• Previously published data have shown an allele-specific variation in the in vitro binding of apolipoprotein E (apoE) to tau, which prompted the hypothesis that apoE binding may protect tau from phosphorylation, apoE3 being more efficient than apoE4. (ox.ac.uk)
  • Additionally, of the 15 peptides phosphorylated in the presence or absence of apoE, subtle differences, some isoform-specific, in the relative amounts of phosphorylation were observed. (ox.ac.uk)
  • Poisson regression analysis showed that white matter hyperintensities (OR=1.22, 95% CI: 1.16- 1.29), APOE ϵ4+ carrier (OR=2.16, 95% CI: 1.18- 3.96) and CR1 non-F/F isoform (OR=7.78, 95% CI: 4.34- 13.96) were associated with CMBs. (dovepress.com)
  • Cardiovascular risk factors, CSVD markers, and genetic factors (APOE ϵ4, CR1 non-F/F isoform) were associated with CMBs, suggesting an interaction of multiple pathogenesis in Chinese stroke-free community population. (dovepress.com)
  • Apolipoprotein E (ApoE) is the strongest genetic risk factor for Alzheimer's disease and has been implicated in the risk for other neurological disorders. (wustl.edu)
  • The three common ApoE isoforms (ApoE2, E3, and E4) each differ by a single amino acid, with ApoE4 increasing and ApoE2 decreasing the risk of Alzheimer's disease (AD). (wustl.edu)
  • Both the isoform and amount of ApoE in the brain modulate AD pathology by altering the extent of amyloid beta (Aβ) peptide deposition. (wustl.edu)
  • Therefore, quantifying ApoE isoform production and clearance rates may advance our understanding of the role of ApoE in health and disease. (wustl.edu)
  • To measure the kinetics of ApoE in the central nervous system (CNS), we applied in vivo stable isotope labeling to quantify the fractional turnover rates of ApoE isoforms in 18 cognitively-normal adults and in ApoE3 and ApoE4 targeted-replacement mice. (wustl.edu)
  • However, CNS and peripheral ApoE isoform turnover rates differed substantially, which is consistent with previous reports and suggests that the pathways responsible for ApoE metabolism are different in the CNS and the periphery. (wustl.edu)
  • Apolipoprotein E (APOE) gene variants have been reported to influence psoriasis risk. (hindawi.com)
  • Lipid metabolism in the epidermis may be regulated by the expression of apolipoprotein E (APOE), a glycoprotein which is synthesized in a wide variety of extrahepatic tissues including skin [ 27 - 29 ]. (hindawi.com)
  • The apolipoproteinE (APOE) gene provides instructions for the production of the apolipoprotein E (apoE) protein. (randox.com)
  • Apolipoprotein E (apoE) is a multifunctional glycoprotein with central roles in lipid metabolism, neurobiology, and neurodegenerative diseases. (randox.com)
  • ApoE has three major isoforms (apoE2, apoE3, and apoE4) all of which have different effects on lipid and neuronal homeostasis (fig 1). (randox.com)
  • The C 2 N test relies on the ratio of two isoforms of the amyloid-β protein, Aβ42 and Aβ40, that aggregate to form amyloid plaques in the brain, combined with the presence of isoforms of apolipoprotein E (ApoE) that reflect whether the patient caries a genetic variant associated with Alzheimer's risk. (the-scientist.com)
  • The APOE gene encodes 3 isoforms Ɛ4, Ɛ3 and Ɛ2 with APOE Ɛ4 associated with higher plasma cholesterol levels and increased pathogenesis in several infectious diseases (HIV, HSV). (edu.au)
  • There is some evidence that apolipoprotein E (apoE) binds to Aß peptide and modulates its aggregation into plaques. (brightfocus.org)
  • ApoE has three isoforms, apoE2, apoE3 and apoE4, and reports have shown that each apoE form may affect Aß aggregation in a specific manner. (brightfocus.org)
  • We have used FPOP to characterize the oligomeric structures of three human apolipoprotein E: ApoE) isoforms and a monomeric mutant in their lipid-free states. (wustl.edu)
  • We find that the three common isoforms of ApoE are very similar in their solvent accessible footprint, that their oligomeric interactions involve several regions in the C-terminal domain, and that the N-terminal domain of each resembles the monomeric mutant's N-terminal domain, the truncated form of which has been characterized as a four-helix bundle. (wustl.edu)
  • Apolipoprotein E (ApoE) is expressed as Molecular Biology of Neurodegenerative Diseases. (web.app)
  • APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. (web.app)
  • Apolipoprotein E spielt im Katabolismus von Chylomikronen, IDL und VLDL-Remnants wie auch von ApoE-reichem HDL eine wichtige Rolle. (web.app)
  • Apolipoprotein E (APOE) plays an important role in cholesterol transport and genetic variants in APOE have been linked to the risk of Alzheimer's disease. (web.app)
  • 2020-08-16 · The APOE gene provides instructions for making a protein called apolipoprotein E. This protein combines with fats (lipids) in the body to form molecules called lipoproteins. (web.app)
  • APOE / Apolipoprotein E Protein LS-G39871 is a Recombinant Human APOE / Apolipoprotein E produced in Human Cells Lys19-His317 with 6His, C-terminus tag(s). (web.app)
  • Human apoE exists as three common isoforms and the parent form, apoE3, operates optimally in promoting clearance of triglyceride (TG)‐rich lipoproteins and is associated with normal plasma lipid levels. (web.app)
  • Noting that apolipoprotein E (apoE) has been shown to enhance cellular uptake and gene silencing for ionizable lipid nanoparticles, the scientists set out to study the effects various apolipoproteins would have on cKK-E12. (genomeweb.com)
  • In vitro experimentation revealed that the addition of an apoE isoform called apoE3 boosted cell uptake of the nanoparticle over nine-fold, while improving the escape of siRNAs from endosomes into cytosol. (genomeweb.com)
  • Researchers highlight recent research investigating whether gut microbiota regulates tau pathology and tau-mediated neurodegeneration in an ApoE isoform-dependent manner. (news-medical.net)
  • Apolipoprotein E (ApoE), an important mediator of lipid transportation in plasma and the nervous system, plays a large role in diseases such as atherosclerosis and Alzheimer's. (diva-portal.org)
  • Small-angle neutron scattering shows that the ApoE containing lipid particles form elliptical disc-like structures, similar in shape but larger than nascent or discoidal HDL based on Apolipoprotein A1 (ApoA1). (diva-portal.org)
  • Apolipoprotein E (ApoE) is a major lipid carrier that supports lipid transport and injury repair in the brain. (biomedcentral.com)
  • Maintaining normal levels of cholesterol is essential for the Apolipoprotein E has been found in amyloid plaques in the cerebral cortex of patients with Alzheimer's disease as well as in other types of amyloid. (web.app)
  • The apoE4 isoform is associated with increased cholesterol, cardiovascular risk, and Alzheimer's Disease risk, however, its distribution is not well-understood among US Latinos. (elsevierpure.com)
  • Researchers characterize the effects of neuronal apolipoprotein E4 on Alzheimer's disease-associated pathology. (news-medical.net)
  • The apolipoprotein E allele ϵ4 is overrepresented in patients with the Lewy body variant of Alzheimer's disease. (jamanetwork.com)
  • St Clair DNorrman JPerry RYates CWilcock GBrookes A Apolipoprotein E ϵ4 allele frequency in patients with Lewy body dementia, Alzheimer's disease and age-matched controls. (jamanetwork.com)
  • Apolipoprotein E ϵ4 allele in Alzheimer's disease and vascular dementia. (jamanetwork.com)
  • SPECT and MRI analysis in Alzheimer's disease: relation to apolipoprotein E ϵ4 allele. (jamanetwork.com)
  • Juottonen KLehtovirta MHelisalmi SRiekkinen Sr PJSoininen H Major decrease in the volume of the entorhinal cortex in patients with Alzheimer's disease carrying the apolipoprotein E ϵ4 allele. (jamanetwork.com)
  • Kalaria RNCohen DLPremkumar DRD Apolipoprotein E alleles and brain vascular pathology in Alzheimer's disease. (jamanetwork.com)
  • No isoform-specific differences in CNS ApoE3 and ApoE4 turnover rates were observed when measured in human CSF or mouse brain. (wustl.edu)
  • It has three major isoforms (apoE2, apoE3, and apoE4) with different effects on lipid and neuronal homeostasis. (web.app)
  • The protective ApoE4 isoform lacks these cysteines and is resistant to phase separation and condensate formation. (jci.org)
  • Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. (google.es)
  • Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease. (google.es)
  • 1997) No association between apolipoprotein E epsilon4 allele and the age of onset in type I familial amyloid polyneuropathy. (web.app)
  • The apolipoprotein E polymorphism and the cholesterol-raising effect of coffee. (web.app)
  • Neuropathological evaluation and apolipoprotein E gene polymorphism analysis in diffuse Lewy body disease. (jamanetwork.com)
  • Apolipoprotein E polymorphism in patients with different neurodegenerative disorders. (jamanetwork.com)
  • characterized by low overall levels of glycosylation with elevated levels of asialo- (no sialic acids) or monosialotransferrin (one sialic acid) isoforms, instead of the normal tetrasialotransferrin. (cdghub.com)
  • Other indirect alcohol biomarkers of emerging interest include total serum sialic acid (TSA), 5-hydroxytryptophol (5-HTOL), N-acetyl-beta-hexosaminidase (Beta-Hex), plasma sialic acid index of apolipoprotein J (SIJ), and salsolinol. (medscape.com)
  • Apolipoprotein B binds to specific receptors on cell membranes and is involved in removal of LDL and very low density lipoprotein (VLDL) cholesterol from circulation. (thermofisher.com)
  • Apolipoprotein E is the recognition site for receptors involved in the clearance of remnants of very low density lipoproteins and chylomicrons (summary by Blum, 2016). (web.app)
  • Epistatic Interactions between apolipoprotein E and hemoglobin S Genes in regulation of malaria para. (edu.au)
  • The protein diversity of mammalian cells is determined by arrays of isoforms from genes. (elifesciences.org)
  • Apolipoprotein E genes in Lewy body and Parkinson's disease [letter]. (jamanetwork.com)
  • 1-3 Although individuals carrying the ε4 allele have higher and those carrying the Apolipoprotein (apo) E is a 299‐residue protein which functions as a key regulator of plasma lipid levels. (web.app)
  • To that end, the team synthesized a collection of synthetic lipopeptides designed to mimic apolipoproteins by conjugating lipid tails to amino acids, peptides, and polypeptide head groups. (genomeweb.com)
  • Apolipoprotein B is mostly synthesized in the liver, and is a major apolipoprotein of very low density, intermediate density and low density lipoproteins (LDL) as well as being a major component of lipoprotein (a). (thermofisher.com)
  • Apolipoprotein C-II (Apo-CII, or Apoc-II), or apolipoprotein C2 is a protein that in humans is encoded by the APOC2 gene. (wikipedia.org)
  • Apolipoprotein B (apo B) in human plasma is a major protein of low density lipoproteins (LDL) with a molecular mass of approximately 260-500 kDa. (thermofisher.com)
  • While protein expression is dictated by the level of gene expression, the structure and function of the protein is largely determined by the isoforms of the mRNA of a given gene and are impacted by mutations or other structural alterations to the amino acids ( Faustino and Cooper, 2003 ). (elifesciences.org)
  • CDT is a collection of various isoforms of the iron transport protein transferrin. (medscape.com)
  • Isoform-dependent lysosomal degradation and internalization of apolipoprotein E requires autophagy proteins. (bvsalud.org)
  • The intestinal and the hepatic forms of Apolipoprotein B are encoded by a single gene from a single, very long mRNA. (thermofisher.com)
  • Through Uniform Manifold Approximation and Projection (UMAP) analysis, we identified a panel of mutation mRNA isoforms highly specific to HCC cells. (elifesciences.org)
  • To understand the role of each cell in an organism, broad spectrum mRNA isoform and mutational gene expression analyses at the single-cell level is necessary. (elifesciences.org)
  • Moreover, apolipoprotein genotype analysis revealed that AD subjects with the E3/E4 alleles had the highest content of mitochondrial APP. (jneurosci.org)
  • Apolipoprotein E alleles, dyslipidemia, and coronary heart disease: the Framingham Off spring Study. (web.app)
  • Volumes of hippocampus, amygdala and frontal lobe in Alzheimer patients with different apolipoprotein E genotypes. (jamanetwork.com)
  • Isoe KUrakami KSato KTakahashi K Apolipoprotein E in patients with dementia of the Alzheimer type and vascular dementia. (jamanetwork.com)
  • Apolipoprotein E Abnormal Function of Metalloproteins Underlies Most Neurodegenerative Diseases. (web.app)
  • Immunofluorescence analysis of Apolipoprotein B was performed using 70% confluent log phase Hep G2 cells. (thermofisher.com)
  • In this report, we developed a strategy to integrate Element Biosciences' LoopSeq intramolecular barcoding technique with 10x Genomics' cell barcoding scheme to create a single-cell long-read isoform analysis vehicle. (elifesciences.org)
  • Differential effects of apolipoprotein E isoforms on phosphorylation at specific sites on tau by glycogen synthase kinase-3 beta identified by nano-electrospray mass spectrometry. (ox.ac.uk)
  • Normal plasma apolipoprotein B levels are around 800mg/L. Apolipoprotein B occurs in plasma as two main isoforms, apoB-48 and apoB-100. (thermofisher.com)
  • Scientific Reports] Apolipoprotein isoforms were explored for their associations with HCC. (stemcellsciencenews.com)
  • and thus may be most suited for the mutational isoform expression analyses. (elifesciences.org)
  • Randox offer dedicated apolipoprotein calibrator and controls for a complete testing package . (randox.com)
  • unfortunately, the structural reason for this association is not known, in part because no high resolution structure exists of any isoform. (wustl.edu)