• The crystal structures of mitochondrial aconitase with isocitrate and nitroisocitrate bound have been solved and refined to R factors of 0.179 and 0.161, respectively, for all observed data in the range 8.0-2.1 A. Porcine heart enzyme was used for determining the structure with isocitrate bound. (proteopedia.org)
  • The enzyme aconitase catalyzes both steps, since the intermediate is cis -aconitate. (encyclopedia.com)
  • The inhibitor binds to the enzyme in a manner virtually identical to that of isocitrate. (proteopedia.org)
  • Catalyzes the isomerization of citrate to isocitrate via cis-aconitate (By similarity). (smpdb.ca)
  • Catalyzes the isomerization of citrate to isocitrate via cis-aconitate. (nih.gov)
  • An enzyme that catalyzes the reversible hydration of cis-aconitate to yield citrate or isocitrate. (bvsalud.org)
  • It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. (nih.gov)
  • Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. (nih.gov)