• Responses in the presence of the combination of phorbol-12-myrisate-13-acetate and volatile anesthetics (isoflurane, halothane, or sevoflurane) were not greater than those when volatile anesthetic was present alone. (silverchair.com)
  • The National Halothane Study, a retrospective analysis, reviewed the incidence and mortality rates of postoperative hepatic necrosis from 1959-1962. (medscape.com)
  • We evaluated various dimensions of this replacement through a literature review to assess the incidence of halothane-induced hepatitis and costs of anaesthetics in the country. (who.int)
  • The results indicate that the incidence of halothane hepatitis in the Islamic Republic of Iran is very low and could mostly be avoided by strict adherence to guidelines. (who.int)
  • The high incidence of severe liver damage on repeated exposure to halothane has limited its use. (johogo.com)
  • Halothane Vaporizers require a five year service. (dremed.com)
  • Most vaporizers used today in veterinary practices are used with either Isoflurane or Sevoflurane. (dispomed.com)
  • L-Glutamate-induced responses were increased gradually with the increased concentrations of isoflurane, a volatile anesthetic. (silverchair.com)
  • Sevoflurane, a potent inhalation agent, was successful in a single case report in which it was used when conventional treatment failed in a woman aged 26 years. (medscape.com)
  • Standard general anaesthesia involves volatile anaesthetics (VAs), such as isoflurane (I), sevoflurane (S), and halothane (H) as an alternative to intravenous application. (sciendo.com)
  • 05). Exposure to 1 and 2 MAC isoflurane was similarly effective, whereas basal adhesion was not significantly influenced. (silverchair.com)
  • Type I (mild) halothane hepatotoxicity occurs within hours of halothane exposure. (medscape.com)
  • Type II (fulminant) halothane hepatotoxicity usually occurs 5-7 days following exposure, although it can be delayed by up to 4 weeks. (medscape.com)
  • This occupational exposure limit was recommended by NIOSH for the type of anesthetic gas to which isoflurane and sevoflurane belong, but before they effectively came into use. (cdc.gov)
  • In rare cases, cirrhosis may develop following halothane hepatitis. (medscape.com)
  • However, the findings in halothane hepatitis are indistinguishable from those of fulminant viral hepatitis . (medscape.com)
  • Because halothane hepatitis is a diagnosis of exclusion, ruling out other causes is essential. (medscape.com)
  • Anaesthesia has been influential in dif- Iran in 2006 when a number of experts thane-induced hepatitis, some profes- ferent fields of medical practice, espe- claimed that halothane should be sionals have insisted on the necessity cially in surgical procedures and efforts considered a major health threat [10]. (who.int)
  • Based on this study, the risk of fatal halothane hepatotoxicity was estimated to be 1 in 35,000. (medscape.com)
  • Halothane hepatotoxicity is more likely to occur in lower resource settings where halothane continues to be used. (medscape.com)
  • Halothane hepatotoxicity is a diagnosis of exclusion. (medscape.com)
  • Physical findings in type II halothane hepatotoxicity include delayed pyrexia (up to 75% of patients). (medscape.com)
  • Eosinophilia occurs in 8-32% of patients with type II halothane hepatotoxicity. (medscape.com)
  • Serum autoantibodies may be present in 30-44% of patients with type II halothane hepatotoxicity. (medscape.com)
  • No specific therapy is available for either fulminant hepatic necrosis or mild hepatotoxicity due to halothane. (medscape.com)
  • Two major types of hepatotoxicity are associated with halothane administration. (medscape.com)
  • Halothane is too soluble and poses a risk of severe hepatotoxicity. (nih.gov)
  • of complete replacement of halothane have been ongoing over the years to Consequently, under supervision of with other inhalation agents such as find the most suitable anaesthetic agent. (who.int)
  • Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required. (curehunter.com)
  • Halothane, isoflurane, and sevoflurane, each at 1 and 2 minimal alveolar concentration (MAC), were vaporized in the gas mixture and applied from 14 min before ischemia until the end of the experiment. (silverchair.com)
  • 05) and an identical reduction resulted when sevoflurane (1 MAC) was applied only with the onset of reperfusion. (silverchair.com)
  • The Committee on the Safety of Medicines (now the Commission on Human Medicines) recommends that repeated use of halothane should be avoided. (johogo.com)
  • We investigated the effects of halothane, isoflurane, and sevoflurane on postischemic adhesion of human PMNs in the intact coronary system of isolated perfused guinea pig hearts. (silverchair.com)
  • Comprehensive cost-effectiveness studies are needed before a decision is made on complete replacement of halothane with other anaesthetics. (who.int)