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Progenitor cellsIschemiaResulting from acuteRegenerationAbstractHeart diseaseCurrentHumanHeart
Progenitor cells1
  • There is a growing body of evidence which demonstrates that following ACS, microRNAs might inhibit fibroblast proliferation and scarring, as well as harmful apoptosis of cardiomyocytes, and stimulate fibroblast reprogramming into induced cardiac progenitor cells. (archivesofmedicalscience.com)
Ischemia4
  • Progenitor cell therapy is being investigated for the treatment of damaged myocardium resulting from acute or chronic cardiac ischemia and for refractory angina. (southcarolinablues.com)
  • For individuals who have acute cardiac ischemia who receive progenitor cell therapy, the evidence includes 2 randomized controlled trials (RCTs) with 200 patients, numerous small RCTs, and meta-analyses of these RCTs. (southcarolinablues.com)
  • For individuals who have chronic cardiac ischemia who receive progenitor cell therapy, the evidence includes a nonrandomized comparative trial and systematic reviews of smaller RCTs. (southcarolinablues.com)
  • In this review, we focus on the role of cardiomyocyte-derived and cardiac fibroblast-derived microRNAs that are involved in the regulation of genes associated with cardiomyocyte and fibroblast function and in atherosclerosis-related cardiac ischemia. (archivesofmedicalscience.com)
Resulting from acute1
  • Atherosclerotic plaque rupture is the leading cause of cardiovascular death resulting from acute coronary syndrome (ACS) and leads to cardiac remodeling and fibrosis following ACS. (archivesofmedicalscience.com)
Regeneration1
  • Progenitor cell therapy describes the use of multipotent cells of various cell lineages (autologous or allogeneic) for tissue repair and/or regeneration. (southcarolinablues.com)
Abstract1
  • These minutes have: nonrefractory perfusion Sphenoid, transient weakening injury and congestive ventilatory care number, mucous Abstract, and cardiac neuropathy depression. (augenta.net)
Heart disease2
  • Despite impressive advances in treatment, ischemic heart disease is still associated with high morbidity and mortality. (southcarolinablues.com)
  • Current treatments for ischemic heart disease seek to revascularize occluded arteries, optimize pump function, and prevent future myocardial damage. (southcarolinablues.com)
Current1
  • and salvage cells, driving biologic patients, Current cardiac functional transplantation, determinants with dual subgroups, ventricular ST, Adrenergic activity for identified available nervous and expanded events, compromised genes, and ischemic inhibitors with CHF. (augenta.net)
Human1
  • Ischemic heart disease is a leading cause of human deaths worldwide. (thno.org)
Heart3
  • Acute and chronic ischemic injury leads to a permanent loss of cardiac tissue and ultimately heart failure. (thno.org)
  • Recently, cell-based therapy has emerged as a novel potential approach for regenerating heart tissue. (thno.org)
  • Several cell types have been shown to improve heart functional recovery after ischemic injury. (thno.org)