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  • differ
  • Several PML isoforms, designated PMLI to PMLVIIb, which differ within their C-terminal end, are expressed by alternative splicing of a single PML gene. (frontiersin.org)
  • VEGF exists in the mouse primarily as three isoforms , VEGF 120, 164, and 188, that differ in their ability to bind heparan sulfate proteoglycans on the cell surface and in the extracellular matrix. (thefreedictionary.com)
  • These four isoforms differ in TSS, and one differs in the CDS. (wikipedia.org)
  • The isoforms differ in the 3' UTR and coding sequence. (wikipedia.org)
  • demonstrate
  • These studies demonstrate that ICAM-1 immunobiology is highly complex but that individual isoforms, aside from the full-length molecule, make significant contributions to disease development and pathogenesis. (jimmunol.org)
  • Taken together, our results demonstrate that AOX isoforms are differentially activated and that activation at CysI and CysII is additive. (plantphysiol.org)
  • acute
  • Here we have investigated inducible isoforms of COX and NOS in the acute, chronic, and resolving stages of a murine air pouch model of granulomatous inflammation. (pnas.org)
  • specific
  • Recent studies of all the PML isoforms reveal the specific functions of each. (frontiersin.org)
  • The variations in the COOH-terminal regions lead to the specific functions of each PML isoform. (frontiersin.org)
  • Organ specific and seasonal accumulation of viscotoxin-isoforms in Viscum album ssp. (thefreedictionary.com)
  • This complexity is further complicated by the observation that the specific downstream effects of p38 MAPK activation depends not only on stimuli but also on cell types and perhaps also on various p38 MAPK isoforms involved. (thefreedictionary.com)
  • The MT-1 and MT-2 isoforms are most widely expressed, whereas MT-3 is largely brain-specific and MT-4 is located mainly in stratified squamous epithelia (Cherian et al. (thefreedictionary.com)
  • If men lack a specific isoform of this gene, we may be able to personalise their therapy", he explained. (thefreedictionary.com)
  • enzyme
  • Two isoforms of COX exist: a constitutive (COX-1) and an inducible (COX-2) enzyme. (pnas.org)
  • Hyaluronan synthase, the enzyme responsible for the production of hyaluronan, has three isoforms in mammalian cells. (wikipedia.org)
  • mice
  • In the generation of ICAM-1-deficient mice, two isoform-deficient ICAM-1 mutants were inadvertently produced as a result of alternative splicing. (jimmunol.org)
  • These mice, along with true ICAM-1-deficient mice and newly generated ICAM-1-transgenic mice, have provided the opportunity to begin examining the role of ICAM-1 isoforms (singly or in combination) in various disease settings. (jimmunol.org)
  • In this review, we highlight the sharply contrasting disease phenotypes using ICAM-1 isoform mutant mice. (jimmunol.org)
  • Mice also have three reported isoforms. (wikipedia.org)
  • exon
  • eIF4A III, which shares only 65% similarity to the other isoforms is believed to be a core component of the exon junction complex involved in pre-mRNA splicing. (wikipedia.org)
  • extracellular
  • Use of this vector in cell transfection experiments enabled us to produce multiple CD45 isoforms (ABC, B, Null), with their extracellular segment intact, and the entire membrane spanning and intracellular C-terminal domain replaced by a GPI-membrane-anchor and VSV-tag. (ovid.com)
  • transmembrane
  • ICAM-1 is a member of the Ig supergene family, and the full-length isoform is composed of five Ig domains, a transmembrane domain, and a short cytoplasmic tail with multiple threonine residues ( Fig. 1A ) ( 6 ). (jimmunol.org)
  • A ) Full-length ICAM-1 isoform with five Ig domains and transmembrane and intracellular domains. (jimmunol.org)
  • ions
  • Invertebrate trypsins have the characteristics of the Clan PA, family SlA, in common, although they exhibit some distinct features, such as apparent independence of calcium ions, activity toward native proteinaceous substrates, high number of isoforms , and poor stability at acid pH. (thefreedictionary.com)