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AutoantibodiesInsulin AntibodiesIslets of LangerhansGlutamate DecarboxylaseDiabetes Mellitus, Type 1Receptor-Like Protein Tyrosine Phosphatases, Class 8AutoimmunityC-PeptideHLA AntigensHLA-DR3 AntigenHLA-DR AntigensAntigensHLA-DR4 AntigenIslets of Langerhans TransplantationHLA-DR Serological SubtypesHLA-DQ AntigensAntigens, BacterialGenotypeHLA-DR2 AntigenAntigens, NeoplasmAutoantigensAntigens, SurfaceAntigens, ViralAntibodies, AntinuclearEpitopesImmunoglobulin GHistocompatibility Antigens Class IIAutoimmune DiseasesHLA-DR7 AntigenHistocompatibility TestingAntibody SpecificityLupus Erythematosus, SystemicEnzyme-Linked Immunosorbent AssayHLA-DRB1 ChainsKeratoconjunctivitis SiccaHLA-DR1 AntigenGold Sodium ThiomalateAntibodies, MonoclonalGenes, MHC Class IIAntigens, ProtozoanIslet Amyloid PolypeptideMolecular Sequence DataAntigens, CDAntigens, Polyomavirus TransformingAmino Acid SequenceAllelesArthritis, RheumatoidH-2 AntigensAntigens, FungalHLA-A AntigensHLA-B AntigensT-LymphocytesPemphigusCross ReactionsB-LymphocytesInsulinAntigens, HelminthEpitopes, T-LymphocyteCD4-Positive T-LymphocytesImmunoglobulin MHistocompatibility Antigens Class IMice, Inbred BALB CInsulin-Secreting CellsFluorescent Antibody TechniqueCarcinoembryonic AntigenAntigen-Antibody ReactionsReceptors, Antigen, T-CellHLA-D AntigensHistocompatibility AntigensAntigens, Viral, TumorMice, Inbred C57BLHaplotypesHLA-A2 AntigenHLA-DQ beta-ChainsReceptors, Antigen, B-CellLymphocyte ActivationProliferating Cell Nuclear AntigenAntibody FormationAntigen-Antibody ComplexGenetic Predisposition to DiseaseCells, CulturedMice, Inbred NZBPemphigoid, BullousCell LineSjogren's SyndromeRheumatoid FactorScleroderma, SystemicDesmoglein 3Dipeptidyl Peptidase 4Antigens, CD8Epitope MappingProstate-Specific AntigenO AntigensAntigens, CD15Binding Sites, AntibodyGlucoseLupus VulgarisImmunizationAntigens, CD3Mice, Inbred Strains
DiabetesCellType
Diabetes4
  • With DR3 this DQ2 has the second strongest linkage to Type 1 diabetes, and when paired with HLA-DQ8 is the most abundant phenotype found in late onset, "Type1-Type2" diabetes mellitus type 1. (wikipedia.org)
  • The haplotype is positively associated with coeliac disease, dermatitis herpetiformis, juvenile diabetes, Lambert-Eaton myasthenic syndrome (LEMS), Sjögren syndrome, and autoimmune hepatitis (although significant proportion of the risk is secondary to coeliac disease). (wikipedia.org)
  • Type 1 diabetes is a chronic illness characterized by the body's inability to produce insulin due to the autoimmune destruction of the beta cells in the pancreas. (medscape.com)
  • [ 2 ] However, in patients at high risk (eg, those who have first-degree relatives with type 1 diabetes), it may be appropriate to perform annual screening for anti-islet antibodies before the age of 10 years, along with 1 additional screening during adolescence. (medscape.com)
Cell1
  • DQ2.5 isoform or heterodimer is shorthand for the cell surface receptor HLA-DQ α5β2. (wikipedia.org)
Type1
  • Transplantation of pancreatic islet cells into patients with type 1 DM, as a means of enabling these individuals to produce their own insulin, has been under investigation. (medscape.com)