• The most frequently cultured bacterial species was Staphylococcus epidermidis, representing 27% of the isolates. (bmj.com)
  • According to them, Staphylococcus epidermidis and Staphylococcus aureus are the most frequently isolated organisms in adult lacrimal sac infections. (bmj.com)
  • Uncomplicated and complicated skin and skin structure infections, including cellulitis, cutaneous abscesses and ischemic/diabetic foot infections caused by β-lactamase producing isolates of Staphylococcus aureus . (sdrugs.com)
  • Nosocomial pneumonia (moderate to severe) caused by β-lactamase producing isolates of Staphylococcus aureus and by piperacillin/tazobactam-susceptible Acinetobacter baumannii , Haemophilus influenzae , Klebsiella pneumoniae , and Pseudomonas aeruginosa (Nosocomial pneumonia caused by P. aeruginosa should be treated in combination with an aminoglycoside) [ see Dosage and Administration (2) ]. (sdrugs.com)
  • Some H influenzae strains have no capsule and are termed nonencapsulated H influenzae or nontypeable H influenzae (NTHi). (medscape.com)
  • We show that nontypeable H. influenzae isolates survive for up to 20. (edu.au)
  • Nontypeable Haemophilus influenzae (NTHI) may play a role as an infectious trigger in the pathogenesis of chronic obstructive pulmonary disease (COPD). (nih.gov)
  • 2005. Identification, distribution, and expression of novel (nonRd) genes in ten clinical isolates of nontypeable Haemophilus influenzae . (centerforgenomicsciences.org)
  • Clinical evidence suggests these isolates may rep- tests (NAATs). (cdc.gov)
  • Infection experiments were performed with two different clinical isolates. (nih.gov)
  • A 4.4-kb EcoRI fragment, common to both DNA clones, was used to characterize clinical isolates representing all six encapsulated serotypes as well as several capsule-deficient H. influenzae by Southern hybridization analysis. (jci.org)
  • After 24 hours of incubation at 37 °C, otic resistance of clinical H. influenzae in and children. (who.int)
  • to evaluate the efficiency of the standard influenzae may produce various clinical phenotypic identification by comparing Capsular typing syndromes including meningitis [4]. (who.int)
  • The tasks of the National Reference Laboratory for Meningococci and Haemophilus influenzae (NRZMHi) assigned by the Robert Koch Institute for the surveillance of invasive Haemophilus influenzae disease include serotyping of clinical isolates from blood or cerebrospinal fluid (CSF) and the detection of antibiotic resistance against ß-lactam antibiotics. (uni-wuerzburg.de)
  • The broth microdilution methods was used to determine minimum inhibitory concentrations (MIC) of blood-borne isolates according to guildlines of the Clinical and Laboratory Standards Institute (CLSI). (biomedcentral.com)
  • Nevertheless, subsequent findings revealed that H influenzae was responsible for a wide spectrum of clinical diseases. (medscape.com)
  • An extensive collection of isolates for some bacterial pathogens are available through the Active Bacterial Core surveillance (ABCs) Isolate Bank. (cdc.gov)
  • Patient specimens and bacterial isolates from the communicable diseases and pathogens listed below should be referred routinely by diagnostic laboratories to the relevant ESR laboratory for typing/surveillance purposes (this does not include specimens for diagnostic testing, nor for requests on a fee for test basis). (cri.nz)
  • In the present study, attempt was made to isolate bacterial pathogens in blood and determination of their antibiogram. (scialert.net)
  • A total of 448 blood samples (405 aerobically and 43 aerobically) were cultured, out of them, 111 (27%) pathogens from aerobic and 6 (5%) pathogens from anaerobic culture were isolated and identified. (scialert.net)
  • The three commonly isolated microorganisms were Acinetobacter ( n = 75), Klebsiella ( n = 39), and Pseudomonas aeruginosa ( n = 29). (biomedcentral.com)
  • The highest proportion of susceptible A.baumannii isolates was 70.8% for minocycline. (biomedcentral.com)
  • Among P.aeruginose isolates worldwide, 71.1-94.9% were susceptible to six antibiotics. (biomedcentral.com)
  • Alpit is a combination product consisting of a penicillin-class antibacterial, piperacillin, and a β-lactamase inhibitor, tazobactam, indicated for the treatment of patients with moderate to severe infections caused by susceptible isolates of the designated bacteria in the conditions listed below. (sdrugs.com)
  • Of the rare serotypes, three Hia, and no Hic or Hid were isolated. (uni-wuerzburg.de)
  • Detection and characterization of extended-spectrum β-lactamases among bloodstream isolates of Enterobacter spp. (hku.hk)
  • METHODS: H. influenzae isolates (n=191) were collected from paediatric patients (1 month to 12 years old) between 2000 and 2011 for three types of infections: pneumonia (n=61), acute otitis media (AOM) (n=68) and meningitis (n=62). (elsevierpure.com)
  • Some types of H. influenzae contain a polysaccharide capsule around the outer membrane to aid in protection and colonization. (wikipedia.org)
  • A major virulence factor of H influenzae is its polysaccharide capsule, which plays a central role in molecular pathogenesis and the immune response. (medscape.com)
  • Like other Gram-negative bacteria, H. influenzae has a thin peptidoglycan layer surrounded by an outer membrane containing lipopolysaccharide. (wikipedia.org)
  • Therefore, attempt was made to isolate and identify the common bacteria from blood culture and their antibiotic resistance pattern. (scialert.net)
  • That changed in 1892, when German physician Richard Pfeiffer observed and isolated bacteria ultimately shown to cause meningitis in children and concluded that those bacteria cause influenza. (barnesandnoble.com)
  • Haemophilus influenzae , as thee meningitis-causing bacteria have been erroneously named ever since, continued their strange journey to discovery in the decades that followed. (barnesandnoble.com)
  • Gram positive bacteria were isolated in 79 (62%) samples. (bmj.com)
  • The most virulent strain is H influenzae type b (Hib). (medscape.com)
  • For this surveillance, diagnostic laboratories throughout New Zealand refer specimens or bacterial isolates from their patients to ESR's national reference laboratories for strain identification and epidemiological typing. (cri.nz)
  • However, resistant isolates had alarmingly high minimum inhibitory concentration shifts (16- to >128-fold) compared to the parent strain. (rcsb.org)
  • A virulent H. influenzae type b strain was used to construct a lambda library of chromosomal DNA in Charon 4. (jci.org)
  • Lâm TT, Elias J, Frosch M, Vogel U, Claus H. New diagnostic PCR for Haemophilus influenzae serotype e based on the cap locus of strain ATCC 8142. (uni-wuerzburg.de)
  • Because the entire genome of a laboratory strain of H influenzae has been sequenced, additional insights into its molecular mechanisms of pathogenesis will undoubtedly be gained in the near future. (medscape.com)
  • Whole-genome analysis of haemophilus influenzae invasive strains isolated from Campinas state University hospital. (bvsalud.org)
  • Haemophilus influenzae b vaccine in the binding protein (PBP) is also of concern cultured on chocolate agar + polyvita- industrialized world and the decreased as it relates to 20% of non-encapsulated min supplement + bacitracin (Bio-rad, incidence of invasive diseases [1], Hae- strains isolated in Europe [9]. (who.int)
  • Whole genome sequencing and phylogenetic analysis of six SARS-CoV-2 strains isolated during COVID-19 pandemic in Tunisia, North Africa. (cdc.gov)
  • The recent work conducted at JCVI and led by David Spiro, Ph.D. in sequencing and analyzing the H1N1 (swine origin) influenza isolates, is supported by NIAID as part of the GSCID contract. (jcvi.org)
  • Experimental combined viral and bacterial infection (influenza C and Hemophilus influenzae type b) in embryonated eggs. (microbiologyresearch.org)
  • A study of the population dynamics of strains of Hemophilus influenzae type b in combined infection with influenza C virus in embryonated eggs. (microbiologyresearch.org)
  • First isolated in 1892 by Robert Pfeiffer from the sputum of patients with pandemic influenza infection, H influenzae was thought to be the infectious agent responsible for flu. (medscape.com)
  • In 1920, the organism was named Haemophilus influenzae (from the Greek haemophilus, meaning "blood-loving") to reflect the fastidious growth requirement of the organism, as well as its apparent association with influenza. (medscape.com)
  • H. Influenzae type b, also known as Hib, is the most common form, recognizable by its polyribosyl ribitol phosphate (PRP) capsule, and found mostly in children. (wikipedia.org)
  • Molecular cloning of DNA was used to investigate the expression of type b capsule and its association with H. influenzae virulence. (jci.org)
  • Two independently isolated recombinant phage were isolated from the library and were found to possess DNA necessary for expression of type b capsule. (jci.org)
  • Using a well-characterized rat model of H. influenzae systemic infection, we showed that type b transformants elicited by the cloned DNA were pathogenic, causing bacteremia and meningitis, whereas the untransformed capsule-deficient H. influenzae organisms were not. (jci.org)
  • Analysis of non-typeable Haemophilus influenzae in invasive disease reveals lack of the capsule locus. (uni-wuerzburg.de)
  • Positive antigen test results from urine or serum samples are unreliable for diagnosis of Haemophilus influenzae disease and should not be used as a basis for case classification. (cdc.gov)
  • Ten (6.7%) isolates were resistant to ampicillin and chloramphenicol. (fiocruz.br)
  • Of these, two isolates, a -lactamase and non- -lactamase producer, were resistant to amoxacillin-clavulinic acid. (fiocruz.br)
  • Treatment consists of antibiotics, however H. influenzae is often resistant to the penicillin family but amoxicillin/clavulanic acid can be used in mild cases. (wikipedia.org)
  • No isolates were resistant to gemifloxacin or grepafloxacin. (who.int)
  • Whole-genome sequencing of resistant isolates revealed that either BC target mutations or efflux pump overexpression can lead to the development of high-level resistance. (rcsb.org)
  • Vancomycin-resistant (VR) isolates represented 1.4% of Enterococcus faecalis (VR. (biomedcentral.com)
  • Carolina Duarte participated in all the stages of the un hospital pediátrico de tercer nivel en Colombia - 2016 study. (bvsalud.org)
  • Antimicrobial activity of tigecycline and comparator agents was assessed in vitro against 27857 isolates source from blood samples collected between 2012 and 2016 as part of the Tigecycline Evaluation and Surveillance Trial (TEST). (biomedcentral.com)
  • The aim of this study was to characterize circulating isolates of H. influenzae genotypically by BLNAR-PCR and multilocus sequence typing (MLST), and to determine any associations between them. (elsevierpure.com)
  • Meropenem resistance was observed in 8% of K.pneumoniae isolates worldwide. (biomedcentral.com)
  • Extended-spectrum β-lactamase (ESBL) was produced in 15.9 and 20.9% E.coli and K.pneumoniae isolates, respectively. (biomedcentral.com)
  • Haemophilus influenzae (formerly called Pfeiffer's bacillus or Bacillus influenzae) is a Gram-negative, non-motile, coccobacillary, facultatively anaerobic, capnophilic pathogenic bacterium of the family Pasteurellaceae. (wikipedia.org)
  • Another important component of the H influenzae cell wall that contributes to pathogenesis is lipopolysaccharide (LPS). (medscape.com)
  • Haemophilus influenzae remains a major cause of disease worldwide requiring continued study. (edu.au)
  • Isolates were from patients with invasive disease at 4 hospitals in Saudi Arabia between 1996 and 1998. (who.int)
  • Haemophilus influenzae non-type b strains can cause invasive disease clinically similar to type b (Hib) disease (pneumonia, bacteremia, meningitis, epiglottitis, septic arthritis, cellulitis, or purulent pericarditis). (cdc.gov)
  • Nontypable Haemophilus influenzae now causes the majority of invasive disease in all age groups, with the greatest burden of disease among the youngest and oldest age groups. (cdc.gov)
  • From 1999 through 2008, the annual incidence of invasive nontypable Haemophilus influenzae disease was 1.73/100,000 in children younger than 5 years of age and 4.08/100,000 in adults ≥65 years of age. (cdc.gov)
  • Acute bacterial exacerbation of chronic bronchitis caused by S. pneumoniae, H. influenzae (non-betalactamase- producing strains only), or M. catarrhalis. (globalrph.com)
  • Janet R. Gilsdorf, MD, is the Robert P. Kelch Research Professor Emerita at the University of Michigan, where she cares for children with complex infectious diseases and formerly directed the Haemophilus influenzae research laboratory. (barnesandnoble.com)
  • Diagnostic laboratories may choose to identify further than genus level but should refer isolates for confirmatory speciation to the Enteric Reference Laboratory at ESR. (tewhatuora.govt.nz)
  • Isolates were sent to the National Microbiology Laboratory for confirmation of serogroup and further studies including phenotype and clonal complex identification. (canada.ca)
  • These findings indicate that present antibiotic regimens in Brazil may not be appropriate for the treatment of H. influenzae meningitis. (fiocruz.br)
  • Five percent of these changes occurred because the initial antibiotic therapy did not cover the microbial isolates. (aafp.org)
  • The recommended form of prevention of the type b form of H. influenzae is a series of the Hib vaccine and boosters, which are most often given under the age of 5, and sometimes in conjunction with other vaccines in the form of the DTaP-IPV/Hib vaccine. (wikipedia.org)
  • Prior to the availability of an effective vaccine, H influenzae type b (Hib) was the most common cause of pediatric bacterial meningitis in the United States. (medscape.com)
  • We describe genomes of 2 of these N. meningitidfiis sequence type 11 complex urethritis tive for gonococcus by specific nucleic acid amplification isolates. (cdc.gov)
  • H. Influenzae is a small Gram-negative bacterium, approximately 0.3 micrometer to 1 micrometer. (wikipedia.org)
  • The cell wall of H. influenzae bacterium contains various proteins, referred to as autotransporters, for adherence and colony formation. (wikipedia.org)
  • Haemophilus influenzae is a bacterium that has encapsulated (typable) or unencapsulated (nontypable) strains. (cdc.gov)
  • The H. Influenzae pili, unlike those of E. coli, resist unwinding, allowing for stronger adhesion to resist expulsion when coughing or sneezing. (wikipedia.org)
  • H influenzae encodes 3 distinct immunoglobulin A (IgA) proteases that may be involved as virulence factors by interfering with host mucosal defenses. (medscape.com)
  • Although the type of infectious diseases caused by Haemophilus influenzae has changed considerably in recent years because of the widespread and routine immunization of children against type b organisms, H influenzae remains a significant pathogen. (medscape.com)
  • Detection of H. influenzae from these materials must be notified according to the German Infection Protection Act (IfSG). (uni-wuerzburg.de)