining why in the absence of isomerases or an outside energy source such as ultraviolet radiation a given cis isomer tends to be present in greater amounts than the trans isomer. (wikipedia.org)
  • Isomerases can increase the reaction rate by lowering the isomerization energy. (wikipedia.org)
  • A comprehensive analysis of the overall chemistry of isomerase reactions based on bond changes, reaction centres and substrates and products revealed that isomerase reactions are chemically diverse and difficult to classify using a hierarchical system. (researchgate.net)
  • n I, Moliner V, Hynes JT, Roca M. Dynamic effects on reaction rates in a Michael addition catalyzed by chalcone isomerase. (ucdenver.edu)
  • Such cases exist: for example, a mutase such as phosphoglucomutase catalyses the transfer of a phospho group from one position to another, and isomerase is a more general term for an enzyme that catalyses any one-substrate one-product reaction, such as triosephosphate isomerase . (wikipedia.org)
  • Isomerases are further classified into six subclasses: This category (EC 5.1) includes (racemases) and epimerases). (wikipedia.org)
  • Isomerases catalyze reactions across many biological processes, such as in glycolysis and carbohydrate metabolism. (wikipedia.org)
  • Isomerase-catalyzed reactions have their own EC category: EC 5. (wikipedia.org)
  • First, isomerases are more likely to evolve new functions in different EC primary classes, especially lyases (EC 4), rather than evolve to perform different isomerase reactions. (researchgate.net)
  • This complexity was characterised for isomerase reactions and used to develop an approach to automatically explore it across the entire EC classification. (researchgate.net)
  • Isomerases facilitate intramolecular rearrangements in which bonds are broken and formed. (wikipedia.org)
  • The subclass \other isomerases' (EC 5.99) sits apart from other subclasses and exhibits great diversity. (researchgate.net)
  • The current classification of isomerases in six subclasses reduces to two subclasses if the type of isomerism is considered. (researchgate.net)
  • This list contains a list of EC numbers for the fifth group, EC 5 , isomerases , placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology . (wikidoc.org)
  • Enzymes of the isomerase class that catalyze reactions in which a group can be regarded as eliminated from one part of a molecule, leaving a double bond, while remaining covalently attached to the molecule. (bvsalud.org)
  • The systematic name of this enzyme class is 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing). (wikipedia.org)