Isoform between 1. Medical search. Frequent questions

However, it is not yet known whether the relative abundance of transcript isoforms may be informative for clinical stage and survival. (biorxiv.org)
Methods Using information theory and machine learning methods, we integrated RNA sequencing and clinical data from The Cancer Genome Atlas project to perform the first systematic analysis of the prognostic potential of transcript isoforms in 12 solid tumors to build new predictive signatures for stage and prognosis. (biorxiv.org)
Results Transcript isoform signatures accurately separate early from late stage and metastatic from non-metastatic tumors, and are predictive of the survival of patients with undetermined lymph node invasion or metastatic status. (biorxiv.org)
Furthermore, we show frequent transcript isoform changes in breast tumors according to estrogen receptor status, and in melanoma tumors according to the invasive or proliferative phenotype, and derive accurate predictive models of stage and survival within each patient subgroup. (biorxiv.org)
Conclusions Our analyses reveal new signatures based on transcript isoform abundances that characterize tumor phenotypes and their progression independently of gene expression. (biorxiv.org)
Transcript isoform signatures appear especially relevant to determine lymph node invasion and metastasis, and may potentially contribute towards current strategies of precision cancer medicine. (biorxiv.org)
On the other hand, gene expression summarizes the output of RNA transcripts from a gene locus, which is mostly explained by one transcript isoform [ 10 ]. (biorxiv.org)
This prompts the question of whether transcript isoform changes, which remain largely unexplored as predictive signatures of tumor stage and survival, could hold relevant novel mechanisms of tumor progression. (biorxiv.org)
We investigated the predictive potential of the relative abundances of transcript isoforms for tumor staging and clinical outcome in 12 different tumor types, integrating RNA sequencing and clinical annotation data for 12 tumor types from The Cancer Genome Atlas (TCGA) project. (biorxiv.org)
Knowledge about the relative abundance of transcript isoforms in tumors can potentially help predicting stage and clinical outcome and contribute towards current molecular strategies in precision cancer medicine. (biorxiv.org)
The predominant human CDKL5 brain isoform is a 9.7kb transcript comprised of 18 exons with a large 6.6kb 3'-untranslated region (UTR). (nih.gov)
In this study we characterise, both bioinformatically and experimentally, the rat Cdkl5 gene structure and its associated transcript isoforms. (nih.gov)
New exonic regions, splice sites and UTRs are described, confirming the presence of four distinct transcript isoforms. (nih.gov)
In other words, the identification of true orthology relationships between gene products now should progress beyond primary sequence and "splicing orthology", consisting in ancestrally shared exon-intron structures, is required to define orthologous isoforms at transcript level. (biomedcentral.com)
A typical human gene, then, produces multiple transcript isoforms (ten per gene, on average), that can differ both in their coding and untranslated regions. (biomedcentral.com)
Transcript levels of SREBP1c, the most abundant isoform in adipose tissue, were significantly decreased in the subcutaneous adipose tissue of obese normoglycemic and type 2 diabetic subjects compared with that of nonobese normoglycemic control subjects. (diabetesjournals.org)

The predominant isoform in the brain, which we name rCdkl5_1, is orthologous to the human hCDKL5_1 and mouse mCdkl5_1 isoforms and is the most highly expressed isoform across all brain regions tested. (nih.gov)

The protein encoded by the casein kinase 1 epsilon gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. (wikipedia.org)
Like other casein kinase 1 protein family members, casein kinase 1 epsilon recognizes the Ser(p)XXSer/Thr motif for phosphorylation. (wikipedia.org)
The Casein kinase 1 epsilon protein is part of the mammalian oscillator, a group of proteins that keep cells on a roughly 24-hour schedule. (wikipedia.org)
The autosomal dominant monogenetic disease neurofibromatosis type 1 (NF1) affects approximately one in 3,000 individuals and is caused by mutations in the NF1 tumour suppressor gene, leading to dysfunction in the protein neurofibromin (Nf1) 1 , 2 . (nature.com)
Objective -To investigate whether protein kinase C (PKC) isoforms are expressed in equine skeletal muscle and determine their distribution in various types of fibers by use of immunofluorescence microscopy. (avma.org)
Sterol regulatory element binding protein (SREBP)-1 is a transcription factor with important roles in the control of fatty acid metabolism and adipogenesis. (diabetesjournals.org)
Exposure of isolated human adipocytes to tumor necrosis factor-α (TNF-α) produced a marked and specific decrease in the mRNA encoding the SREBP1c isoform and completely blocked the insulin-induced cleavage of SREBP1 protein. (diabetesjournals.org)
During validation of a yeast two-hybrid screen using p120 as bait, I detected an isoform-specific interaction with Delta-Interacting Protein A (DIPA). (vanderbilt.edu)
DIPA is the first protein discovered to selectively interact with isoform p120-1, and my data suggest that their relationship is potentially important for a novel, cell contact mediated function. (vanderbilt.edu)
The human IL22RA2 gene co-produces three protein isoforms in dendritic cells [IL-22 binding protein isoform-1 (IL-22BPi1), IL-22BPi2, and IL-22BPi3]. (ehu.eus)
Identification and localization of an actin-binding motif that is unique to the epsilon isoform of protein kinase C and participates in the regulation of synaptic function. (rupress.org)
Individual isoforms of the protein kinase C (PKC) family of kinases may have assumed distinct responsibilities for the control of complex and diverse cellular functions. (rupress.org)
Thus, actin appears to be a bifunctional anchoring protein that is specific for the PKC epsilon isoform. (rupress.org)
Using hybrid/integrative modeling, involving multiple experimental and computational methods, we have been able provide mechanistic insights into the role of cryptochromes a core clock protein, in regulating circadian period length, thus directly relating protein structure and dynamics to in vitro and in vivo experimental observations [1]. (imsc.res.in)
Expression of Uncoupling Protein 1 in Mouse Brown Adipose Tissue Is Thyroid Hormone Receptor- Isoform Specific and Required for Adaptive Thermogenesis. (deiodinase.org)
Heat production from BAT requires sympathetic nervous system stimulation, T3, and uncoupling protein 1 (UCP1) expression. (deiodinase.org)
The S. cerevisiae Yck2 protein is a plasma membrane-associated member of the casein kinase 1 protein kinase family that, with its homolog Yck1p, is required for bud morphogenesis, cytokinesis, endocytosis and other cellular processes. (elsevierpure.com)
Prion diseases are neurodegenerative conditions prion protein (PrPC), which predominantly accumulates associated with a misfolded and infectious protein, scrapie in the central nervous system ( 1 ). (cdc.gov)
The abnormal isoform, prion protein (PrPSc). (cdc.gov)

Furthermore, atazanavir and ritonavir are themselves substrates for CYP3A4 isoform of cytochrome P450. (who.int)
metabolised by the 3A4 isoform of cytochrome P450 (CYP3A4), and some drugs can substantially increase the plasma levels of these statins. (who.int)
Therefore, the statin chosen for the study is pitavastatin since its concentration according to in vitro and in vivo data indicates that it is not is metabolised by the 3A4 isoform of cytochrome P450 in a clinically significant amount, making it the statin with the fewest interactions. (who.int)

The cryo-electron microscopy structure reveals domain organization and structural details of the Nf1 exon 23a splicing 3 isoform 2 in a closed, self-inhibited, Zn-stabilized state and an open state. (nature.com)
Inclusion of exon 23a is found in most human tissues but predominately skipped in neurons of the central nervous system 3 , and variation of the isoform 1/2 splicing ratio leads to disturbed neuronal differentiation 11 . (nature.com)
Mice carrying a allele deleted in the third exon common to both and isoform display normal erythropoiesis.9 Together these findings suggest that is required for the differentiation of fetal erythroid progenitors. (bioerc-iend.org)
Some 30% of PPH-causing mutations localize to exon 12, which may be spliced out forming an isoform depleted of the unusually long BMPR-II cytoplasmic tail. (lincoln.ac.uk)
We now report that Tctex-1, a light chain of the motor complex dynein, interacts with the cytoplasmic domain of BMPR-II and demonstrate that Tctex-1 is phosphorylated by BMPR-II, a function disrupted by PPH disease causing mutations within exon 12. (lincoln.ac.uk)
We used q-RT-PCR and exon-exon spanning assays to analyze the expression of four alternatively spliced CD44 isoforms as well as the total expression of CD44 in 187 breast tumors and 13 cell lines. (lu.se)

2020 Jan;16(1):178-191. (alzforum.org)
Sci Rep . 2020 Nov 13;10(1):19769. (alzforum.org)

Our high-resolution single particle cryo-electron microscopy (EM) structures reveal the domain organization and structural details of the full-length Nf1-23a isoform 2 dimer (Fig. 1a-c , Extended Data Figs. 1 - 3 ). (nature.com)
Neurons are capable of expressing a surprising diversity of trk receptor structural isoforms that arise via alternative splicing ( Barbacid, 1994 ). (jneurosci.org)
In this study, we report the cryoEM structure of pannexin 3 at 3.9 Å and characterize the structural differences with pannexin isoforms 1 and 2. (sciety.org)
The results showcase a complete comparison of the three pannexin isoform structures that along with the structure of Pannexin 1 congenital mutant highlight distinct structural features of pannexin isoforms and the allosteric role of distant substitutions in dictating channel behavior in Pannexin 1. (sciety.org)

Alternative splicing of the avian trkB receptor generates an extracellular deletion (ED) isoform missing 11 amino acids from the neurotrophin-binding domain of the full-length (FL) receptor. (jneurosci.org)
When expressed in fibroblasts, the ED isoform exhibited restricted neurotrophin specificity compared with that of the FL receptor. (jneurosci.org)
As found for the ED isoform, the FL mutated receptor displayed a similar loss of NT-3- and NT-4-mediated activation, in addition to a diminished responsiveness to BDNF. (jneurosci.org)
Because of these profound effects on ligand specificity, reverse transcription-PCR was used to understand the expression of the FL and ED receptor isoforms at the level of single neurons. (jneurosci.org)
In this study, comparison of the ligand specificity of the full-length (FL) and ED receptor isoforms revealed that ED trkB exhibits a more restricted neurotrophin specificity than does FL trkB. (jneurosci.org)
Feline leukemia virus subgroup C receptor 1 (isoforms during erythropoiesis. (bioerc-iend.org)
Mechanistically, hyperpolarization-activated cyclic nucleotide-gated 4 (HCN4) channels form functional microdomains almost exclusively with ACI, while ryanodine receptor and L-type Ca2+ channels likely compartmentalize with ACI and other AC isoforms. (ox.ac.uk)
Our previous studies with a thyroid hormone receptor- (TR ) isoform-selective agonist demonstrated that after TR stimulation alone, adaptive thermo- genesis was markedly impaired, although UCP-1 expression in BAT was normal. (deiodinase.org)
BT-474 cells, obtained expression of the receptor has important implications for their biology from American Type Culture Collection, were maintained in RPMI 1640 and therapy (1). (lu.se)
A high expression of the CD44v2-v10 isoform, which retain all variant exons, was correlated to positive steroid receptor status, low proliferation and luminal A subtype. (lu.se)

The ubiquitous Nf1 isoform-2 splice variant Nf1-23a (2839aa) is, together with Nf1 isoform 1, which lacks the 23a insertion (2818aa), one of the two biologically relevant alternative Nf1 isoforms. (nature.com)
In this study, I show that DIPA co-localizes and co-immunoprecipitates reciprocally with the long p120-1 isoform, but not the shorter p120-3 isoform, which lacks an N-terminal head domain. (vanderbilt.edu)
Tumors characterized as positive for the CD44+/CD24- phenotype by immunohistochemistry were associated to all isoforms except the CD44 standard (CD44S) isoform, which lacks all variant exons. (lu.se)

We performed bioassays to the host's PrPC through a PrPSc-templated conversion in transgenic mice expressing human PrP to assess prion process ( 1 ). (cdc.gov)

Tumors advance through stages that are generally characterized by their size and spread to lymph nodes and other parts of the body [ 1 ]. (biorxiv.org)
Furthermore, we described before how solid tumors present frequent changes in the relative abundances of isoforms in comparison to normal tissues [ 11 ]. (biorxiv.org)
Unsupervised hierarchical cluster analysis of CD44 isoform expression data divided tumors into four main clusters, which showed significant correlations to molecular subtypes and differences in 10-year overall survival. (lu.se)

Although HDACs share redundant functions and common substrates, the unique isoform-specific roles of different HDACs in GBM remain unclear. (jci.org)

There are current gaps in our knowledge regarding the dominant AC isoforms and the specific roles of Ca2+-activated ACs in the SAN. (ox.ac.uk)
The findings provide insights into the critical roles of the Ca2+-activated isoform of AC in sustaining SAN automaticity that is distinct from contractile cardiomyocytes. (ox.ac.uk)
This allows us to consider the extent to which the atrial vs ventricular mechanical characteristics are defined by the myosin isoform expressed, and how the isoform properties are matched to their physiological roles. (cam.ac.uk)

Notably, the ventricle expresses predominantly β-cardiac myosin while the atrium expresses mostly the α-isoform. (cam.ac.uk)

Both the NOD mouse and human Deaf1 variant isoforms suppressed PTA expression by inhibiting the transcriptional activity of canonical Deaf1. (nih.gov)
Skeletal actin mRNA increases in the human heart during ontogenic development and is the major isoform of control and failing adult hearts. (jci.org)
In the case of dot blot analysis, quantification of each isoform was performed by using as standards RNA transcripts obtained from cloned human alpha-actin sequences, and the total amount of sarcomeric actin mRNA was evaluated as a function of total poly(A+)RNA. (jci.org)
Figure 1: CD3/CD46 stimulation induces IL-10 production in human peripheral blood CD4 + T lymphocytes. (nature.com)
Alpha and beta myosin isoforms and human atrial and ventricular contraction. (cam.ac.uk)
Fipronil induces CYP isoforms and cytotoxicity in human hepatocytes. (cdc.gov)
These guidelines update previous CDC recommendations for treating and preventing active tuberculosis (TB) among adults and children coinfected with human immunodeficiency virus (HIV) (1-3). (cdc.gov)
The ambiguous tole of the Na+-H(+) exchange isoform 1 (NHE1) in leptin-induced oxidative stress in human monocytes. (bvsalud.org)

Also, p120-1 expression is required for the plasma membrane localization of DIPA. (vanderbilt.edu)

Contrasting an unpublished low-resolution, symmetric Nf1 model 15 , two distinct populations of the Nf1-23a dimer are present: (1) a major population with both protomers showing a closed, auto-inhibited conformation (closed Nf1 state) stabilized by Zn and (2) a second population (open Nf1 state) with one protomer in the auto-inhibited conformation and the other protomer in an open configuration necessary for Ras binding (Fig. 1d ). (nature.com)
The current study tests the hypothesis that distinct AC isoforms are preferentially expressed in the SAN and compartmentalize within microdomains to orchestrate heart rate regulation during β-AR signaling. (ox.ac.uk)
We observe the organization of the Pannexin 3 vestibule into two distinct chambers with a wider pore radius in comparison to both PANX1 and 2 isoforms. (sciety.org)

There is currently a lack of protocols for the accurate quantification of A-to-I-edited microRNA isoforms using qPCR. (lu.se)

Additionally, NRG1 isoform-specific expression patterns in the brain have been described, but isoform-specific functions remain unclear. (uni-goettingen.de)

Deficiency in plasma membrane calcium ATPase isoform 2 increases susceptibility to noise -induced hearing loss in mice. (cdc.gov)

abstract = "Early non-invasive detection of recanalisation within 1 hour of its implementation pharmacologically is needed to facilitate optimal selection of patients requiring further aggressive management of acute myocardial infarction. (elsevierpure.com)

Neuregulin 1 (NRG1) is the best characterized member of a family of epidermal growth factor (EGF)-like domain containing proteins that serve as ligands for tyrosine kinase receptors of the ErbB family. (uni-goettingen.de)
The present study unveils the structure-function and evolutionary aspects of 1-aminocyclopropane-1-carboxylic acid deaminase (ACCD) proteins of fungal origin. (springeropen.com)

Somatic Nf1 mutations are also present in 5-10% of cancers, demonstrating the role of Nf1 as a tumour suppressor 1 . (nature.com)

Operation of the schizophrenia susceptibility gene, neuregulin 1, across traditional diagnostic boundaries to increase risk for bipolar disorder. (cdc.gov)
Support for neuregulin 1 as a susceptibility gene for bipolar disorder and schizophrenia. (cdc.gov)

gene including isoforms A-G (1 2 Reduction or altered appearance of RASSF1A by either homozygous or heterozygous deletions from the gene (1) or by hypermethylation from the gene promoter (2 -7) continues EPZ005687 to be from the pathogenesis of a number of malignancies. (healthandwellnesssource.org)

We identified an equivalent variant Deaf1 isoform in the PLNs of patients with type 1 diabetes. (nih.gov)
The effects of a neuregulin 1 variant on white matter density and integrity. (cdc.gov)

Adenylyl cyclase isoform 1 contributes to sinoatrial node automaticity via functional microdomains. (ox.ac.uk)

J Cell Biol (1996) 132 (1): 77-90. (rupress.org)
These previous documents are summarized and referenced in Table 1 and in Part I of the 1996 Guideline for Isolation Precautions in Hospitals 1 . (cdc.gov)

16(1): 257, 2023 Oct 05. (bvsalud.org)

Type 1 diabetes may result from a breakdown in peripheral tolerance that is partially controlled by the expression of peripheral tissue antigens (PTAs) in lymph nodes. (nih.gov)
Lower PTA expression resulting from the alternative splicing of DEAF1 may contribute to the pathogenesis of type 1 diabetes. (nih.gov)
The predominant expression pattern of either FL or ED isoforms in single embryonic DRG neurons establishes the existence of two subpopulations exhibiting differential responsiveness to trkB ligands, indicating that regulated splicing of the extracellular domain of trkB may serve as a mechanism to restrict neuronal responsiveness to the neurotrophins. (jneurosci.org)
Breast cancer cell lines showed a heterogeneous expression pattern of the CD44 isoforms, which shifted considerably when cells were grown as mammospheres. (lu.se)
The CD44v3-v10 isoform showed similar correlations, while high expression of CD44v8-v10 was correlated to positive EGFR, negative/low HER2 status and basal-like subtype. (lu.se)
Efforts to link CD44 to CSCs and tumor progression should consider the expression of various CD44 isoforms. (lu.se)

Conclusions and Clinical Relevance -Results indicated that PKC isoforms are expressed in equine skeletal muscle in a fiber type-specific manner. (avma.org)

Accordingly, assessment of activities of MM CK isoforms in plasma should prove useful in differentiating patients with and without reperfusion at a time when additional interventions needed to consolidate the gains accompanied by initial pharmacological treatment can still be initiated effectively. (elsevierpure.com)

157(1):1-2, January 2016. (lww.com)
157(1):3-4, January 2016. (lww.com)
157(1):5-6, January 2016. (lww.com)
157(1):7-29, January 2016. (lww.com)
157(1):30-54, January 2016. (lww.com)
157(1):55-64, January 2016. (lww.com)
157(1):65-69, January 2016. (lww.com)
157(1):70-79, January 2016. (lww.com)
157(1):80-91, January 2016. (lww.com)
157(1):92-102, January 2016. (lww.com)

Casein kinase I isoform epsilon or CK1ε, is an enzyme that is encoded by the CSNK1E gene in humans. (wikipedia.org)
Only the delta and epsilon isoforms have been shown to play an important role in circadian rhythm regulation. (wikipedia.org)
In this study, we show that an isoform specific interaction between PKC epsilon and filamentous actin may serve as a necessary prelude to the enhancement of glutamate exocytosis from nerve terminals. (rupress.org)
The binding of PKC epsilon to actin required that the kinase be activated, presumably to expose a cryptic binding site that we have identified and shown to be located between the first and second cysteine-rich regions within the regulatory domain of only this individual isoform of PKC. (rupress.org)

therefore, this kinase is very similar to other members of the casein kinase 1 family, of which there are seven mammalian isoforms (α, β, γ1, γ2, γ3, δ and ε). (wikipedia.org)
Isoform-selective regulation of mammalian cryptochromes. (imsc.res.in)

Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2006 Jan 141B (1): 102-9. (cdc.gov)
Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010 Jan 153B (1): 141-7. (cdc.gov)

heterogeneity, all classic prion diseases are characterized by PrPSc is generally considered the major, if not the sole, the presence of an abnormal isoform of the normal cellular component of the infectious agent in prion diseases ( 1 , 4 , 5 ). (cdc.gov)

Taken together, these data demonstrate a discrete function for the cytoplasmic domain of BMPR-II and justify further investigation of whether the interaction with and phosphorylation of Tctex-1 contributes to the pathogenesis of PPH. (lincoln.ac.uk)

The different isoforms differ mostly in the length and structure of their C-terminal non-catalytic region. (wikipedia.org)

The p120 family members ARVCF, p0071, and δ-catenin have similar N-terminal regions to p120-1 and also bind to DIPA, suggesting that the interaction is highly conserved. (vanderbilt.edu)

The sCJDMM1 affecting humans and animals, have received subtype (affecting persons homozygous for methionine considerable attention largely because of their intriguing at codon 129 and carrying the PrPSc type 1) accounts for pathogenetic mechanism and the threat they pose to public 70% of all cases of sCJD and unquestionably is the most health because of their insidious infectivity. (cdc.gov)
Equine rhinitis A virus, formerly known as equine rhinovirus 1, causes a respiratory disease in horses similar to the common cold in humans. (warf.org)

2017 Mar 1;603:21-26. (nih.gov)

We propose potential mechanisms underlying transcriptional induction of endothelial MT isoforms. (go.jp)
In this talk, I will present the work that we have been doing to not only enhance the understanding of molecular mechanisms regulating circadian clock [1] but also to develop therapeutic interventions to modulate the circadian rhythms in mammals [2, 3]. (imsc.res.in)

Cryosections of equine muscle were stained with PKC isoform (α, β1, β2, δ, ξ, or ζ)-specific polyclonal antibodies and examined by use of a fluorescence microscope. (avma.org)
For some PKC isoforms, distribution was specific for fiber type. (avma.org)
The specific reduction in the SREBP1c isoform seen in the adipose tissue of obese and type 2 diabetic subjects can be recapitulated ex vivo by TNF-α, suggesting a possible mechanism for this association. (diabetesjournals.org)
For this purpose, a conditional transgenic mouse line was produced that permits stage- and cell type-specific overexpression of the Ig-NRG1 isoform under control of the β-actin promoter after Cre-mediated removal of a "floxed" STOP-cassette. (uni-goettingen.de)
10 Nevertheless the specific role of isoforms in erythropoiesis is still debated. (bioerc-iend.org)
To get insights into the specific functions of and in erythropoiesis we used animal and cultured cell models that differentially express the two isoforms. (bioerc-iend.org)
The assembly of this isoform-specific signaling complex appears to play a primary role in the PKC-dependent facilitation of glutamate exocytosis. (rupress.org)
Our study highlights the importance of HDAC1 in GBM and the need to develop isoform-specific drugs. (jci.org)

In the present study, we investigated the binding sites of MTF-1 and Nrf2 in the promoter regions of MT s in cultured bovine aortic endothelial cells treated with these organopnictogen compounds. (go.jp)
Specifically, both MRE activation by MTF-1 and that of ARE in the promoter region of the MT-2A gene by Nrf2 are involved in transcriptional induction of MT-1A , whereas only MRE activation by MTF-1 or other transcriptional factor(s) is required for transcriptional induction of MT-2A in vascular endothelial cells. (go.jp)
Analysis of a promoter polymorphism in the SMDF neuregulin 1 isoform in Schizophrenia. (cdc.gov)

Here, we describe a protocol to quantify microRNA editing isoforms using two-tailed RT-qPCR, with either SYBR Green or hydrolysis probes. (lu.se)

2022 May 1, In: Journal of Lipid Research. (lu.se)

We aimed to investigate potential associations between alternatively spliced isoforms of CD44 and CSCs as well as to various breast cancer biomarkers and molecular subtypes. (lu.se)

These family members can recruit DIPA to the plasma membrane in the absence of p120-1. (vanderbilt.edu)

[ 1 , 2 ] Meningiomas are believed to arise from the meningothelial cell (arachnoid cap cell) and usually are attached to the inner surface of the dura mater. (medscape.com)

Analysis of polymorphisms in AT-rich domains of neuregulin 1 gene in schizophrenia. (cdc.gov)
An association study of the neuregulin 1 gene, bipolar affective disorder and psychosis. (cdc.gov)
Neuregulin 1 and age of onset in the major psychoses. (cdc.gov)

Anatomy41

Organisms16

Diseases1

Chemicals and Drugs97

Analytical, Diagnostic and Therapeutic Techniques and Equipment28

Phenomena and Processes69

Disciplines and Occupations1

Information Science3

Transcript16

Predominant isoform1

Protein19

Cytochrome3

Exon6

20202

Structural4

Receptor10

Lacks3

Transgenic mice1

Tumors3

Substrates1

Roles3

Cardiac1

Human8

Localization1

Distinct3

Quantification1

Remain unclear1

Mice1

Abstract1

Proteins2

Mutations1

Susceptibility2

Deletions1

Variant2

Functional1

19962

20231

Expression6

Skeletal muscle1

Assessment1

201610

Epsilon4

Mammalian2

Genetics2

Abnormal1

Contributes1

Differ1

Interaction1

Humans2

20171

Mechanisms2

Specific8

Promoter3

Describe1

20221

Biomarkers1

Plasma membrane1

Arise1

Neuregulin3