Isocarboxazid (Marplan, Marplon, Enerzer) is a non-selective, irreversible monoamine oxidase inhibitor (MAOI) of the hydrazine class used as an antidepressant. (wikipedia.org)
Phenelzine4
For instance, the MAOIs-chiefly isocarboxazid, phenelzine, and tranylcypromine-in general are used only after treatment with tricyclic drugs has proved unsatisfactory, because these drugs' side effects are unpredictable and their complex interactions are incompletely understood. (britannica.com)
The pharmacokinetic profile of isocarboxazid have not been fully studied but it is suggested that its properties should be fairly similar to the ones of some analogs like phenelzine and tranylcypromine. (drugbank.com)
Examples of MAOIs include phenelzine, isocarboxazid, etc. (medicinenet.com)
This includes isocarboxazid, phenelzine, or tranylcypromine. (mskcc.org)
MAOIs1
Classical MAOIs, including isocarboxazid, are used only rarely due to prominent food and drug interactions and have been largely superseded by newer antidepressants such as the selective serotonin reuptake inhibitors (SSRIs). (wikipedia.org)
Monoamine oxidase i3
Isocarboxazid is a monoamine oxidase inhibitor used to treat enduring and debilitating symptoms of depression following inadequate clinical response to other antidepressant drugs. (drugbank.com)
The isocarboxazid half-life is of little interest as it is an irreversible monoamine oxidase inhibitor. (drugbank.com)
Isocarboxazid is an antidepressant (monoamine oxidase inhibitor). (webmd.com)
Inhibitors1
The increase of one or more monoamines is the basis for the antidepressant activity of MAO inhibitors like isocarboxazid. (drugbank.com)
Epinephrine1
The reduced MAO activity, caused by isocarboxazid, results in an increased concentration of serotonin, epinephrine, norepinephrine, and dopamine in storage sites throughout the central nervous system (CNS) and sympathetic nervous system. (drugbank.com)
Antidepressant drugs1
Isocarboxazid is indicated for the treatment of the enduring and debilitating symptoms of depression that have not responded to other antidepressant drugs. (drugbank.com)
Vitro2
In vivo and in vitro studies demonstrated isocarboxazid-driven inhibition of MAO in the brain, heart, and liver. (drugbank.com)
Moroi K, Sato T. Comparison between procaine and isocarboxazid metabolism in vitro by a liver microsomal amidase-esterase. (medscape.com)
Pharmacist1
Read the Medication Guide provided by your pharmacist before you start using isocarboxazid and each time you get a refill. (webmd.com)
Depression1
Isocarboxazid was more effective than placebo in major, but not in minor, depression. (biopsychiatry.com)
Mood2
Isocarboxazid is primarily used to treat mood and anxiety disorders. (wikipedia.org)
Isocarboxazid can improve your mood and feelings of well-being. (webmd.com)
Effect1
Using the word 'isocarboxazid' in Scrabble will fetch you 34 points while using it in Words with Friends will fetch you 36 points (without taking into consideration the effect of any multipliers). (wordgamehelper.com)
High1
Withdrawal is more likely if you have used isocarboxazid for a long time or in high doses. (webmd.com)
A small number of children, teenagers, and young adults (up to 24 years of age) who took antidepressants ('mood elevators') such as isocarboxazid during clinical studies became suicidal (thinking about harming or killing oneself or planning or trying to do so). (medlineplus.gov)
You should know that your mental health may change in unexpected ways when you take isocarboxazid or other antidepressants even if you are an adult over 24 years of age. (medlineplus.gov)
Isocarboxazid is used to treat depression in people who have not been helped by other antidepressants. (medlineplus.gov)
Dose of isocarboxazid2
Your doctor will probably start you on a low dose of isocarboxazid and gradually increase your dose, not more often than once every 2 to 4 days at first, and then not more often than once every week. (medlineplus.gov)
The usual initial adult dose of isocarboxazid is 10 mg twice daily, with increase in the dose based upon efficacy and tolerance to a maximum of 60 mg per day. (nih.gov)
Inhibitor5
Isocarboxazid is a non-selective hydrazine monoamine oxidase (MAO) inhibitor. (nih.gov)
Isocarboxazid is an antidepressant (monoamine oxidase inhibitor). (webmd.com)
Isocarboxazid is a monoamine oxidase inhibitor (MAO inhibitor) used in therapy of severe depression. (nih.gov)
The serum aminotransferase elevations that occur on isocarboxazid and on other MAO inhibitor therapy are usually self-limited and do not require dose modification or discontinuation of therapy. (nih.gov)
Uptake was not blocked by pretreatment with the monoamine oxidase inhibitor isocarboxazid. (snmjournals.org)
Serotonin4
Isocarboxazid (eye" soe kar box' a zid) is a hydrazine antidepressant that acts through inhibition of monoamine oxidase, an enzyme that inactivates several neurotransmitter amines such as norepinephrine and serotonin. (nih.gov)
By inhibition of catabolism of serotonin and norepinephrine, isocarboxazid increases brain levels of these neurotransmitters which probably underlie its antidepressant effects. (nih.gov)
isocarboxazid and amitriptyline both increase serotonin levels. (medscape.com)
isocarboxazid and desvenlafaxine both increase serotonin levels. (medscape.com)
Tablet2
Isocarboxazid comes as a tablet to take by mouth. (medlineplus.gov)
Isocarboxazid interacts with many medications as well as many foods and beverages, and patients require careful monitoring and education. (nih.gov)
Tell your doctor or pharmacist that you recently stopped taking isocarboxazid before you start taking any new medications. (rxwiki.com)
Increases effects1
isocarboxazid increases effects of armodafinil by pharmacodynamic synergism. (medscape.com)
Severe2
Stop taking isocarboxazid and get medical help right away if any of these serious side effects occur: frequent/severe headache , fast/slow/irregular/pounding heartbeat, chest pain , neck stiffness/soreness, severe nausea/vomiting, sweating /clammy skin (sometimes with fever), widened pupils, sudden sensitivity to light ( photophobia ). (webmd.com)
Prior to taking this drug, tell your doctor if you are allergic to Isocarboxazid, or if you have a history of severe or frequent headaches or a history of stroke or blood clots, heart disease or high blood pressure, liver or kidney disease, and pheochromocytoma. (canadianpharmacyking.com)
Mechanism2
The mechanism by which isocarboxazid causes serum aminotransferase elevation is not known. (nih.gov)
carbamazepine increases toxicity of isocarboxazid by unknown mechanism. (medscape.com)
Substance1
Isocarboxazid is a colorless, crystalline substance with very little taste. (nih.gov)
Acute1
Isocarboxazid therapy is associated with rare instances of clinically apparent acute liver injury. (nih.gov)
Liver1
Isocarboxazid has not been directly implicated in cases of drug-induced liver injury but it has had limited clinical use. (nih.gov)
Withdrawal1
Withdrawal is more likely if you have used isocarboxazid for a long time or in high doses. (webmd.com)
Effects2
isocarboxazid and bupropion both increase dopaminergic effects. (medscape.com)
This is not a complete list of isocarboxazid side effects. (rxwiki.com)
Treat1
Children younger than 18 years of age should not normally take isocarboxazid, but in some cases, a doctor may decide that isocarboxazid is the best medication to treat a child's condition. (medlineplus.gov)
Treatment1
Your healthcare provider will want to see you often while you are taking isocarboxazid, especially at the beginning of your treatment. (medlineplus.gov)