Isoflurane significantly. Medical search. Frequent questions

A request was received from the Department of Surgery at Primary Childrens Hospital (SIC-8070) to investigate exposures in operating rooms and recovery room for nitrous - oxide (10024972), ethrane (13838169), halothane (151677), and isoflurane. (cdc.gov)
All operating rooms exhibited excessive exposures to ethrane, halothane, isoflurane and nitrous - oxide due to a lack of sufficient air changes per hour. (cdc.gov)
The authors conclude that a health hazard existed for overexposure to ethrane, halothane, isoflurane and nitrous - oxide in the operating rooms. (cdc.gov)
We have examined the short-term effects of three volatile anaesthetics, halothane, isoflurane and desflurane, on mucociliary activity in the rabbit maxillary sinus in vivo. (lu.se)
Administration of 1.0 MAC of halothane, isoflurane or desflurane caused a temporary increase in mucociliary activity, with mean peak responses of 47.8 (SEM 13.0)%, 44.0 (9.6)% and 45.1 (23.7)% (n = 6), respectively. (lu.se)
The second peak at 3-5 min was less pronounced for halothane than for isoflurane or desflurane. (lu.se)
THE ED 50 and LD 50 of intravenous isoflurane lipid emulsion (ILE) in mice, 1 the anesthetic and physiologic effects of intravenous halothane lipid emulsion in swine, 2 and the hemodynamics effects of intravenous infusion of halothane lipid emulsion in dogs 3 have been studied. (asahq.org)
Standard general anaesthesia involves volatile anaesthetics (VAs), such as isoflurane (I), sevoflurane (S), and halothane (H) as an alternative to intravenous application. (sciendo.com)
The inhalation anaesthetics, namely sevoflurane (Sevorane ® ), isoflurane (Forane ® ), and halothane (Halothane ® ) were procured from Abbott Laboratories (Queenborough, UK). (sciendo.com)
The kidney effects of halothane, enflurane and isoflurane were evaluated by using the ratio of urinary excretion of alanine aminopeptidase (AAP) to urine creatinine. (hacettepe.edu.tr)
Groups 1, 2 and 3 received halothane, enflurane and isoflurane respectively, Creatinine and AAP activities in urine spot tests, serum creatinine and BUN levels were determined preoperatively and on the first and second postoperative days. (hacettepe.edu.tr)
The present study did not reveal any significant difference in the kidney effects of halothane, enflurane and isoflurane through AAP/creatinine in spot urine values. (hacettepe.edu.tr)

Inhalation anesthesia was then begun using 50% N2O in O2 with end-tidal 1.3% isoflurane. (druglib.com)
Twelve healthy adult mongrel dogs were assigned randomly to an intravenous anesthesia group with 8% ILE or to an inhalation anesthesia group with isoflurane vapor. (asahq.org)
The MAC of intravenous anesthesia with 8% ILE was less than that of inhalation anesthesia with isoflurane vapor in dogs. (asahq.org)

Recovery following intracardiac administration of propofol was significantly longer than recovery following induction of anesthesia with isoflurane in oxygen. (avma.org)
In mice with normal cardiac function, CMR during deep sedation causes significantly less depression of heart rate and ejection fraction than imaging during general anesthesia with isoflurane. (biomedcentral.com)
We report that deep sedation caused no statistically significant depression of heart rate in normal mice, compared to conscious sedation, produced significantly less depression of systolic function, and yielded comparable image quality, compared to general anesthesia with isoflurane. (biomedcentral.com)

Objective -To assess the clinical differences between induction of anesthesia in ball pythons with intracardiac administration of propofol and induction with isoflurane in oxygen and to assess the histologic findings over time in hearts following intracardiac administration of propofol. (avma.org)
Procedures -Anesthesia was induced with intracardiac administration of propofol (10 mg/kg [4.5 mg/lb]) in 18 ball pythons and with 5% isoflurane in oxygen in 12 ball pythons. (avma.org)
Results -Induction time with intracardiac administration of propofol was significantly shorter than induction time with 5% isoflurane in oxygen. (avma.org)
Anesthesia was induced with propofol and maintained with isoflurane. (dvm360.com)
Two different anesthetic protocols were used: inhalation using isoflurane (ISO) and combined-inhalation and epidural (EPI) with propofol being the induction agent. (biomedcentral.com)

To measure the change in the minimum alveolar concentration of isoflurane (EtISO) associated with epidural nalbuphine and the postoperative analgesic requirements in dogs after ovariohysterectomy. (scielo.br)
This study was designed to determine the minimum alveolar concentration (MAC) and the time course of washout of isoflurane for intravenously infused ILE by monitoring end-tidal isoflurane concentration. (asahq.org)

and direct systolic, mean, and diastolic blood pressures were significantly higher during isoflurane anesthesia compared with sevoflurane anesthesia (Table 1). (vin.com)
Sevoflurane anesthesia had fewer side effects overall, suggesting sevoflurane may be preferable to isoflurane, especially in compromised bald eagles. (vin.com)
Comparison of selected significantly different results from isoflurane and sevoflurane anesthesia in bald eagles. (vin.com)
Hereditary and pharmacologic blockade of endogenous orexin signaling does not alter induction of isoflurane or sevoflurane anesthesia axis depicts the portion of mice which have dropped their righting reflex like a function from the log10 of raising concentrations of isoflurane or sevoflurane. (gasyblog.com)

The volatile anesthetic isoflurane differentially inhibits glutamatergic and GABAergic synaptic vesicle (SV) exocytosis by reducing presynaptic Ca 2+ influx without affecting the Ca 2+ -exocytosis relationship, but its effects on dopaminergic exocytosis are unclear. (eneuro.org)
Isoflurane, a widely used volatile anesthetic, inhibits voltage-gated sodium channels and differentially inhibits synaptic vesicle exocytosis depending on neurotransmitter phenotype. (eneuro.org)
These findings provide a synaptic mechanism for the observed role of reduced dopamine release in anesthetic-induced unconsciousness and implicate presynaptic Ca 2+ channels of dopaminergic neurons as important targets of isoflurane. (eneuro.org)
General anesthetic regimens yield satisfactory images, but have the potential to significantly perturb cardiac function. (biomedcentral.com)
The anesthetic dosage [minimal alveolar concentration of which half the mice shed their righting reflex, MACLORR (ED50)] of which half from the orexin/ataxin-3 mice dropped their righting reflex was indistinguishable from wild-type sibling settings for both isoflurane and sevoflurane (Desk 1 and Fig. 2and Desk 1). (gasyblog.com)

Due to reported isoflurane-associated arrhythmias in bald eagles ( Haliaeetus leucocephalus ), 1 other anesthetics may be superior in this species. (vin.com)
Segment growth is attributed to wide adoption of isoflurane owing to its cost-effectiveness in comparison with other anesthetics. (gminsights.com)
There was no significant difference in the duration of surgery and anesthesia, but the consumption of crystalloids, volatile anesthetics, and opioids was significantly lower in the restrictive group, compared with the low and high liberal groups. (dovepress.com)
We examined the effects of the anesthetics isoflurane and pentobarbital, or hypothermia (30 degrees C), on the ability of rabbits to acquire an eyeblink conditioned response after 6.5 min of cerebral ischemia. (silverchair.com)
Volatile anesthetics such as isoflurane modulate synaptic and extrasynaptic neurotransmission through multiple postsynaptic targets, primarily by potentiating inhibitory GABA A receptors and depressing excitatory glutamatergic transmission via ionotropic glutamate receptors ( Rudolph and Antkowiak, 2004 ). (eneuro.org)
As anesthetics can modulate the inflammatory response, the current study evaluated the effect of two different anesthetics, isoflurane and pentobarbital, on splenic cellular and molecular parameters in a VNS rat model. (hal.science)
These differences between the two anesthetics could be related to the anti-inflammatory properties of isoflurane. (hal.science)

Orexin/ataxin-3 mice demonstrated markedly delayed introduction from anesthesia (50% additional time to emerge), for both isoflurane and sevoflurane ( BSF 208075 0.001) (Fig. 3 0.001) (Fig. 3= 6 mice per group). (gasyblog.com)

A comparison of extradural and intravenous methadone on intraoperative isoflurane and postoperative analgesia requirements in dogs. (scielo.br)
2 , 3 Traditional fluid therapy consists of significantly higher doses of intravenous fluids than the clinical losses that occur because of tissue trauma or surgery. (dovepress.com)
As with inhaled isoflurane anesthesia, the primarily eliminative route of isoflurane by intravenous infusion of ILE is also through the lungs. (asahq.org)
Conclusion Intravenous maropitant administration significantly decreases arterial blood pressure during inhalant anesthesia. (iastate.edu)

Isoflurane anesthesia does not activate sleep-promoting dFB neurons. (jneurosci.org)
E , Activity heatmap of the same neurons as in B , under isoflurane anesthesia. (jneurosci.org)
K , Activity heatmap of responses to the UV for the same neurons in H , under isoflurane anesthesia. (jneurosci.org)
L , Average response profile for the same neurons, under isoflurane. (jneurosci.org)
M , Comparison of mean activity levels (left) and the number of UV-responsive neurons (right) during baseline (black) and isoflurane (orange). (jneurosci.org)
Q , Activity heatmap of responses to the air puff for the same neurons in N , under isoflurane. (jneurosci.org)
R , Average response profile (blue) for the same neurons, under isoflurane. (jneurosci.org)
We tested the hypothesis that isoflurane inhibits exocytosis in dopaminergic neurons. (eneuro.org)
Thus, isoflurane inhibits exocytosis from dopaminergic neurons by a mechanism distinct from that in non-dopaminergic neurons involving reduced Ca 2+ entry through Ca V 2.1 and/or Ca V 2.2. (eneuro.org)
Here, we show that in dopaminergic neurons of the ventral tegmental area isoflurane acts via a sodium channel-independent mechanism to inhibit synaptic vesicle exocytosis in proportion to reduced presynaptic Ca 2+ flux mediated by Ca V 2.1 and/or Ca V 2.2, in contrast to its effects in non-dopaminergic neurons. (eneuro.org)
Particular inactivation of orexinergic neurons in wild-type mice by contact with anesthetizing dosages of isoflurane and sevoflurane. (gasyblog.com)

The other echocardiographic methods yielded values significantly different from cardiac MRI and results correlated less well with results of cardiac MRI for EDV, ESV, and EF. (avma.org)

The results obtained in the present study allow for the conclusion that general complex anaesthesia with low isoflurane concentration does not ensure a full stabilisation of both systemic and cerebral circulation in the most important stages of the operation of intracranial aneurysm. (medscimonit.com)
Isoflurane concentration and partial pressure in end-tidal gas, femoral arterial blood, and jugular venous blood were measured simultaneously just before each tail clamping and during washout. (asahq.org)
The higher concentration of isoflurane with the longer time of exposure had a negative effect on the initial newborn vitality as well as the umbilical cord blood gas parameters. (biomedcentral.com)
Therefore, the present study aimed to determine the effect of adding remifentanilinfusion to Isoflurane and reducing the concentration of Isoflurane on the reduction of agitation recovery in children undergoing Adenotonsillectomy.Material and Methods: In a clinical trial study, 86 patients who candidate for Adenotonsillectomy were selected and randomly divided in two groups. (ac.ir)
Isoflurane MAC determination began 45 min after fentanyl administration at each target fentanyl concentration. (uky.edu)
The fentanyl concentrations of 0.72 and 8.43 ng ml -1 did not significantly alter the MAC of isoflurane, but an 18 (7)% ISO-MAC reduction was observed at the 13.31 ng ml -1 concentration. (uky.edu)

Enflurane is a structural isomer of isoflurane. (wikipedia.org)

At the conclusion of CPB, maintenance anesthesia for patients in both groups involved the "balanced" technique of isoflurane and fentanyl. (ispub.com)
In conclusion, pentobarbital is more adapted than isoflurane in the study of the anti-inflammatory effect of VNS on an anesthetized rat model in that it allows more accurate monitoring of subtle immunomodulatory processes. (hal.science)

Following determination of baseline MAC of isoflurane, fentanyl was administered i.v. to target plasma concentrations of 1, 8 and 16 ng ml -1 . (uky.edu)

In animals randomized to the isoflurane and pentobarbital groups, a pattern of burst suppression was achieved on the electroencephalogram before the start of the ischemic episode. (silverchair.com)
However, the use of pentobarbital brought to light immune modifications in non-stimulated animals that were not observed with isoflurane, and also revealed a specific effect of VNS, notably at the level of T lymphocytes' activation. (hal.science)

These differences held whether we induced anesthesia with urethane or isoflurane and whether awake mice were stationary or running on a treadmill. (jneurosci.org)
Whole-body PET/CT imaging of male and female mice were carried out 2 h after [ 18 F]FDG ip administration under 3% isoflurane anesthesia. (omicsdi.org)
Hualpha-Syn (A53T) mice had significantly lower [ 18 F]FDG uptake in several brain regions compared to the no-carrier mice. (omicsdi.org)

Epidural nalbuphine significantly reduces the intra-operative isoflurane requirement and provides prolonged postoperative analgesia after ovariohysterectomy in dogs. (scielo.br)

Rats were then anesthetized with isoflurane, and induction time was quantified as loss of righting reflex. (silverchair.com)

LPS-stimulated TNF-α production could not be inhibited by an α7 nicotinic acetylcholine receptor agonist, whereas inhibition by the β(2) adrenergic agonist, salmeterol, was significantly less (-35%) than that obtained in HCR rats. (duke.edu)

The use of isoflurane displayed a non-specific effect of VNS characterized by a decrease of most splenic lymphocytes sub-populations studied, and also led to a significantly lower TNF-α secretion by splenocytes. (hal.science)

Anesthesia was maintained using a "balanced" technique consisting of isoflurane (MAC range 0.6 to 1.6) and fentanyl (up to 20 mcg/kg). (ispub.com)
We hypothesized that i.v. fentanyl would decrease the MAC of isoflurane in horses in a dose-dependent manner. (uky.edu)
Les critères d'inclusion étaient: être opérée pour césarienne en chirurgie programmée ou en urgence relative, être sous rachianesthésie réalisée avec l'association bupivacaïne, fentanyl et morphine. (bvsalud.org)

Syngeneic rat hepatocytes (1.0 × 107) were transplanted to analbuminemic rats with (ISO group) and without (AW group) isoflurane . (bvsalud.org)
Isoflurane-anesthetized LCR and HCR rats either underwent aseptic trauma involving tibial fracture (surgery) or not (sham). (duke.edu)

Eighty patients with no preexisting renal disease undergoing elective gynecologic surgery were randomly assigned to receive sevoflurane or isoflurane anesthesia with one of four carbon dioxide absorbent products (Sodasorblime®, Sodalyme®, Sodasorb®, Spherasorb®) at the same fresh gas flow of 2 L/min. (ekja.org)

B , Example movement trace from a single fly following exposure to isoflurane. (jneurosci.org)

Comparative study of emergence agitation between isoflurane with isoflurane-remifentanil infusion in. (ac.ir)

This is significantly higher than the metabolism of its structural isomer isoflurane. (wikipedia.org)
for all suture materials, inflammatory response scores were significantly higher than values for the negative control 90 days after implantation. (avma.org)
The serum albumin levels of the ISO group were significantly higher in comparison to the AW group (p (bvsalud.org)
ICa,L displayed significantly higher current amplitudes at 36 degrees C than at 21 degrees C and significantly accelerated time-dependent inactivation. (asahq.org)

Recovery time was significantly longer during isoflurane anesthesia versus sevoflurane. (vin.com)
A significant decrease in respiratory rate over time occurred with both agents, while heart rate significantly decreased with sevoflurane only. (vin.com)
Use of the Teichholz method resulted in LV volume overestimation, whereas the Simpson method of disk and real-time 3-D echocardiography significantly underestimated LV volumes. (avma.org)
No significant difference was found between the two groups in the time course of washout of isoflurane. (asahq.org)

13 patients subjected to the operational treatment of intracranial aneurysm with isoflurane anaesthesia manifested haemodynamic changes in systemic and cerebral circulation. (medscimonit.com)

The serum IL-1 ß, IL-10 , IL-18 , MCP-1, RNTES, Fractalkine and LIX levels were significantly suppressed in the ISO group. (bvsalud.org)
Animals in the isoflurane group had an intermediate number of conditioned responses that was not significantly different from the normothermia group. (silverchair.com)

In the isoflurane and IsoR sessions, heart rate increased significantly after stimulation. (avma.org)

Atropine pretreatment did not affect, whereas CP-99 significantly reduced, the response to desflurane. (lu.se)
Desflurane segment held over USD 255 million revenue in 2018 and is projected to grow significantly by 2025. (gminsights.com)

Populations of pigeon guillemots have declined significantly in Prince William Sound, Alaska, USA, possibly because of residual effects of crude oil in the environment after the Exxon Valdez oil spill in March 1989. (usgs.gov)

Decreasing pontine reticular formation GABA levels comprises one mechanism by which isoflurane causes loss of consciousness, altered cortical excitability, muscular hypotonia, and decreased respiratory rate. (silverchair.com)

G , The effect of isoflurane (orange) on activity level (number of frames spent active, left), activity number (% cells active, middle), and behavioral responsiveness as measure by responses to an air puff stimulus (right). (jneurosci.org)

Postintubation Rrs was significantly lower in the fenoterol-treated patients than in the placebo-treated patients. (druglib.com)
Patients premedicated with acepromazine prior to isoflurane anesthesia may develop clinically significant hypotension. (iastate.edu)

Significantly L-glutamine supplementation mitigates alcohol-induced acid-base imbalances and modifications in fetal local brain blood circulation. (exposed-skin-care.net)

These levels would be significantly lower if adequate ventilation was provided. (cdc.gov)

Results -The isoflurane session had the overall lowest prestimulation SDNN (SD of all R-R intervals) values. (avma.org)
We hypothesized that isoflurane may be a possible reason for the discrepancy between the results of animal experiments and the clinical outcomes of HTx. (bvsalud.org)

Isoflurane anesthesia does not add to the bronchodilating effect of a beta 2-adrenergic agonist after tracheal intubation. (druglib.com)
This double-blind study investigates whether isoflurane/N2O anesthesia adds to the bronchodilating effect of the beta 2-adrenergic agonist, fenoterol, after an endotracheal tube (ETT)-induced increase in airway resistance. (druglib.com)
However, isoflurane, while a potent bronchodilator, does not add to the effect of fenoterol. (druglib.com)
The effect of isoflurane on whole-brain neural activity and responsiveness. (jneurosci.org)

Prestimulation SDNN values decreased significantly with increasing MAC in all sessions. (avma.org)
In the IsoD session, poststimulation SDNN was increased significantly, compared with prestimulation values, at 0.75 and 1.0 MAC. (avma.org)

Relative to wakefulness, GABA levels were significantly decreased by isoflurane. (silverchair.com)
Increased power in the electroencephalogram and decreased activity in the electromyogram caused by isoflurane covaried with pontine reticular formation GABA levels. (silverchair.com)

Sevoflurane and isoflurane were compared in 17 captive bald eagles in a crossover study. (vin.com)

Anatomy1

Organisms2

Chemicals and Drugs18

Analytical, Diagnostic and Therapeutic Techniques and Equipment7

Phenomena and Processes4

Health Care1

Halothane12

Inhalation anesthesia3

Anesthesia with isoflurane3

Propofol5

Minimum alveolar conc2

Sevoflurane anesthesia4

Anesthetic5

Anesthetics7

0.0011

Intravenous4

Neurons11

Echocardiographic methods1

Concentration6

Enflurane1

CONCLUSION2

Concentrations1

Pentobarbital2

Mice3

Epidural1

Induction time1

Inhibition1

Secretion1

Fentanyl3

Rats2

Randomly assigned1

Exposure1

Remifentanil1

Higher4

Time4

Cerebral1

Group2

Stimulation1

Desflurane2

Effects1

Mechanism1

Responses1

Patients2

Acid1

Lower1

Results2

Effect4

Values2

Levels2

Study1