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  • hypoxia
  • Natural formation of oxidants during mitochondrial electron transport, auto-oxidation of some neurotransmitters (e.g. norepinephrine, dopamine) and initiation of events during hypoxia or ischemia, can result in oxidant formation and subsequent tissue damage. (biologists.org)
  • The uptake of misonidazole in regions of tissue hypoxia prompted the development of [ 18 F]fluoromisonidazole to image hypoxic tissue. (ahajournals.org)
  • kidney
  • This study investigates the contribution of the acute phase proteins α 1 -acid glycoprotein (AGP) and α 1 -antitrypsin (AAT) to the protective effect of ischemic preconditioning in the kidney. (ahajournals.org)
  • Various pathophysiological states and medications can contribute to reduction of RBF, causing generalized or localized ischemia to the kidney leading to AKI. (jci.org)
  • This figure represents a partial list and points to ischemia as being a common pathway in a variety of clinical states affecting the kidney. (jci.org)
  • subsequent
  • We hypothesized that this change of conductivity would account for local epicardial ST depression during a subsequent ischemia. (egms.de)
  • Our results show that, if lateralized connexins form sufficient gap junctions, this would influence ST deviation during a subsequent ischemia. (egms.de)
  • There is mounting evidence that reperfusion triggers 'early' components such as release of stored factors (like P-selectin and cytokines), and subsequent 'late' components are more likely to be mediated by changes in de novo protein synthesis and expression. (ahajournals.org)
  • necrosis
  • Nonetheless, it is generally found that the ischemic heart from the mildly diabetic animal resists the accumulation of calcium, a major cause of necrosis. (ahajournals.org)
  • Differential gene expression analysis showed myocardial ischemia plus reperfusion increased expression of proinflammatory genes like P-selectin, E-selectin, intercellular adhesion molecule, tumor necrosis factor-α, tumor necrosis factor-α receptor, interleukin-6, monocyte chemoattractant protein-1, p53, and Fas (CD59). (ahajournals.org)
  • Finally, differential protein expression analysis demonstrated increased intercellular adhesion molecule-1, tumor necrosis factor-α, and p53 after myocardial ischemia plus reperfusion, and this effect was diminished by aprotinin. (ahajournals.org)
  • diabetes
  • Ischemic stroke (particularly atherothrombotic cerebral infarction) and coronary artery disease are atherosclerotic diseases that share various aspects of their underlying pathogenesis, as well as several risk factors, including hypertension, dyslipidemia, diabetes mellitus and smoking. (spandidos-publications.com)
  • accumulation
  • There is mismatch of local tissue oxygen supply and demand and accumulation of waste products of metabolism. (jci.org)
  • coronary artery
  • A major complication of coronary artery disease is sudden death caused by spontaneous VF secondary to acute ischemia. (ahajournals.org)
  • In contrast, administration of HMGB1 after myocardial infarction induced by permanent coronary artery ligation ameliorates cardiac performance by promoting tissue regeneration. (springer.com)
  • Recent genome-wide association studies (GWASs) and their meta-analyses have identified various genes and loci underlying the predisposition to ischemic stroke or coronary artery disease in Caucasian populations. (spandidos-publications.com)
  • Given that ischemic stroke and coronary artery disease may have a shared genetic architecture, certain polymorphisms may confer genetic susceptibility to these two diseases. (spandidos-publications.com)
  • The aim of the present study was to examine the possible association of ischemic stroke with 29 single‑nucleotide polymorphisms (SNPs) previously identified by the meta‑analyses of GWASs as susceptibility loci for coronary artery disease. (spandidos-publications.com)
  • Twin and family studies have demonstrated that ischemic stroke and coronary artery disease are highly heritable ( 6 , 7 ) with evidence of a shared heritability for the two conditions ( 8 ). (spandidos-publications.com)
  • Among these genes and loci, some of the genetic variants that were originally detected to affect a risk of coronary artery disease were also associated with ischemic stroke ( 16 - 18 ), suggesting a shared genetic architecture. (spandidos-publications.com)
  • Although ischemic stroke and coronary artery disease have been suggested to have a shared genetic architecture in Caucasian populations, the genes that confer susceptibility to the two conditions in Japanese individuals have not been identified definitively. (spandidos-publications.com)
  • lung tissue
  • Traditionally it has been believed that RPE was due to the generation of excessively low intra-pleural pressures pulling fluid into the lung tissue (based on Starling's equation ). (emcrit.org)
  • skeletal
  • At the end of the study, skeletal muscle tissue was obtained for the determination of total oxidant status (TOS) and total antioxidant status (TAS) levels. (dovepress.com)
  • stimulus
  • Patients will be randomized to RIPC (exposed to cycles of inflation of a blood pressure cuff on the upper arm prior to undergoing surgery) or control (no ischemic stimulus). (clinicaltrials.gov)
  • shock
  • In the S/C and S/C + EP groups, hemorrhagic shock, lower torso ischemia, and reperfusion were created, S/C group was given 1 mL saline and S/C + EP group was given 40 mg/kg EP. (hindawi.com)