Isolate stem cell. Medical search. Frequent questions

These cells are excellent regenerative cells due to their multipotent nature, therefore MSCs derived exosomes are superior to other exosomes products. (stemcellsgroup.com)
Adipose tissue (AT) represents a commonly used source of mesenchymal stem/stromal cells (MSCs) whose proregenerative potential has been widely investigated in multiple clinical trials worldwide. (mdpi.com)
Mesenchymal stromal/stem cells (MSCs) have been identified in multiple human tissues, including the vascular wall. (unibo.it)
The goal of the present study is to review the main findings regarding the MSCs isolated from the human vascular wall. (unibo.it)
Further, the main priming strategies tested on MSCs from different sources are reported, together with the experience on vascular MSCs isolated from healthy cryopreserved and pathological arteries. (unibo.it)
2013): Ultrastructural characteristics of sheep and horse mesenchymal stem cells (MSCs). (ankara.edu.tr)
2013): Mesenchymal stem cells (Mscs) in scanning electron microscopy (SEM) world. (ankara.edu.tr)
Bone marrow mesenchymal stem cells (MSCs) have been identified to have the potential to differentiate into multiple types of cells. (nih.gov)
However, the rejection reaction often occurs in the transplantation of MSCs and could induce cell death. (nih.gov)
MSCs were isolated from bone marrow in mice femoral bone marrow. (nih.gov)
Interestingly, MaR1 also regulated the actions of primary isolated human lung mesenchymal stem (stromal) cells (MSCs). (cdc.gov)
Furthermore, when conditioned medium from DHA-treated MSCs was used to culture bronchial epithelial cells, the epithelial cells exhibited modulation of protease activation. (cdc.gov)
Our results identify DHA and MaR1 as regulators of reparative processes after lung inflammation and wounding, including effects on two pivotal cellular players-bronchial epithelial cells and MSCs. (cdc.gov)
These dental stem cells are considered mesenchymal stem cells (MSCs) and possess different levels of capacities to become specific tissue forming cells. (bvsalud.org)

The bone marrow contains various populations of skeletal stem cells (SSCs) in the stromal compartment, which are important regulators of bone formation. (nature.com)
It is well-described that leptin receptor (LepR) + perivascular stromal cells provide a major source of bone-forming osteoblasts in adult and aged bone marrow. (nature.com)
These Fgfr3-creER -marked endosteal stromal cells contribute to a stem cell fraction in young stages, which is later replaced by Lepr-cre -marked stromal cells in adult stages. (nature.com)
Further, Fgfr3 + endosteal stromal cells give rise to aggressive osteosarcoma-like lesions upon loss of p53 tumor suppressor through unregulated self-renewal and aberrant osteogenic fates. (nature.com)
These Fgfr3 + stem/stromal cells with OCT identities are abundant in the young bone marrow and depleted in the old bone marrow, denoting their transitional nature. (nature.com)
Overall, our findings indicate that Fgfr3 + endosteal stem/stromal cells with OCT identities dictate active and aggressive osteogenesis, identifying these cells as an important regulator of long-term bone homeostasis. (nature.com)
2001): Thiazolidinediones and glucocorticoids induce differentiation of human adipose tissue stromal cells: Biochemical, cellular, and molecular analysis. (ankara.edu.tr)
2004): Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells. (ankara.edu.tr)
2002): Neurogenic differentiation of murine and human adipose- derived stromal cells. (ankara.edu.tr)
We investigated the effects of transplanting nonhematopoietic adult bone marrow stem/progenitor cells (multipotent stromal cells) into the corpus cavernosum in a rat model of bilateral cavernous nerve crush injury. (cellsurgicalnetwork.com)
MATERIALS AND METHODS: Multipotent stromal cells were isolated from the bone marrow of transgenic green fluorescent protein rats by plastic adherence (rat multipotent stromal cells) or magnetic activated cell sorting using antibodies against p75 low affinity nerve growth factor receptor (p75 derived multipotent stromal cells). (cellsurgicalnetwork.com)
Immediately after injury 8 rats each were injected intracavernously with phosphate buffered saline (vehicle control), fibroblasts (cell control), rat multipotent stromal cells (cell treatment) or p75 derived multipotent stromal cells (cell treatment). (cellsurgicalnetwork.com)
Rats injected with typical multipotent stromal cells had partial erectile function rescue compared with animals that received p75 derived multipotent stromal cells. (cellsurgicalnetwork.com)
Enzyme-linked immunosorbent assay suggested that basic fibroblast growth factor secreted by p75 derived multipotent stromal cells protected the cavernous nerve after bilateral cavernous nerve crush injury. (cellsurgicalnetwork.com)
The mesenchymal stromal cells (MSC) have immunomodulatory properties and a high regenerative capacity. (frontiersin.org)

Recently, we and others have shown that allogeneic hematopoietic stem cell transplantation (allo-HSCT) may represent a valid treatment option in leukemic myeloid sarcoma. (haematologica.org)
Transplantation of nonhematopoietic adult bone marrow stem/progenitor cells isolated by p75 nerve growth factor receptor into the penis rescues erectile function in a rat model of cavernous nerve injury. (cellsurgicalnetwork.com)
CONCLUSIONS: Transplantation of adult stem/progenitor cells may provide an effective treatment for erectile dysfunction after radical prostatectomy. (cellsurgicalnetwork.com)
For the first [time] in human history, we showed that the extremely severe COPD patients could be treated by lung progenitor cell transplantation. (upi.com)
Hematopoietic stem cell (HSC) replacement transplantation can ameliorate diseased hematologic system, thus inhibiting immune disorders including autoimmune diseases and immunodeficient disorders. (stanford.edu)
Anticipated to undergo 3 cycles of chemotherapy (solid tumour cancer participants) OR autologous stem cell transplantation (haematological cancers - HSCT participants). (who.int)
ECTRIMS 2022 Stem Cell Transplant Trumps Fingolimod for RRMS Relapse Risk Autologous hematopoietic stem cell transplantation is linked to significantly lower relapse rates than fingolimod in patients with relapsing-remitting multiple sclerosis. (medscape.com)
The clinical team from Lund headed by Prof. Olle Lindval in collaboration with Prof. Anders Björklund, were the first to show in patients the proof of principle that cell transplantation therapy is feasible approach to treat the patients with Parkinson's disease. (lu.se)
Hematopoietic stem cells (HSCs) enable hematopoietic stem cell transplantation (HCT) through their ability to replenish the entire blood system. (lu.se)
We isolated bone marrow from mice at 8 time points after transplantation and examined the reconstitution dynamics and transcriptional profiles of stem and progenitor populations. (lu.se)

Pancreatic endocrine progenitors obtained from human embryonic stem cells (hESCs) represent a promising source to develop cell-based therapies for diabetes. (crick.ac.uk)

Induced pluripotent stem cells (iPS) can be generated from various somatic cells and can subsequently be differentiated to multiple cell types of the body. (biomedcentral.com)
The main property that sets ESC apart from other cells is their pluripotent nature, meaning they can give rise/differentiate to cells of the three primary germ layers (mesoderm, endoderm and ectoderm) [ 13 ]. (biomedcentral.com)
Stem cells reside at the growing tip of meristems, where they differentiate to produce new organs throughout the life of plant and maintain a constant reservoir of pluripotent stem cells. (nature.com)
Using human pluripotent stem cells, scientists engineered an amniotic sac-like structure, potentially useful for uncovering the elusive cellular signals that lead to infertility. (the-scientist.com)
Pluripotent stem cells have the innate potential for unrestricted self-renewal and the ability to differentiate into any cell type in the body. (genengnews.com)
In 2012 Shinya Yamanaka and Sir John Gurdon were awarded the Nobel Prize for directly generating induced pluripotent stem cells (iPSCs) from somatic cells by introducing four genes, now collectively called the Yamanaka factors (Myc, Oct3/4, Sox2 and Klf4). (genengnews.com)
In reality, gene somatic cells to a pluripotent cell state by a handful of transcrip- expression is graded, making the potential gene expression tion factors (Takahashi and Yamanaka, 2006). (lu.se)
ES cells are pluripotent cells, which mean that they can give rise to all differentiated cell types derived from all three germ layers. (bvsalud.org)
For gene therapy, a combinatorial approach with multiple target genes, as well as more complex optogenetic approaches are studied, while for cell-therapy human induced pluripotent stem cells and human induced neuronal cells are investigated. (lu.se)
Many existing protocols for neuronal differentiation of human pluripotent cells result in heterogeneous cell populations and unsynchronized differentiation, necessitating the development of methods for labeling specific cell populations. (lu.se)
This strategy provides a useful tool for visualization and identification of neural progeny derived from human pluripotent stem cells. (lu.se)
Given this, human pluripotent stem cells, such as human embryonic stem cells (hESCs) and induced pluripo- tent stem cells (hiPSCs), have become a unique cell source for study- ing early human brain development. (lu.se)
However, current protocols for deriving neurons from human pluripotent stem cells give rise to heterogeneous cell populations both in regard to the temporal aspects and the cellular composition. (lu.se)
These strat- egies provide a robust way to visualize and isolate specific cell pop- ulations of differentiated pluripotent stem cells. (lu.se)

The therapy would consist of using a skin biopsy to harvest dermis-isolated, adult stem cells (DIAS cells), which will undergo processing to yield neocartilage. (ca.gov)
Exosomes are potent microvesicles released by adult mesenchymal stem cells. (stemcellsgroup.com)
When compared to adult stem cells, exosomes have much more growth factors which give them a better clinical and aesthetic potential than stem cells. (stemcellsgroup.com)
To gain pluripotency, the reprogramming process typically involves transfecting adult somatic cells with certain pluripotency markers. (biomedcentral.com)
Scientists have isolated adult stem cells in human hair follicles. (loe.org)
HACK: In their search for regenerative cell therapies that might some day cure Parkinson's, Alzheimer's, and other diseases, scientists have studied adult stem cells found in the hair follicles of mice. (loe.org)
Now, for the first time, Pathologist Dr. George Xu, at the University of Pennsylvania, has isolated a new adult stem cell in the human hair follicle. (loe.org)
We have studied the in vitro proliferation of isolated SSC from adult alpaca (Vicugna pacos) testes. (edu.pe)
They also took the cells from adult rats, while clinics have to take tissue from children who haven't yet gone through puberty. (newscientist.com)
Dermal papilla (DP) cells are required for SC activation during the adult hair cycle, but signal exchange between niche and SC precursors/transit-amplifying cell (TAC) progenitors that regulates HF morphogenetic growth is largely unknown. (nih.gov)
Literature review: This review summarizes current knowledge, barriers, and challenges in the clinical use of adult stem cells, scaffolds, and growth factors for the development and evaluation of regenerative endodontic therapies. (bvsalud.org)
The most valuable cells for regenerative endodontics are postnatal or adult stem cells. (bvsalud.org)
Based on their origin, there are two main types of stem cells - embryonic stem cells (ES cells) and postnatal or adult stem cells (AS cells). (bvsalud.org)
NSCs are derived from the embryonic stem (ES) cells or fetal and adult nervous system, and can generate different type of neural cells. (lu.se)

Mesenchymal cell-derived exosomes are preferably used in regenerative medicine . (stemcellsgroup.com)
Therefore, research on exosomes produced by MSC has been intensified for use in cell-free regenerative medicine. (frontiersin.org)
Researchers at the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC analyzed sections of the forebrain in animal model embryos to investigate Ryk's function in vivo. (phys.org)
This study will help in our efforts to produce nerve cells from embryonic stem cells, and may lead to the development of new strategies for the repair of the nervous system, using protein or small molecule therapeutic agents," says Martin Pera, Ph.D., director of the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC. (phys.org)
Regenerative medicine aims to derive specialized cell types from iPSCs that can provide disease models for therapeutic development and can be used to transplant, replace, engineer or regenerate diseased cells. (genengnews.com)
In an effort to advance the treatment strategies for the ocular surface diseases, I am focused on a regenerative medicine and single cell RNA sequencing based approaches to better comprehend the cellular biomarkers and molecular mechanisms involved in corneal tissue development and diseases. (stanford.edu)
Evidence the fate of stem cells has broad ramifications for biomedical suggests that during development or differentiation, cells make science from elucidating the causes of cancer to the use of very precise transitions between apparently stable ``network stem cells in regenerative medicine. (lu.se)

By culturing these multipotent cells with proteins and minerals, Dr. Xu has already gotten the hair follicle stem cells to differentiate into skin, nerve, muscle, bone, cartilage, and fat tissue. (loe.org)
Isolated NGN3eGFP(+) cells express PDX1, NKX6.1, and chromogranin A and differentiate in vivo toward insulin, glucagon, and somatostatin single hormone-expressing cells but not to ductal or exocrine pancreatic cells or other endodermal, mesodermal, or ectodermal lineages. (crick.ac.uk)
2004): Subcutaneous adipocytes can differentiate into bone- forming cells in vitro and in vivo. (ankara.edu.tr)
Stem cells rely on extracellular signals produced by the niche, which dictate their ability to self-renew, expand and differentiate. (karger.com)
however, PFGE could not differentiate the outbreak strain from several different isolates obtained from South Asia and Africa within a five-year period. (cdc.gov)
A stem cell is commonly defined as a cell that has the ability to continuously divide and produce progeny cells that differentiate (develop) into various other types of cells or tissues. (bvsalud.org)

Traditional purification method used to yield a reasonable purity level of mouse hematopoietic stem cells, in general, requires a large (~10-12) battery of markers, most of which were surrogate markers with little functional significance, and thus partial overlap with the stem cell populations and sometimes other closely related cells that are not stem cells. (wikipedia.org)
Stem cell numbers usually decline during aging thereby confounding results when total cell populations are surveyed. (pasteur.fr)
Among these are traits that depend on functional meristems, populations of stem cells maintained by the CLAVATA-WUSCHEL (CLV-WUS) negative feedback-loop that controls the expression of the WUS homeobox transcription factor. (nature.com)
Here we use six transgenic reporters to isolate 14 major skin and HF cell populations. (nih.gov)
Understanding cell-fate decisions in stem cell populations is a major goal of modern biology. (lu.se)
Stem and progenitor cell populations are often heterogeneous, which may reflect stem cell subsets that express subtly different properties, including different propensities for lineage selection upon differentiation, yet remain able to interconvert. (lu.se)
We will use lung cells taken from healthy patients and patients with underlying diseases known to have increased risk for developing Covid-19 from SARS-CoV-2 infection to hopefully identify approved compounds which could be repurposed for preventive SARS-CoV-2 therapy in vulnerable populations. (lu.se)
Here we describe how microRNA-regulated lentiviral vectors can be used to visualize specific cell populations by exploiting endogenous microRNA expression patterns. (lu.se)
To track differentiating cell populations, reporter cell lines generated by homologous recombination (knock-in) or via BAC transgenes have been widely used in mouse cells (5-8 ). (lu.se)

Orbay H, Tobita M, Mizuno H (2012): Mesenchymal Stem Cells Isolated from Adipose and Other Tissues: Basic Biological Properties and Clinical Applications. (ankara.edu.tr)
Background The association between homocysteine and isolated systolic hypertension in older adults was evaluated using a case-control design, and the relationship between homocysteine and clinical or subclinical atherosclerosis was explored. (drcalapai.com)
Scientists working in basic, translational, and clinical cancer metabolism research are invited to join the Academy in New York on April 17th to discuss the intersection between cell signaling and metabolism. (nyas.org)
The biological properties and clinical potential of stem cells elicit that are generated must not be unduly sensitive to small fluctu- continued scientific, commercial, and public interest. (lu.se)

It is a superior product to autologous stem cell therapy because the patient's cells have the same age and the same quality. (stemcellsgroup.com)
1999): Autologous Mesenchymal Stem Cell-Mediated Repair of Tendon. (ankara.edu.tr)

University of Texas at Dallas researchers have managed to formulate a new technique by which they can isolate aggressive cells which can be the main cause behind metastasized cancers or cancers that have spread to other major organs from their primary site of occurrence. (blogspot.com)
UT Dallas researchers used 40,000 tiny plastic beads (blue), each coated with a unique chemical compound, to identify one compound that bound only to breast cancer stem cells (red). (blogspot.com)
For this breakthrough, Lee and his team of researchers scanned through 40,000 chemical compounds to find which one would successfully bind to the breast cancer stem cells. (blogspot.com)
Seeking understand the decline in function of tissues in organisms, researchers from the Stem Cells and Development unit at Institut Pasteur made a discovery on the still unknown mechanisms of the epigenetic clock in stem cells. (pasteur.fr)
The Global Stem Cells Group GMP facility is equipped with the most advanced technologies available, and is operated by a world-class team of qualified medical researchers and practitioners, experienced in administering stem cell protocols using highly manipulated cells. (stemcellslab.net)
Founded in 2012, the company combines dedicated researchers, physician and patient educators and solution providers with the shared goal of meeting the growing worldwide need for leading edge stem cell treatments and solutions. (stemcellslab.net)
Working in a mouse model, the researchers isolated a novel type of lung cell that can divide into fresh copies of itself and into the two more specialized kinds of cells deep in the lung. (news-medical.net)
Researchers at the University of Southern California (USC) have identified a novel mechanism in the regulation and differentiation of neural stem cells. (phys.org)
Researchers found that the protein receptor Ryk has a key role in the differentiation of neural stem cells, and demonstrated a signaling mechanism that regulates neuronal differentiation as stem cells begin to grow into neurons. (phys.org)
Researchers are now expanding their research to studies of differentiation of human embryonic stem cells into neural stem cells and neurons. (phys.org)
Compounds found in purple potatoes may help kill colon cancer stem cells and limit the spread of the cancer, according to a team of researchers. (sciencedaily.com)
In the initial laboratory study, the researchers found that the baked potato extract suppressed the spread of colon cancer stem cells while increasing their deaths. (sciencedaily.com)
According to the researchers, there may be several substances in purple potatoes that work simultaneously on multiple pathways to help kill the colon cancer stem cells, including anthocyanins and chlorogenic acid, and resistant starch. (sciencedaily.com)
In the study, researchers removed lung cells with a brush from COPD patients by passing a scope into the lungs. (upi.com)
The researchers froze isolated testicle stem cells, while clinics are freezing whole tissue samples. (newscientist.com)
In March, researchers announced that a teenage boy in France had been cured of sickle-cell disease after receiving an experimental gene therapy developed by Bluebird Bio. (technologyreview.com)
This explains why researchers are now focusing attention on developing stem cell therapies using postnatal stem cells donated by the patients themselves or their close relatives. (bvsalud.org)
This model will allow the researchers to directly infect human airway cells ex vivo with a SARS-CoV-2 pseudovirus, as well as examining the potential efficacy of drugs in cells derived from patients with underlying co-morbidities known to increase Covid-19-associated disease severity and mortality. (lu.se)
Together with an industrial partner Cellevate, an innovative biotech company based in Lund, the researchers developed a new method for medium-high throughput drug screening of human airway cells which allows several hundred compounds to be evaluated on cells from individual patients. (lu.se)

These cells contribute to the aggressive behavior of glial tumors by altering the environment favorable for the proliferation of glioma stem cells. (cns.org)
Likewise, they have the ability to activate the angiogenesis, proliferation, migration, and differentiation of the main cell types involved in skin regeneration. (frontiersin.org)
During brain development, neural stem cells respond to the surrounding environment by either proliferation or differentiation, but the molecular mechanisms underlying the development of neural stem cells and neurons are unclear, Lu notes. (phys.org)
Stem cell maintenance in the shoot is under the control of the CLAVATA-WUSCHEL (CLV-WUS) negative feedback-loop, which is tightly integrated with hormone function, in particular auxin and cytokinin that promote cell differentiation and proliferation, respectively 2 . (nature.com)
WUS is a homeodomain transcription factor (TF) produced in the organizing center (OC) domain of apical meristems and is transported via plasmodesmata into the apical domain (called central zone, CZ) to promote proliferation of stem cells 3 . (nature.com)
Altogether our FACS (fluorescence-activated cell sorter) analyses reveal that the neonatal subventricular zone is far more heterogeneous than previously suspected and our studies provide new insights into the signals and mechanisms that regulate their self-renewal and proliferation. (karger.com)
Cell proliferation involves the replication of all cellular contents with the required energy for this to happen. (hindawi.com)
To prevent aberrant cell proliferation, these pathways are tightly regulated. (hindawi.com)
This activation is necessary for both cell proliferation as well as glucose uptake and use. (hindawi.com)

Unlike some other cellular therapies, exosomes do not produce host graft reactions, because they do not carry HLA genetic information and are not cells but extracts of the cells (released by cells). (stemcellsgroup.com)
Regardless of when contamination occurred, this investigation highlights the serious potential risks to patients of stem cell therapies administered for unapproved and unproven uses other than hematopoietic or immunologic reconstitution ( 5 ). (cdc.gov)
The GSCG therapeutic center in Santiago-a separate facility from the CMP 1000-will begin seeing international patients as of Dec. 1, 2015 to make its stem cell therapies and facilities available to international patients as well. (stemcellslab.net)
In addition, this hESC reporter line constitutes a unique tool that may aid in gaining insight into the developmental mechanisms underlying fate choices in human pancreas and in developing cell-based therapies. (crick.ac.uk)
In his search for effective therapies for Parkinson's disease, Lorenz Studer is uncovering pluripotency switches and clues to what makes cells age. (the-scientist.com)
Called CAR-T therapies, these "living drugs" are made by extracting T cells from patients and genetically engineering them to go after and destroy cancer cells. (technologyreview.com)

Tobin Hack reports that these cells are surprisingly similar, but far less controversial, than their embryonic stem cell brothers. (loe.org)
We discuss these properties with examples both from the hematopoietic and embryonic stem cell (ESC) systems. (lu.se)

This Development Candidate Feasibility Award is a first step toward the overall goal of developing a cell-based cartilage repair therapy using stem cells derived from the skin. (ca.gov)
It's a cell-free cell therapy , this makes it safer compared to other cellular therapy, because there's no risk of rejection in graft Vs host. (stemcellsgroup.com)
Exosomes are less complicated products to transport because the cells used in cellular therapy must be applied to the patient very quickly because they are live cells. (stemcellsgroup.com)
However, the standardization of the manufacturing process of MSC-based cell therapy medicinal products in compliance with the requirements of the local authorities is obligatory and will allow us to obtain the necessary permits for product administration according to its intended use. (mdpi.com)
GMPs are critical for cell therapy success. (stemcellslab.net)
Neural stem cells can potentially be used for cell-replacement therapy for neurodegenerative diseases such as Alzheimer's and Parkinson's Disease, as well as spinal cord injury," Lu says. (phys.org)
Hopefully, the first COPD cell therapy could be approved by authorities within two to three years. (upi.com)
Some scientists consider stem cell therapy to be "the holy grail of modern medicine," Edelman said. (upi.com)
A successful therapy must therefore eliminate these cells known to be highly resistant to apoptosis. (hindawi.com)
I'm on a pill form of chemo - jakafi - and beginning the stem cell therapy transplant process. (cancer.org)
A study by Tang et al determined that long-term TKI therapy may reduce the abundance of leukemic stem cells in select patients. (medscape.com)
Lund center for Stem Cell Biology and Cell Therapy is one of six Swedish strategic centers of excellence in life sciences, supported by the Swedish Foundation for Strategic Research. (lu.se)
The possibility to isolate and propagate NSCs and their potential applications in cell therapy have attracted a lot of research interest in recent years. (lu.se)
The work with stem cell-based therapy in stroke is in initial phase and recently Dr. Zaal Kokaia started a consortium within EU to develop the preclinical protocol for cell therapy in stroke. (lu.se)
Prof. Lindvall and Dr. Kokaia were the first in the world to show that the brain produces new neurons in response to stroke which opened new possibilities for cell therapy by developing the way to modulate and direct brains this self-repair mechanisms. (lu.se)
Main emphasis of Epilepsy Center is to explore mechanisms underlying epileptogenesis, and develop gene- and cell-therapy based treatment strategies for epilepsy. (lu.se)

iPS were generated via a platelet lysate or fetal bovine serum-based culturing protocol from matched dermal, buccal and gingival human fibroblasts, isolated from healthy donors ( n = 2) after informed consent, via episomal plasmid transfection. (biomedcentral.com)
They include endothelial cells, fibroblasts, and keratinocytes. (frontiersin.org)
The EasySep™ Human CD56 Positive Selection Kit II is designed to isolate CD56+ cells from fresh or previously frozen peripheral blood mononuclear cells and human skeletal muscle (myoblasts and fibroblasts) cultures by positive selection. (stemcell.com)
We hypothesize that iPSC reprogrammed from ocular epithelial cells will be more efficient in differentiating into ocular lineages and exhibit higher functionality than non-ocular sources such as fibroblasts or blood. (stanford.edu)
2008). Historically, this concept is highlighted by the experi- factors are key intrinsic regulators of these fate decisions and mental phenomenon of lineage reprogramming, for example, that fate choice involves modulating networks of transcription by the conversion of fibroblasts to muscles cells following trans- factors. (lu.se)

It should be noted that epigenetic clocks based on DNA methylation are constructed from data from multiple tissues from a mixture of different cell types. (pasteur.fr)
Currently we are collecting and growing epithelial cells from the ocular surface of donor eye tissues. (stanford.edu)
The knowledge gained from separating and identifying different cells types of the eye will provide greater understanding into the physiology and overall function of the various eye tissues. (stanford.edu)
All tissues originate from stem cells. (bvsalud.org)
Postnatal stem cells have been sourced from umbilical cord blood, umbilical cord, bone marrow, peripheral blood, body fat, and almost all body tissues, including the pulp tissue of teeth 8 . (bvsalud.org)
Cells Tissues Organs. (cancercentrum.se)

Cancer stem cells (CSCs) are thought to the underlying reason for cancer initiation, metastasis, and relapse. (springer.com)
However, due to their elusive character and differences in identification among different types of cancer, it remains a challenge to study such cells. (springer.com)
Here, we employ a fluorescent reporter system to track and isolate stem-like cancer cells of cholangiocarcinoma cell lines. (springer.com)
Cancer stem cells (CSCs) represent a small subset of the tumor population and reside at the apex of the hierarchy [ 9 ]. (springer.com)
These cancer cells that grow more aggressively than others are the cancer stem cells. (blogspot.com)
and Dr. Jiyong Lee, assistant professor of chemistry and biochemistry, were involved in the cancer stem cell study. (blogspot.com)
Stem cells and cancer recurrence and spread are innately connected. (blogspot.com)
Cancer stem cells are found in some aggressive tumours that help them grow rapidly and also spread to distant organs. (blogspot.com)
Treatments that can cure the cancer cells at the primary sites are usually fruitless against these cancer stem cells which can travel via blood stream to different organs as cause metastasis or spread of the tumors. (blogspot.com)
Once bound the chemical would isolate the cells from their surrounding normal breast cells and breast cancer cells that were not aggressive in nature. (blogspot.com)
They could finally isolate five different compounds or ligands that could bind to the cancer stem cells. (blogspot.com)
Lee explained that similar methods could be used to separate the cancer cells from normal cells as well but this study is unique because it could isolate the cancer stem cells from other cancer cells. (blogspot.com)
According to Lee, if these cancer stem cells could be isolated and killed, the risk of spread of the cancer would be reduced. (blogspot.com)
At present there are no drugs that can specifically kill these cancer stem cells he said. (blogspot.com)
They incubated a mixture of breast cancer cells and breast cancer stem cells and 40,000 tiny plastic beads that were coated with the new found ligand that could bind to the cancer stem cells. (blogspot.com)
They noted that the ligand could bind specifically to the cancer stem cells and separate them. (blogspot.com)
Now these cancer stem cells thus isolated and the cancer cells left behind were each injected to lab mice. (blogspot.com)
They noted that the lab mice that were given cancer stem cells showed more rapid cancer growth and bigger and aggressive tumors compared to those injected with the cancer cells that were not stem cells. (blogspot.com)
Chemotherapy , in its most general sense, refers to treatment of disease by chemicals that kill cells, specifically those of micro-organisms or cancer . (wikidoc.org)
It was reasoned that an agent that damaged the rapidly growing white blood cells might have a similar effect on cancer. (wikidoc.org)
Cancer is the uncontrolled growth of cells coupled with malignant behavior: invasion and metastasis . (wikidoc.org)
This knowledge can also be used to inhibit the growth of brain cancer stem cells. (phys.org)
Baked purple-fleshed potatoes suppressed the growth of colon cancer tumors in petri dishes and in mice by targeting the cancer's stem cells. (sciencedaily.com)
Attacking stem cells is an effective way to counter cancer, according to Jairam K.P. Vanamala, associate professor of food sciences, Penn State and faculty member, at the Penn State Hershey Cancer Institute. (sciencedaily.com)
You might want to compare cancer stem cells to roots of the weeds," Vanamala said. (sciencedaily.com)
You may cut the weed, but as long as the roots are still there, the weeds will keep growing back and, likewise, if the cancer stem cells are still present, the cancer can still grow and spread. (sciencedaily.com)
The butyric acid regulates immune function in the gut, suppresses chronic inflammation and may also help to cause cancer cells to self-destruct. (sciencedaily.com)
When you eat from the rainbow, instead of one compound, you have thousands of compounds, working on different pathways to suppress the growth of cancer stem cells," said Vanamala. (sciencedaily.com)
Chemotherapy to treat cancer can kill stem cells in the testicles that make sperm. (newscientist.com)
Accumulating evidence shows that cancer stem cells are key drivers of tumor formation, progression, and recurrence. (hindawi.com)
In this paper, we describe the metabolic changes as well as the mechanisms of resistance to apoptosis occurring in cancer cells and cancer stem cells, underlying the connection between these two processes. (hindawi.com)
However, cancer cells overcome these controls, in particular by acquiring genetic mutations leading to the activation of oncogenes (pten, myc) or loss of tumor suppressors (p53) [ 1 ]. (hindawi.com)
In contrast to normal cells, most cancer cells predominantly produce energy by a high rate of glycolysis followed by lactate fermentation, even in the presence of oxygen, a less efficient metabolism compared to a low rate of glycolysis followed by mitochondrial oxidation of pyruvate [ 2 ]. (hindawi.com)
In contrast, cancer cells shift their metabolism toward lactate production even in the presence of oxygen [ 4 ], partly through genetic modifications that stabilize the transcription factor Hypoxia Inducible Factor (HIF) involved in the adaptation of the cells to hypoxia, under nonhypoxic conditions as well as generating an adaptive response to the hypoxic microenvironment (Figure 1 ). (hindawi.com)
Metabolic adaptations of cancer cells. (hindawi.com)
Glucose and glutamine are the 2 major substrates used by cancer cells. (hindawi.com)
3-D balls of cells can be used to screen for potential cancer drugs. (the-scientist.com)
This year the FDA approved two pioneering treatments, Kymriah and Yescarta , that use a patient's own immune cells to fight rare types of cancer. (technologyreview.com)
I understand just a tad the feeling that you are having about the type of cancer you have being isolating. (cancer.org)

In fact, the Science list of six Areas to Watch in 2012 puts genomic epidemiology fourth-right after the Higgs boson, faster-than-light neutrinos, and stem-cell metabolism. (cdc.gov)

Exosomes are extracellular vesicles (that's particles that release naturally from a cell that cannot replicate) that are responsible for certain genetic information, otherwise known as Exosomes cell to cell communication. (stemcellsgroup.com)
The cells secrete extracellular vesicles (EV) that may have an endosomal origin, or from evaginations of the plasma membrane. (frontiersin.org)
The exosome vesicles are a type of extracellular vesicles (EV), which are defined as lipid-bilayer spheroid structures, without replicating capacity, that are released from cells, including both prokaryotes and eukaryotes. (frontiersin.org)
3-D cell culture recapitulates in vivo environments for generating physiologically relevant extracellular vesicles. (the-scientist.com)

We used G-CSF-mobilized CD34 + HSPCs, FACS-sorted from healthy donor peripheral blood mononuclear cells (PBMCs). (hindawi.com)

In addition cells derived from carious pulps (almost always discarded) may have potential for future applications in mineralized tissue repair and regeneration. (whiterose.ac.uk)
The hair follicle (HF) is a complex miniorgan that serves as an ideal model system to study stem cell (SC) interactions with the niche during growth and regeneration. (nih.gov)
There are limited numbers of publications about ES cells in pulp regeneration, due to the restricted policies regarding ES cell research over the past few years. (bvsalud.org)

Differential proteomic analysis of cells cultured from low grade vs. high grade tumors was performed by 2-DE and MALDI-TOF-MS. (cns.org)
whereas in the cells isolated from high grade tumors, five isoforms of vimentin, transgelin, Mn-SOD, pyruvate kinase (PKM), GTP-binding nuclear protein Ran and 40S ribosomal protein SA were detected to be overexpressed. (cns.org)
For the first time we analyzed the proteomic profile of mesenchymal stem cells isolated from glioma tumors. (cns.org)
Once the primary tumors are treated and cured, these aggressive stem cells that have migrated to other major organs such as the liver, lungs, bones etc., continue to migrate and set up shop at different parts of the body so to speak. (blogspot.com)
As chemotherapy affects cell division, tumors with high growth fractions (such as acute myelogenous leukemia and the aggressive lymphomas , including Hodgkin's disease ) are more sensitive to chemotherapy, as a larger proportion of the targeted cells are undergoing cell division at any time. (wikidoc.org)
Drugs affect "younger" tumors (i.e. more differentiated) more effectively, because mechanisms regulating cell growth are usually still preserved. (wikidoc.org)
With succeeding generations of tumor cells, differentiation is typically lost, growth becomes less regulated, and tumors become less responsive to most chemotherapeutic agents. (wikidoc.org)

Global Stem Cells Group today announced the opening of a new, Good Manufacturing Practice (GMP) 10000 in the Santiago Marriott. (stemcellslab.net)
The Global Stem Cells Group GMP 1000 facility will begin receiving international patients in early January 2016. (stemcellslab.net)
Global Stem Cells Group, Inc. is the parent company of six wholly owned operating companies dedicated entirely to stem cell research, training, products and solutions. (stemcellslab.net)
With a singular focus on this exciting new area of medical research, Global Stem Cells Group and its subsidiaries are uniquely positioned to become global leaders in cellular medicine. (stemcellslab.net)
Global Stem Cells Group is a publicly traded company operating under the symbol MSSV. (stemcellslab.net)

They found that during neurogenesis, when neural stem cells start to grow into neurons, Ryk protein is cleaved and translocates to the cell nucleus to regulate neuronal differentiation. (phys.org)
This finding is extremely important for understanding the regulation of self-renewal and differentiation of neural stem cells, Lu says. (phys.org)
However, the role of Ryk in neural stem cells and the molecular mechanism of Ryk signaling have not previously been known. (phys.org)
The main objective of the Stem Cell Center´s Neuroscience Program is to study the properties of neural stem cells (NSCs) and explore the possibilities to use these cells for treatment of neurodegenerative diseases such as Parkinson's disease and stroke. (lu.se)

Furthermore, a phylogenetic analysis incorporating previously reported whole genome sequence data found that the Haitian isolates were indistinguishable from one of four closely related genetic clusters among the isolates from Nepal. (cdc.gov)
Research groups are gathered within five main research clusters: MultiPark, Stem Cell Center and Epilepsy Center. (lu.se)

It is used to isolate HSC for reconstitution of patients who are haematologically incompetent as a result of chemotherapy or disease. (wikipedia.org)
The only Food and Drug Administration (FDA)-approved stem cell products are derived from umbilical cord blood, and their only approved use is hematopoietic and immunologic reconstitution ( 1 ). (cdc.gov)
On September 17, 2018, the Texas Department of State Health Services received notification of Enterobacter cloacae and Citrobacter freundii bloodstream infections in three patients who had received injections or infusions of non-FDA-approved umbilical cord blood-derived stem cell products processed by Genetech, Inc., and distributed by Liveyon, LLC, for other than hematopoietic or immunologic reconstitution at an outpatient clinic on September 12. (cdc.gov)

Our study is aimed at investigating whether precursors of myeloid angiogenic cells (PACs) treated with known pharmaceuticals would produce media with better proangiogenic activity in vitro and if such media can be used to stimulate blood vessel growth in vivo . (hindawi.com)
Concluding, high concentrations of atorvastatin stabilize tubes and enhance the paracrine angiogenic activity of human PAC cells in vitro . (hindawi.com)
Bioactive lipid mediators regulate lung epithelial and mesenchymal cell reparative processes in vitro. (cdc.gov)

HSCs can be identified or isolated by the use of flow cytometry where the combination of several different cell surface markers are used to separate the rare HSCs from the surrounding blood cells. (wikipedia.org)
Round cell subpopulations were identified with FITC-DBA by flow cytometry: strongly positive DBA (sDBA+) as SSC, weakly positive DBA (wDBA+) as in early differentiation and negative DBA as differentiated. (edu.pe)
Here we define a 4-color flow cytometry panel using CD133, LeX, CD140a, NG2 to define a neural stem cell (NSC) as well as 4 classes of multipotential progenitors and 3 classes of bipotential progenitors, several of which have not been described previously. (karger.com)
Finally, we provide protocols for analyzing these cells through flow cytometry and immunocytochemistry. (lu.se)

These multipotent stem cells contain certain proteins - called markers - that have previously been found only in embryonic stem cells. (loe.org)

As substantial differences exist between human and murine pancreas biology, we investigated whether it is possible to isolate pancreatic endocrine progenitors from differentiating hESC cultures by lineage tracing of NGN3. (crick.ac.uk)

Our exercise studies include muscle biopsies and skeletal muscle satellite cells. (lu.se)

To date, four types of human dental stem cells have been isolated and characterized: (i) dental pulp stem cells (DPSCs) 12 (ii) stem cells from exfoliated deciduous teeth (SHED) 21 (iii) stem cells from apical papilla (SCAP) 31 (iv) periodontal ligament stem cells (PDLSCs) 28 . (bvsalud.org)

We intend to harness the inherent epigenetic memory of the ocular epithelial cells for superior and quicker protocol to regenerate cornea. (stanford.edu)
When primary isolated human bronchial epithelial cells were treated with 1-100 nM MaR1, transforming growth factor (TGF)-B1-induced EMT processes were altered. (cdc.gov)

There are many differences between the human and murine hematopoietic cell markers for the commonly accepted type of hematopoietic stem cells. (wikipedia.org)
Project preparation includes setting up facilities and approvals for work with human DIAS cells, identifying sources and acquiring human skin for DIAS cell isolation, and hiring and training personnel. (ca.gov)
Scientific progress includes a publication on co-cultures using stem cells, work on culturing larger numbers of cells using low oxygen tension, comparing stem cells from human skin of different anatomical locations, and gaining an understanding of the niches where skin stem cells may reside. (ca.gov)
The project now has a consistent source of human dermis tissue from which stem cells can be isolated. (ca.gov)
Spherical culture of human skin-derived stem cells has been performed. (ca.gov)
Since much of the prior work on directing stem cells from the skin to form neocartilage has been done using animal-derived stem cells, in the next project period neocartilage will be formed using human stem cells instead. (ca.gov)
Comparing animal skin and human skin showed notable differences, including morphology, response to enzymatic digestion, and the rate at which cells attach to tissue culture plastic. (ca.gov)
As a result, protocols that successfully yielded DIAS cells using animal models could not be directly applied to isolating DIAS cells from human skin. (ca.gov)
During the first six months of this reporting period, human DIAS cells were isolated and used to engineer neocartilage. (ca.gov)
Characterizing the human DIAS cell population showed that cells shared similar characteristics with stem and progenitor cells previously identified by other groups as originating from various niches of the skin. (ca.gov)
Neocartilage constructs generated from human DIAS cells also contained five times higher compressive modulus and close to twice the tensile modulus of constructs generated using sheep DIAS cells. (ca.gov)
For the scaling-up of constructs to be used in an athymic mouse study, an experiment was conducted to finalize our protocol for generating human DIAS cell constructs, using what have been learned both from Milestone 1 and also from literature sources. (ca.gov)
Aspergillus fumigatus , the epidemiology and evolution tionwide study of scedosporiosis in Australia (2003-2005) of human infections caused by uncommon but emerging and 46 additional isolates were genotyped by internal tran- fungi are incompletely understood. (cdc.gov)
Although stem cells from human hair follicles are much harder to come by, and less versatile than embryonic stem cells, they're less controversial in today's political and religious debates over the ethics of stem cell research. (loe.org)
Although endocrine pancreas progenitor cells have been isolated from mouse pancreata on the basis of Ngn3 expression, human endocrine progenitors have not been isolated yet. (crick.ac.uk)
2002): Improvement of postnatal neovascularization by human adipose tissue-derived stem cells. (ankara.edu.tr)
2002): Myogenic differentiation by human processed lipoaspirate cells. (ankara.edu.tr)
2004): Plasticity of human adipose lineage cells toward endothelial perspectives. (ankara.edu.tr)
Conditioned media from such cells were then used to stimulate human aortic endothelial cells (HAoECs) to enhance tube-like structure formation in a Matrigel assay. (hindawi.com)
Regenerated airway and alveolar cells derived from human iPSCs express proteins that match human respiratory cell biomarkers and play an important role in pathogenesis, such as ACE2 receptor protein in SARS-CoV-2 infections. (genengnews.com)
Our aim is to establish phenotypically and transcriptionally characterized different subsets of primary human ocular cells. (stanford.edu)
The possible donor-host rejection of human ES cells is another concern 3 . (bvsalud.org)
This model that has been developed with our collaborators will fill an important gap for current and future drug screening efforts for the upper or lower airways using human airway cells", says Sinem Tas, associate researcher. (lu.se)
We provide detailed protocols for lentiviral transduction, neural differentiation, and subsequent analysis of human embryonic stem cells. (lu.se)
Although possible, these strategies are often complicated to transfer to human cells due to technical issues (9 ), and only a few successful cases have been described ( 10, 11 ). (lu.se)
Here we describe how this system can be used for human embry- onic stem cells. (lu.se)

Myeloid sarcoma (MS), also known as granulocytic sarcoma or chloroma, is a rare extramedullary tumor composed of immature myeloid cells at different stages of differentiation which can involve any site of the body. (haematologica.org)
Additionally, characterization of the tumor microenvironment such as interactions with immune cells remain largely unknown. (springer.com)
Apart from CSCs, there are a myriad of factors and interactions between various cell types and the tumor microenvironment (TME) that ultimately affect CCA progression. (springer.com)
They'd be able to study how tumor cells migrate: how they look, how they. (yasni.com)
Typically, rapidly proliferating tumor cells have glycolytic rates up to 200 times higher than those of their normal tissue of origin, even in the presence of oxygen [ 3 ]. (hindawi.com)

Cell Rep . 2016 Mar 29;14(12):3001-18. (nih.gov)

This confirms that NGN3(+) cells represent pancreatic endocrine progenitors in humans. (crick.ac.uk)
In our study, we worked on cells derived from the CD34 + hematopoietic stem and progenitor cells, enriched with CD133 + population, and used culture media promoting growth of hematopoietic progenitors. (hindawi.com)
It is essential to have sensitive and reproducible methods of either quantifying or isolating these stem cells and progenitors to understand their intrinsic properties and how extrinsic signals regulate their development. (karger.com)
However, stem cells are difficult to distinguish from multipotential progenitors, which may look and act like them. (karger.com)

More rarely, myeloid sarcoma could also be observed in the setting of myelodysplastic syndrome or myeloproliferative neoplasms, or as an isolated myeloid sarcoma (also designated as de novo , non-leukemic or primary MS). 1 Common practice suggests that patients with isolated myeloid sarcoma should receive AML-like induction chemotherapy. (haematologica.org)
7 , 8 However, it is still unclear whether allo-HSCT is also a good option for patients with isolated myeloid sarcoma. (haematologica.org)
To assess the role of allo-HSCT in patients with isolated myeloid sarcoma and compare the outcome of such patients with leukemic myeloid sarcoma patients, we performed a retrospective multicenter study assessing the results of allo-HSCT in 99 patients reported to the EBMT registry between January 1991 and June 2009 with isolated (n=30) or leukemic (n=69) myeloid sarcoma. (haematologica.org)
Comparison of outcomes between isolated myeloid sarcoma and leukemic myeloid sarcoma. (haematologica.org)
Overall results and comparison of outcomes between isolated and leukemic myeloid sarcoma are given in Table 2 . (haematologica.org)
8 As outcomes of isolated and leukemic myeloid sarcoma were found to be similar, data for the two groups were pooled to perform univariate and multivariate analyses. (haematologica.org)
This study included the largest series of isolated myeloid sarcoma patients having undergone allo-HSCT reported so far. (haematologica.org)
Myeloid angiogenic cells (MAC) derive from hematopoietic stem/progenitor cells (HSPCs) that are mobilized from the bone marrow. (hindawi.com)
Such myeloid angiogenic cells (MAC) [ 1 ] of bone marrow origin were known as endothelial progenitor cells (EPCs). (hindawi.com)
Cells previously known as endothelial progenitor cells are considered now to be rather myeloid angiogenic cells than endothelial precursors [ 4 ]. (hindawi.com)
Therefore, the cells we used should be considered as hematopoietic precursors of myeloid angiogenic cells and are referred as PACs. (hindawi.com)

CD150+CD48− gave stem cell purity comparable to Thy1loSCA-1+lin−c-kit+ in mice. (wikipedia.org)
By examining the transcriptome and epigenome of individual muscle stem cells simultaneously, we found that DNA transcribes* more chaotically in older muscle stem cells compared to those in younger mice. (pasteur.fr)
This matrix protein is decreased in muscle stem cells in old mice thereby destabilising contact with the fibre. (pasteur.fr)
We hypothesize that either small changes in cell composition during ageing may affect the epigenetic age of a tissue, or that our epigenetic clocks for mice need further refinement" says Shahragim Tajbakhsh. (pasteur.fr)
Rat testicle cells that were frozen for 23 years have produced sperm after being implanted into mice. (newscientist.com)
They took advantage of stem cells from rats that had been isolated and frozen 23 years earlier, thawing and implanting them into the testes of mice. (newscientist.com)
The mice had been treated with a drug that killed their own sperm-making cells - which is too toxic to use on rats - and had defective immune systems so they couldn't reject the transplant. (newscientist.com)
For comparison, the same procedure was also done in other mice using rat cells that had been removed and immediately implanted, as well as with rat cells that had been frozen a few months ago. (newscientist.com)

They isolated skin stem cells and added copies of a healthy version of the gene. (technologyreview.com)

Neither AT alone in control media nor conditioned media nor AT-stimulated cells affected numbers of endothelial cells in the plug or plug's vascularization. (hindawi.com)
The process of neovascularization can be influenced not only by the residual endothelial cells but also by the circulating cells. (hindawi.com)
However, the features initially ascribed to endothelial progenitor cells, i.e ., phenotype, expression of endothelial markers, and ability to form tube-like structures on Matrigel, can be mimicked by blood monocytes [ 3 ]. (hindawi.com)
Although patent channels were identified at 8 weeks, no evidence suggested that the channels had developed an endothelial cell lining, thus confirming successful rearterialization. (medscape.com)

The discovery of this new class of SSCs is based on the conjunction of evidence from unbiased single-cell molecular profiling and functional dissection of the BMSC lineage hierarchy using in vivo cell lineage analysis. (nature.com)
Then, we used atorvastatin-stimulated cells or conditioned media from them in the Matrigel plug in vivo angiogenic assay. (hindawi.com)

Proteins as the functional molecules in the cells are the main effectors of normal cellular and disease processes. (cns.org)
Ryk functions as a receptor of Wnt proteins required for cell-fate determination, axon guidance and neurite outgrowth in organisms. (phys.org)

Although they were genetically related to isolates from both India and Cameroon, none of these was a perfect match. (cdc.gov)
Thus, it is not surprising that PFGE patterns from the Haitian cholera outbreak isolates matched several others from Asia and Africa, even though they were not genetically identical. (cdc.gov)

In stem cells in aged individuals, both transcriptional and epigenetic changes associated with ageing have been observed. (pasteur.fr)
In terminally differentiated cell fate is coupled to appropriate regulation of the alternative cells, transcriptional networks must be stable and irreversible, pathways. (lu.se)

Cuyrrently taking Jakafi to control Graft-versus-Host-Disease following an allogeneic stem cell transplant. (cancer.org)
Haematopoeitic stem cell transplant (HSCT) recipients - from day of admission (~day -7) to day +35. (who.int)

Lack of expression of lineage markers is used in combination with detection of several positive cell-surface markers to isolate HSCs. (wikipedia.org)
Following verification of a stem-like signature (upregulated expression of stemness markers, resistance to chemotherapy, increased spheroid formation, and tumorigenesis capabilities despite inoculation of a small number of cells), we analyzed the interaction of these cells with macrophages via direct and indirect coculture assays. (springer.com)
2009): Characterization of mesenchymal stem cells from rat bone marrow: potential and immunophenotypic markers. (ankara.edu.tr)

Spermatogonial stem cell (SSC) is known for its self-renewal capacity. (edu.pe)
To varying degrees, these fates also extend to the Such state stability is required in stem and progenitor cells to immediate progeny of stem cells, known as progenitor or support self-renewal and maintenance of the uncommitted transit-amplifying cells. (lu.se)

The specific kind of lung stem cell, p63+, was isolated and cultured. (upi.com)

Proteomic analysis of these cells can elucidate their molecular properties and mechanism of action. (cns.org)
Through proteomic analyses the molecular mechanisms of tumorigenesis and malignant behaviors of tumoral cells can be elucidated. (cns.org)
Moreover, we observed molecular changes in cell cycle, MYC and mTOR signaling in both HSCs, and progenitor subsets. (lu.se)

This discovery on ageing underscores the importance of basic research in understanding the mechanisms that regulate stem cell properties and function to pave the way for future development of innovative diagnostic or therapeutic strategies. (pasteur.fr)

Despite not being a cell, Exosome has proven to be quite important in maintaining a healthy cellular terrain. (stemcellsgroup.com)
In normal cells, glucose participates in cellular energy production through glycolysis as well as through its complete catabolism via the tricarboxylic acid (TCA) cycle and oxidative phosphorylation (OXPHOS). (hindawi.com)
The perturbances in cellular redox homeostasis leads to high free radical burden thereby causing oxidative stress in the cells. (stanford.edu)

Anatomy47

Organisms22

Diseases16

Chemicals and Drugs53

Analytical, Diagnostic and Therapeutic Techniques and Equipment58

Phenomena and Processes55

Disciplines and Occupations9

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture2

Information Science4

Health Care8

MSCs14

Stromal15

Transplantation10

Obtained from human embr1

Pluripotent14

Adult14

Regenerative medicine7

Differentiate6

Populations9

Clinical4

Autologous2

Researchers19

Proliferation9

Therapies6

Embryonic stem2

Therapy16

Fibroblasts5

Tissues6

Cancer39

Metabolism1

Extracellular vesicles4

Peripheral blood mononuclear cells1

Regeneration3

Tumors7

Global Stem Cells Group5

Neural stem4

Clusters2

Reconstitution3

Vitro3

Flow cytometry4

Multipotent1

Biology1

Skeletal muscle1

Dental pulp1

Epithelial cells2

Human26

Tumor5

20161

Progenitors4

Myeloid11

Mice8

Skin stem cells1

Endothelial4

Vivo2

Proteins2

Genetically2

Transcriptional2

Transplant2

Markers3

Self-renewal2

Lung stem1

Molecular3

Regulate1

Cellular3