Background The presence of antibodies to aquaporin-4 (AQP4) has been identified as a key characteristic of neuromyelitis optica spectrum disorder (NMOSD), an autoimmune inflammatory demyelinating central nervous system (CNS) disorder. (guthyjacksonfoundation.org)
IHC staining of FFPE human small intestine with Aquaporin 4 antibody (clone AQP4/3324). (nsjbio.com)
SDS-PAGE analysis of purified, BSA-free Aquaporin 4 antibody (clone AQP4/3324) as confirmation of integrity and purity. (nsjbio.com)
Analysis of HuProt(TM) microarray containing more than 19,000 full-length human proteins using Aquaporin 4 antibody (clone AQP4/3324). (nsjbio.com)
In skeletal muscle, AQP4 (Aquaporin 4, also known as mercurial insensitive water channel), localizes to the sarcolemma of fast-twitch muscle fibers. (nsjbio.com)
The overlapping clinical features of relapsing remitting multiple sclerosis (RRMS), aquaporin-4 (AQP4)-antibody (Ab) neuromyelitis optica spectrum disorder (NMOSD), and myelin oligodendrocyte glycoprotein (MOG)-Ab disease mean that detection of disease specific serum antibodies is the gold standard in diagnostics. (biomedcentral.com)
SIGNIFICANCE Declaration We characterize the physiological top features of connections between your astroglial bloating sensor transient receptor potential isoform 4 (TRPV4) as well as the aquaporin 4 (AQP4) drinking water route in retinal Mller cells. (californiaehealth.org)
2013). Eradication of aquaporin 4 (AQP4) stations abolished hypotonically induced swelling-mediated Ca2+ indicators, altered activity-dependent adjustments in ECS quantity, and affected glial RVD (Pannicke et al. (californiaehealth.org)
Plasma membrane4
Original Article Neuromyelitis optica IgG does not alter aquaporin-4 waterpermeability, plasma membrane M1/M23 isoform content, or supramolecular assembly Andrea Rossi1,2, Julien Ratelade1,2, Marios C. Papadopoulos3, Jeffrey L. (guthyjacksonfoundation.org)
2 hours) ABA application to the roots of ABA-deficient barley, increased tissue ABA concentrations and AQP abundance (especially the plasma-membrane localised isoforms HvPIP2;1 and HvPIP2;2) were spatially correlated in root epidermal cells and the cortical cell layer located beneath, in conjunction with increased LpCell of the cortical cells. (botany.one)
Aharon R, Shahak Y, Wininger S, Bendov R, Kapulnik Y, Galili G (2003) Overexpression of a plasma membrane aquaporins in transgenic tobacco improves plant vigour under favourable growth conditions but not under drought or salt stress. (usal.es)
Aroca R, Porcel R, Ruiz-Lozano JM (2007) How does arbuscular mycorrhizal symbiosis regulate root hydraulic properties and plasma membrane aquaporins in Phaseolus vulgaris under drought, cold or salinity stresses? (usal.es)
Permeability1
However, because water is a polar molecule this process of simple diffusion is relatively slow, and in tissues with high waterpermeability the majority of water passes through aquaporin. (wikipedia.org)
AQPs4
The Role of Aquaporins in the Kidneys The majority of water reabsorption that occurs in the nephron is facilitated by the AQPs. (urhelpmate.com)
Aquaporins (AQPs) are a large family of integral membrane water transport channel proteins that facilitate the transport of water through the cell membrane. (nsjbio.com)
Aquaporins (AQPs) are water-transporting transmembrane proteins, and some isoforms have been shown to facilitate a bidirectional transport of H2O2 across cellular membranes in addition to water. (uni-greifswald.de)
Vella J, Zammit C, Di Giovanni G, Muscat R, Valentino M. The central role of aquaporins in the pathophysiology of ischemic stroke. (benthamscience.com)
Proteins6
Aquaporins, also called water channels, are channel proteins from a larger family of major intrinsic proteins that form pores in the membrane of biological cells, mainly facilitating transport of water between cells. (wikipedia.org)
This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. (antibodies-online.com)
These water channels consist of a family of proteins called aquaporin. (urhelpmate.com)
The well-characterized mammalian proteins are found in renal (IIa isoform) and intestinal (IIb isoform) brush border membranes and are about 640 amino acyl residues long with 8-12 putative TMSs. (tcdb.org)
Membrane3
Aquaporins have six membrane-spanning alpha helical domains with both carboxylic and amino terminals on the cytoplasmic side. (wikipedia.org)
Because aquaporins are usually always open and are prevalent in just about every cell type, this leads to a misconception that water readily passes through the cell membrane down its concentration gradient. (wikipedia.org)
In response to parathyroid hormone and dietary inorganic phosphate, the renal cotransporter is rapidly inserted into and retrieved from the renal brush border membrane in a fashion similar to that by which the glucose transporter (Glut4) (TC# 2.A.1.1) is regulated by insulin, and aquaporins 1 and 2 (TC# 1.A.8.1) are regulated by vasopressin (Levi et al. (tcdb.org)
Genes2
Genetic defects involving aquaporin genes have been associated with several human diseases including nephrogenic diabetes insipidus and neuromyelitis optica. (wikipedia.org)
and descriptions of promote all the genes and is into a complex isoform. (erik-mill.de)
Dp713
0.05), whereas the level of the shorter Dp71 isoform did not differ. (frontiersin.org)
Cognitive deficit has been identified in one third of patients affected by Duchenne Muscular Dystrophy, primarily attributed to loss of the short Dp71 dystrophin, the major brain dystrophin isoform. (biomedcentral.com)
Mutations in the dmd gene are responsible for the Duchenne muscular dystrophy (DMD) disease [ 1 ], in which muscular degeneration is also associated with cognitive defects likely due to loss of the smallest product of the dmd gene, the Dp71 dystrophin isoform [ 2 ]. (biomedcentral.com)
Transcript variants2
Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. (antibodies-online.com)
Alternatively spliced transcript variants encoding different isoforms have been described for this gene. (assaygenie.com)
Transporters2
Aquaporins are multifunctional water and solute transporters highly divergent in living organisms. (benthamscience.com)
Novel ways to modulate CSF formation emanate from recent analyses of choroid plexus transcription factors (E2F5), ion transporters (NaHCO3 cotransport), transport enzymes (isoforms of carbonic anhydrase), aquaporin 1 regulation, and plasticity of receptors for fluid-regulating neuropeptides. (scienceopen.com)
Inhibitor2
Preincubation in 0.1 mM HgCl(2), a standard aquaporin inhibitor, prevented such cell swelling. (wikigenes.org)
Igarashi H, Huber VJ, Tsujita M, Nakada T. Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema. (benthamscience.com)
Characterization1
2017). Characterization of the isoforms of type IIb sodium-dependent phosphate cotransporter (Slc34a2) in yellow catfish, Pelteobagrus fulvidraco, and their vitamin D3-regulated expression under low-phosphate conditions. (tcdb.org)
Ions1
Aquaporins selectively conduct water molecules in and out of the cell, while preventing the passage of ions and other solutes. (wikipedia.org)
Gene2
A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. (assaygenie.com)
Circadian rhythmicity of active GSK3 isoforms modulates molecular clock gene rhythms in the suprachiasmatic nucleus. (rochester.edu)
AQP91
Although most aquaporins are only permeable to water, AQP3, AQP7, AQP9 and one of the two AQP10 transcripts are also permeable to urea and glycerol. (nsjbio.com)
Solute1
Aquaporin-4-dependent glymphatic solute transport in the rodent brain. (rochester.edu)
Renal1
Aquaporins are involved in renal water absorption, generation of pulmonary secretions, lacrimation and the secretion and reabsorption of cerebrospinal fluid and aqueous humor. (nsjbio.com)
Regulation1
Insights into Populus XIP aquaporins: evolutionary expansion, protein functionality, and environmental regulation. (inrae.fr)
This protein is the predominant aquaporin found in brain and has an important role in brainwater homeostasis. (assaygenie.com)
Loss of aquaporin-4 results in glymphatic system dysfunction via brain-wide interstitial fluid stagnation. (rochester.edu)
Hydraulic1
The AM symbiosis also improves root hydraulic conductivity under saline conditions, and this may be due to enhanced symplastic and apoplastic radial water flow in rice roots, mediated by the induction of specific aquaporin isoforms and also by the additional water-absorbing surface of AM fungal hyphae. (usal.es)
Cells2
The cell membranes of a variety of different bacteria, fungi, animal and plant cells contain aquaporins through which water can flow more rapidly into and out of the cell than by diffusing through the phospholipid bilayer. (wikipedia.org)
Water moves through cells in an organized way, most rapidly in tissues that have aquaporin water channels. (wikipedia.org)
Kidney1
At least seven different aquaporin isoforms are expressed in the kidney. (urhelpmate.com)
A strong applicant is certainly transient receptor potential isoform 4 (TRPV4), a polymodal non-selective cation route that was suggested to bind and/or functionally connect to multiple AQP isoforms (Liu et al. (californiaehealth.org)
Discovery1
The 2003 Nobel Prize in Chemistry was awarded jointly to Peter Agre for the discovery of aquaporins and Roderick MacKinnon for his work on the structure and mechanism of potassium channels. (wikipedia.org)
Type1
Aquaporins are widely distributed and it is not uncommon for more than one type of AQP to be present in the same cell. (nsjbio.com)
Change1
Aquaporins can change their activity reversibly, if exposed to a change in nutrients. (botany.one)
Research1
In 1999, together with other research teams, Agre reported the first high-resolution images of the three-dimensional structure of an aquaporin, namely, aquaporin-1. (wikipedia.org)