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  • cerebral ischemia
  • In patients having silent cerebral ischemia the incidence of ischemic infarction is ten times greater than in the normal population. (ebscohost.com)
  • The effect of dialysis treatment and chronic renal failure disease on the development of cerebral ischemia and infarct has not been explained, In this study we analyzed the prevalence of silent cerebral ischemia and infarct in the cronic renal failure patients having hemodialysis and peritoneal dialysis treatment, using magnetic resonance imaging. (ebscohost.com)
  • Results: Although the case and control groups having similar demographical properties and risk factors, the prevalence of silent cerebral ischemia and infarct is determined as significantly increased in the chronic renal failure patient group. (ebscohost.com)
  • Conclusion: It is determined by MR that chronic renal failure has significant effects on developing cerebral ischemia and infarct. (ebscohost.com)
  • Investigates the diagnosis of cerebral ischemia and hemorrhage in acute stroke patients. (ebscohost.com)
  • Testing of potential biomarkers of cerebral ischemia and vasospasm in patients with cerebral aneurysm surgery. (ebscohost.com)
  • The objective of this study was to determine whether MR spectra of ischemic brains might allow the precise estimation of cerebral ischemia onset time. (epfl.ch)
  • cardiac
  • A pacing system delivers cardiac protection pacing to protect the heart from injuries associated with ischemic events. (google.com)
  • The pacing system detects an ischemic event and, in response, initiates one or more cardiac protection pacing sequences each including alternative pacing and non-pacing periods. (google.com)
  • 7. The system of claim 6 , wherein the cardiac protection pacing sequence initiator is adapted to initiate the one or more cardiac protection pacing sequences in response to the detection of the onset of the ischemic event and one or more commands, and wherein the external system further comprises a user input device adapted to receive the one or more commands. (google.com)
  • Complex I and complex III of the electron transport chain are considered the primary sources of ROS emission during cardiac ischemia and reperfusion (IR) injury. (frontiersin.org)
  • The apparatus facilitates the determination of the existence of various conditions based on these analyses which portend cardiac complications including myocardial ischemia, and arrhythemia activity and further instructs the patient on the manner of treatment required for the detected condition. (google.com)
  • Further understanding of I/R tolerance rhythms will potentially provide novel insight regarding the etiology and treatment of ischemia-induced cardiac dysfunction. (ahajournals.org)
  • Carmeliet E. Cardiac ionic currents and acute ischemia: From channels to arrhythmias. (springer.com)
  • 3 . The system of claim 1 , wherein the cardiac protection pacing sequence initiator comprises a postconditioning sequence initiator adapted to initiate at least one postconditioning sequence in response to the detection of the ischemic event, the postconditioning sequence being one of the one or more cardiac protection pacing sequences. (google.com)
  • detector
  • an implantable medical device including at least the ischemia detector, the pulse output circuit, and the control circuit. (google.com)
  • 4 . The system of claim 3 , wherein the postconditioning sequence initiator is adapted to initiate the at least one postconditioning sequence after an end of the ischemic event is detected by the ischemia detector. (google.com)
  • 5 . The system of claim 4 , wherein the postconditioning sequence initiator is adapted to initiate the at least one postconditioning pacing sequence when a post-ischemia time interval expires, the post-ischemia time interval starting when the end of the ischemic event is detected by the ischemia detector. (google.com)
  • mechanism
  • This will help the investigators to understand the mechanism by which ischaemia-reperfusion injury may occur and to devise new treatments for heart attacks. (clinicaltrials.gov)
  • 5 This mechanism allows the cell to anticipate alterations in environmental stimuli, through time-of-day-dependent modulation of cellular responsiveness to extrinsic factors. (ahajournals.org)
  • Given that the cardiomyocyte circadian clock influences myocardial physiology, 1,11 and that this mechanism becomes rapidly inactivated following an ischemic event, 12 we hypothesized that the cardiomyocyte circadian clock modulates I/R tolerance in a time-of-day-dependent manner. (ahajournals.org)
  • mice
  • Genetic ablation of the cardiomyocyte circadian clock (termed cardiomyocyte-specific circadian clock mutant [CCM] mice) attenuated/abolished time-of-day variations in I/R outcomes observed in wild-type hearts. (ahajournals.org)
  • Wild-type (WT) and CCM mice were housed under controlled conditions in a 12-hour light/12-hour dark cycle (lights on at zeitgeber time [ZT]0, lights off at ZT12). (ahajournals.org)
  • Following an artificially induced case of ischemia, these mice experienced considerably less tissue damage and necrosis, and had far fewer sites of inflammation than control animals. (eurekalert.org)
  • causes
  • Working with their colleagues from the MDC, the Charit√©, FMP in Berlin and Hannover Medical School, Dr Lajos Mark√≥ and Emilia Vigolo have traced one of the causes of ischemia-related renal failure to a signaling molecule called NF-kappaB and a specific type of tissue: tubular epithelial cells. (eurekalert.org)
  • thus, choroidal ischemia causes predominant change in the corresponding tissue. (springer.com)
  • injury
  • However in restoring the supply of blood local damage known as 'ischaemia-reperfusion injury' may occur. (clinicaltrials.gov)
  • The objective of this study was to determine whether AKI leads to premature, stress-induced senescence, as well as whether human umbilical cord-derived MSCs (huMSCs) can prevent ischaemia/reperfusion injury (IRI)-induced renal senescence in rats. (biomedcentral.com)
  • Porcine laparotomies, as part of an animal protocol approved by National Institutes of Health, National Cancer Institute, the Institutional Animal Care and Use Committee, were used to assess the extent of ischemic injury (i.e., decreased tissue oxygenation) incurred during surgery. (spiedigitallibrary.org)
  • Curcumin [diferuloylmethane, 1,7-bis(4-hydroxy-3-methoxiphenyl)-1,6-heptadiene-3,5-dione)] is a polyphenol compound derived from Curcuma longa (turmeric) and was shown to have a renoprotective effect on ischemia-reperfusion injury (IRI) in a previous study. (frontiersin.org)
  • Such clinical studies have clearly pushed the boundary of our understanding about reperfusion injury and therapeutic time window. (springer.com)
  • molecular
  • Dr. Tischkau is a broadly trained neuroendocrinologist, with specific expertise in the design and conduct of studies that examine the function of the circadian timing system at the molecular, physiological and behavioral levels. (siumed.edu)
  • In the study, to investigate the molecular mechanisms of curcumin effects in kidney ischemia/reperfusion model, we observed the effect of curcumin in experimental models of IR-induced AKI and we found that curcumin treatment significantly increased the expression of APPL1 and inhibited the activation of Akt after IR treatment in the kidney. (frontiersin.org)
  • We found that brief antecedent ischemia: i) attenuates molecular indices of platelet activation-aggregation (i.e. (ahajournals.org)
  • Rodrigo R, Prieto JC, Castillo R. Cardioprotection against ischaemia/reperfusion by vitamins C and E plus n-3 fatty acids: molecular mechanisms and potential clinical applications. (springer.com)
  • wherein
  • 7. The method of claim 6 wherein said waveform is selected from the group steady, square, triangle, sine, step-function, and custom time dependence. (patents.com)
  • anterior
  • Always had abnormal ECG due to inverted Twaves last ECG said ST & Twave abnormality, consider Anterior ischemia cant rule out inferior infarct. (healthtap.com)
  • decrease
  • Several factors modulate ischemic ROS emission, such as an increase in extra-matrix Ca 2+ , a decrease in extra-matrix pH, and a change in substrate utilization. (frontiersin.org)
  • Circadian
  • Her lab has focused on understanding systemic control of circadian rhythms, with particular emphasis on regulation of the master clock in the suprachiasmatic nucleus, its relationship to environmental signals and mechanisms by which circadian timing is conveyed throughout organisms. (siumed.edu)
  • An understanding of how light affects the master clock allowed the development of environmental paradigms that mimic clock disturbances in real-life scenarios to disrupt the systemic circadian timing system. (siumed.edu)
  • We expose a profound time-of-day dependence for I/R tolerance, which is mediated by the cardiomyocyte circadian clock. (ahajournals.org)
  • significantly
  • Following 1 month of reperfusion, prior ischemic event at ZT12 versus ZT0 resulted in significantly greater infarct volume, fibrosis, and adverse remodeling, as well as greater depression of contractile function. (ahajournals.org)
  • diagnostic
  • Presents a correction to a previous article on the diagnostic imaging of ischemic Foix-Chavany-Marie Syndrome in Volume 249, 2002 issue. (ebscohost.com)
  • therapeutic
  • The effects of therapeutic or preventive-therapeutic administration of water-soluble echinochrome analog U-441 on arrhythmia severity assessed by a set of myocardial spatio-temporal depolarization and repolarization parameters were examined on the model of acute myocardial ischemia in cats. (springer.com)
  • reduction
  • Various pathophysiological states and medications can contribute to reduction of RBF, causing generalized or localized ischemia to the kidney leading to AKI. (jci.org)
  • event
  • Abstracts and presentations are embargoed for release at date and time of presentation or time of AHA/ASA news event. (ahajournals.org)
  • heart
  • Ischemia means an area of the heart is not getting enough blood usually because of a blockage in an artery . (healthtap.com)
  • effects
  • Ischaemia/reperfusion stimulates the antioxidant enzyme heme oxygenase-1 (HO-1), responsible for raising the level of manganese superoxide dismutase (MnSOD), a major antioxidant that scavenges superoxide radicals generated within the mitochondria, thereby countering the effects of ROS. (biomedcentral.com)